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Gene: Kcna6 (potassium voltage-gated channel subfamily A member 6) Rattus norvegicus

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Symbol:

Kcna6

Name:

potassium voltage-gated channel subfamily A member 6

RGD ID:

62083

Description:

Enables delayed rectifier potassium channel activity. Involved in potassium ion transmembrane transport. Located in plasma membrane. Part of voltage-gated potassium channel complex. Orthologous to human KCNA6 (potassium voltage-gated channel subfamily A member 6); INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; 4,4'-sulfonyldiphenol; ammonium chloride.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

Kv1.6; kv2; potassium channel, voltage gated shaker related subfamily A, member 6; potassium channel-Kv2; potassium voltage gated channel shaker related subfamily member 6; potassium voltage gated channel, shaker related subfamily, member 6; RCK2; voltage-gated potassium channel subunit Kv1.6; voltage-gated potassium channel subunit Kv2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	161,229,103 - 161,262,352 (-)	NCBI		GRCr8
mRatBN7.2	4	159,542,941 - 159,576,189 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	159,542,615 - 159,576,189 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	165,772,732 - 165,805,991 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	161,555,642 - 161,588,899 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	160,189,668 - 160,222,923 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	159,253,934 - 159,287,193 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	159,253,934 - 159,287,193 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	232,324,385 - 232,357,644 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	163,087,398 - 163,125,320 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	163,366,297 - 163,369,040 (-)	NCBI
Celera	4	148,259,785 - 148,292,606 (-)	NCBI		Celera
Cytogenetic Map	4	q42	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Kcna6	Rat	cerebellar ataxia		ISO	KCNA6 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Cerebellar ataxia	ClinVar	PMID:25741868
Kcna6	Rat	episodic ataxia type 1		ISO	KCNA6 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Episodic ataxia type 1	ClinVar	PMID:28492532
Kcna6	Rat	esophageal atresia		ISO	KCNA6 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Esophageal atresia	ClinVar
Kcna6	Rat	Flatfoot		ISO	KCNA6 (Homo sapiens)	8554872	ClinVar Annotator: match by term: flatfoot	ClinVar	PMID:25741868
Kcna6	Rat	focal epilepsy		ISO	KCNA6 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Focal-onset seizure	ClinVar	PMID:25741868
Kcna6	Rat	generalized epilepsy		ISO	KCNA6 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Generalized-onset seizure	ClinVar	PMID:25741868
Kcna6	Rat	genetic disease		ISO	KCNA6 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Inborn genetic diseases	ClinVar
Kcna6	Rat	hyperopia		ISO	KCNA6 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Hyperopia	ClinVar	PMID:25741868
Kcna6	Rat	Hyperphosphatemic Familial Tumoral Calcinosis 1		ISO	KCNA6 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Tumoral calcinosis more ...	ClinVar	PMID:25378588 and PMID:29389098
Kcna6	Rat	lymphoproliferative syndrome 2		ISO	KCNA6 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Lymphoproliferative syndrome 2	ClinVar	PMID:28492532
Kcna6	Rat	Macrocephaly		ISO	KCNA6 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Macrocephaly	ClinVar	PMID:25741868

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Kcna6	Rat	2,3,7,8-tetrachlorodibenzodioxine	affects expression	ISO	Kcna6 (Mus musculus)	6480464	Tetrachlorodibenzodioxin affects the expression of KCNA6 mRNA	CTD	PMID:21570461
Kcna6	Rat	2,3,7,8-Tetrachlorodibenzofuran	decreases expression	EXP		6480464	2 more ...	CTD	PMID:32109520
Kcna6	Rat	4,4'-sulfonyldiphenol	multiple interactions	EXP		6480464	[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of KCNA6 mRNA	CTD	PMID:36041667
Kcna6	Rat	Aflatoxin B2 alpha	increases methylation	ISO	KCNA6 (Homo sapiens)	6480464	aflatoxin B2 results in increased methylation of KCNA6 intron	CTD	PMID:30157460
Kcna6	Rat	ammonium chloride	affects expression	EXP		6480464	Ammonium Chloride affects the expression of KCNA6 mRNA	CTD	PMID:16483693
Kcna6	Rat	antirheumatic drug	increases expression	ISO	KCNA6 (Homo sapiens)	6480464	Antirheumatic Agents results in increased expression of KCNA6 mRNA	CTD	PMID:24449571
Kcna6	Rat	benzo[a]pyrene	increases methylation	ISO	KCNA6 (Homo sapiens)	6480464	Benzo(a)pyrene results in increased methylation of KCNA6 5' UTR and Benzo(a)pyrene results in increased methylation of KCNA6 exon	CTD	PMID:27901495
Kcna6	Rat	benzo[a]pyrene	decreases methylation	ISO	KCNA6 (Homo sapiens)	6480464	Benzo(a)pyrene results in decreased methylation of KCNA6 3' UTR	CTD	PMID:27901495
Kcna6	Rat	benzo[a]pyrene	affects methylation	ISO	KCNA6 (Homo sapiens)	6480464	Benzo(a)pyrene affects the methylation of KCNA6 promoter	CTD	PMID:27901495
Kcna6	Rat	bisphenol A	decreases expression	EXP		6480464	bisphenol A results in decreased expression of KCNA6 mRNA	CTD	PMID:25181051 more ...
Kcna6	Rat	bisphenol A	multiple interactions	EXP		6480464	[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of KCNA6 mRNA	CTD	PMID:36041667
Kcna6	Rat	bisphenol A	increases methylation	EXP		6480464	bisphenol A results in increased methylation of KCNA6 gene	CTD	PMID:28505145
Kcna6	Rat	bisphenol A	decreases expression	ISO	Kcna6 (Mus musculus)	6480464	bisphenol A results in decreased expression of KCNA6 mRNA	CTD	PMID:25594700
Kcna6	Rat	bisphenol F	multiple interactions	EXP		6480464	[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of KCNA6 mRNA	CTD	PMID:36041667
Kcna6	Rat	carbon nanotube	decreases expression	ISO	Kcna6 (Mus musculus)	6480464	Nanotubes more ...	CTD	PMID:25554681
Kcna6	Rat	CGP 52608	multiple interactions	ISO	KCNA6 (Homo sapiens)	6480464	CGP 52608 promotes the reaction [RORA protein binds to KCNA6 gene]	CTD	PMID:28238834
Kcna6	Rat	chloroprene	increases expression	ISO	Kcna6 (Mus musculus)	6480464	Chloroprene results in increased expression of KCNA6 mRNA	CTD	PMID:23125180
Kcna6	Rat	cocaine	increases expression	EXP		6480464	Cocaine results in increased expression of KCNA6 mRNA	CTD	PMID:16076954
Kcna6	Rat	copper atom	increases expression	EXP		6480464	Copper deficiency results in increased expression of KCNA6 mRNA	CTD	PMID:26033743
Kcna6	Rat	copper(0)	increases expression	EXP		6480464	Copper deficiency results in increased expression of KCNA6 mRNA	CTD	PMID:26033743
Kcna6	Rat	copper(II) sulfate	increases expression	ISO	KCNA6 (Homo sapiens)	6480464	Copper Sulfate results in increased expression of KCNA6 mRNA	CTD	PMID:19549813
Kcna6	Rat	dibutyl phthalate	increases expression	ISO	Kcna6 (Mus musculus)	6480464	Dibutyl Phthalate results in increased expression of KCNA6 mRNA	CTD	PMID:17361019 and PMID:21266533
Kcna6	Rat	ethanol	affects expression	ISO	Kcna6 (Mus musculus)	6480464	Ethanol affects the expression of KCNA6 mRNA	CTD	PMID:30319688
Kcna6	Rat	fenvalerate	increases expression	EXP		6480464	fenvalerate results in increased expression of KCNA6 mRNA	CTD	PMID:30307764
Kcna6	Rat	fluoxetine	decreases expression	EXP		6480464	Fluoxetine results in decreased expression of KCNA6 mRNA	CTD	PMID:17033635
Kcna6	Rat	glyphosate	affects methylation	ISO	KCNA6 (Homo sapiens)	6480464	Glyphosate affects the methylation of KCNA6 promoter	CTD	PMID:35377194
Kcna6	Rat	lead(0)	affects expression	ISO	KCNA6 (Homo sapiens)	6480464	Lead affects the expression of KCNA6 mRNA	CTD	PMID:28903495
Kcna6	Rat	methoxychlor	affects methylation	EXP		6480464	Methoxychlor affects the methylation of KCNA6 gene	CTD	PMID:35440735
Kcna6	Rat	methylamine	affects response to substance	ISO	Kcna6 (Mus musculus)	6480464	KCNA6 protein affects the susceptibility to methylamine	CTD	PMID:15100162
Kcna6	Rat	sodium arsenite	decreases expression	ISO	Kcna6 (Mus musculus)	6480464	sodium arsenite results in decreased expression of KCNA6 mRNA	CTD	PMID:37682722
Kcna6	Rat	titanium dioxide	decreases expression	EXP		6480464	titanium dioxide results in decreased expression of KCNA6 mRNA	CTD	PMID:30012374
Kcna6	Rat	trimellitic anhydride	decreases expression	ISO	Kcna6 (Mus musculus)	6480464	trimellitic anhydride results in decreased expression of KCNA6 mRNA	CTD	PMID:19042947
Kcna6	Rat	valproic acid	increases methylation	ISO	KCNA6 (Homo sapiens)	6480464	Valproic Acid results in increased methylation of KCNA6 gene	CTD	PMID:29154799

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Kcna6	Rat	action potential	involved_in	IBA	FB:FBgn0003380 more ...	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Kcna6	Rat	monoatomic ion transmembrane transport	involved_in	IEA	UniProtKB-KW:KW-0407 and UniProtKB-KW:KW-0851	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Kcna6	Rat	monoatomic ion transport	involved_in	IEA	UniProtKB-KW:KW-0406	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Kcna6	Rat	monoatomic ion transport	involved_in	IEA	InterPro:IPR005821	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Kcna6	Rat	potassium ion transmembrane transport	involved_in	IDA		10047274	PMID:15618540	UniProt
Kcna6	Rat	potassium ion transmembrane transport	involved_in	IBA	MGI:102663 more ...	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Kcna6	Rat	potassium ion transmembrane transport	involved_in	IEA	UniProtKB-KW:KW-0631	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Kcna6	Rat	potassium ion transmembrane transport	involved_in	ISO	KCNA6 (Homo sapiens)	1624291	PMID:2347305	RGD	PMID:2347305
Kcna6	Rat	potassium ion transport	involved_in	IEA	UniProtKB-KW:KW-0633	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Kcna6	Rat	potassium ion transport	involved_in	IEA	InterPro:IPR003968 more ...	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Kcna6	Rat	protein homooligomerization	involved_in	IEA	InterPro:IPR003131	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Kcna6	Rat	transmembrane transport	involved_in	IEA	InterPro:IPR005821	1600115	GO_REF:0000002	InterPro	GO_REF:0000002

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Kcna6	Rat	axon	located_in	ISO	Kcna6 (Mus musculus)	1624291	PMID:21233214	RGD	PMID:21233214
Kcna6	Rat	axon terminus	located_in	ISO	Kcna6 (Mus musculus)	1624291	PMID:21233214	RGD	PMID:21233214
Kcna6	Rat	cytosol	located_in	ISO	KCNA6 (Homo sapiens)	1624291		RGD	GO_REF:0000052
Kcna6	Rat	intracellular membrane-bounded organelle	located_in	ISO	KCNA6 (Homo sapiens)	1624291		RGD	GO_REF:0000052
Kcna6	Rat	membrane	is_active_in	IBA	FB:FBgn0003380 more ...	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Kcna6	Rat	membrane	located_in	IEA	UniProtKB-SubCell:SL-0162	1600115	GO_REF:0000044	UniProt	GO_REF:0000044
Kcna6	Rat	membrane	located_in	IEA	InterPro:IPR005821	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Kcna6	Rat	membrane	located_in	IEA	UniProtKB-KW:KW-0472	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Kcna6	Rat	monoatomic ion channel complex	part_of	IEA	UniProtKB-KW:KW-0851	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Kcna6	Rat	plasma membrane	located_in	ISO	KCNA6 (Homo sapiens)	1624291	PMID:14575698 and PMID:2347305	RGD	GO_REF:0000052 more ...
Kcna6	Rat	plasma membrane	located_in	IEA	UniProtKB-SubCell:SL-0039	1600115	GO_REF:0000044	UniProt	GO_REF:0000044
Kcna6	Rat	plasma membrane	located_in	IEA	UniProtKB-KW:KW-1003	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Kcna6	Rat	plasma membrane	located_in	IMP		10047274	PMID:15618540	UniProt
Kcna6	Rat	potassium channel complex	part_of	IDA		10047182	PMID:9334400	UniProt
Kcna6	Rat	voltage-gated potassium channel complex	part_of	IDA		10047274	PMID:15618540	UniProt
Kcna6	Rat	voltage-gated potassium channel complex	part_of	IEA	InterPro:IPR003968 more ...	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Kcna6	Rat	voltage-gated potassium channel complex	part_of	IBA	FB:FBgn0003380 more ...	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Kcna6	Rat	delayed rectifier potassium channel activity	enables	IDA		10047274	PMID:15618540	UniProt
Kcna6	Rat	delayed rectifier potassium channel activity	enables	IBA	MGI:96654 more ...	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Kcna6	Rat	delayed rectifier potassium channel activity	enables	ISO	KCNA6 (Homo sapiens)	1624291	PMID:2347305	RGD	PMID:2347305
Kcna6	Rat	monoatomic ion channel activity	enables	IEA	InterPro:IPR005821	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Kcna6	Rat	potassium channel activity	enables	IEA	UniProtKB-KW:KW-0631	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Kcna6	Rat	protein binding	enables	ISO	KCNA6 (Homo sapiens)	1624291	UniProtKB:Q9UPQ8 more ...	RGD	PMID:28514442 more ...
Kcna6	Rat	protein binding	enables	ISO	Kcna6 (Mus musculus)	1624291	UniProtKB:Q9CPW0 and PMID:25707359	RGD	PMID:25707359
Kcna6	Rat	voltage-gated potassium channel activity	enables	IDA		405866200	PMID:1993474	UniProt
Kcna6	Rat	voltage-gated potassium channel activity	enables	IEA	InterPro:IPR003968 more ...	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Kcna6	Rat	voltage-gated potassium channel activity	enables	ISO	KCNA6 (Homo sapiens)	1624291	PMID:14575698 and PMID:36318112	RGD	PMID:14575698 and PMID:36318112

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Cloning and expression of a human voltage-gated potassium channel. A novel member of the RCK potassium channel family.	Grupe A, etal., EMBO J 1990 Jun;9(6):1749-56.
4.	Electrophysiological characterization of a new member of the RCK family of rat brain K+ channels.	Kirsch GE, etal., FEBS Lett. 1991 Jan 14;278(1):55-60. doi: 10.1016/0014-5793(91)80082-e.
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
7.	Heteromultimeric Kv1 channels contribute to myogenic control of arterial diameter.	Plane F, etal., Circ Res. 2005 Feb 4;96(2):216-24. Epub 2004 Dec 23.
8.	GOA pipeline	RGD automated data pipeline
9.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
11.	Association and colocalization of the Kvbeta1 and Kvbeta2 beta-subunits with Kv1 alpha-subunits in mammalian brain K+ channel complexes.	Rhodes KJ, etal., J Neurosci. 1997 Nov 1;17(21):8246-58.
12.	PDGF upregulates delayed rectifier via Src family kinases and sphingosine kinase in oligodendroglial progenitors.	Soliven B, etal., Am J Physiol Cell Physiol 2003 Jan;284(1):C85-93.

PMID:2361015	PMID:16624997	PMID:21233214	PMID:21352098	PMID:22079321	PMID:22871113	PMID:24924920	PMID:38043654

Kcna6
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	161,229,103 - 161,262,352 (-)	NCBI		GRCr8
mRatBN7.2	4	159,542,941 - 159,576,189 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	159,542,615 - 159,576,189 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	165,772,732 - 165,805,991 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	161,555,642 - 161,588,899 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	160,189,668 - 160,222,923 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	159,253,934 - 159,287,193 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	159,253,934 - 159,287,193 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	232,324,385 - 232,357,644 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	163,087,398 - 163,125,320 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	163,366,297 - 163,369,040 (-)	NCBI
Celera	4	148,259,785 - 148,292,606 (-)	NCBI		Celera
Cytogenetic Map	4	q42	NCBI

KCNA6
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	4,809,334 - 4,851,112 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	4,809,334 - 4,813,318 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	4,918,500 - 4,960,278 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	4,788,603 - 4,792,839 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	12	4,788,602 - 4,792,839	NCBI
Celera	12	6,540,177 - 6,582,117 (+)	NCBI		Celera
Cytogenetic Map	12	p13.32	NCBI
HuRef	12	4,775,114 - 4,817,084 (+)	NCBI		HuRef
CHM1_1	12	4,917,927 - 4,959,949 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	4,816,353 - 4,858,155 (+)	NCBI		T2T-CHM13v2.0

Kcna6
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	126,685,292 - 126,717,610 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	126,685,292 - 126,717,637 (-)	Ensembl		GRCm39 Ensembl
GRCm38	6	126,708,328 - 126,740,834 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	126,708,329 - 126,740,674 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	126,658,347 - 126,690,692 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	126,702,307 - 126,705,772 (-)	NCBI		MGSCv36	mm8
Celera	6	128,378,065 - 128,410,554 (-)	NCBI		Celera
Cytogenetic Map	6	F3	NCBI
cM Map	6	61.72	NCBI

Kcna6
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955413	2,614,685 - 2,676,292 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955413	2,614,685 - 2,676,292 (+)	NCBI	ChiLan1.0	ChiLan1.0

KCNA6
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	10,356,962 - 10,362,502 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	10,351,747 - 10,357,884 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	4,926,069 - 4,968,475 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	4,846,651 - 4,889,190 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	4,847,510 - 4,849,099 (+)	Ensembl	panpan1.1		panPan2

KCNA6
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	27	40,042,051 - 40,045,812 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	27	40,044,334 - 40,045,812 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	27	6,635,593 - 6,639,492 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	27	40,397,855 - 40,401,770 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	27	40,400,162 - 40,401,748 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	27	40,286,847 - 40,290,747 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	27	40,311,960 - 40,315,859 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	27	6,046,284 - 6,050,185 (+)	NCBI		UU_Cfam_GSD_1.0

Kcna6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	104,211,782 - 104,214,883 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936606	4,969,787 - 4,971,446 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936606	4,969,282 - 4,972,383 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

KCNA6
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	65,657,225 - 65,658,835 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	65,625,581 - 65,659,557 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	67,830,814 - 67,865,506 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

KCNA6
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	4,853,706 - 4,894,406 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	4,854,570 - 4,856,162 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666063	3,352,889 - 3,393,600 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Kcna6
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624860	1,835,685 - 1,867,104 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624860	1,835,679 - 1,867,606 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants in Kcna6
214 total Variants

Predicted Target Of

	Summary Value
Count of predictions:	360
Count of miRNA genes:	193
Interacting mature miRNAs:	228
Transcripts:	ENSRNOT00000075771
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
6478754	Anxrr43	Anxiety related response QTL 43		0.14035	locomotor behavior trait (VT:0001392)	distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)	4	144639524	182687754	Rat
724558	Plsm2	Polydactyly-luxate syndrome (PLS) morphotypes QTL 2		0.0003	hindlimb integrity trait (VT:0010563)	hind foot phalanges count (CMO:0001949)	4	132422778	177422778	Rat
1582237	Kidm34	Kidney mass QTL 34	4	0.0001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	4	148090542	168069246	Rat
6478693	Anxrr32	Anxiety related response QTL 32		0.00092	locomotor behavior trait (VT:0001392)	measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)	4	144639524	182687754	Rat
10755501	Bp390	Blood pressure QTL 390	2.5		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	4	26775591	168368347	Rat
631683	Bp116	Blood pressure QTL 116		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	124303370	169303370	Rat
61451	Ciaa4	CIA Autoantibody QTL 4	3.1		blood autoantibody amount (VT:0003725)	calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)	4	126395976	167139601	Rat
1331738	Bp209	Blood pressure QTL 209	2.979		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	138503169	179293946	Rat
6478700	Anxrr33	Anxiety related response QTL 33		0.00896	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	144639524	182687754	Rat
1298524	Oia8	Oil induced arthritis QTL 8			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	138503169	173369699	Rat
10053718	Scort25	Serum corticosterone level QTL 25	2.15	0.0097	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	155561574	182687754	Rat
1549827	Scl46	Serum cholesterol level QTL 46	3.5		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	4	132396220	177396220	Rat
634335	Anxrr16	Anxiety related response QTL 16	7.22		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	4	93308457	167139447	Rat
737821	Hcar9	Hepatocarcinoma resistance QTL 9	3.7		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	4	109866907	167139601	Rat
7411558	Bw133	Body weight QTL 133	13.84	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	4	125590636	170590636	Rat
6478778	Anxrr51	Anxiety related response QTL 51		0.25384	locomotor behavior trait (VT:0001392)	measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)	4	124778595	169778595	Rat
10401796	Kidm48	Kidney mass QTL 48			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	4	145568712	182687754	Rat
6478718	Anxrr34	Anxiety related response QTL 34		0.00896	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	144639524	182687754	Rat
631511	Pia7	Pristane induced arthritis QTL 7	4.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	131730738	167139601	Rat
1300109	Rf13	Renal function QTL 13	3.91		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	4	157710145	182687754	Rat
634347	Hcar8	Hepatocarcinoma resistance QTL 8	5.8		liver integrity trait (VT:0010547)	liver tumorous lesion area to total liver area ratio (CMO:0001075)	4	123143783	168143783	Rat
1576316	Ept5	Estrogen-induced pituitary tumorigenesis QTL 5	3.8		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	4	83428419	177635233	Rat
2303623	Vencon2	Ventilatory control QTL 2	3.8		respiration trait (VT:0001943)	minute ventilation (CMO:0000132)	4	135204660	180204660	Rat
1578674	Bmd12	Bone mineral density QTL 12	3.8		femur mineral mass (VT:0010011)	compact volumetric bone mineral density (CMO:0001730)	4	135699135	180699135	Rat
1358202	Gluco11	Glucose level QTL 11	2.4	0.02	adipocyte glucose uptake trait (VT:0004185)	absolute change in adipocyte glucose uptake (CMO:0000873)	4	85379421	167139601	Rat
61422	Cia13	Collagen induced arthritis QTL 13	4.5		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	132642577	167139601	Rat
634342	Cia24	Collagen induced arthritis QTL 24	4.5		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	146565735	175236377	Rat
737978	Pia23	Pristane induced arthritis QTL 23	5.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	131730738	167139601	Rat
61362	Oia2	Oil induced arthritis QTL 2		0.001	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	138503169	173369699	Rat
12798519	Anxrr54	Anxiety related response QTL 54	2.54	0.05	locomotor behavior trait (VT:0001392)	distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)	4	114627026	159627026	Rat
2293659	Bmd35	Bone mineral density QTL 35	4.5	0.0001	femur strength trait (VT:0010010)	femoral neck ultimate force (CMO:0001703)	4	137755016	181392681	Rat
1331759	Hrtrt13	Heart rate QTL 13	3.54628		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	4	110275411	168266883	Rat
724535	Cm18	Cardiac mass QTL 18	2.6		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	4	118856416	163856416	Rat
2316958	Gluco58	Glucose level QTL 58	10		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	11320076	180699135	Rat
6478748	Anxrr42	Anxiety related response QTL 42		0.28008	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	144639524	182687754	Rat
12798525	Anxrr57	Anxiety related response QTL 57	3.21	0.05	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	147278504	167139601	Rat

D4Got133

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	159,549,565 - 159,549,725 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	159,260,569 - 159,260,728	NCBI	Rnor6.0
Rnor_5.0	4	232,350,850 - 232,351,009	UniSTS	Rnor5.0
RGSC_v3.4	4	163,094,025 - 163,094,184	UniSTS	RGSC3.4
RGSC_v3.4	4	163,094,024 - 163,094,184	RGD	RGSC3.4
RGSC_v3.1	4	163,338,961 - 163,339,120	RGD
RH 3.4 Map	4	1003.8	UniSTS
RH 3.4 Map	4	1003.8	RGD
Cytogenetic Map	4	q42	UniSTS

RH132337

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	159,543,035 - 159,543,240 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	159,254,029 - 159,254,233	NCBI	Rnor6.0
Rnor_5.0	4	232,357,345 - 232,357,549	UniSTS	Rnor5.0
RGSC_v3.4	4	163,087,493 - 163,087,697	UniSTS	RGSC3.4
Celera	4	148,259,880 - 148,260,084	UniSTS
RH 3.4 Map	4	1009.1	UniSTS
Cytogenetic Map	4	q42	UniSTS

BE107724

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	159,576,690 - 159,576,854 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	159,287,695 - 159,287,858	NCBI	Rnor6.0
Rnor_5.0	4	232,323,720 - 232,323,883	UniSTS	Rnor5.0
RGSC_v3.4	4	163,125,822 - 163,125,985	UniSTS	RGSC3.4
Celera	4	148,293,108 - 148,293,271	UniSTS
RH 3.4 Map	4	1008.6	UniSTS
Cytogenetic Map	4	q42	UniSTS

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	6	45	109	54	56	26	15	26	5	141	72	93	28	53	30


RefSeq Transcripts	NM_023954	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063286664	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AJ276137	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CB581370	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473964	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ212954	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M27159	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000080139 ⟹ ENSRNOP00000071895

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	159,542,941 - 159,576,189 (-)	Ensembl
Rnor_6.0 Ensembl	4	159,253,934 - 159,287,193 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000097393 ⟹ ENSRNOP00000086088

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	159,542,615 - 159,575,340 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000104566 ⟹ ENSRNOP00000086058

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	159,567,014 - 159,575,340 (-)	Ensembl

RefSeq Acc Id:

NM_023954 ⟹ NP_076444

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	161,229,103 - 161,262,352 (-)	NCBI
mRatBN7.2	4	159,542,941 - 159,576,189 (-)	NCBI
Rnor_6.0	4	159,253,934 - 159,287,193 (-)	NCBI
Rnor_5.0	4	232,324,385 - 232,357,644 (+)	NCBI
RGSC_v3.4	4	163,087,398 - 163,125,320 (-)	RGD
Celera	4	148,259,785 - 148,292,606 (-)	RGD

Sequence:

show sequence

TTAGATGGCTGTATTGTTTATTGACATTGTATTGTACCTCCTTTTTGTTTATCCTTCCCTCCCCTTTCTCGACATAGATAAATGTAAATTGCACAATCTTTTCTTTTTTTCTTTCCCCCCTAGGGAGG
CTTGGAGCAAAGATTCCTGGCTGCCATTCCTTTATATAGTGTTTCTTCAGTAACATAGCCTCCTGGTGCTTTATCATGGAGATGATGGTGGATGTCTTCTGGACACCATGAGAGGACGGTTTCCTACT
CACTGGGCATGAACAGGTTTTTCCTGCCCTCTTACTTTCACTATGCCTTGAAGGTGAGATTCGGCCTTGCCTTTCCAGGTTGTAGAAGTGAGAGTCTGTTGGGGAATTAACACTGGGACACAGCCGAG
ATGGAAAGCTCTCAAGACATTTAAAAATACTTCACCCCCCCCAACCCCCAGTAGAGGTTGAAACTGGCAAATGTGTCTTCGTGGATATAGAAAACATGGGTCCCCCGCCCGCCACCCCCCCAGTAAAC
AGCGTTTGAGGGGTCAGGTGCTGAGTATAGCTTATTGGGCAGGGTGTGTGGGGGGCTAGCGTGTGATTTCTTTTTTGATGAAATACACTGCGTAGGTCAGCCCGGTGAACAGAAATGAGAGGAGACGA
TTTGTGGAGGATGGAGTGGGTGTGTTATTAGGATACTGCGGCTTGGTTGGGGTGGGGGTGGGGGTGGGGGCGTGCGTGTGAATGTGAGAAAGCAAGAGGCATGCCAGGAGAGCGCGGGAAAGATTACC
GGGAAGGCAAGTGTGCATCTCTCTCTCTCTCTCTCCAGCATCCAGGCTTGCTGCAGCCCCTAGCTGGGTAAGGGGTGTGATGTGAGAGTGGGGTGGGAGGGGGCAGCAGGCGGGGCCTGCCACGTCAC
TTGGAGAGTGTGTTAAGGAGGAAGGGCAGAGCTGAGAGCTGAGCCTGCTGCTGCTGTTGCTGCTGCTGCTGTTGCTGCTGCTTGCTGTTGCTGCTGCTGCTGGGGCTGCTGCGGGTGCGGGCAAGGAT
TGATGCGGTGGGGAGGTGGGTCTCTGCGCTCCGGCGCCCGGGCAGGCCCAGGGCGGTTCCGAGGCCTGTAGAACAGCTCCTGGGAAGAAGGTGGCGGCTGCAATCGCGACCTTGGCCAGACCTAGTTC
GTGGTGGACGTAGGGCGGAGGCGGAGGCCGAGCCCGGGCAGGAGTCTTTGGCGAGCCAGAGGGAGGCGCATCTGGCGCTTCGGTACCAGCGGCAGCCTTGTGAGTCTTGTGAGGCTGGAGAAGCGCAG
CAGGACCTGGTGAGAGCTAGCAAGTCTGGAGGGCGGACCTGTGGGTCCCGAGCCCAGTTTTAGGCACCACCGAGAGCTAAGCCAAGCGTCTTTTCGGGCAGCCAGTTTCACGCGCGCGACAGTTTGCG
GGTTCCAGGCATCTCAGAAATCTTGAGCACGGAGGCGCGGCTACTGAGAGCCAGAGCCACATCCCAGACCTAGCCTGGCAGAGAGACCAGCTGCAGGGTTCACCGACCTAACCGCCAGGTCAGAGCAC
GGGCCCCACCCTAAAGGAGGGCGCAGCCGGAGCTGGGAAGCCGGTGCCGCGCTCCGGAGCTCGTGTCGTGGGCGCCGTCCTAGTGGCGGGGAGCGCACCGCCGAGGTGACATGAGATCGGAGAAATCC
CTGACGCTGGCGGCGCCGGGGGAGGTCCGTGGGCCGGAGGGGGAGCAACAGGATGCGGGTGAGTTCCAGGAGGCCGAGGGCGGCGGCGGCTGCTGTAGTAGTGAGAGGCTGGTGATCAACATCTCTGG
GCTGCGCTACGAGACGCAGCTGCGCACCTTGTCGCTGTTCCCTGACACGCTGCTAGGAGACCCTGGCCGCAGAGTCCGCTTCTTTGACCCCTTGAGGAATGAGTACTTCTTTGACCGCAACCGACCCA
GCTTCGACGCTATCCTTTATTACTACCAGTCGGGGGGTCGCCTGCGCAGGCCGGTTAACGTGCCCCTTGACATCTTTATGGAAGAGATTCGCTTCTATCAGTTGGGAGATGAAGCCCTGGCGGCCTTC
CGGGAGGATGAGGGTTGCCTGCCCGAAGGTGGTGAGGATGAGAAGCCACTCCCCTCCCAGCCTTTCCAGCGACAGGTCTGGCTCCTCTTTGAGTATCCGGAGAGTTCTGGGCCCGCCCGAGGCATTGC
CATCGTCTCAGTGTTGGTCATCCTCATCTCCATTGTCATCTTTTGCCTGGAGACCTTGCCTCAGTTCCGTGCAGATGGGCGCGGTGGAAGCAACGAGGGGAGTGGGACCCGCATGTCCCCGGCCTCCA
GGGGGAGCCACGAGGAGGAAGATGAAGACGAGGATTCCTATGCATTTCCTGGTAGCATTCCCTCTGGGGGGTTGGGGACCGGAGGAACTTCTTCATTTAGTACTCTCGGGGGTTCCTTCTTCACAGAC
CCCTTCTTCCTGGTGGAAACTCTGTGTATCGTCTGGTTCACCTTTGAGCTCCTGGTGCGCTTCTCTGCCTGTCCCAGCAAGGCGGCCTTCTTTCGCAATATCATGAACATCATTGACTTGGTGGCCAT
CTTCCCCTACTTTATCACCCTGGGCACCGAGCTAGTGCAACGTCACGAGCAGCAGCCTGTGAGTGGTGGCAGTGGTCAGAATGGGCAGCAGGCCATGTCCCTAGCCATCCTCAGGGTGATCCGCCTGG
TCCGGGTGTTTCGGATCTTCAAGCTCTCCCGCCACTCCAAGGGGTTGCAGATCCTGGGTAAGACCTTGCAAGCATCCATGCGGGAGCTCGGGCTACTCATCTTCTTCCTCTTCATTGGAGTCATCCTC
TTCTCCAGCGCTGTCTACTTCGCAGAGGCAGATGACGTTGACTCGCTCTTCCCTAGCATCCCAGATGCCTTTTGGTGGGCTGTGGTTACAATGACCACAGTAGGTTATGGGGACATGTACCCCATGAC
GGTGGGAGGCAAGATTGTGGGCTCACTGTGTGCCATTGCTGGGGTCCTCACCATTGCATTACCGGTACCGGTCATTGTCTCCAATTTCAACTACTTCTACCACCGAGAGACGGAGCAGGAGGAACAAG
GCCAGTATACCCACGTCACTTGTGGGCAGCCTACACCGGACCTGAAGGCAACGGACAATGGGCTTGGCAAACCTGACTTTGCGGAGGCTTCACGGGAACGGCGGTCCAGCTACCTTCCAACTCCACAT
CGAGCTTATGCAGAGAAAAGGATGCTCACCGAGGTTTGATGGATGCGGGCAGGCCTGCAGGAAAACAGGAGCTCTGAGCAAGTCATCTCTCAGGCTTCCTTCTCATGCTCACTACTCCCGCCTTAGCT
CCAGAGGACCTCGAACCCCCGCCCCGCCCCCTCCCGTACACAGTACACGGCATCCTGGACCAAATATCTGGACTATAGACTGTTGCTCGCTCCTCGCAGCATTCGAGGTTTCTCCATCTTAGTGACAT
TTTTGGAAATTTCAACGGTGCCACCCAATCATGCCCATCAGTCACGTGAATGAGATGCACATTTCTGACTGACCTTCCCTCAAGACTGAGTTCTCATGCCTGGGTCTTGTAATATCTCTAGGAATGGT
GACACCAATAGAATAGGAAGCAGCTACACTCAGGTCCCTTCTTTAGAGTCCTTTGCTTTGGGTCATGCGCCTTCCTTAGCTTCTGGTCACGTGGTCACTGGCAGACTCTGGACTATGGAAGATTTCAG
CTTGCCGTTTTGGTGCTCTCTCCAGCTTCTGGCTGGTAGAGCTATTAGCTGCCCGGCTTTGAAAGTTATCCACAGCTAAATTTGGATGGAATTAGAGAAAATACTACCCAACTGGATTATTTGAAGGA
CACGAGGGTCAGTTCTAGATCAATGGGGGCCAGTGGACCTCTCAGTTGTGATCTGTCACAGGAGACCACAGCAGGGGGGTCTACAGTAGACCTCACCACCCAGATTCCCTGACTCCCTTGAGCTTCCA
AGAAGGCACCTTCTCAGAGCCAAGTTCTTTTTGTGTGCAAGCGCCTTGGTGTGAGGAGGAACTGGAAAACAGAACCACGGAGACAGGAGAAAAGCCTGACCAGAGCCGAAGGACTGGCTGGACCACAC
ATCTGAAGCGAGGTGCCCCTTAGCAGAGACTGTCAACTTAGAACAGGCAGAGGGACCCTGCTGCAGTCAGCAGCCAATTCTCCGAGATTAGCCCAGATCTCTCTAAGGTATCCTCTTCCCTTCTCCCT
GGGAACCTGACCTAGGATTGCAGATTGTTTTTATAAAGCAAACCTCAGCTCTAACCTACAGACAGGTGAGTTCACACATCGAATGCCAGCAGAGCTTTTCTCTTATGCTGCGGCAACAGCCTTTGGTT
GGGAGCCAGGAAAGGGCACGGCTATGTTGTTGGCAGCCTCTGTTCTGCTGAGTCAAGCAAACGTTGGTCTGCTCTGCTCTTCCTTTGGAGCTGCATTCGGCCTGCTCTAACTGCTAAGGTAACTCGGT
GGTTCCCACTTGGACCAAGCCATCTTCTACCATTGTGAAATCACTGCCACCCTCCCAGCTGCCCACTGCCCCCTCCCTCCCATAACATTGCCATTTAGTTTTGCCTTTGATAAACTGTGACACACTGT
TCTCAGTTCTCATGGGTACAGTTCTGAAACTCAAAGGACTGTTAACATGTTTTTAATTTTATATTGATGCTTTAAAGTTCTTCAAAGAGAATGCTTTTTCAAAAGATTTTCCTGAAGAGCAACTTAGT
AAGGAGAGTGACATTGATTACTGGCTTGAGAGGCCACTGTGGCTCCAGGGAGTGACAGATCACAGTCTGAGTTTTGCCACAGCTTTACAGGGTAACTCTGGTGTCACGGTCCCTCATTGTGCCTCAGT
TTCTTCCACCCGTTAAATGAGAACATTAAAGTCTTCCCCTCCCTACCTCATGGGGGAATTATCAATAAACTCACCCAGGAAGGTGGGGAAGATGCTATGCAAGTGTATGAATTATAGTAATGGCTTTG
AGTTTTCGTTCATTATACTGCCTGCCTATCTCTCAAAGGCAAGGCCTTTCCCCCAGAAATTTCCACTGTGGATCCAAAGCCTAAGACTAGGTCATTGTAGACCAACAGCTTTCTAAGTCTCTCCTTGG
TATTTTGGGCTTGGGTCTTCATCCTTTCTTTCACCCTTCAGAATGGACTATATTCTTGTGGTAGACTTGGTGGCCAGAAGTCATTTCCTTGGAGGCTTGACTTCTCCAAGCCTGCAGCAGAGTAAAAG
ACTGAGATGTTTAAGACTCCGGAGATCTATTCCAAGGCCAGTAAGAAAGTATTTTGTTTCCAGTGATTTTAGTTGTTAGGAGCCCACCCCAGTGACCAAAGGGAGGCCCCCAGCTGAGGATGGATGAG
GGGATATGTGTGCATGGATCTCTCTCTCTCTGTGTATATATTGTCACCCTCATCACTATCCCTGTCTTTATGCAAACATTGCCTTTTCAAGTCAGAACATGCCTGAAAGTAAAAGGTTTGTGGAGAGC
CAGGCTCTCCAGGGACTCTGGTTGCTGTAGCAACCTTCCAGACTGTTCTCTCTACTGATTTGGGTATCAAGGGGGAACAGACTACATATCCCAGCTTCTCATATGGGAACACCTCCAATCTATCGATT
TAGGCATTGGCAGAACTAAAGCAAGGACTCAGGACCTTTGACAACGTGGGGGAAGTAGATTCTCAACACTTCCTGCCTAGACATTTCTTCCTGGCTCTTTATCTGGTCACTGAAGCTGCCACATCTTA
CCCCGATTCTTCAGAAACTTGAATGCTTAGAAACTGCCCAACTCTGCCAACACCAATGTCAGGTTTTCAAAAGGAGACCTCAGAGAGGGGTACAAAAGGTCCTCTCCGTAGCAGTCAGACTGGGCCTT
GAGGACACAGAGGACACCAGTCTGGGGTGTCATGGTATTCTCATCTCAGATGCAGGCTCTTCCCAGCTCTAAGAGAGATCGAGAAGAATGGAACTCCTCCCTCCCAGGGAGCAGCATTGCTCCTGACG
AAAATTATGGAAGCGATTCTTAAGATGTCAGACAGAAACTGAGAGGCCGTGACTCAATCTAGCTTTTGTGAAGAGTTTTGTCCAGTGAGCTCTCCCTGCTTCTGAGCCTCCCTGTGGATGACGTAACC
TTGGCATCCAGAGAGAACGTGTACCACCGTGTGCTGCCTCAGCAGCTGGAATAGCATCACAGCTGCCTGAGAAGGTGGGGTTCAAGCCATCTCAATGACTGACTTAAGCCAGTGGGGGCTCCCAGAGG
ACGCCCTAGGACTGCCAGTTTCTGCTTGGGATGAGGACATTCCTCCTGCCTAGCATCCTAGAGGAGCAAGGAACAGCTGGCCTTCCTTGCCTCTGAGGGCTGTGCTGCTCGTGGTCACTCTGGAAAAC
CTGTGCATCCAAAGACCTTTAACTTCTCTGGAGGATGAGACCCCACGCCTCCTCACTGAATAACTCAGCCTGGCAGCCCCTGGCGGCCTTCCGCAAGCACTGACTGGGAAGGAAAAGGCTGAGACGGG
GGATTCTGGATGTTGCGGTGGGGCCATAGGAAGGCGGGGAGAGCTGCTGGCCTGATCGAAGGAGAAAGGGTGTTAGGATGATGTGGGATCATGTGTGCTGCAGAGCCGCCCAGGCAGGCACTCGCTGG
CTGGGGAAGAGTAACTAATAAATAAATGACAGTCTCAGAGAAAAAAAAAAAAAAAAAAAACGGTTCGCGGCCGCAAGCTT

hide sequence

RefSeq Acc Id:

XM_063286664 ⟹ XP_063142734

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	161,229,104 - 161,261,497 (-)	NCBI


Protein RefSeqs	NP_076444	(Get FASTA)	NCBI Sequence Viewer
	XP_063142734	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA41499	(Get FASTA)	NCBI Sequence Viewer
	CAC03592	(Get FASTA)	NCBI Sequence Viewer
	EDM01828	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000071895
GenBank Protein	P17659	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_076444 ⟸ NM_023954

- UniProtKB:

P19025 (UniProtKB/Swiss-Prot), P17659 (UniProtKB/Swiss-Prot), G3V8L6 (UniProtKB/TrEMBL), A6ILW1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MRSEKSLTLAAPGEVRGPEGEQQDAGEFQEAEGGGGCCSSERLVINISGLRYETQLRTLSLFPDTLLGDPGRRVRFFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFMEEIRFYQLGD
EALAAFREDEGCLPEGGEDEKPLPSQPFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPQFRADGRGGSNEGSGTRMSPASRGSHEEEDEDEDSYAFPGSIPSGGLGTGGTSSFSTLG
GSFFTDPFFLVETLCIVWFTFELLVRFSACPSKAAFFRNIMNIIDLVAIFPYFITLGTELVQRHEQQPVSGGSGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFL
FIGVILFSSAVYFAEADDVDSLFPSIPDAFWWAVVTMTTVGYGDMYPMTVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEQEEQGQYTHVTCGQPTPDLKATDNGLGKPDFAEASRERRSS
YLPTPHRAYAEKRMLTEV

hide sequence

Ensembl Acc Id:

ENSRNOP00000071895 ⟸ ENSRNOT00000080139

Ensembl Acc Id:

ENSRNOP00000086058 ⟸ ENSRNOT00000104566

Ensembl Acc Id:

ENSRNOP00000086088 ⟸ ENSRNOT00000097393

RefSeq Acc Id:	XP_063142734 ⟸ XM_063286664
- Peptide Label:	isoform X1
- UniProtKB:	P19025 (UniProtKB/Swiss-Prot), P17659 (UniProtKB/Swiss-Prot), A6ILW1 (UniProtKB/TrEMBL), G3V8L6 (UniProtKB/TrEMBL)

Protein Domains

BTB Ion transport

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P17659-F1-model_v2	AlphaFold	P17659	1-530	view protein structure

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Database	Acc Id	Source(s)
BioCyc Gene	G2FUF-42963	BioCyc
Ensembl Genes	ENSRNOG00000052486	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000080139	ENTREZGENE
Gene3D-CATH	1.10.287.70	UniProtKB/Swiss-Prot
	1.20.120.350	UniProtKB/Swiss-Prot
	Potassium Channel Kv1.1, Chain A	UniProtKB/Swiss-Prot
InterPro	BTB/POZ_dom	UniProtKB/Swiss-Prot
	Ion_trans_dom	UniProtKB/Swiss-Prot
	K_chnl_volt-dep_Kv	UniProtKB/Swiss-Prot
	K_chnl_volt-dep_Kv1	UniProtKB/Swiss-Prot
	K_chnl_volt-dep_Kv1.6	UniProtKB/Swiss-Prot
	KCNA6_BTB_POZ	UniProtKB/Swiss-Prot
	SKP1/BTB/POZ_sf	UniProtKB/Swiss-Prot
	T1-type_BTB	UniProtKB/Swiss-Prot
	VG_K_chnl	UniProtKB/Swiss-Prot
	Volt_channel_dom_sf	UniProtKB/Swiss-Prot
NCBI Gene	64358	ENTREZGENE
PANTHER	PTHR11537	UniProtKB/Swiss-Prot
	PTHR11537:SF104	UniProtKB/Swiss-Prot
Pfam	BTB_2	UniProtKB/Swiss-Prot
	Ion_trans	UniProtKB/Swiss-Prot
PhenoGen	Kcna6	PhenoGen
PRINTS	KCHANNEL	UniProtKB/Swiss-Prot
	KV16CHANNEL	UniProtKB/Swiss-Prot
	KVCHANNEL	UniProtKB/Swiss-Prot
	SHAKERCHANEL	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000052486	RatGTEx
SMART	BTB	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF54695	UniProtKB/Swiss-Prot
	Voltage-gated potassium channels	UniProtKB/Swiss-Prot
UniProt	A6ILW1	ENTREZGENE, UniProtKB/TrEMBL
	G3V8L6	ENTREZGENE, UniProtKB/TrEMBL
	KCNA6_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	P19025	ENTREZGENE
	Q9ESW1_RAT	UniProtKB/TrEMBL
UniProt Secondary	P19025	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-11	Kcna6	potassium voltage-gated channel subfamily A member 6	Kcna6	potassium channel, voltage gated shaker related subfamily A, member 6	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2015-01-26	Kcna6	potassium channel, voltage gated shaker related subfamily A, member 6	Kcna6	potassium voltage gated channel, shaker related subfamily, member 6	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-06-10	Kcna6	potassium voltage gated channel, shaker related subfamily, member 6			Name updated	70584	APPROVED

Note Type	Note	Reference
gene_expression	expressed in midbrain areas and brainstem	61641
gene_function	voltage-gated potassium channel subunit	628546
gene_process	may act on cell cycle progression by affecting membrane potential, cell volume regulation, intracellular calcium levlels or Cdk inhibitor levels	628546
gene_process	involved in cell survival, cell cycle progression, membrane excitability and secretory function	628546
gene_regulation	expression induced by platelet-derived growth factor (Pdgf) and basic fibroblast growth factor	628546

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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