Kcna6 (potassium voltage-gated channel subfamily A member 6) - Rat Genome Database

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Gene: Kcna6 (potassium voltage-gated channel subfamily A member 6) Rattus norvegicus
Analyze
Symbol: Kcna6
Name: potassium voltage-gated channel subfamily A member 6
RGD ID: 62083
Description: Enables delayed rectifier potassium channel activity. Involved in potassium ion transmembrane transport. Located in plasma membrane. Part of voltage-gated potassium channel complex. Orthologous to human KCNA6 (potassium voltage-gated channel subfamily A member 6); INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; 4,4'-sulfonyldiphenol; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Kv1.6; kv2; potassium channel, voltage gated shaker related subfamily A, member 6; potassium channel-Kv2; potassium voltage gated channel shaker related subfamily member 6; potassium voltage gated channel, shaker related subfamily, member 6; RCK2; voltage-gated potassium channel subunit Kv1.6; voltage-gated potassium channel subunit Kv2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24159,542,941 - 159,576,189 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4159,542,615 - 159,576,189 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4165,772,732 - 165,805,991 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.04161,555,642 - 161,588,899 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.04160,189,668 - 160,222,923 (-)NCBIRnor_WKY
Rnor_6.04159,253,934 - 159,287,193 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4159,253,934 - 159,287,193 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04232,324,385 - 232,357,644 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44163,087,398 - 163,125,320 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14163,366,297 - 163,369,040 (-)NCBI
Celera4148,259,785 - 148,292,606 (-)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Cloning and expression of a human voltage-gated potassium channel. A novel member of the RCK potassium channel family. Grupe A, etal., EMBO J 1990 Jun;9(6):1749-56.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. Heteromultimeric Kv1 channels contribute to myogenic control of arterial diameter. Plane F, etal., Circ Res. 2005 Feb 4;96(2):216-24. Epub 2004 Dec 23.
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Association and colocalization of the Kvbeta1 and Kvbeta2 beta-subunits with Kv1 alpha-subunits in mammalian brain K+ channel complexes. Rhodes KJ, etal., J Neurosci. 1997 Nov 1;17(21):8246-58.
11. PDGF upregulates delayed rectifier via Src family kinases and sphingosine kinase in oligodendroglial progenitors. Soliven B, etal., Am J Physiol Cell Physiol 2003 Jan;284(1):C85-93.
Additional References at PubMed
PMID:1993474   PMID:2361015   PMID:16624997   PMID:21233214   PMID:21352098   PMID:22079321   PMID:22871113   PMID:24924920  


Genomics

Comparative Map Data
Kcna6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24159,542,941 - 159,576,189 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4159,542,615 - 159,576,189 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4165,772,732 - 165,805,991 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.04161,555,642 - 161,588,899 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.04160,189,668 - 160,222,923 (-)NCBIRnor_WKY
Rnor_6.04159,253,934 - 159,287,193 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4159,253,934 - 159,287,193 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04232,324,385 - 232,357,644 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44163,087,398 - 163,125,320 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14163,366,297 - 163,369,040 (-)NCBI
Celera4148,259,785 - 148,292,606 (-)NCBICelera
Cytogenetic Map4q42NCBI
KCNA6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38124,809,334 - 4,851,112 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl124,809,334 - 4,813,318 (+)EnsemblGRCh38hg38GRCh38
GRCh37124,918,500 - 4,960,278 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36124,788,603 - 4,792,839 (+)NCBINCBI36Build 36hg18NCBI36
Build 34124,788,602 - 4,792,839NCBI
Celera126,540,177 - 6,582,117 (+)NCBICelera
Cytogenetic Map12p13.32NCBI
HuRef124,775,114 - 4,817,084 (+)NCBIHuRef
CHM1_1124,917,927 - 4,959,949 (+)NCBICHM1_1
T2T-CHM13v2.0124,816,353 - 4,858,155 (+)NCBIT2T-CHM13v2.0
Kcna6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396126,685,291 - 126,717,797 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6126,685,292 - 126,717,637 (-)EnsemblGRCm39 Ensembl
GRCm386126,708,328 - 126,740,834 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6126,708,329 - 126,740,674 (-)EnsemblGRCm38mm10GRCm38
MGSCv376126,658,347 - 126,690,692 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366126,702,307 - 126,705,772 (-)NCBIMGSCv36mm8
Celera6128,378,065 - 128,410,554 (-)NCBICelera
Cytogenetic Map6F3NCBI
cM Map661.72NCBI
Kcna6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554132,614,685 - 2,676,292 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554132,614,685 - 2,676,292 (+)NCBIChiLan1.0ChiLan1.0
KCNA6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1124,846,651 - 4,889,190 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl124,847,510 - 4,849,099 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0124,926,069 - 4,968,475 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
KCNA6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12740,042,051 - 40,045,812 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2740,044,334 - 40,045,812 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha276,635,593 - 6,639,492 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02740,397,855 - 40,401,770 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2740,400,162 - 40,401,748 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12740,286,847 - 40,290,747 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02740,311,960 - 40,315,859 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0276,046,284 - 6,050,185 (+)NCBIUU_Cfam_GSD_1.0
Kcna6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945104,211,782 - 104,214,883 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366064,969,787 - 4,971,446 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049366064,969,282 - 4,972,383 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNA6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl565,657,225 - 65,658,835 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1565,625,581 - 65,659,557 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2567,830,814 - 67,865,506 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KCNA6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1114,853,706 - 4,894,406 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl114,854,570 - 4,856,162 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660633,352,889 - 3,393,600 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcna6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248601,835,685 - 1,867,104 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248601,835,679 - 1,867,606 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kcna6
176 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:360
Count of miRNA genes:193
Interacting mature miRNAs:228
Transcripts:ENSRNOT00000075771
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4118856416163856416Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4132642577167139601Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4146565735175236377Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4147278504167139601Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4148090542168069246Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4155561574182687754Rat
1300109Rf13Renal function QTL 133.91renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)4157710145182687754Rat

Markers in Region
D4Got133  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24159,549,565 - 159,549,725 (+)MAPPERmRatBN7.2
Rnor_6.04159,260,569 - 159,260,728NCBIRnor6.0
Rnor_5.04232,350,850 - 232,351,009UniSTSRnor5.0
RGSC_v3.44163,094,025 - 163,094,184UniSTSRGSC3.4
RGSC_v3.44163,094,024 - 163,094,184RGDRGSC3.4
RGSC_v3.14163,338,961 - 163,339,120RGD
RH 3.4 Map41003.8UniSTS
RH 3.4 Map41003.8RGD
Cytogenetic Map4q42UniSTS
RH132337  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24159,543,035 - 159,543,240 (+)MAPPERmRatBN7.2
Rnor_6.04159,254,029 - 159,254,233NCBIRnor6.0
Rnor_5.04232,357,345 - 232,357,549UniSTSRnor5.0
RGSC_v3.44163,087,493 - 163,087,697UniSTSRGSC3.4
Celera4148,259,880 - 148,260,084UniSTS
RH 3.4 Map41009.1UniSTS
Cytogenetic Map4q42UniSTS
BE107724  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24159,576,690 - 159,576,854 (+)MAPPERmRatBN7.2
Rnor_6.04159,287,695 - 159,287,858NCBIRnor6.0
Rnor_5.04232,323,720 - 232,323,883UniSTSRnor5.0
RGSC_v3.44163,125,822 - 163,125,985UniSTSRGSC3.4
Celera4148,293,108 - 148,293,271UniSTS
RH 3.4 Map41008.6UniSTS
Cytogenetic Map4q42UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 54
Low 29 6 6 2 6 20 14 26 6
Below cutoff 3 10 20 8 9 8 6 6 6 9 5 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000080139   ⟹   ENSRNOP00000071895
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4159,542,941 - 159,576,189 (-)Ensembl
Rnor_6.0 Ensembl4159,253,934 - 159,287,193 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000097393   ⟹   ENSRNOP00000086088
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4159,542,615 - 159,575,340 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000104566   ⟹   ENSRNOP00000086058
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4159,567,014 - 159,575,340 (-)Ensembl
RefSeq Acc Id: NM_023954   ⟹   NP_076444
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24159,542,941 - 159,576,189 (-)NCBI
Rnor_6.04159,253,934 - 159,287,193 (-)NCBI
Rnor_5.04232,324,385 - 232,357,644 (+)NCBI
RGSC_v3.44163,087,398 - 163,125,320 (-)RGD
Celera4148,259,785 - 148,292,606 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_076444 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41499 (Get FASTA)   NCBI Sequence Viewer  
  CAC03592 (Get FASTA)   NCBI Sequence Viewer  
  EDM01828 (Get FASTA)   NCBI Sequence Viewer  
  P17659 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_076444   ⟸   NM_023954
- UniProtKB: G3V8L6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000071895   ⟸   ENSRNOT00000080139
RefSeq Acc Id: ENSRNOP00000086058   ⟸   ENSRNOT00000104566
RefSeq Acc Id: ENSRNOP00000086088   ⟸   ENSRNOT00000097393
Protein Domains
BTB   Ion transport

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P17659-F1-model_v2 AlphaFold P17659 1-530 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:62083 AgrOrtholog
BioCyc Gene G2FUF-42963 BioCyc
Ensembl Genes ENSRNOG00000052486 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000071895 ENTREZGENE
  ENSRNOP00000071895.1 UniProtKB/TrEMBL
  ENSRNOP00000086058.1 UniProtKB/TrEMBL
  ENSRNOP00000086088.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000080139 ENTREZGENE
  ENSRNOT00000080139.2 UniProtKB/TrEMBL
  ENSRNOT00000097393.1 UniProtKB/TrEMBL
  ENSRNOT00000104566.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.120.350 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro BTB/POZ_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv1.6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KCNA6_BTB_POZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SKP1/BTB/POZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  T1-type_BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Volt_channel_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64358 UniProtKB/TrEMBL
NCBI Gene 64358 ENTREZGENE
PANTHER PTHR11537 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11537:SF104 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BTB_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Kcna6 PhenoGen
PRINTS KCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KV16CHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KVCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SHAKERCHANEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54695 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Voltage-gated potassium channels UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt G3V8L6 ENTREZGENE, UniProtKB/TrEMBL
  KCNA6_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q9ESW1_RAT UniProtKB/TrEMBL
UniProt Secondary P19025 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Kcna6  potassium voltage-gated channel subfamily A member 6  Kcna6  potassium channel, voltage gated shaker related subfamily A, member 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-26 Kcna6  potassium channel, voltage gated shaker related subfamily A, member 6  Kcna6  potassium voltage gated channel, shaker related subfamily, member 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Kcna6  potassium voltage gated channel, shaker related subfamily, member 6       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in midbrain areas and brainstem 61641
gene_function voltage-gated potassium channel subunit 628546
gene_process may act on cell cycle progression by affecting membrane potential, cell volume regulation, intracellular calcium levlels or Cdk inhibitor levels 628546
gene_process involved in cell survival, cell cycle progression, membrane excitability and secretory function 628546
gene_regulation expression induced by platelet-derived growth factor (Pdgf) and basic fibroblast growth factor 628546