Ube2e1 (ubiquitin-conjugating enzyme E2E 1) - Rat Genome Database

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Gene: Ube2e1 (ubiquitin-conjugating enzyme E2E 1) Rattus norvegicus
Analyze
Symbol: Ube2e1
Name: ubiquitin-conjugating enzyme E2E 1
RGD ID: 2324438
Description: Predicted to enable ISG15 transferase activity and ubiquitin conjugating enzyme activity. Predicted to be involved in ISG15-protein conjugation; positive regulation of transcription by RNA polymerase II; and protein K48-linked ubiquitination. Predicted to act upstream of or within protein ubiquitination. Predicted to be part of ubiquitin ligase complex. Predicted to be active in nucleus. Orthologous to human UBE2E1 (ubiquitin conjugating enzyme E2 E1); INTERACTS WITH atrazine; bisphenol A; paracetamol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC100366017; ubiquitin-conjugating enzyme E2 E1; ubiquitin-conjugating enzyme E2E 1-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8159,870,528 - 9,924,194 (+)NCBIGRCr8
mRatBN7.2157,439,751 - 7,493,410 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl157,439,759 - 7,493,400 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx159,586,863 - 9,639,117 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01510,499,658 - 10,551,914 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0158,800,075 - 8,852,332 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0158,124,869 - 8,178,252 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl158,125,526 - 8,177,781 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01512,188,488 - 12,240,293 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera157,495,553 - 7,546,701 (+)NCBICelera
Cytogenetic Map15p16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8576256   PMID:9990509   PMID:12477932   PMID:15247280   PMID:15936721   PMID:16307923   PMID:16428300   PMID:16522193   PMID:18845142   PMID:20061386   PMID:25018020  


Genomics

Comparative Map Data
Ube2e1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8159,870,528 - 9,924,194 (+)NCBIGRCr8
mRatBN7.2157,439,751 - 7,493,410 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl157,439,759 - 7,493,400 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx159,586,863 - 9,639,117 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01510,499,658 - 10,551,914 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0158,800,075 - 8,852,332 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0158,124,869 - 8,178,252 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl158,125,526 - 8,177,781 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01512,188,488 - 12,240,293 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera157,495,553 - 7,546,701 (+)NCBICelera
Cytogenetic Map15p16NCBI
UBE2E1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38323,805,955 - 23,891,640 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl323,805,955 - 23,891,640 (+)EnsemblGRCh38hg38GRCh38
GRCh37323,847,446 - 23,933,131 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36323,822,443 - 23,907,811 (+)NCBINCBI36Build 36hg18NCBI36
Build 34323,822,442 - 23,907,810NCBI
Celera323,783,561 - 23,868,992 (+)NCBICelera
Cytogenetic Map3p24.2NCBI
HuRef323,793,438 - 23,879,219 (+)NCBIHuRef
CHM1_1323,799,158 - 23,884,951 (+)NCBICHM1_1
T2T-CHM13v2.0323,810,731 - 23,896,417 (+)NCBIT2T-CHM13v2.0
Ube2e1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39144,137,852 - 4,186,967 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl144,137,837 - 4,186,974 (+)EnsemblGRCm39 Ensembl
GRCm381418,282,726 - 18,332,004 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1418,282,722 - 18,331,859 (-)EnsemblGRCm38mm10GRCm38
MGSCv371419,115,243 - 19,164,358 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361417,075,847 - 17,124,962 (-)NCBIMGSCv36mm8
Celera1413,974,286 - 14,024,829 (-)NCBICelera
Cytogenetic Map14A1NCBI
cM Map147.08NCBI
Ube2e1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543015,648,476 - 15,734,767 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543015,648,736 - 15,734,767 (+)NCBIChiLan1.0ChiLan1.0
UBE2E1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2223,768,360 - 23,852,050 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1323,773,125 - 23,856,807 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0323,719,632 - 23,803,302 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1324,045,758 - 24,127,826 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl324,045,747 - 24,127,820 (+)Ensemblpanpan1.1panPan2
UBE2E1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12319,863,136 - 19,937,272 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2319,863,253 - 19,937,247 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2319,861,218 - 19,936,689 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02320,176,162 - 20,251,667 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12319,985,486 - 20,061,512 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02320,094,687 - 20,170,077 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02320,203,814 - 20,279,270 (-)NCBIUU_Cfam_GSD_1.0
Ube2e1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118182,348,783 - 182,418,938 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647315,487,014 - 15,557,513 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647315,487,341 - 15,557,516 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC102160336
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1310,605,503 - 10,683,816 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11310,605,837 - 10,683,819 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21312,058,613 - 12,131,848 (+)NCBISscrofa10.2Sscrofa10.2susScr3
UBE2E1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11568,483,247 - 68,566,645 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1568,484,589 - 68,568,987 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604141,607,680 - 41,690,874 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Ube2e1
270 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:80
Count of miRNA genes:62
Interacting mature miRNAs:73
Transcripts:ENSRNOT00000011653
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15129912054Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
5684946Bss98Bone structure and strength QTL 983.90.0026tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)15105825014481294Rat
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)colorectal tumor number (CMO:0001794)15226636822711984Rat
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15226636822711984Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat

Markers in Region
RH129032  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2157,493,152 - 7,493,356 (+)MAPPERmRatBN7.2
Rnor_6.0158,177,996 - 8,178,199NCBIRnor6.0
Rnor_5.01512,240,037 - 12,240,240UniSTSRnor5.0
RGSC_v3.4159,071,441 - 9,071,644UniSTSRGSC3.4
Celera157,546,445 - 7,546,648UniSTS
RH 3.4 Map1572.2UniSTS
Cytogenetic Map15p16UniSTS
BE120096  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2157,452,809 - 7,452,989 (+)MAPPERmRatBN7.2
Rnor_6.0158,137,940 - 8,138,119NCBIRnor6.0
Rnor_5.01512,200,843 - 12,201,022UniSTSRnor5.0
RGSC_v3.4159,029,607 - 9,029,786UniSTSRGSC3.4
Celera157,508,068 - 7,508,247UniSTS
RH 3.4 Map1573.3UniSTS
Cytogenetic Map15p16UniSTS
RH141730  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2157,437,329 - 7,437,543 (+)MAPPERmRatBN7.2
Rnor_6.0158,122,464 - 8,122,677NCBIRnor6.0
Rnor_5.01512,185,520 - 12,185,733UniSTSRnor5.0
RGSC_v3.4159,014,055 - 9,014,268UniSTSRGSC3.4
Celera157,492,894 - 7,493,107UniSTS
RH 3.4 Map1591.7UniSTS
Cytogenetic Map15p16UniSTS
AU049898  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2157,424,117 - 7,424,261 (+)MAPPERmRatBN7.2
Rnor_6.0158,109,256 - 8,109,399NCBIRnor6.0
Rnor_5.01512,172,312 - 12,172,455UniSTSRnor5.0
RGSC_v3.4159,000,363 - 9,000,506UniSTSRGSC3.4
Celera157,479,693 - 7,479,836UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 35 51 35 19 35 8 11 74 35 41 11 8
Low 8 6 6 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000011653   ⟹   ENSRNOP00000011653
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl157,439,759 - 7,493,400 (+)Ensembl
Rnor_6.0 Ensembl158,125,526 - 8,177,781 (+)Ensembl
RefSeq Acc Id: NM_001399579   ⟹   NP_001386508
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8159,870,542 - 9,924,194 (+)NCBI
mRatBN7.2157,439,751 - 7,493,409 (+)NCBI
RefSeq Acc Id: XM_039093737   ⟹   XP_038949665
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8159,870,816 - 9,924,194 (+)NCBI
mRatBN7.2157,440,011 - 7,493,409 (+)NCBI
RefSeq Acc Id: XM_039093739   ⟹   XP_038949667
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8159,870,906 - 9,924,194 (+)NCBI
mRatBN7.2157,440,203 - 7,493,409 (+)NCBI
RefSeq Acc Id: XM_039093740   ⟹   XP_038949668
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8159,870,528 - 9,924,194 (+)NCBI
mRatBN7.2157,439,792 - 7,493,410 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000011653   ⟸   ENSRNOT00000011653
RefSeq Acc Id: XP_038949668   ⟸   XM_039093740
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038949665   ⟸   XM_039093737
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038949667   ⟸   XM_039093739
- Peptide Label: isoform X2
RefSeq Acc Id: NP_001386508   ⟸   NM_001399579
- UniProtKB: F1M3L4 (UniProtKB/TrEMBL),   A6K033 (UniProtKB/TrEMBL)
Protein Domains
UBC core

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M3L4-F1-model_v2 AlphaFold F1M3L4 1-173 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2324438 AgrOrtholog
BioCyc Gene G2FUF-14462 BioCyc
BioCyc Pathway PWY-7511 [protein ubiquitination] BioCyc
BioCyc Pathway Image PWY-7511 BioCyc
Ensembl Genes ENSRNOG00000008794 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000011653 ENTREZGENE
  ENSRNOT00000011653.7 UniProtKB/TrEMBL
Gene3D-CATH 3.10.110.10 UniProtKB/TrEMBL
InterPro UBQ-conjugat_E2 UniProtKB/TrEMBL
  UBQ-conjugating_AS UniProtKB/TrEMBL
  UBQ-conjugating_enzyme/RWD UniProtKB/TrEMBL
KEGG Report rno:100366017 UniProtKB/TrEMBL
NCBI Gene 100366017 ENTREZGENE
PANTHER UBIQUITIN-CONJUGATING ENZYME E2 UniProtKB/TrEMBL
  UBIQUITIN-CONJUGATING ENZYME E2 E1 UniProtKB/TrEMBL
Pfam UQ_con UniProtKB/TrEMBL
PhenoGen Ube2e1 PhenoGen
PROSITE UBIQUITIN_CONJUGAT_1 UniProtKB/TrEMBL
  UBIQUITIN_CONJUGAT_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008794 RatGTEx
SMART UBCc UniProtKB/TrEMBL
Superfamily-SCOP UBQ-conjugat/RWD-like UniProtKB/TrEMBL
UniProt A6K033 ENTREZGENE, UniProtKB/TrEMBL
  F1M3L4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-08 Ube2e1  ubiquitin-conjugating enzyme E2E 1  LOC100366017  ubiquitin-conjugating enzyme E2E 1-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-06 LOC100366017  ubiquitin-conjugating enzyme E2E 1-like      Symbol and Name status set to provisional 70820 PROVISIONAL