Prdx1l1 (peroxiredoxin 1-like 1) - Rat Genome Database

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Gene: Prdx1l1 (peroxiredoxin 1-like 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Prdx1l1
Name: peroxiredoxin 1-like 1
RGD ID: 2323165
Description: Predicted to enable thioredoxin peroxidase activity. Predicted to be involved in several processes, including cell redox homeostasis; hydrogen peroxide catabolic process; and removal of superoxide radicals. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in methylmalonic aciduria and homocystinuria type cblC. Orthologous to human PRDX1 (peroxiredoxin 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AABR07012795.1; LOC100363379; peroxiredoxin-1-like
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82196,290,455 - 196,291,398 (+)NCBIGRCr8
mRatBN7.22193,602,142 - 193,603,085 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2193,602,121 - 193,603,084 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.02208,738,117 - 208,738,952 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2208,738,132 - 208,739,047 (+)NCBIRnor6.0rn6Rnor6.0
Rnor_5.02228,162,068 - 228,162,908 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42201,373,420 - 201,374,019 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2186,293,389 - 186,294,224 (+)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Prdx1l1Ratcell redox homeostasis involved_inIBAFB:FBgn0038519 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Prdx1l1Rathydrogen peroxide catabolic process involved_inIBACGD:CAL0000174369 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Prdx1l1Ratleukocyte activation involved_inIBAMGI:109486 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Prdx1l1Ratremoval of superoxide radicals involved_inIBAMGI:109486 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Prdx1l1Ratresponse to oxidative stress involved_inIBACGD:CAL0000174369 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Prdx1l1Ratcytosol is_active_inIBAFB:FBgn0040308 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033

Molecular Function
1 to 10 of 10 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Prdx1l1Ratantioxidant activity enablesIEAInterPro:IPR0008661600115GO_REF:0000002InterProGO_REF:0000002
Prdx1l1Ratantioxidant activity enablesIEAUniProtKB-KW:KW-00491600115GO_REF:0000043UniProtGO_REF:0000043
Prdx1l1Ratoxidoreductase activity enablesIEAUniProtKB-KW:KW-05601600115GO_REF:0000043UniProtGO_REF:0000043
Prdx1l1Ratoxidoreductase activity enablesIEAInterPro:IPR0008661600115GO_REF:0000002InterProGO_REF:0000002
Prdx1l1Ratperoxidase activity enablesIEAUniProtKB-KW:KW-05751600115GO_REF:0000043UniProtGO_REF:0000043
Prdx1l1Ratperoxidase activity enablesIEAUniRule:UR0013487721600115GO_REF:0000104UniProtGO_REF:0000104
Prdx1l1Ratperoxiredoxin activity enablesIEAInterPro:IPR0194791600115GO_REF:0000002InterProGO_REF:0000002
Prdx1l1Ratthioredoxin peroxidase activity enablesIBACGD:CAL0000174369 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Prdx1l1Ratthioredoxin-dependent peroxiredoxin activity enablesIEARHEA:626201600115GO_REF:0000116RHEAGO_REF:0000116
Prdx1l1Ratthioredoxin-dependent peroxiredoxin activity enablesIEAEC:1.11.1.241600115GO_REF:0000003UniProtGO_REF:0000003
1 to 10 of 10 rows


#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:22082260  



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Variants in Prdx1l1
7 total Variants

1 to 10 of 65 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2122609194206936711Rat
61458Bp10Blood pressure QTL 103.42arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat

1 to 10 of 65 rows
RH127925  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5q36UniSTS
Prdx1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22193,602,573 - 193,602,643 (+)MAPPERmRatBN7.2
mRatBN7.25130,154,646 - 130,156,228 (+)MAPPERmRatBN7.2
mRatBN7.25130,156,177 - 130,156,228 (+)MAPPERmRatBN7.2
Rnor_6.02208,738,546 - 208,738,615NCBIRnor6.0
Rnor_6.05135,543,785 - 135,545,366NCBIRnor6.0
Rnor_5.02228,162,502 - 228,162,571UniSTSRnor5.0
Rnor_5.05139,340,009 - 139,341,590UniSTSRnor5.0
RGSC_v3.45136,983,429 - 136,985,010UniSTSRGSC3.4
RGSC_v3.42201,373,781 - 201,373,850UniSTSRGSC3.4
Celera2186,293,818 - 186,293,887UniSTS
Celera5128,681,817 - 128,683,398UniSTS
Cytogenetic Map2q34UniSTS
Cytogenetic Map5q36UniSTS
UniSTS:470676  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22193,602,443 - 193,602,900 (+)MAPPERmRatBN7.2
mRatBN7.2647,072,314 - 47,072,784 (+)MAPPERmRatBN7.2
Rnor_6.0649,393,315 - 49,393,784NCBIRnor6.0
Rnor_6.02208,738,416 - 208,738,872NCBIRnor6.0
Rnor_5.0658,073,558 - 58,074,027UniSTSRnor5.0
Rnor_5.02228,162,372 - 228,162,828UniSTSRnor5.0
RGSC_v3.42201,373,651 - 201,374,107UniSTSRGSC3.4
RGSC_v3.4648,332,780 - 48,333,249UniSTSRGSC3.4
Celera646,276,343 - 46,276,812UniSTS
Celera2186,293,688 - 186,294,144UniSTS
Cytogenetic Map2q34UniSTS
Cytogenetic Map6q16UniSTS
Cytogenetic Map5q36UniSTS







Ensembl Acc Id: ENSRNOT00000023972   ⟹   ENSRNOP00000072842
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2193,602,121 - 193,603,084 (+)Ensembl
RefSeq Acc Id: NM_001408808   ⟹   NP_001395737
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82196,290,455 - 196,291,398 (+)NCBI
mRatBN7.22193,602,142 - 193,603,085 (+)NCBI
Protein RefSeqs NP_001395737 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000072842
  ENSRNOP00000072842.1
Ensembl Acc Id: ENSRNOP00000072842   ⟸   ENSRNOT00000023972
RefSeq Acc Id: NP_001395737   ⟸   NM_001408808
- UniProtKB: A0A0G2K3Z9 (UniProtKB/TrEMBL)
Thioredoxin

Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K3Z9-F1-model_v2 AlphaFold A0A0G2K3Z9 1-199 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 22 of 22 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-51712 BioCyc
Ensembl Genes ENSRNOG00000017695 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000023972 ENTREZGENE
  ENSRNOT00000023972.4 UniProtKB/TrEMBL
Gene3D-CATH Glutaredoxin UniProtKB/TrEMBL
InterPro AhpC/TSA UniProtKB/TrEMBL
  Peroxiredoxin UniProtKB/TrEMBL
  Peroxiredoxin_AhpC-typ UniProtKB/TrEMBL
  Peroxiredoxin_C UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/TrEMBL
  Thioredoxin_domain UniProtKB/TrEMBL
NCBI Gene 100363379 ENTREZGENE
PANTHER PEROXIREDOXIN-1 UniProtKB/TrEMBL
  THIOREDOXIN PEROXIDASE UniProtKB/TrEMBL
Pfam 1-cysPrx_C UniProtKB/TrEMBL
  AhpC-TSA UniProtKB/TrEMBL
PhenoGen Prdx1l1 PhenoGen
PIRSF AHPC UniProtKB/TrEMBL
PROSITE THIOREDOXIN_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017695 RatGTEx
Superfamily-SCOP SSF52833 UniProtKB/TrEMBL
UniProt A0A0G2K3Z9 ENTREZGENE, UniProtKB/TrEMBL
1 to 22 of 22 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Prdx1l1  peroxiredoxin 1-like 1  AABR07012795.1    Data merged from RGD:15003457 737654 PROVISIONAL
2019-11-08 AABR07012795.1        Symbol and Name status set to provisional 45752 PROVISIONAL
2012-09-11 Prdx1l1  peroxiredoxin 1-like 1  LOC100363379  peroxiredoxin-1-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-06 LOC100363379  peroxiredoxin-1-like      Symbol and Name status set to provisional 70820 PROVISIONAL