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Gene: Dennd5b (DENN domain containing 5B) Rattus norvegicus

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Symbol:

Dennd5b

Name:

DENN domain containing 5B

RGD ID:

2318606

Description:

Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in positive regulation of triglyceride transport. Predicted to be located in membrane. Orthologous to human DENND5B (DENN domain containing 5B); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; amphetamine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

DENN domain-containing protein 5B; DENN/MADD domain containing 5B; DENN/MADD domain containing 5B-like; LOC100365679

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	DENND5B (DENN domain containing 5B)	HGNC	HomoloGene, NCBI
Mus musculus (house mouse):	Dennd5b (DENN domain containing 5B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Dennd5b (DENN domain containing 5B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	DENND5B (DENN domain containing 5B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	DENND5B (DENN domain containing 5B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Dennd5b (DENN domain containing 5B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	DENND5B (DENN domain containing 5B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	DENND5B (DENN domain containing 5B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Dennd5b (DENN domain containing 5B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	DENND5B (DENN domain containing 5B)	Alliance	DIOPT (Ensembl Compara\|HGNC\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Mus musculus (house mouse):	Dennd5b (DENN domain containing 5B)	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	dennd5b (DENN/MADD domain containing 5B)	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	lst-6	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	pns	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	dennd5b	Alliance	DIOPT (InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	183,688,039 - 183,821,012 (-)	NCBI		GRCr8
mRatBN7.2	4	181,959,597 - 182,089,661 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	181,961,386 - 182,089,362 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	4	183,476,093 - 183,604,940 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	183,476,093 - 183,544,850 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	247,608,015 - 247,704,356 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	4	170,433,402 - 170,556,221 (-)	NCBI		Celera
Cytogenetic Map	4	q44	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Dennd5b	Rat	(+)-catechin	multiple interactions	ISO	RGD:1605273	6480464	[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of DENND5B mRNA	CTD	PMID:24763279
Dennd5b	Rat	(1->4)-beta-D-glucan	multiple interactions	ISO	RGD:1617988	6480464	[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of DENND5B mRNA	CTD	PMID:36331819
Dennd5b	Rat	1,2-dimethylhydrazine	decreases expression	ISO	RGD:1617988	6480464	1,2-Dimethylhydrazine results in decreased expression of DENND5B mRNA	CTD	PMID:22206623
Dennd5b	Rat	17alpha-ethynylestradiol	increases expression	EXP		6480464	Ethinyl Estradiol results in increased expression of DENND5B mRNA	CTD	PMID:29097150
Dennd5b	Rat	2,3',4,4',5-Pentachlorobiphenyl	increases expression	ISO	RGD:1617988	6480464	2,3',4,4',5-pentachlorobiphenyl results in increased expression of DENND5B mRNA	CTD	PMID:31388691
Dennd5b	Rat	2,3,7,8-tetrachlorodibenzodioxine	affects expression	ISO	RGD:1617988	6480464	Tetrachlorodibenzodioxin affects the expression of DENND5B mRNA	CTD	PMID:21570461
Dennd5b	Rat	2,3,7,8-tetrachlorodibenzodioxine	increases expression	EXP		6480464	Tetrachlorodibenzodioxin results in increased expression of DENND5B mRNA	CTD	PMID:32109520
Dennd5b	Rat	3,4-methylenedioxymethamphetamine	decreases expression	ISO	RGD:1617988	6480464	N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of DENND5B mRNA	CTD	PMID:26251327
Dennd5b	Rat	4,4'-sulfonyldiphenol	affects expression	ISO	RGD:1617988	6480464	bisphenol S affects the expression of DENND5B mRNA	CTD	PMID:39298647
Dennd5b	Rat	4,4'-sulfonyldiphenol	decreases methylation	ISO	RGD:1605273	6480464	bisphenol S results in decreased methylation of DENND5B gene	CTD	PMID:31601247
Dennd5b	Rat	4,4'-sulfonyldiphenol	increases methylation	ISO	RGD:1617988	6480464	bisphenol S results in increased methylation of DENND5B exon	CTD	PMID:33297965
Dennd5b	Rat	4-hydroxyphenyl retinamide	increases expression	ISO	RGD:1617988	6480464	Fenretinide results in increased expression of DENND5B mRNA	CTD	PMID:28973697
Dennd5b	Rat	aflatoxin B1	increases expression	ISO	RGD:1617988	6480464	Aflatoxin B1 results in increased expression of DENND5B mRNA	CTD	PMID:19770486
Dennd5b	Rat	all-trans-retinoic acid	increases expression	ISO	RGD:1605273	6480464	Tretinoin results in increased expression of DENND5B mRNA	CTD	PMID:21934132
Dennd5b	Rat	all-trans-retinoic acid	decreases expression	ISO	RGD:1605273	6480464	Tretinoin results in decreased expression of DENND5B mRNA	CTD	PMID:33167477
Dennd5b	Rat	amphetamine	decreases expression	EXP		6480464	Amphetamine results in decreased expression of DENND5B mRNA	CTD	PMID:30779732
Dennd5b	Rat	antirheumatic drug	increases expression	ISO	RGD:1605273	6480464	Antirheumatic Agents results in increased expression of DENND5B mRNA	CTD	PMID:24449571
Dennd5b	Rat	aristolochic acid A	decreases expression	ISO	RGD:1605273	6480464	aristolochic acid I results in decreased expression of DENND5B mRNA	CTD	PMID:33212167
Dennd5b	Rat	arsane	multiple interactions	ISO	RGD:1605273	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ...	CTD	PMID:39836092
Dennd5b	Rat	arsenic atom	multiple interactions	ISO	RGD:1605273	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ...	CTD	PMID:39836092
Dennd5b	Rat	atrazine	decreases expression	ISO	RGD:1605273	6480464	Atrazine results in decreased expression of DENND5B mRNA	CTD	PMID:22378314
Dennd5b	Rat	avobenzone	increases expression	ISO	RGD:1605273	6480464	avobenzone results in increased expression of DENND5B mRNA	CTD	PMID:31016361
Dennd5b	Rat	benzo[a]pyrene	increases mutagenesis	ISO	RGD:1605273	6480464	Benzo(a)pyrene results in increased mutagenesis of DENND5B gene	CTD	PMID:25435355
Dennd5b	Rat	benzo[a]pyrene	decreases expression	ISO	RGD:1605273	6480464	Benzo(a)pyrene results in decreased expression of DENND5B mRNA	CTD	PMID:32234424
Dennd5b	Rat	benzo[a]pyrene	increases methylation	ISO	RGD:1605273	6480464	Benzo(a)pyrene results in increased methylation of DENND5B promoter	CTD	PMID:27901495
Dennd5b	Rat	benzo[a]pyrene	multiple interactions	ISO	RGD:1617988	6480464	AHR protein affects the reaction [Benzo(a)pyrene affects the expression of DENND5B mRNA]	CTD	PMID:22228805
Dennd5b	Rat	bisphenol A	decreases expression	ISO	RGD:1617988	6480464	bisphenol A results in decreased expression of DENND5B mRNA	CTD	PMID:26063408
Dennd5b	Rat	bisphenol A	multiple interactions	ISO	RGD:1605273	6480464	[bisphenol A co-treated with Fulvestrant] results in increased methylation of DENND5B gene	CTD	PMID:31601247
Dennd5b	Rat	bisphenol A	decreases methylation	ISO	RGD:1605273	6480464	bisphenol A results in decreased methylation of DENND5B gene	CTD	PMID:31601247
Dennd5b	Rat	caffeine	decreases phosphorylation	ISO	RGD:1605273	6480464	Caffeine results in decreased phosphorylation of DENND5B protein	CTD	PMID:35688186
Dennd5b	Rat	carbon nanotube	decreases expression	ISO	RGD:1617988	6480464	Nanotubes, Carbon analog results in decreased expression of DENND5B mRNA	CTD	PMID:25554681
Dennd5b	Rat	chlorpyrifos	decreases expression	ISO	RGD:1617988	6480464	Chlorpyrifos results in decreased expression of DENND5B mRNA	CTD	PMID:37019170
Dennd5b	Rat	cisplatin	multiple interactions	ISO	RGD:1605273	6480464	[Cisplatin co-treated with jinfukang] results in decreased expression of DENND5B mRNA	CTD	PMID:27392435
Dennd5b	Rat	cisplatin	decreases expression	ISO	RGD:1605273	6480464	Cisplatin results in decreased expression of DENND5B mRNA	CTD	PMID:27392435
Dennd5b	Rat	cobalt dichloride	increases expression	EXP		6480464	cobaltous chloride results in increased expression of DENND5B mRNA	CTD	PMID:24386269
Dennd5b	Rat	folic acid	increases expression	ISO	RGD:1617988	6480464	Folic Acid results in increased expression of DENND5B mRNA	CTD	PMID:25629700
Dennd5b	Rat	FR900359	increases phosphorylation	ISO	RGD:1605273	6480464	FR900359 results in increased phosphorylation of DENND5B protein	CTD	PMID:37730182
Dennd5b	Rat	fulvestrant	multiple interactions	ISO	RGD:1605273	6480464	[bisphenol A co-treated with Fulvestrant] results in increased methylation of DENND5B gene	CTD	PMID:31601247
Dennd5b	Rat	genistein	increases expression	ISO	RGD:1617988	6480464	Genistein results in increased expression of DENND5B mRNA	CTD	PMID:32186404
Dennd5b	Rat	gentamycin	increases expression	EXP		6480464	Gentamicins results in increased expression of DENND5B mRNA	CTD	PMID:33387578
Dennd5b	Rat	GSK-J4	increases expression	ISO	RGD:1605273	6480464	GSK-J4 results in increased expression of DENND5B mRNA	CTD	PMID:29301935
Dennd5b	Rat	manganese atom	multiple interactions	ISO	RGD:1605273	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ...	CTD	PMID:39836092
Dennd5b	Rat	manganese(0)	multiple interactions	ISO	RGD:1605273	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ...	CTD	PMID:39836092
Dennd5b	Rat	manganese(II) chloride	multiple interactions	ISO	RGD:1605273	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ...	CTD	PMID:39836092
Dennd5b	Rat	ozone	multiple interactions	ISO	RGD:1617988	6480464	[Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased more ...	CTD	PMID:34911549
Dennd5b	Rat	paracetamol	decreases expression	ISO	RGD:1605273	6480464	Acetaminophen results in decreased expression of DENND5B mRNA	CTD	PMID:21420995
Dennd5b	Rat	paracetamol	increases expression	EXP		6480464	Acetaminophen results in increased expression of DENND5B mRNA	CTD	PMID:33387578
Dennd5b	Rat	parathion	increases expression	ISO	RGD:1617988	6480464	Parathion results in increased expression of DENND5B mRNA	CTD	PMID:34813904
Dennd5b	Rat	perfluorooctane-1-sulfonic acid	multiple interactions	ISO	RGD:1617988	6480464	[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of DENND5B mRNA	CTD	PMID:36331819
Dennd5b	Rat	phenobarbital	affects expression	ISO	RGD:1617988	6480464	Phenobarbital affects the expression of DENND5B mRNA	CTD	PMID:23091169
Dennd5b	Rat	potassium dichromate	decreases expression	ISO	RGD:1605273	6480464	Potassium Dichromate results in decreased expression of DENND5B protein	CTD	PMID:23718831
Dennd5b	Rat	potassium dichromate	decreases expression	ISO	RGD:1617988	6480464	Potassium Dichromate results in decreased expression of DENND5B mRNA	CTD	PMID:23608068
Dennd5b	Rat	sodium arsenite	increases expression	ISO	RGD:1605273	6480464	sodium arsenite results in increased expression of DENND5B mRNA	CTD	PMID:38568856
Dennd5b	Rat	sodium arsenite	multiple interactions	ISO	RGD:1605273	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ...	CTD	PMID:39836092
Dennd5b	Rat	sodium fluoride	increases expression	ISO	RGD:1617988	6480464	Sodium Fluoride results in increased expression of DENND5B mRNA	CTD	PMID:27862939
Dennd5b	Rat	testosterone	decreases expression	ISO	RGD:1605273	6480464	Testosterone results in decreased expression of DENND5B mRNA	CTD	PMID:33359661
Dennd5b	Rat	trichostatin A	increases expression	ISO	RGD:1605273	6480464	trichostatin A results in increased expression of DENND5B mRNA	CTD	PMID:24935251
Dennd5b	Rat	triphenyl phosphate	affects expression	ISO	RGD:1605273	6480464	triphenyl phosphate affects the expression of DENND5B mRNA	CTD	PMID:37042841
Dennd5b	Rat	troglitazone	decreases expression	ISO	RGD:1617988	6480464	troglitazone results in decreased expression of DENND5B mRNA	CTD	PMID:28973697
Dennd5b	Rat	trovafloxacin	increases expression	ISO	RGD:1617988	6480464	trovafloxacin results in increased expression of DENND5B mRNA	CTD	PMID:35537566
Dennd5b	Rat	tungsten	decreases expression	ISO	RGD:1617988	6480464	Tungsten results in decreased expression of DENND5B mRNA	CTD	PMID:30912803
Dennd5b	Rat	valproic acid	decreases expression	ISO	RGD:1605273	6480464	Valproic Acid results in decreased expression of DENND5B mRNA	CTD	PMID:23179753
Dennd5b	Rat	valproic acid	increases expression	ISO	RGD:1605273	6480464	Valproic Acid results in increased expression of DENND5B mRNA	CTD	PMID:23179753\|PMID:24935251\|PMID:27188386
Dennd5b	Rat	zinc atom	increases expression	ISO	RGD:1605273	6480464	Zinc deficiency results in increased expression of DENND5B mRNA	CTD	PMID:22171008
Dennd5b	Rat	zinc(0)	increases expression	ISO	RGD:1605273	6480464	Zinc deficiency results in increased expression of DENND5B mRNA	CTD	PMID:22171008

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Dennd5b	Rat	positive regulation of triglyceride transport	involved_in	IEA	UniProtKB:A2RSQ0\|ensembl:ENSMUSP00000107182	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Dennd5b	Rat	positive regulation of triglyceride transport	involved_in	ISO	RGD:1617988	1624291	PMID:30837651	RGD	PMID:30837651

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Dennd5b	Rat	membrane	located_in	IEA	UniProtKB-SubCell:SL-0162	1600115	GO_REF:0000044	UniProt	GO_REF:0000044
Dennd5b	Rat	membrane	located_in	IEA	UniProtKB-KW:KW-0472	1600115	GO_REF:0000043	UniProt	GO_REF:0000043

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Dennd5b	Rat	guanyl-nucleotide exchange factor activity	enables	ISO	RGD:1605273	1624291	PMID:20937701	RGD	PMID:20937701
Dennd5b	Rat	guanyl-nucleotide exchange factor activity	enables	IBA	PANTHER:PTN001329172\|UniProtKB:Q6IQ26\|UniProtKB:Q6ZUT9	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Dennd5b	Rat	guanyl-nucleotide exchange factor activity	enables	IEA	InterPro:IPR047278	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Dennd5b	Rat	guanyl-nucleotide exchange factor activity	enables	IEA	UniProtKB-KW:KW-0344	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Dennd5b	Rat	small GTPase binding	enables	IBA	MGI:1201681\|PANTHER:PTN001329172	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Dennd5b	Rat	small GTPase binding	enables	IEA	InterPro:IPR047278	1600115	GO_REF:0000002	InterPro	GO_REF:0000002

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

PMID:20937701	PMID:30837651

Dennd5b
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	183,688,039 - 183,821,012 (-)	NCBI		GRCr8
mRatBN7.2	4	181,959,597 - 182,089,661 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	181,961,386 - 182,089,362 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	4	183,476,093 - 183,604,940 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	183,476,093 - 183,544,850 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	247,608,015 - 247,704,356 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	4	170,433,402 - 170,556,221 (-)	NCBI		Celera
Cytogenetic Map	4	q44	NCBI

DENND5B
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	31,382,226 - 31,591,136 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	31,382,226 - 31,591,136 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	31,535,160 - 31,744,070 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	31,426,424 - 31,635,219 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	12	11,356,369 - 11,566,294 (-)	NCBI		Celera
Cytogenetic Map	12	p11.21	NCBI
HuRef	12	31,287,816 - 31,496,409 (-)	NCBI		HuRef
CHM1_1	12	31,500,166 - 31,708,943 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	12	31,258,770 - 31,467,670 (-)	NCBI		T2T-CHM13v2.0

Dennd5b
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	148,889,566 - 149,003,178 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	148,889,569 - 149,003,178 (-)	Ensembl		GRCm39 Ensembl
GRCm38	6	148,988,069 - 149,101,680 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	148,988,071 - 149,101,680 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	148,936,591 - 149,050,202 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	148,971,158 - 149,058,708 (-)	NCBI		MGSCv36	mm8
Celera	6	152,026,106 - 152,141,735 (-)	NCBI		Celera
Cytogenetic Map	6	G3	NCBI
cM Map	6	78.71	NCBI

Dennd5b
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955505	4,208,320 - 4,295,112 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955505	4,134,686 - 4,295,112 (+)	NCBI	ChiLan1.0	ChiLan1.0

DENND5B
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	65,179,861 - 65,390,784 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	65,176,281 - 65,387,177 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	54,650,609 - 54,858,862 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	57,236,855 - 57,444,819 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	57,236,973 - 57,444,819 (+)	Ensembl	panpan1.1		panPan2

DENND5B
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	27	17,250,526 - 17,366,021 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	27	17,044,309 - 17,361,570 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	27	29,051,206 - 29,250,680 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	27	17,348,446 - 17,549,134 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	27	17,348,446 - 17,548,801 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	27	17,159,010 - 17,358,756 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	27	17,191,053 - 17,389,619 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	27	29,204,343 - 29,403,719 (-)	NCBI		UU_Cfam_GSD_1.0

Dennd5b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	77,825,694 - 77,945,439 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936607	4,663,703 - 4,775,956 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936607	4,598,370 - 4,777,241 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DENND5B
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	42,643,115 - 42,879,729 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	42,642,676 - 42,870,980 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	45,983,366 - 46,005,315 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DENND5B
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	30,858,764 - 31,060,928 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	30,859,822 - 31,060,633 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666069	3,926,033 - 4,127,804 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Dennd5b
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624778	4,680,389 - 4,873,418 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624778	4,680,320 - 4,870,818 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants in Dennd5b
391 total Variants

Predicted Target Of

	Summary Value
Count of predictions:	26
Count of miRNA genes:	25
Interacting mature miRNAs:	26
Transcripts:	ENSRNOT00000071407
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
6478754	Anxrr43	Anxiety related response QTL 43		0.14035	locomotor behavior trait (VT:0001392)	distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)	4	144639524	182687754	Rat
6478693	Anxrr32	Anxiety related response QTL 32		0.00092	locomotor behavior trait (VT:0001392)	measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)	4	144639524	182687754	Rat
10401796	Kidm48	Kidney mass QTL 48			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	4	145568712	182687754	Rat
6478718	Anxrr34	Anxiety related response QTL 34		0.00896	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	144639524	182687754	Rat
6478748	Anxrr42	Anxiety related response QTL 42		0.28008	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	144639524	182687754	Rat
6478700	Anxrr33	Anxiety related response QTL 33		0.00896	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	144639524	182687754	Rat
1300109	Rf13	Renal function QTL 13	3.91		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	4	157710145	182687754	Rat
10053718	Scort25	Serum corticosterone level QTL 25	2.15	0.0097	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	155561574	182687754	Rat

D4Got145

Rat Assembly	Chr	Position (strand)	Source
Celera	4	170,557,329 - 170,557,455	UniSTS
RH 3.4 Map	4	1123.61	UniSTS
RH 3.4 Map	4	1123.61	RGD

D4Got244

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	4	183,736,889 - 183,737,148 (+)	Marker Load Pipeline
Rnor_6.0	4	183,519,270 - 183,519,510	NCBI	Rnor6.0
Rnor_5.0	4	247,647,242 - 247,647,499	UniSTS	Rnor5.0
Celera	4	170,472,849 - 170,473,107	UniSTS

AI852444

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	181,956,754 - 181,956,868 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	183,470,149 - 183,470,262	NCBI	Rnor6.0
Rnor_5.0	4	247,598,648 - 247,598,761	UniSTS	Rnor5.0
Celera	4	170,424,501 - 170,424,614	UniSTS

RH138972

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	182,085,815 - 182,085,939 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	183,601,459 - 183,601,582	NCBI	Rnor6.0
Rnor_5.0	4	247,726,314 - 247,726,437	UniSTS	Rnor5.0
Celera	4	170,552,283 - 170,552,406	UniSTS
RH 3.4 Map	10	499.9	UniSTS

RH141419

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	181,961,361 - 181,961,558 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	183,474,755 - 183,474,951	NCBI	Rnor6.0
Rnor_5.0	4	247,603,254 - 247,603,450	UniSTS	Rnor5.0
Celera	4	170,429,106 - 170,429,302	UniSTS
RH 3.4 Map	4	1122.2	UniSTS

AI104522

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	181,956,766 - 181,956,997 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	183,470,161 - 183,470,391	NCBI	Rnor6.0
Rnor_5.0	4	247,598,660 - 247,598,890	UniSTS	Rnor5.0
Celera	4	170,424,513 - 170,424,743	UniSTS
RH 3.4 Map	4	1125.62	UniSTS

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31


RefSeq Transcripts	NM_001431960	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001431961	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001431962	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006225139	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006225140	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008775873	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017593097	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039108922	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039108923	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039108924	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039108925	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039108926	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063286868	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAXUCZ010000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000071407 ⟹ ENSRNOP00000064573

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	181,961,386 - 182,029,466 (-)	Ensembl
Rnor_6.0 Ensembl	4	183,476,093 - 183,544,850 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000101410 ⟹ ENSRNOP00000086881

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	181,961,386 - 182,089,362 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000105569 ⟹ ENSRNOP00000085174

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	181,961,386 - 182,089,362 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000107257 ⟹ ENSRNOP00000096895

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	181,961,386 - 182,089,362 (-)	Ensembl

RefSeq Acc Id:

XM_039108922 ⟹ XP_038964850

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	183,688,039 - 183,821,009 (-)	NCBI
mRatBN7.2	4	181,959,597 - 182,089,657 (-)	NCBI

RefSeq Acc Id:

XM_039108923 ⟹ XP_038964851

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	183,688,039 - 183,821,009 (-)	NCBI
mRatBN7.2	4	181,959,597 - 182,089,656 (-)	NCBI

RefSeq Acc Id:

XM_039108924 ⟹ XP_038964852

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	183,688,039 - 183,821,007 (-)	NCBI
mRatBN7.2	4	181,959,597 - 182,089,655 (-)	NCBI

RefSeq Acc Id:

XM_039108925 ⟹ XP_038964853

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	183,688,039 - 183,821,012 (-)	NCBI
mRatBN7.2	4	181,959,597 - 182,089,661 (-)	NCBI

RefSeq Acc Id:

XM_039108926 ⟹ XP_038964854

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	183,688,039 - 183,821,007 (-)	NCBI
mRatBN7.2	4	181,959,597 - 182,089,654 (-)	NCBI

RefSeq Acc Id:

XM_063286868 ⟹ XP_063142938

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	183,688,039 - 183,797,689 (-)	NCBI


Protein RefSeqs	NP_001418889	(Get FASTA)	NCBI Sequence Viewer
	NP_001418890	(Get FASTA)	NCBI Sequence Viewer
	NP_001418891	(Get FASTA)	NCBI Sequence Viewer
	XP_038964850	(Get FASTA)	NCBI Sequence Viewer
	XP_038964851	(Get FASTA)	NCBI Sequence Viewer
	XP_038964852	(Get FASTA)	NCBI Sequence Viewer
	XP_038964853	(Get FASTA)	NCBI Sequence Viewer
	XP_038964854	(Get FASTA)	NCBI Sequence Viewer
	XP_063142938	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000064573.3
	ENSRNOP00000085174
	ENSRNOP00000085174.1
	ENSRNOP00000086881
	ENSRNOP00000086881.1
	ENSRNOP00000096895
	ENSRNOP00000096895.1
	ENSRNOP00000101456

Ensembl Acc Id:

ENSRNOP00000064573 ⟸ ENSRNOT00000071407

RefSeq Acc Id:	XP_038964853 ⟸ XM_039108925
- Peptide Label:	isoform X4
- UniProtKB:	A0A8I6AR19 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038964850 ⟸ XM_039108922
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6AR19 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038964851 ⟸ XM_039108923
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038964852 ⟸ XM_039108924
- Peptide Label:	isoform X3

Protein Domains

PLAT RUN uDENN

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-M0R5A9-F1-model_v2	AlphaFold	M0R5A9	1-977	view protein structure

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Database	Acc Id	Source(s)
BioCyc Gene	G2FUF-42368	BioCyc
Ensembl Genes	ENSRNOG00000049378	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000071407.3	UniProtKB/TrEMBL
	ENSRNOT00000101410	ENTREZGENE
	ENSRNOT00000101410.1	UniProtKB/TrEMBL
	ENSRNOT00000105569	ENTREZGENE
	ENSRNOT00000105569.1	UniProtKB/TrEMBL
	ENSRNOT00000107257	ENTREZGENE
	ENSRNOT00000107257.1	UniProtKB/TrEMBL
	ENSRNOT00000158066	ENTREZGENE
Gene3D-CATH	1.20.58.900	UniProtKB/TrEMBL
	3.30.450.200	UniProtKB/TrEMBL
	3.40.50.11500	UniProtKB/TrEMBL
	PLAT/LH2 domain	UniProtKB/TrEMBL
InterPro	cDENN_dom	UniProtKB/TrEMBL
	dDENN_dom	UniProtKB/TrEMBL
	DEN5A/B	UniProtKB/TrEMBL
	DENN_C	UniProtKB/TrEMBL
	PLAT/LH2_dom	UniProtKB/TrEMBL
	PLAT/LH2_dom_sf	UniProtKB/TrEMBL
	PLAT_RAB6IP1	UniProtKB/TrEMBL
	RUN1_DENND5B	UniProtKB/TrEMBL
	RUN2_DENND5B	UniProtKB/TrEMBL
	Run_dom	UniProtKB/TrEMBL
	Run_dom_sf	UniProtKB/TrEMBL
	Tripartite_DENN	UniProtKB/TrEMBL
	uDENN_dom	UniProtKB/TrEMBL
NCBI Gene	100365679	ENTREZGENE
PANTHER	DENN DOMAIN-CONTAINING PROTEIN 5B	UniProtKB/TrEMBL
	PINSTRIPE, ISOFORM A	UniProtKB/TrEMBL
Pfam	dDENN	UniProtKB/TrEMBL
	DENN	UniProtKB/TrEMBL
	PLAT	UniProtKB/TrEMBL
	RUN	UniProtKB/TrEMBL
	uDENN	UniProtKB/TrEMBL
PhenoGen	Dennd5b	PhenoGen
PROSITE	DENN	UniProtKB/TrEMBL
	PLAT	UniProtKB/TrEMBL
	RUN	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000049378	RatGTEx
SMART	dDENN	UniProtKB/TrEMBL
	DENN	UniProtKB/TrEMBL
	RUN	UniProtKB/TrEMBL
	uDENN	UniProtKB/TrEMBL
Superfamily-SCOP	SSF140741	UniProtKB/TrEMBL
	SSF49723	UniProtKB/TrEMBL
UniProt	A0A8I5ZYN4	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6A6X2	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6AR19	ENTREZGENE, UniProtKB/TrEMBL
	M0R5A9_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-17	Dennd5b	DENN domain containing 5B	Dennd5b	DENN/MADD domain containing 5B	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2013-08-08	Dennd5b	DENN/MADD domain containing 5B	LOC100365679	DENN/MADD domain containing 5B-like	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2010-05-05	LOC100365679	DENN/MADD domain containing 5B-like			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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