Adra2b (adrenoceptor alpha 2B) - Rat Genome Database

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Gene: Adra2b (adrenoceptor alpha 2B) Rattus norvegicus
Analyze
Symbol: Adra2b
Name: adrenoceptor alpha 2B
RGD ID: 2057
Description: Enables alpha2-adrenergic receptor activity. Involved in several processes, including female pregnancy; positive regulation of MAPK cascade; and regulation of smooth muscle contraction. Predicted to be located in cell surface; cytosol; and intracellular membrane-bounded organelle. Predicted to be active in plasma membrane. Used to study hypertension. Human ortholog(s) of this gene implicated in diabetic neuropathy; hypertension; myocardial infarction; obesity; and type 2 diabetes mellitus. Orthologous to human ADRA2B (adrenoceptor alpha 2B); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; alpha-Zearalanol; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Adrenergic alpha2B- receptor class III; adrenergic receptor, alpha 2b; adrenergic, alpha-2B-, receptor; Adrenergic, alpha2B-, receptor class III; alpha-2B adrenergic receptor; alpha-2B adrenoceptor; alpha-2B adrenoreceptor; alpha-2BAR
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83135,038,481 - 135,042,527 (+)NCBIGRCr8
mRatBN7.23114,585,174 - 114,589,220 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3114,585,169 - 114,589,355 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3118,474,365 - 118,478,411 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03127,069,926 - 127,073,972 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03124,730,297 - 124,734,343 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03119,805,941 - 119,809,987 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3119,805,941 - 119,809,987 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03126,332,318 - 126,336,364 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43114,867,357 - 114,869,680 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13114,772,929 - 114,775,253 (+)NCBI
Celera3113,423,833 - 113,427,879 (+)NCBICelera
Cytogenetic Map3q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. alpha 2B-adrenergic receptor activates MAPK via a pathway involving arachidonic acid metabolism, matrix metalloproteinases, and epidermal growth factor receptor transactivation. Cussac D, etal., J Biol Chem 2002 May 31;277(22):19882-8. Epub 2002 Mar 12.
2. [The effect of the ARC 239 on the myometrial and cervical action in the rat, in vitro] Gal A, etal., Acta Pharm Hung. 2009;79(2):75-80.
3. The roles of alpha2-adrenoceptor subtypes in the control of cervical resistance in the late-pregnant rat. Gal A, etal., Eur J Pharmacol. 2009 Aug 1;615(1-3):193-200. Epub 2009 May 15.
4. Different roles of alpha2-adrenoceptor subtypes in non-pregnant and late-pregnant uterine contractility in vitro in the rat. Gaspar R, etal., Neurochem Int. 2007 Oct;51(5):311-8. Epub 2007 Jul 1.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. A deletion polymorphism of the alpha2B-adrenergic receptor gene is not associated with late complications in Type 1 diabetic patients. Heinonen P, etal., Diabet Med. 2005 Feb;22(2):226-8.
8. Identification of a three-amino acid deletion in the alpha2B-adrenergic receptor that is associated with reduced basal metabolic rate in obese subjects. Heinonen P, etal., J Clin Endocrinol Metab 1999 Jul;84(7):2429-33.
9. alpha2B-adrenoceptor agonist ST-91 antagonizes beta2-adrenoceptor-mediated relaxation in rat mesenteric artery rings. Kato E, etal., Eur J Pharmacol. 2008 Feb 12;580(3):361-5. Epub 2007 Nov 13.
10. Physical activity, diet, and incident diabetes in relation to an ADRA2B polymorphism. Laaksonen DE, etal., Med Sci Sports Exerc. 2007 Feb;39(2):227-32.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. An insertion/deletion polymorphism in the alpha2B adrenoceptor gene is associated with peripheral neuropathy in patients with type 2 diabetes mellitus. Papanas N, etal., Exp Clin Endocrinol Diabetes. 2007 May;115(5):327-30.
15. An insertion/deletion polymorphism in the alpha2B adrenoceptor gene is associated with age at onset of type 2 diabetes mellitus. Papazoglou D, etal., Exp Clin Endocrinol Diabetes. 2006 Sep;114(8):424-7.
16. Physiological significance of alpha(2)-adrenergic receptor subtype diversity: one receptor is not enough. Philipp M, etal., Am J Physiol Regul Integr Comp Physiol. 2002 Aug;283(2):R287-95.
17. GOA pipeline RGD automated data pipeline
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Long-term inhibition of the central alpha(2B)-adrenergic receptor gene via recombinant AAV-delivered antisense in hypertensive rats. Shenouda SM, etal., Am J Hypertens. 2006 Nov;19(11):1135-43.
20. Variation in the alpha2B-adrenoceptor gene as a risk factor for prehospital fatal myocardial infarction and sudden cardiac death. Snapir A, etal., J Am Coll Cardiol. 2003 Jan 15;41(2):190-4.
21. Association of insertion/deletion polymorphism of alpha-adrenoceptor gene in essential hypertension with or without type 2 diabetes mellitus in Malaysian subjects. Vasudevan R, etal., Int J Biol Sci. 2008;4(6):362-7. Epub 2008 Oct 5.
22. Molecular characterization of a rat alpha 2B-adrenergic receptor. Zeng DW, etal., Proc Natl Acad Sci U S A 1990 Apr;87(8):3102-6.
23. Regulation of α2B-Adrenergic Receptor Cell Surface Transport by GGA1 and GGA2. Zhang M, etal., Sci Rep. 2016 Nov 30;6:37921. doi: 10.1038/srep37921.
24. alpha(2)-adrenergic receptor-mediated increase in NO production buffers renal medullary vasoconstriction. Zou AP and Cowley AW Jr, Am J Physiol Regul Integr Comp Physiol 2000 Sep;279(3):R769-77.
Additional References at PubMed
PMID:7755946   PMID:12068299   PMID:15218143   PMID:15680702   PMID:15993847   PMID:17215105   PMID:17716866   PMID:20691504   PMID:21357695   PMID:25407049   PMID:30929926   PMID:32340145  


Genomics

Comparative Map Data
Adra2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83135,038,481 - 135,042,527 (+)NCBIGRCr8
mRatBN7.23114,585,174 - 114,589,220 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3114,585,169 - 114,589,355 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3118,474,365 - 118,478,411 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03127,069,926 - 127,073,972 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03124,730,297 - 124,734,343 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03119,805,941 - 119,809,987 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3119,805,941 - 119,809,987 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03126,332,318 - 126,336,364 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43114,867,357 - 114,869,680 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13114,772,929 - 114,775,253 (+)NCBI
Celera3113,423,833 - 113,427,879 (+)NCBICelera
Cytogenetic Map3q36NCBI
ADRA2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38296,112,876 - 96,116,571 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl296,112,876 - 96,116,571 (-)EnsemblGRCh38hg38GRCh38
GRCh37296,778,624 - 96,782,310 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36296,142,350 - 96,145,615 (-)NCBINCBI36Build 36hg18NCBI36
Build 34296,200,496 - 96,203,762NCBI
Celera291,219,432 - 91,222,707 (-)NCBICelera
Cytogenetic Map2q11.2NCBI
HuRef290,739,785 - 90,743,060 (-)NCBIHuRef
CHM1_1296,782,950 - 96,786,215 (-)NCBICHM1_1
T2T-CHM13v2.0296,619,491 - 96,623,187 (-)NCBIT2T-CHM13v2.0
Adra2b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392127,205,099 - 127,209,141 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2127,205,128 - 127,209,141 (+)EnsemblGRCm39 Ensembl
GRCm382127,363,179 - 127,367,221 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2127,363,208 - 127,367,221 (+)EnsemblGRCm38mm10GRCm38
MGSCv372127,189,022 - 127,192,957 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362127,054,727 - 127,058,662 (+)NCBIMGSCv36mm8
Celera2128,605,637 - 128,609,581 (+)NCBICelera
Cytogenetic Map2F1NCBI
cM Map261.95NCBI
Adra2b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554703,711,031 - 3,714,241 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554703,711,075 - 3,714,450 (-)NCBIChiLan1.0ChiLan1.0
ADRA2B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21232,191,623 - 32,195,678 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A32,194,382 - 32,198,437 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A103,198,432 - 103,202,506 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A97,038,208 - 97,041,901 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A97,040,126 - 97,041,472 (-)Ensemblpanpan1.1panPan2
ADRA2B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11734,615,121 - 34,618,480 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1734,615,096 - 34,656,791 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1734,384,544 - 34,387,878 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01735,386,143 - 35,389,429 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1735,386,281 - 35,392,341 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11734,515,433 - 34,518,767 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01734,583,739 - 34,587,073 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01734,790,948 - 34,794,282 (+)NCBIUU_Cfam_GSD_1.0
Adra2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629282,996,684 - 83,000,132 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936744251,467 - 252,816 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936744249,673 - 253,040 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADRA2B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl345,760,541 - 45,764,175 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1345,760,966 - 45,762,306 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2348,584,007 - 48,585,347 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADRA2B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.114558,876 - 562,959 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl14561,057 - 562,400 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041167,968,245 - 167,971,966 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adra2b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247492,226,738 - 2,230,381 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247492,226,809 - 2,230,413 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Adra2b
8 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:212
Count of miRNA genes:158
Interacting mature miRNAs:170
Transcripts:ENSRNOT00000018584
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)364655305115665732Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)373376539118376539Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)389772419134772419Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)391797474136797474Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)395735366140735366Rat
1582219Bw63Body weight QTL 633.80.001body mass (VT:0001259)body weight (CMO:0000012)396127817115665732Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
1582216Bw65Body weight QTL 656.3body mass (VT:0001259)body weight (CMO:0000012)3102200529115665732Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3112287552135181505Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat

Markers in Region
D3Mco1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.03126,340,138 - 126,340,449NCBIRnor5.0
RGSC_v3.43114,875,178 - 114,875,488RGDRGSC3.4
RGSC_v3.13114,780,751 - 114,781,061RGD
Cytogenetic Map3q36UniSTS
D3Mco2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23114,583,342 - 114,583,648 (+)MAPPERmRatBN7.2
Rnor_6.03119,804,112 - 119,804,415NCBIRnor6.0
Rnor_5.03126,330,489 - 126,330,792UniSTSRnor5.0
RGSC_v3.43114,865,527 - 114,866,426RGDRGSC3.4
RGSC_v3.43114,865,528 - 114,865,831UniSTSRGSC3.4
RGSC_v3.13114,771,100 - 114,771,404RGD
Celera3113,422,004 - 113,422,307UniSTS
RH 3.4 Map3997.6UniSTS
RH 3.4 Map3997.6RGD
Cytogenetic Map3q36UniSTS
RH143739  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23114,588,446 - 114,588,714 (+)MAPPERmRatBN7.2
Rnor_6.03119,809,214 - 119,809,481NCBIRnor6.0
Rnor_5.03126,335,591 - 126,335,858UniSTSRnor5.0
RGSC_v3.43114,870,630 - 114,870,897UniSTSRGSC3.4
Celera3113,427,106 - 113,427,373UniSTS
RH 3.4 Map3986.8UniSTS
Cytogenetic Map3q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 10 21 21 21 2 17 2
Low 1 26 33 20 11 20 7 9 58 18 31 11 7
Below cutoff 2 7 3 8 1 2 14 7 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000018584   ⟹   ENSRNOP00000018584
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3114,585,169 - 114,589,355 (+)Ensembl
Rnor_6.0 Ensembl3119,805,941 - 119,809,987 (+)Ensembl
RefSeq Acc Id: NM_138505   ⟹   NP_612514
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83135,038,481 - 135,042,527 (+)NCBI
mRatBN7.23114,585,174 - 114,589,220 (+)NCBI
Rnor_6.03119,805,941 - 119,809,987 (+)NCBI
Rnor_5.03126,332,318 - 126,336,364 (+)NCBI
RGSC_v3.43114,867,357 - 114,869,680 (+)RGD
Celera3113,423,833 - 113,427,879 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_612514   ⟸   NM_138505
- UniProtKB: Q63021 (UniProtKB/Swiss-Prot),   Q925E4 (UniProtKB/Swiss-Prot),   P19328 (UniProtKB/Swiss-Prot),   A6HQ14 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000018584   ⟸   ENSRNOT00000018584
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P19328-F1-model_v2 AlphaFold P19328 1-453 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692404
Promoter ID:EPDNEW_R2929
Type:multiple initiation site
Name:Adra2b_1
Description:adrenoceptor alpha 2B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03119,805,934 - 119,805,994EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2057 AgrOrtholog
BioCyc Gene G2FUF-47993 BioCyc
Ensembl Genes ENSRNOG00000013887 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055006213 UniProtKB/Swiss-Prot
  ENSRNOG00060019138 UniProtKB/Swiss-Prot
  ENSRNOG00065014694 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000018584 ENTREZGENE
  ENSRNOT00000018584.7 UniProtKB/Swiss-Prot
  ENSRNOT00055010090 UniProtKB/Swiss-Prot
  ENSRNOT00060033087 UniProtKB/Swiss-Prot
  ENSRNOT00065024286 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ADR_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADRA2B_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24174 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 24174 ENTREZGENE
PANTHER ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ALPHA-2B ADRENERGIC RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB ADRA2B RGD
PhenoGen Adra2b PhenoGen
PRINTS ADRENERGICR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADRENRGCA2BR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013887 RatGTEx
  ENSRNOG00055006213 RatGTEx
  ENSRNOG00060019138 RatGTEx
  ENSRNOG00065014694 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6HQ14 ENTREZGENE, UniProtKB/TrEMBL
  ADA2B_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q63021 ENTREZGENE
  Q925E4 ENTREZGENE
UniProt Secondary Q63021 UniProtKB/Swiss-Prot
  Q925E4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-07-13 Adra2b  adrenoceptor alpha 2B  Adra2b  adrenergic, alpha-2B-, receptor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-24 Adra2b  adrenergic, alpha-2B-, receptor  Adra2b  adrenergic receptor, alpha 2b  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Adra2b  adrenergic receptor, alpha 2b    Adrenergic, alpha2B-, receptor class III  Name updated 625702 APPROVED
2002-06-10 Adra2b  Adrenergic, alpha2B-, receptor class III      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease not responsible for the altered phenotype in salt-sensitive and salt-resistant Sabra rats 631771
gene_expression mRNA expressed in kidney and neonatal lung 631714
gene_expression expressed in vasa recta, medullary thick ascending limb and collecting duct 628574
gene_function binds adrenergic drugs 631714
gene_process may mediate norepinephrine induced nitric oxide production in the renal medulla 628574
gene_product member of the G-protein coupled receptor family 631714