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Gene: ADRA2B (adrenoceptor alpha 2B) Homo sapiens
Symbol: ADRA2B
Name: adrenoceptor alpha 2B
RGD ID: 731080
Description: Exhibits alpha2-adrenergic receptor activity and epinephrine binding activity. Involved in several processes, including positive regulation of neuron differentiation; positive regulation of protein phosphorylation; and receptor transactivation. Localizes to cell surface. Implicated in diabetic neuropathy; hypertension; myocardial infarction; obesity; and type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: aadrenergic, alpha-2b-, receptor; ADRA2B adrenergic, alpha-2B-, receptor; ADRA2L1; ADRA2RL1; ADRARL1; adrenergic receptor alpha 2B; adrenergic, alpha-2B-, receptor; alpha-2 adrenergic receptor subtype C2; alpha-2-adrenergic receptor-like 1; alpha-2B adrenergic receptor; alpha-2B adrenoceptor; alpha-2B adrenoreceptor; alpha-2B-adrenergic receptor; alpha-2BAR; ALPHA2BAR; FAME2; G-protein coupled receptor
Mus musculus (house mouse) : Adra2b (adrenergic receptor, alpha 2b)  MGI  Alliance
Rattus norvegicus (Norway rat) : Adra2b (adrenoceptor alpha 2B)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Adra2b (adrenoceptor alpha 2B)
Pan paniscus (bonobo/pygmy chimpanzee) : ADRA2B (adrenoceptor alpha 2B)
Canis lupus familiaris (dog) : ADRA2B (adrenoceptor alpha 2B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Adra2b (adrenoceptor alpha 2B)
Sus scrofa (pig) : ADRA2B (adrenoceptor alpha 2B)
Chlorocebus sabaeus (African green monkey) : ADRA2B (adrenoceptor alpha 2B)
Heterocephalus glaber (naked mole-rat) : Adra2b (adrenoceptor alpha 2B)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl296,112,876 - 96,116,571 (-)EnsemblGRCh38hg38GRCh38
GRCh38296,112,876 - 96,116,571 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37296,778,623 - 96,782,281 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36296,142,350 - 96,145,615 (-)NCBINCBI36hg18NCBI36
Build 34296,200,496 - 96,203,762NCBI
Celera291,219,432 - 91,222,707 (-)NCBI
Cytogenetic Map2q11.2NCBI
HuRef290,739,785 - 90,743,060 (-)NCBIHuRef
CHM1_1296,782,950 - 96,786,311 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on ADRA2B
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731080
Created: 2003-12-10
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.