Spata45 (spermatogenesis associated 45) - Rat Genome Database

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Gene: Spata45 (spermatogenesis associated 45) Rattus norvegicus
Analyze
Symbol: Spata45
Name: spermatogenesis associated 45
RGD ID: 1593182
Description: Orthologous to human SPATA45 (spermatogenesis associated 45); INTERACTS WITH lidocaine; 2,2',4,4',5,5'-hexachlorobiphenyl (ortholog); 2,2',5,5'-tetrachlorobiphenyl (ortholog).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hypothetical LOC498316; hypothetical protein LOC498316; LOC498316; SPATA45l1; spermatogenesis associated 45-like 1; spermatogenesis-associated protein 45; uncharacterized protein LOC498316
RGD Orthologs
Human
Mouse
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Spata45-ps1  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr813105,155,421 - 105,162,321 (+)NCBIGRCr8
mRatBN7.213102,624,298 - 102,631,191 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl13102,625,273 - 102,631,191 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx13105,145,348 - 105,151,266 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.013106,529,312 - 106,535,230 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.013103,744,297 - 103,750,215 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013109,645,480 - 109,652,233 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13109,646,455 - 109,652,229 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013114,240,426 - 114,247,156 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera13102,091,408 - 102,097,326 (+)NCBICelera
Cytogenetic Map13q27NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Spata45Ratgastrointestinal stromal tumor  ISOSPATA45 (Homo sapiens)8554872ClinVar Annotator: match by term: Gastrointestinal stromal tumorClinVarPMID:28492532
Spata45Ratparathyroid carcinoma  ISOSPATA45 (Homo sapiens)8554872ClinVar Annotator: match by term: Parathyroid carcinomaClinVarPMID:28492532

1 to 14 of 14 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Spata45Rat2,2',4,4',5,5'-hexachlorobiphenyl multiple interactionsISOSpata45 (Mus musculus)6480464[2 more ...CTDPMID:25510870
Spata45Rat2,2',5,5'-tetrachlorobiphenyl multiple interactionsISOSpata45 (Mus musculus)6480464[2 more ...CTDPMID:25510870
Spata45Rataflatoxin B1 decreases methylationISOSPATA45 (Homo sapiens)6480464Aflatoxin B1 results in decreased methylation of SPATA45 intronCTDPMID:30157460
Spata45Ratbenzo[a]pyrene decreases expressionISOSPATA45 (Homo sapiens)6480464Benzo(a)pyrene results in decreased expression of SPATA45 mRNACTDPMID:32234424
Spata45Ratbenzo[a]pyrene decreases methylationISOSPATA45 (Homo sapiens)6480464Benzo(a)pyrene results in decreased methylation of SPATA45 promoterCTDPMID:27901495
Spata45Ratdichloroacetic acid increases expressionISOSpata45 (Mus musculus)6480464Dichloroacetic Acid results in increased expression of SPATA45 mRNACTDPMID:28962523
Spata45Ratlidocaine increases expressionEXP 6480464Lidocaine results in increased expression of PYHIN1 mRNACTDPMID:35283115
Spata45Ratlipopolysaccharide multiple interactionsISOSPATA45 (Homo sapiens)6480464[S-(1 and 2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of SPATA45 mRNACTDPMID:35811015
Spata45RatPCB138 multiple interactionsISOSpata45 (Mus musculus)6480464[2 more ...CTDPMID:25510870
Spata45Ratpropanal increases expressionISOSPATA45 (Homo sapiens)6480464propionaldehyde results in increased expression of SPATA45 mRNACTDPMID:26079696
Spata45RatS-(1,2-dichlorovinyl)-L-cysteine multiple interactionsISOSPATA45 (Homo sapiens)6480464[S-(1 and 2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of SPATA45 mRNACTDPMID:35811015
Spata45RatS-(1,2-dichlorovinyl)-L-cysteine increases expressionISOSPATA45 (Homo sapiens)6480464S-(1 and 2-dichlorovinyl)cysteine results in increased expression of SPATA45 mRNACTDPMID:35811015
Spata45Ratsilver atom increases expressionISOSpata45 (Mus musculus)6480464Silver results in increased expression of SPATA45 mRNACTDPMID:27131904
Spata45Ratsilver(0) increases expressionISOSpata45 (Mus musculus)6480464Silver results in increased expression of SPATA45 mRNACTDPMID:27131904

1 to 14 of 14 rows

#
Reference Title
Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions


Spata45
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr813105,155,421 - 105,162,321 (+)NCBIGRCr8
mRatBN7.213102,624,298 - 102,631,191 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl13102,625,273 - 102,631,191 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx13105,145,348 - 105,151,266 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.013106,529,312 - 106,535,230 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.013103,744,297 - 103,750,215 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013109,645,480 - 109,652,233 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13109,646,455 - 109,652,229 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013114,240,426 - 114,247,156 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera13102,091,408 - 102,097,326 (+)NCBICelera
Cytogenetic Map13q27NCBI
SPATA45
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381212,830,141 - 212,847,649 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1212,830,141 - 212,847,649 (-)EnsemblGRCh38hg38GRCh38
GRCh371213,003,483 - 213,020,991 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361211,070,106 - 211,087,614 (-)NCBINCBI36Build 36hg18NCBI36
Celera1186,229,475 - 186,246,986 (-)NCBICelera
Cytogenetic Map1q32.3NCBI
HuRef1183,680,222 - 183,698,104 (-)NCBIHuRef
T2T-CHM13v2.01212,075,115 - 212,092,629 (-)NCBIT2T-CHM13v2.0
Spata45
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391190,768,106 - 190,775,139 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1190,768,836 - 190,775,139 (+)EnsemblGRCm39 Ensembl
GRCm381191,035,909 - 191,042,942 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1191,036,639 - 191,042,942 (+)EnsemblGRCm38mm10GRCm38
MGSCv371192,860,701 - 192,866,820 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361192,737,437 - 192,743,557 (+)NCBIMGSCv36mm8
Celera1197,961,735 - 197,967,537 (+)NCBICelera
Cytogenetic Map1H6NCBI
cM Map196.28NCBI

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Variants in Spata45
28 total Variants

Predicted Target Of
Summary Value
Count of predictions:44
Count of miRNA genes:35
Interacting mature miRNAs:39
Transcripts:ENSRNOT00000073985
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 9 of 9 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)1365613454109350286Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1367635937109350286Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1367635937109350286Rat
1576318Schws5Schwannoma susceptibility QTL 50.0351nervous system integrity trait (VT:0010566)post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)1364497900109350286Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1364375743109350286Rat
8655951Rf63Renal function QTL 6312.2blood urea nitrogen amount (VT:0005265)plasma urea nitrogen level (CMO:0000586)1371610804109350286Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1383286150109350286Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1367635937109350286Rat

1 to 9 of 9 rows



alimentary part of gastrointestinal system
appendage
ectoderm
endocrine system
endoderm
exocrine system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
2 7 73 18 14 4 4 5 38 8 64 18 44 10



Ensembl Acc Id: ENSRNOT00000073985   ⟹   ENSRNOP00000065792
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl13102,625,273 - 102,631,191 (+)Ensembl
Rnor_6.0 Ensembl13109,646,455 - 109,652,229 (+)Ensembl
RefSeq Acc Id: NM_001109085   ⟹   NP_001102555
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr813105,156,403 - 105,162,321 (+)NCBI
mRatBN7.213102,625,273 - 102,631,191 (+)NCBI
Rnor_6.013109,646,455 - 109,652,229 (+)NCBI
Rnor_5.013114,240,426 - 114,247,156 (+)NCBI
Celera13102,091,408 - 102,097,326 (+)RGD
Sequence:
RefSeq Acc Id: XM_006250489   ⟹   XP_006250551
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr813105,155,421 - 105,162,318 (+)NCBI
mRatBN7.213102,624,298 - 102,631,191 (+)NCBI
Rnor_6.013109,645,480 - 109,652,233 (+)NCBI
Rnor_5.013114,240,426 - 114,247,156 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039090999   ⟹   XP_038946927
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr813105,157,068 - 105,162,318 (+)NCBI
mRatBN7.213102,626,151 - 102,631,191 (+)NCBI
Protein RefSeqs NP_001102555 (Get FASTA)   NCBI Sequence Viewer  
  XP_006250551 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946927 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL94988 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000065792
  ENSRNOP00000065792.1
RefSeq Acc Id: NP_001102555   ⟸   NM_001109085
- UniProtKB: M0R8J6 (UniProtKB/TrEMBL),   A6JGY2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250551   ⟸   XM_006250489
- Peptide Label: isoform X1
- UniProtKB: M0R8J6 (UniProtKB/TrEMBL),   A6JGY2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000065792   ⟸   ENSRNOT00000073985
RefSeq Acc Id: XP_038946927   ⟸   XM_039090999
- Peptide Label: isoform X1
- UniProtKB: M0R8J6 (UniProtKB/TrEMBL),   A6JGY2 (UniProtKB/TrEMBL)

Name Modeler Protein Id AA Range Protein Structure
AF-M0R8J6-F1-model_v2 AlphaFold M0R8J6 1-97 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13699111
Promoter ID:EPDNEW_R9636
Type:initiation region
Name:LOC498316_1
Description:hypothetical LOC498316
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.013109,646,457 - 109,646,517EPDNEW


1 to 13 of 13 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-16869 BioCyc
Ensembl Genes ENSRNOG00000048659 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000073985 ENTREZGENE
  ENSRNOT00000073985.2 UniProtKB/TrEMBL
InterPro SPATA45 UniProtKB/TrEMBL
KEGG Report rno:498316 UniProtKB/TrEMBL
NCBI Gene 498316 ENTREZGENE
PANTHER PTHR35822 UniProtKB/TrEMBL
  SPERMATOGENESIS-ASSOCIATED PROTEIN 45 UniProtKB/TrEMBL
PhenoGen Spata45 PhenoGen
RatGTEx ENSRNOG00000048659 RatGTEx
UniProt A6JGY2 ENTREZGENE, UniProtKB/TrEMBL
  M0R8J6 ENTREZGENE, UniProtKB/TrEMBL
1 to 13 of 13 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2025-02-03 Spata45    SPATA45  spermatogenesis associated 45  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2022-03-10 SPATA45  spermatogenesis associated 45  SPATA45l1  spermatogenesis associated 45-like 1  Name and Symbol changed 629549 APPROVED
2021-10-29 SPATA45l1  spermatogenesis associated 45-like 1  LOC498316  hypothetical LOC498316  Name and Symbol changed 629549 APPROVED
2006-11-20 LOC498316  hypothetical LOC498316      Symbol and Name status set to provisional 70820 PROVISIONAL