Ndufaf8 (NADH:ubiquinone oxidoreductase complex assembly factor 8) - Rat Genome Database

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Gene: Ndufaf8 (NADH:ubiquinone oxidoreductase complex assembly factor 8) Rattus norvegicus
Analyze
Symbol: Ndufaf8
Name: NADH:ubiquinone oxidoreductase complex assembly factor 8
RGD ID: 1590963
Description: Predicted to be involved in mitochondrial respiratory chain complex I assembly. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 34. Orthologous to human NDUFAF8 (NADH:ubiquinone oxidoreductase complex assembly factor 8); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC690871; LOC690871; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8; uncharacterized protein C17orf89 homolog; uncharacterized protein LOC690871
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810105,879,908 - 105,882,059 (+)NCBIGRCr8
mRatBN7.210105,381,491 - 105,383,643 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx10110,485,886 - 110,488,049 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010109,948,917 - 109,951,080 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010105,302,038 - 105,304,189 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010109,278,712 - 109,280,863 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10109,278,712 - 109,280,863 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010108,876,795 - 108,878,946 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410109,510,635 - 109,512,782 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera10103,926,866 - 103,929,017 (+)NCBICelera
Cytogenetic Map10q32.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:18614015   PMID:27499296  


Genomics

Comparative Map Data
Ndufaf8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810105,879,908 - 105,882,059 (+)NCBIGRCr8
mRatBN7.210105,381,491 - 105,383,643 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx10110,485,886 - 110,488,049 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010109,948,917 - 109,951,080 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010105,302,038 - 105,304,189 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010109,278,712 - 109,280,863 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10109,278,712 - 109,280,863 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010108,876,795 - 108,878,946 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410109,510,635 - 109,512,782 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera10103,926,866 - 103,929,017 (+)NCBICelera
Cytogenetic Map10q32.3NCBI
NDUFAF8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381781,239,311 - 81,241,310 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1781,239,305 - 81,241,310 (+)EnsemblGRCh38hg38GRCh38
GRCh371779,213,111 - 79,215,110 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361776,827,706 - 76,829,693 (+)NCBINCBI36Build 36hg18NCBI36
Celera1775,843,655 - 75,845,642 (+)NCBICelera
Cytogenetic Map17q25.3NCBI
HuRef1774,649,430 - 74,651,417 (+)NCBIHuRef
CHM1_11779,299,054 - 79,301,041 (+)NCBICHM1_1
T2T-CHM13v2.01782,148,434 - 82,150,433 (+)NCBIT2T-CHM13v2.0
Ndufaf8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911119,989,760 - 119,991,250 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11119,989,754 - 119,991,531 (+)EnsemblGRCm39 Ensembl
GRCm3811120,098,934 - 120,100,424 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11120,098,928 - 120,100,705 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711119,960,248 - 119,961,738 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611119,915,024 - 119,916,737 (+)NCBIMGSCv36mm8
Celera11131,834,581 - 131,836,071 (+)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1183.96NCBI
Ndufaf8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555061,771,044 - 1,773,471 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555061,771,044 - 1,773,471 (-)NCBIChiLan1.0ChiLan1.0
NDUFAF8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21997,819,428 - 97,821,420 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan117102,719,188 - 102,721,180 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01775,665,568 - 75,667,559 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11781,394,384 - 81,396,095 (+)NCBIpanpan1.1PanPan1.1panPan2
NDUFAF8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.19851,903 - 854,005 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl9851,923 - 854,005 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha91,466,828 - 1,468,913 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.091,458,628 - 1,460,712 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl91,458,865 - 1,460,665 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.191,482,546 - 1,484,630 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.091,608,332 - 1,610,414 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.091,688,537 - 1,690,622 (-)NCBIUU_Cfam_GSD_1.0
Ndufaf8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056021,459,711 - 1,462,153 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365944,949,843 - 4,952,239 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365944,949,826 - 4,952,248 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NDUFAF8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl121,517,485 - 1,519,406 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1121,517,304 - 1,519,478 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2121,426,941 - 1,429,099 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103243713
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11673,190,114 - 73,192,088 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607744,562,906 - 44,564,929 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ndufaf8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480110,260,659 - 10,263,128 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480110,260,664 - 10,263,128 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ndufaf8
18 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:114
Count of miRNA genes:103
Interacting mature miRNAs:109
Transcripts:ENSRNOT00000065565
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
631538Oia5Oil induced arthritis QTL 5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087055121107211142Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087307617107211142Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1088539139107211142Rat
12880395Cm109Cardiac mass QTL 1090.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1090404397107211142Rat
12880396Am13Aortic mass QTL 130.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1090404397107211142Rat
12880398Kidm67Kidney mass QTL 670.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1090404397107211142Rat
12880384Cm107Cardiac mass QTL 1070.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)90404397107211142Rat
12880385Cm108Cardiac mass QTL 1080.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)90404397107211142Rat
1579915Bp280Blood pressure QTL 2800.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090404397107211142Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1090627439107057807Rat
724530Bp149Blood pressure QTL 1490.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090627439107211142Rat
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093223816107057807Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1094759759107211142Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1094759759107211142Rat
1578663Bss18Bone structure and strength QTL 183.6femur width (VT:1000666)femoral neck width (CMO:0001695)1096703043107057807Rat
1578672Bmd16Bone mineral density QTL 166.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)1096703043107057807Rat

Markers in Region
RH138500  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21044,265,917 - 44,266,038 (+)MAPPERmRatBN7.2
mRatBN7.210105,383,439 - 105,383,560 (+)MAPPERmRatBN7.2
Rnor_6.010109,280,660 - 109,280,780NCBIRnor6.0
Rnor_6.01045,830,254 - 45,830,374NCBIRnor6.0
Rnor_5.01045,586,174 - 45,586,294UniSTSRnor5.0
Rnor_5.010108,878,743 - 108,878,863UniSTSRnor5.0
RGSC_v3.410109,512,579 - 109,512,699UniSTSRGSC3.4
RGSC_v3.41045,786,039 - 45,786,159UniSTSRGSC3.4
Celera1043,527,545 - 43,527,665UniSTS
Celera10103,928,814 - 103,928,934UniSTS
Cytogenetic Map10q32.3UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000065565   ⟹   ENSRNOP00000063253
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl10109,278,712 - 109,280,863 (+)Ensembl
RefSeq Acc Id: NM_001195482   ⟹   NP_001182411
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810105,879,908 - 105,882,059 (+)NCBI
mRatBN7.210105,381,491 - 105,383,643 (+)NCBI
Rnor_6.010109,278,712 - 109,280,863 (+)NCBI
Rnor_5.010108,876,795 - 108,878,946 (+)NCBI
Celera10103,926,866 - 103,929,017 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001182411 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM06815 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_001182411   ⟸   NM_001195482
- UniProtKB: A6HLB0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000063253   ⟸   ENSRNOT00000065565

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZUI9-F1-model_v2 AlphaFold D3ZUI9 1-74 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697952
Promoter ID:EPDNEW_R8477
Type:initiation region
Name:Ndufaf8_1
Description:NADH:ubiquinone oxidoreductase complex assembly factor 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.010109,278,719 - 109,278,779EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1590963 AgrOrtholog
BioCyc Gene G2FUF-22454 BioCyc
Ensembl Genes ENSRNOG00000042653 Ensembl
InterPro NDUFAF8 UniProtKB/TrEMBL
KEGG Report rno:690871 UniProtKB/TrEMBL
NCBI Gene 690871 ENTREZGENE
PANTHER NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 8 UniProtKB/TrEMBL
  NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 8 UniProtKB/TrEMBL
PhenoGen Ndufaf8 PhenoGen
PROSITE CHCH UniProtKB/TrEMBL
RatGTEx ENSRNOG00000042653 RatGTEx
UniProt A6HLB0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-07-25 Ndufaf8  NADH:ubiquinone oxidoreductase complex assembly factor 8  LOC690871  hypothetical protein LOC690871  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-05-24 LOC690871  hypothetical protein LOC690871  LOC688300  hypothetical protein LOC688300  Data merged from RGD:1590069 1643240 APPROVED
2006-11-20 LOC690871  hypothetical protein LOC690871      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC688300  hypothetical protein LOC688300      Symbol and Name status set to provisional 70820 PROVISIONAL