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Gene: Lypd8 (Ly6/Plaur domain containing 8) Rattus norvegicus

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Symbol:

Lypd8

Name:

Ly6/Plaur domain containing 8

RGD ID:

1586251

Description:

Predicted to be involved in defense response to Gram-negative bacterium. Predicted to be active in extracellular space. Orthologous to human LYPD8 (LY6/PLAUR domain containing 8); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; bisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

hypothetical protein LOC691259; LOC691259; ly6/PLAUR domain-containing protein 8; uncharacterized protein LOC691259

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	LYPD8 (LY6/PLAUR domain containing 8)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB
Mus musculus (house mouse):	Lypd8 (LY6/PLAUR domain containing 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Lypd8 (LY6/PLAUR domain containing 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	LYPD8 (LY6/PLAUR domain containing 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	LOC106145141 (protein RoBo-1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	LYPD8 (LY6/PLAUR domain containing 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	LYPD8 (LY6/PLAUR domain containing 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Lypd8 (LY6/PLAUR domain containing 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Lypd8 (LY6/PLAUR domain containing 8)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	LYPD8 (LY6/PLAUR domain containing 8)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	43,062,261 - 43,073,108 (+)	NCBI		GRCr8
mRatBN7.2	10	42,561,834 - 42,572,684 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	42,561,816 - 42,572,683 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	47,226,511 - 47,237,372 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	46,716,958 - 46,727,813 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	42,220,465 - 42,231,327 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	43,817,773 - 43,828,812 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	43,817,947 - 43,828,811 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	43,610,271 - 43,621,157 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	44,018,455 - 44,029,319 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	10	41,853,856 - 41,864,831 (+)	NCBI		Celera
Cytogenetic Map	10	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Lypd8	Rat	developmental and epileptic encephalopathy 54		ISO	LYPD8 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Developmental and epileptic encephalopathy and 54	ClinVar	PMID:25741868

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Lypd8	Rat	1,2-dimethylhydrazine	multiple interactions	ISO	Lypd8 (Mus musculus)	6480464	[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of LYPD8 mRNA	CTD	PMID:22206623
Lypd8	Rat	17beta-estradiol	multiple interactions	EXP		6480464	[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of LYPD8 mRNA	CTD	PMID:32741896
Lypd8	Rat	17beta-estradiol	increases expression	EXP		6480464	Estradiol results in increased expression of LYPD8 mRNA	CTD	PMID:32145629
Lypd8	Rat	17beta-estradiol 3-benzoate	multiple interactions	EXP		6480464	[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of LYPD8 mRNA	CTD	PMID:32741896
Lypd8	Rat	benzo[a]pyrene	decreases methylation	ISO	LYPD8 (Homo sapiens)	6480464	Benzo(a)pyrene results in decreased methylation of LYPD8 exon	CTD	PMID:27901495
Lypd8	Rat	benzo[a]pyrene	affects methylation	ISO	LYPD8 (Homo sapiens)	6480464	Benzo(a)pyrene affects the methylation of LYPD8 promoter	CTD	PMID:27901495
Lypd8	Rat	bisphenol A	decreases expression	EXP		6480464	bisphenol A results in decreased expression of LYPD8 mRNA	CTD	PMID:25181051
Lypd8	Rat	folic acid	multiple interactions	ISO	Lypd8 (Mus musculus)	6480464	[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of LYPD8 mRNA	CTD	PMID:22206623
Lypd8	Rat	furan	increases expression	EXP		6480464	furan results in increased expression of LYPD8 mRNA	CTD	PMID:27387713
Lypd8	Rat	methoxychlor	affects methylation	EXP		6480464	Methoxychlor affects the methylation of LYPD8 gene	CTD	PMID:35440735
Lypd8	Rat	paracetamol	increases expression	ISO	LYPD8 (Homo sapiens)	6480464	Acetaminophen results in increased expression of LYPD8 mRNA	CTD	PMID:26690555
Lypd8	Rat	paraquat	increases expression	EXP		6480464	Paraquat results in increased expression of LYPD8 mRNA	CTD	PMID:32680482
Lypd8	Rat	silicon dioxide	increases expression	ISO	LYPD8 (Homo sapiens)	6480464	Silicon Dioxide analog results in increased expression of LYPD8 mRNA	CTD	PMID:23806026
Lypd8	Rat	sodium arsenite	decreases expression	ISO	Lypd8 (Mus musculus)	6480464	sodium arsenite results in decreased expression of LYPD8 mRNA	CTD	PMID:37682722
Lypd8	Rat	testosterone	multiple interactions	EXP		6480464	[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of LYPD8 mRNA	CTD	PMID:32741896
Lypd8	Rat	triptonide	increases expression	ISO	Lypd8 (Mus musculus)	6480464	triptonide results in increased expression of LYPD8 mRNA	CTD	PMID:33045310

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Lypd8	Rat	defense response to Gram-negative bacterium	involved_in	ISO	Lypd8 (Mus musculus)	1624291	PMID:27027293	RGD	PMID:27027293
Lypd8	Rat	defense response to Gram-negative bacterium	involved_in	IBA	MGI:1917413 and PANTHER:PTN000467635	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Lypd8	Rat	extracellular space	located_in	ISO	Lypd8 (Mus musculus)	1624291	PMID:27027293	RGD	PMID:27027293
Lypd8	Rat	extracellular space	is_active_in	IBA	MGI:1917413 and PANTHER:PTN000467635	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

PMID:27027293

Lypd8
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	43,062,261 - 43,073,108 (+)	NCBI		GRCr8
mRatBN7.2	10	42,561,834 - 42,572,684 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	42,561,816 - 42,572,683 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	47,226,511 - 47,237,372 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	46,716,958 - 46,727,813 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	42,220,465 - 42,231,327 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	43,817,773 - 43,828,812 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	43,817,947 - 43,828,811 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	43,610,271 - 43,621,157 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	44,018,455 - 44,029,319 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	10	41,853,856 - 41,864,831 (+)	NCBI		Celera
Cytogenetic Map	10	q22	NCBI

LYPD8
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	248,739,415 - 248,755,759 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	248,739,415 - 248,755,759 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	248,902,716 - 248,903,170 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Celera	1	222,199,317 - 222,211,071 (-)	NCBI		Celera
Cytogenetic Map	1	q44	NCBI
HuRef	1	219,277,503 - 219,287,338 (-)	NCBI		HuRef
CHM1_1	1	250,175,013 - 250,175,468 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	248,177,673 - 248,193,983 (-)	NCBI		T2T-CHM13v2.0

Lypd8
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	58,269,869 - 58,281,365 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	58,269,869 - 58,281,554 (+)	Ensembl		GRCm39 Ensembl
GRCm38	11	58,379,032 - 58,390,541 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	58,379,043 - 58,390,728 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	58,192,534 - 58,204,043 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	58,195,252 - 58,206,734 (+)	NCBI		MGSCv36	mm8
Celera	11	63,136,008 - 63,147,401 (+)	NCBI		Celera
Cytogenetic Map	11	B1.3	NCBI
cM Map	11	36.19	NCBI

Lypd8
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955418	29,811,424 - 29,818,756 (-)	NCBI	ChiLan1.0	ChiLan1.0

LYPD8
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	16	13,633,970 - 13,644,503 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	16	13,633,949 - 13,644,130 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	16	11,566,660 - 11,577,302 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	16	13,609,038 - 13,619,680 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	16	13,609,026 - 13,619,830 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	16	10,750,963 - 10,761,585 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	16	13,144,098 - 13,154,689 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	16	13,319,959 - 13,330,602 (-)	NCBI		UU_Cfam_GSD_1.0

LOC106145141
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	91,616,631 - 91,621,454 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936609	339,319 - 342,625 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LYPD8
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	52,447,144 - 52,458,059 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	52,447,149 - 52,458,070 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	55,347,077 - 55,357,896 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LYPD8
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	85,590,372 - 85,604,723 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	25	85,591,472 - 85,600,481 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666055	88,219,219 - 88,232,291 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Lypd8
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624743	659,691 - 668,880 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants in Lypd8
250 total Variants

Assembly: mRatBN7.2

Chromosome	Start Pos	End Pos	Reference Nucleotide	Variant Nucleotide	Variant Type	Strain	Variant Page
10	42572373	42572374	T	C	snv	ACI/EurMcwi (2019), ACI/N (2020), BUF/N (2020), DA/OlaHsd (2019), F344/DuCrl (2019), F344/NCrl (2019), F344/N (2020), F344/Stm (2019), FXLE18/Stm (2020), HXB4/IpcvMcwi (2020), LEXF1A/Stm (2019), LEXF1C/Stm (2019), LEXF2B/Stm (2019), LEXF10A/StmMcwi (2020), M520/NRrrcMcwi (2019), M520/N (2020), MWF/Hsd (2019), SHRSP/A3NCrl (2019), SHR/OlalpcvMcwi (2019), WKY/NCrl (2019), WKY/N (2020), ACI/EurMcwi (2019NG), BDIX/NemOdaMcwi (2022), BUF/MnaMcwi (2022), BXH6/CubMcwi (2021), DA/OlaHsd (2019NG), F344/DuCrl (2019NG), F344/DuCrl (2019NG), F344/DuCrl (2021), European Variation Archive Release 3, European Variation Archive Release 4, LEXF2A/StmMcwi (2023), FXLE26/StmMcwi (2023), FXLE20/StmMcwi (2023), LEXF8D/StmMcwi (2023), BXH2/CubMcwi (2023), FXLE23/StmMcwi (2023), LEXF6B/StmMcwi (2023), FXLE13/StmMcwi (2023), LEXF5/StmMcwi (2023), European Variation Archive Release 6, F344/NHsd (2021), F344/StmMcwi (2019), FXLE13/Stm (2019NG), FXLE20/Stm (2019NG), FXLE23/Stm (2022), FXLE26/Stm (2022), LEXF1C/StmMcwi (2021), LEXF2A/Stm (2022), LEXF2C/StmMcwi (2022), LEXF5/Stm (2019NG), LEXF6B/Stm (2019NG), LEXF7A/Stm (2019NG), LEXF8A/StmMcwi (2021), LEXF8D/Stm (2022), LEXF9/StmMcwi (2022), M520/NRrrcMcwi (2019NG), MWF/SimwMcwi (2019NG), MWF/SimwMcwi (2019), SHRSP/A3NCrl (2019NG), SHR/NCrl (2021), SHR/NHsd (2021), SHR/NHsd (2021), SHR/OlalpcvMcwi (2019NG), WKY/NCrl (2019NG)	View more Information

Predicted Target Of

	Summary Value
Count of predictions:	125
Count of miRNA genes:	109
Interacting mature miRNAs:	111
Transcripts:	ENSRNOT00000032816
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61441	Btemp1	Thermal response to stress QTL 1	4		body temperature trait (VT:0005535)	core body temperature (CMO:0001036)	10	35392457	63642539	Rat
9589136	Insul27	Insulin level QTL 27	10.46	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	10	11474010	56474010	Rat
152025229	Scl83	Serum cholesterol level QTL 83	4.33		blood cholesterol amount (VT:0000180)		10	35710580	68663659	Rat
1578779	Tcas10	Tongue tumor susceptibility QTL 10	3.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	10	31297439	76297439	Rat
631564	Apr3	Acute phase response QTL 3	3.9		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	10	15275955	60275955	Rat
1298069	Bp168	Blood pressure QTL 168	5.5		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	10	26521957	98003205	Rat
631552	Vetf2	Vascular elastic tissue fragility QTL 2	4.5	0.0002	aorta elastic tissue integrity trait (VT:0010556)	artery internal elastic lamina non-tumorous lesion count (CMO:0001913)	10	41142633	86142633	Rat
631554	Bp133	Blood pressure QTL 133		0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	743364	63851208	Rat
631557	Bp136	Blood pressure QTL 136		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	30632053	75632053	Rat
61325	Aia5	Adjuvant induced arthritis QTL 5		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
1298078	Stresp5	Stress response QTL 5	2.99	0.00025	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	42045676	104670812	Rat
1578761	Stresp21	Stress response QTL 21	3.3		thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	10	6375746	51375746	Rat
2298544	Neuinf9	Neuroinflammation QTL 9	4.6		nervous system integrity trait (VT:0010566)	spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)	10	5801990	62146030	Rat
61332	Eau3	Experimental allergic uveoretinitis QTL 3		0.004	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	10	34490559	45579777	Rat
10401803	Kidm50	Kidney mass QTL 50			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	10	418344	45418344	Rat
61463	Bp12	Blood pressure QTL 12	6.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	41333258	86333258	Rat
1554317	Bmd4	Bone mineral density QTL 4	9.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	10	19816042	99406971	Rat
1598852	Anxrr19	Anxiety related response QTL 19	5.07		body movement coordination trait (VT:0005424)	number of rearing movements in an experimental apparatus (CMO:0001752)	10	18167841	63167841	Rat
1581497	Esta1	Estrogen-induced thymic atrophy QTL 1			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	10	21329805	61345413	Rat
2313095	Bss62	Bone structure and strength QTL 62	1.5	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	10	5387014	50387014	Rat
724527	Bp148	Blood pressure QTL 148		0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	28453136	73453136	Rat
1358897	Stresp6	Stress response QTL 6	4.17	0.022	blood norepinephrine amount (VT:0005663)	plasma norepinephrine level (CMO:0001010)	10	35392267	64155584	Rat
1331762	Rf40	Renal function QTL 40	3.873		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	10	29299504	64155584	Rat
2300171	Bmd58	Bone mineral density QTL 58	4.9	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	10	26944628	71944628	Rat
61354	Pia10	Pristane induced arthritis QTL 10		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
2301967	Cm73	Cardiac mass QTL 73	4.55		heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	10	14487011	89062041	Rat
2303118	Mamtr7	Mammary tumor resistance QTL 7		0.003	mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	10	9658275	104670812	Rat
70188	BpQTLcluster1	Blood pressure QTL cluster 1	4.864		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	1	42323132	87323132	Rat
2313104	Bss61	Bone structure and strength QTL 61	0.9	0.0001	tibia area (VT:1000281)	tibia midshaft cross-sectional area (CMO:0001717)	10	5387014	50387014	Rat
9590310	Scort19	Serum corticosterone level QTL 19	6.3	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	11474010	56474010	Rat
10402859	Bp381	Blood pressure QTL 381		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	27606468	72606468	Rat
2316949	Gluco60	Glucose level QTL 60	3.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	10	14487011	107057807	Rat
70198	BpQTLcluster9	Blood pressure QTL cluster 9	2.94		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	42323132	87323132	Rat
6893352	Bw100	Body weight QTL 100	0.33	0.6	body mass (VT:0001259)	body weight (CMO:0000012)	1	15906665	60906665	Rat
724556	Pur2	Proteinuria QTL 2	5.5		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	10	22427500	90627625	Rat
8662860	Vetf10	Vascular elastic tissue fragility QTL 10			artery integrity trait (VT:0010639)	number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)	10	6154182	73453136	Rat
2313066	Bss63	Bone structure and strength QTL 63	1.4	0.0001	tibia strength trait (VT:1000284)	bone polar moment of inertia (CMO:0001558)	10	5387014	50387014	Rat
2313064	Bmd71	Bone mineral density QTL 71	0.9	0.0001	tibia mineral mass (VT:1000283)	compact volumetric bone mineral density (CMO:0001730)	10	5387014	50387014	Rat
70223	Bp57	Blood pressure QTL 57	5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	1	80676123	Rat
1354587	Kidm21	Kidney mass QTL 21	3.3		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	10	15028513	60430477	Rat
6893350	Bw99	Body weight QTL 99	0.87	0.16	body mass (VT:0001259)	body weight (CMO:0000012)	1	15906665	60906665	Rat
2317043	Aia7	Adjuvant induced arthritis QTL 7	3.82		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	10	37565079	82565079	Rat
70224	Eae3	Experimental allergic encephalomyelitis QTL 3	4.1		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	10	26521957	61345413	Rat
2317042	Aia20	Adjuvant induced arthritis QTL 20	3.38		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	10	37565079	82565079	Rat
2313081	Bss64	Bone structure and strength QTL 64	1.3	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	10	5387014	50387014	Rat
1331791	Cm31	Cardiac mass QTL 31	3.84606		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	10	29299504	107211142	Rat
2313087	Bmd80	Bone mineral density QTL 80	3.2	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	10	19606483	64606483	Rat
1354614	Hpcl1	Hepatic cholesterol level QTL 1	3.3		liver cholesterol amount (VT:0010498)	liver cholesterol level (CMO:0001597)	10	35392267	51793994	Rat
631532	Cm50	Cardiac mass QTL 50	6.6		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	10	17907113	51786432	Rat
1576319	Cia29	Collagen induced arthritis QTL 29			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	33973921	78973921	Rat
8552805	Bw145	Body weight QTL 145	2.2		body mass (VT:0001259)	change in body weight to body weight ratio (CMO:0002216)	10	41944526	78307017	Rat
631267	Cia20	Collagen induced arthritis QTL 20	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
1600371	Mcs21	Mammary carcinoma susceptibility QTL 21	3		mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	10	28875650	52200160	Rat
1576308	Schws1	Schwannoma susceptibility QTL 1		0.0041	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	10	40035094	102359817	Rat
631269	Cia22	Collagen induced arthritis QTL 22	8.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	40035094	104060283	Rat
631268	Cia21	Collagen induced arthritis QTL 21	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	14487011	104060283	Rat
9590268	Scort13	Serum corticosterone level QTL 13	3.26	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	11474010	56474010	Rat
1576311	Pia26	Pristane induced arthritis QTL 26			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	31224026	75632053	Rat
631270	Cia23	Collagen induced arthritis QTL 23	3.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	40035094	104060283	Rat
61427	Cia16	Collagen induced arthritis QTL 16	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	6357896	96121100	Rat
2292441	Bp308	Blood pressure QTL 308			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	27606468	72606468	Rat
2313055	Bw96	Body weight QTL 96	3.6	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	10	19606483	64606483	Rat
631542	Bp82	Blood pressure QTL 82	6.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	26521957	98952741	Rat

RH128771

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	42,572,455 - 42,572,636 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	43,828,584 - 43,828,764	NCBI	Rnor6.0
Rnor_5.0	10	43,620,930 - 43,621,110	UniSTS	Rnor5.0
RGSC_v3.4	10	44,029,092 - 44,029,272	UniSTS	RGSC3.4
Celera	10	41,864,604 - 41,864,784	UniSTS
RH 3.4 Map	10	501.19	UniSTS
Cytogenetic Map	10	q22	UniSTS

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	2	4	31	45	58	32	11	32	2	86	21	26	22	45	26


RefSeq Transcripts	NM_001419311	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC097876	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473948	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000032816 ⟹ ENSRNOP00000034245

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	42,561,816 - 42,572,683 (+)	Ensembl
Rnor_6.0 Ensembl	10	43,817,947 - 43,828,811 (+)	Ensembl

RefSeq Acc Id:

NM_001419311 ⟹ NP_001406240

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	43,062,261 - 43,073,108 (+)	NCBI
mRatBN7.2	10	42,561,834 - 42,572,684 (+)	NCBI


Protein RefSeqs	NP_001406240	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM04541	(Get FASTA)	NCBI Sequence Viewer
	EDM04542	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000034245.4

Ensembl Acc Id:

ENSRNOP00000034245 ⟸ ENSRNOT00000032816

RefSeq Acc Id:	NP_001406240 ⟸ NM_001419311
- Peptide Label:	precursor
- UniProtKB:	D3ZP75 (UniProtKB/TrEMBL), A6HET7 (UniProtKB/TrEMBL)

Protein Domains

UPAR/Ly6

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZP75-F1-model_v2	AlphaFold	D3ZP75	1-249	view protein structure

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

RGD ID:

13697216

Promoter ID:

EPDNEW_R7739

Type:

multiple initiation site

Name:

Lypd8_1

Description:

LY6/PLAUR domain containing 8

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	10	43,817,965 - 43,818,025	EPDNEW

Database	Acc Id	Source(s)
BioCyc Gene	G2FUF-24989	BioCyc
Ensembl Genes	ENSRNOG00000026844	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000032816.5	UniProtKB/TrEMBL
Gene3D-CATH	2.10.60.10	UniProtKB/TrEMBL
InterPro	CNF-like_PLA2_Inhibitor	UniProtKB/TrEMBL
	LY6_UPA_recep-like	UniProtKB/TrEMBL
	Snake_toxin-like_sf	UniProtKB/TrEMBL
NCBI Gene	691259	ENTREZGENE
PANTHER	LY6/PLAUR DOMAIN-CONTAINING PROTEIN 8	UniProtKB/TrEMBL
	LY6_PLAUR DOMAIN-CONTAINING PROTEIN 8	UniProtKB/TrEMBL
Pfam	UPAR_LY6	UniProtKB/TrEMBL
PhenoGen	Lypd8	PhenoGen
RatGTEx	ENSRNOG00000026844	RatGTEx
Superfamily-SCOP	SSF57302	UniProtKB/TrEMBL
UniProt	A6HET7	ENTREZGENE, UniProtKB/TrEMBL
	D3ZP75	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2022-09-15	Lypd8	Ly6/Plaur domain containing 8	Lypd8	LY6/PLAUR domain containing 8	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2012-10-02	Lypd8	LY6/PLAUR domain containing 8	LOC691259	hypothetical protein LOC691259	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-11-19	LOC691259	hypothetical protein LOC691259			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable

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Imported Disease Annotations - ClinVar