Serpinb9b (serine (or cysteine) peptidase inhibitor, clade B, member 9b) - Rat Genome Database

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Gene: Serpinb9b (serine (or cysteine) peptidase inhibitor, clade B, member 9b) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Serpinb9b
Name: serine (or cysteine) peptidase inhibitor, clade B, member 9b
RGD ID: 1562844
Description: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be active in cytoplasm and extracellular space. Orthologous to human SERPINB9 (serpin family B member 9); INTERACTS WITH 17beta-estradiol; bisphenol A; cisplatin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: leukocyte elastase inhibitor A-like; LOC100911107; LOC306892; RGD1562844; serpin B9-like; similar to serine (or cysteine) proteinase inhibitor, clade B, member 9
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81731,586,957 - 31,594,983 (-)NCBIGRCr8
mRatBN7.21731,378,190 - 31,386,218 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1731,378,190 - 31,388,687 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1731,213,155 - 31,221,181 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01732,816,917 - 32,824,943 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01731,208,902 - 31,216,928 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01732,607,893 - 32,619,160 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1732,066,213 - 32,076,181 (-)NCBIRnor6.0rn6Rnor6.0
Rnor_5.01734,500,586 - 34,511,339 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41737,738,390 - 37,748,259 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1730,940,094 - 30,951,107 (-)NCBICelera
Cytogenetic Map17p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Serpinb9bRat17beta-estradiol increases expressionEXP 6480464Estradiol results in increased expression of SERPINB9B mRNACTDPMID:32145629
Serpinb9bRatbisphenol A affects expressionEXP 6480464bisphenol A affects the expression of SERPINB9B mRNACTDPMID:32145629
Serpinb9bRatbisphenol A decreases expressionEXP 6480464bisphenol A results in decreased expression of SERPINB9B mRNACTDPMID:25181051
Serpinb9bRatcisplatin decreases expressionEXP 6480464Cisplatin results in decreased expression of SERPINB9B mRNACTDPMID:22023808
Serpinb9bRatmethoxychlor affects methylationEXP 6480464Methoxychlor affects the methylation of SERPINB9B geneCTDPMID:35440735
Serpinb9bRatsodium dichromate decreases expressionEXP 6480464sodium bichromate results in decreased expression of SERPINB9B mRNACTDPMID:25993096
Serpinb9bRattetrachloromethane decreases expressionEXP 6480464Carbon Tetrachloride results in decreased expression of SERPINB9B mRNACTDPMID:31150632
Serpinb9bRattrichloroethene increases expressionEXP 6480464Trichloroethylene results in increased expression of SERPINB9B mRNACTDPMID:33387578


Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Serpinb9bRatcytoplasm is_active_inIBAMGI:103123 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Serpinb9bRatextracellular space is_active_inIBAFB:FBgn0002930 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Serpinb9bRatextracellular space located_inIEAInterPro:IPR0002151600115GO_REF:0000002InterProGO_REF:0000002

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Serpinb9bRatserine-type endopeptidase inhibitor activity enablesIBAMGI:101780 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Serpinb9bRatserine-type endopeptidase inhibitor activity enablesIEAInterPro:IPR000215 and InterPro:IPR0002401600115GO_REF:0000002InterProGO_REF:0000002


#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions


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Variants in Serpinb9b
32 total Variants

Predicted Target Of
Summary Value
Count of predictions:30
Count of miRNA genes:28
Interacting mature miRNAs:30
Transcripts:ENSRNOT00000074842
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 43 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17999128640540197Rat
1354640Scl32Serum cholesterol level QTL 325.4blood HDL cholesterol amount (VT:0000184)blood high density lipoprotein cholesterol level (CMO:0000052)171578159260781592Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172393042179524188Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17211514934551001Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)172840914773409147Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)172738994653481766Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172245492450909196Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172129303960781592Rat

1 to 10 of 43 rows
BI274644  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21731,378,444 - 31,378,637 (+)MAPPERmRatBN7.2
Rnor_6.01732,608,635 - 32,608,827NCBIRnor6.0
Rnor_6.01732,065,933 - 32,066,125NCBIRnor6.0
Rnor_5.01734,500,841 - 34,501,033UniSTSRnor5.0
Rnor_5.01733,959,752 - 33,959,944UniSTSRnor5.0
RGSC_v3.41737,738,023 - 37,738,215UniSTSRGSC3.4
Celera1730,940,836 - 30,941,028UniSTS
RH 3.4 Map17369.2UniSTS
Cytogenetic Map17p12UniSTS
RH142864  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21731,378,284 - 31,378,528 (+)MAPPERmRatBN7.2
Rnor_6.01732,608,475 - 32,608,718NCBIRnor6.0
Rnor_6.01732,065,773 - 32,066,016NCBIRnor6.0
Rnor_5.01734,500,681 - 34,500,924UniSTSRnor5.0
Rnor_5.01733,959,592 - 33,959,835UniSTSRnor5.0
RGSC_v3.41737,737,863 - 37,738,106UniSTSRGSC3.4
Celera1730,940,676 - 30,940,919UniSTS
RH 3.4 Map17356.8UniSTS
Cytogenetic Map17p12UniSTS







Ensembl Acc Id: ENSRNOT00000074842   ⟹   ENSRNOP00000064132
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1731,378,725 - 31,388,687 (-)Ensembl
Rnor_6.0 Ensembl1732,066,213 - 32,076,181 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118780   ⟹   ENSRNOP00000079679
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1731,378,190 - 31,386,218 (-)Ensembl
RefSeq Acc Id: NM_001346368   ⟹   NP_001333297
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81731,586,957 - 31,594,983 (-)NCBI
mRatBN7.21731,378,190 - 31,386,218 (-)NCBI
Protein RefSeqs NP_001333297 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL98337 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000064132.3
  ENSRNOP00000079679
  ENSRNOP00000079679.1
RefSeq Acc Id: NP_001333297   ⟸   NM_001346368
- UniProtKB: A0A8I5ZNV4 (UniProtKB/TrEMBL),   A6J7I7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000064132   ⟸   ENSRNOT00000074842
Ensembl Acc Id: ENSRNOP00000079679   ⟸   ENSRNOT00000118780
SERPIN

Name Modeler Protein Id AA Range Protein Structure
AF-M0R455-F1-model_v2 AlphaFold M0R455 1-373 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 28 of 28 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-9583 BioCyc
Ensembl Genes ENSRNOG00000048576 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000074842.3 UniProtKB/TrEMBL
  ENSRNOT00000118780 ENTREZGENE
  ENSRNOT00000118780.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.39.10 UniProtKB/TrEMBL
  3.30.497.10 UniProtKB/TrEMBL
InterPro Protease_inhib_I4_serpin_CS UniProtKB/TrEMBL
  Serpin_B9/Maspin UniProtKB/TrEMBL
  Serpin_dom UniProtKB/TrEMBL
  Serpin_fam UniProtKB/TrEMBL
  Serpin_sf UniProtKB/TrEMBL
  Serpin_sf_1 UniProtKB/TrEMBL
  Serpin_sf_2 UniProtKB/TrEMBL
KEGG Report rno:306892 UniProtKB/TrEMBL
NCBI Gene 306892 ENTREZGENE
PANTHER PTHR11461 UniProtKB/TrEMBL
  SERPIN B9 UniProtKB/TrEMBL
Pfam Serpin UniProtKB/TrEMBL
PhenoGen Serpinb9b PhenoGen
PRINTS MASPIN UniProtKB/TrEMBL
PROSITE SERPIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000048576 RatGTEx
SMART SERPIN UniProtKB/TrEMBL
Superfamily-SCOP Prot_inh_serpin UniProtKB/TrEMBL
UniProt A0A8I5ZNV4 ENTREZGENE, UniProtKB/TrEMBL
  A6J7I7 ENTREZGENE, UniProtKB/TrEMBL
  M0R455_RAT UniProtKB/TrEMBL
1 to 28 of 28 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Serpinb9b  serine (or cysteine) peptidase inhibitor, clade B, member 9b  RGD1562844  similar to serine (or cysteine) proteinase inhibitor, clade B, member 9  Symbol and Name Changed 1299863 APPROVED
2021-03-09 RGD1562844  similar to serine (or cysteine) proteinase inhibitor, clade B, member 9  LOC100911107  leukocyte elastase inhibitor A-like  Data merged from RGD:6495052 737654 PROVISIONAL
2012-07-05 LOC100911107  leukocyte elastase inhibitor A-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 RGD1562844  similar to serine (or cysteine) proteinase inhibitor, clade B, member 9   RGD1562844_predicted  similar to serine (or cysteine) proteinase inhibitor, clade B, member 9 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1562844_predicted  similar to serine (or cysteine) proteinase inhibitor, clade B, member 9 (predicted)  LOC306892  similar to serine (or cysteine) proteinase inhibitor, clade B, member 9  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC306892  similar to serine (or cysteine) proteinase inhibitor, clade B, member 9      Symbol and Name status set to provisional 70820 PROVISIONAL