Or8b3c (olfactory receptor family 8 subfamily B member 3C) - Rat Genome Database

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Gene: Or8b3c (olfactory receptor family 8 subfamily B member 3C) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Or8b3c
Name: olfactory receptor family 8 subfamily B member 3C
RGD ID: 1333520
Description: Predicted to enable odorant binding activity and olfactory receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and sensory perception of smell. Predicted to be located in plasma membrane. Orthologous to human OR8B3 (olfactory receptor family 8 subfamily B member 3); INTERACTS WITH furan.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: olfactory receptor 1231; olfactory receptor gene Olr1231; olfactory receptor Olr1231; Olr1231
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8847,379,226 - 47,380,176 (+)NCBIGRCr8
mRatBN7.2838,482,017 - 38,482,967 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl838,482,017 - 38,482,967 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx843,964,966 - 43,965,916 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0842,249,023 - 42,249,973 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0840,111,070 - 40,112,020 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.041,430,948 - 1,431,898 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl41,430,948 - 1,431,898 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.041,422,263 - 1,423,213 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4840,507,303 - 40,508,253NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1840,516,068 - 40,517,019NCBI
Cytogenetic Map8q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or8b3cRatfuran decreases methylationEXP 6480464furan results in decreased methylation of OR8B3C geneCTDPMID:22079235


Biological Process
1 to 9 of 9 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or8b3cRatdetection of chemical stimulus involved in sensory perception of smell  IEA (All species)1303377CREATED_DATE field changed to comply with GOC standards. Original CREATED_DATE: 2005-02-17RGD 
Or8b3cRatdetection of chemical stimulus involved in sensory perception of smell involved_inIEAGO:00049841600115GO_REF:0000108GOCGO_REF:0000108
Or8b3cRatG protein-coupled receptor signaling pathway  IEA (All species)1303377CREATED_DATE field changed to comply with GOC standards. Original CREATED_DATE: 2005-02-17RGD 
Or8b3cRatG protein-coupled receptor signaling pathway involved_inIEAUniProtKB-KW:KW-02971600115GO_REF:0000043UniProtGO_REF:0000043
Or8b3cRatG protein-coupled receptor signaling pathway involved_inIEAInterPro:IPR000276 and InterPro:IPR0007251600115GO_REF:0000002InterProGO_REF:0000002
Or8b3cRatG protein-coupled receptor signaling pathway involved_inIBAMGI:2151908 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Or8b3cRatsensory perception of smell involved_inIBAMGI:2151908 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Or8b3cRatsensory perception of smell involved_inIEAUniProtKB-KW:KW-05521600115GO_REF:0000043UniProtGO_REF:0000043
Or8b3cRatsignal transduction involved_inIEAUniProtKB-KW:KW-08071600115GO_REF:0000043UniProtGO_REF:0000043
1 to 9 of 9 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or8b3cRatmembrane located_inIEAInterPro:IPR000276 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Or8b3cRatmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Or8b3cRatplasma membrane located_inIEAUniProtKB-SubCell:SL-00391600115GO_REF:0000044UniProtGO_REF:0000044
Or8b3cRatplasma membrane located_inIEAUniProtKB-KW:KW-10031600115GO_REF:0000043UniProtGO_REF:0000043

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or8b3cRatG protein-coupled receptor activity enablesIEAUniProtKB-KW:KW-02971600115GO_REF:0000043UniProtGO_REF:0000043
Or8b3cRatG protein-coupled receptor activity enablesIEAInterPro:IPR0002761600115GO_REF:0000002InterProGO_REF:0000002
Or8b3cRatodorant binding enablesIBAMGI:2151908 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Or8b3cRatolfactory receptor activity  IEA (All species)1303377CREATED_DATE field changed to comply with GOC standards. Original CREATED_DATE: 2005-02-17RGD 
Or8b3cRatolfactory receptor activity enablesIEAInterPro:IPR0007251600115GO_REF:0000002InterProGO_REF:0000002
Or8b3cRatolfactory receptor activity enablesIBAMGI:2151908 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or8b3cRattaste/olfaction phenotype  IEA 1303377 RGD 

#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, etal., Nature 2004 Apr 1;428(6982):493-521.
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions


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Variants in Or8b3c
1 total Variants

1 to 10 of 54 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83085640475856404Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83084815461290444Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83173772976737729Rat
1354627Despr14Despair related QTL 140.0056locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)8768895552688955Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
61337Bp22Blood pressure QTL 225.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815442692818Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)82824291273242912Rat

1 to 10 of 54 rows



endocrine system
endoderm
exocrine system
hepatobiliary system
mesenchyme
reproductive system
1 1 1 1 1 8


RefSeq Transcripts NM_001000813 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC097089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000088867   ⟹   ENSRNOP00000073475
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl838,482,017 - 38,482,967 (+)Ensembl
Rnor_6.0 Ensembl41,430,948 - 1,431,898 (+)Ensembl
RefSeq Acc Id: NM_001000813   ⟹   NP_001000813
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8847,379,226 - 47,380,176 (+)NCBI
mRatBN7.2838,482,017 - 38,482,967 (+)NCBI
Rnor_6.041,430,948 - 1,431,898 (+)NCBI
Rnor_5.041,422,263 - 1,423,213 (+)NCBI
RGSC_v3.4840,507,303 - 40,508,253 (+)RGD
Sequence:
Protein RefSeqs NP_001000813 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000073475
  ENSRNOP00000073475.1
RefSeq Acc Id: NP_001000813   ⟸   NM_001000813
- UniProtKB: A0A0G2K5L8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073475   ⟸   ENSRNOT00000088867
G-protein coupled receptors family 1 profile

Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K5L8-F1-model_v2 AlphaFold A0A0G2K5L8 1-316 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 22 of 22 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-30967 BioCyc
Ensembl Genes ENSRNOG00000058298 Ensembl
  ENSRNOG00000068253 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000088867 ENTREZGENE
  ENSRNOT00000088867.2 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
  Olfact_rcpt UniProtKB/TrEMBL
KEGG Report rno:405099 UniProtKB/TrEMBL
NCBI Gene 405099 ENTREZGENE
PANTHER OLFACTORY RECEPTOR UniProtKB/TrEMBL
Pfam 7tm_4 UniProtKB/TrEMBL
PhenoGen Or8b3c PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  OLFACTORYR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000058298 RatGTEx
  ENSRNOG00000068253 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0A0G2K5L8 ENTREZGENE, UniProtKB/TrEMBL
1 to 22 of 22 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-08-16 Or8b3c  olfactory receptor family 8 subfamily B member 3C  Olr1231  olfactory receptor 1231  Symbol and Name Changed 1299863 APPROVED
2008-04-30 Olr1231  olfactory receptor 1231   Olr1231_predicted  olfactory receptor 1231 (predicted)  'predicted' is removed 2292626 APPROVED
2005-02-04 Olr1231_predicted  olfactory receptor 1231 (predicted)      Symbol and Name status set to approved 70820 APPROVED