Or6c216 (olfactory receptor family 6 subfamily C member 216) - Rat Genome Database

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Gene: Or6c216 (olfactory receptor family 6 subfamily C member 216) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Or6c216
Name: olfactory receptor family 6 subfamily C member 216
RGD ID: 1332632
Description: Predicted to enable olfactory receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and detection of chemical stimulus involved in sensory perception of smell. Predicted to be located in plasma membrane; INTERACTS WITH atrazine; bisphenol A; cadmium dichloride.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: olfactory receptor 1055; olfactory receptor gene Olr1055; olfactory receptor Olr1055; Olr1055; ratchr7-7861520-7860576_ORF
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr877,072,450 - 7,074,184 (-)NCBIGRCr8
mRatBN7.276,422,421 - 6,423,365 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl76,422,421 - 6,423,365 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx79,314,095 - 9,315,039 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0711,189,754 - 11,190,698 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.078,997,986 - 8,998,930 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0716,461,899 - 16,462,843 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl716,461,899 - 16,462,843 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0716,624,358 - 16,625,302 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.477,860,576 - 7,861,520 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.177,860,575 - 7,861,520 (-)NCBI
Celera74,647,787 - 4,648,731 (-)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or6c216Ratatrazine affects methylationEXP 6480464Atrazine affects the methylation of OR6C216 geneCTDPMID:28931070
Or6c216Ratbisphenol A decreases expressionEXP 6480464bisphenol A results in decreased expression of OR6C216 mRNACTDPMID:25181051
Or6c216Ratcadmium dichloride decreases methylationEXP 6480464Cadmium Chloride results in decreased methylation of OR6C216 promoterCTDPMID:22457795


Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or6c216Ratdetection of chemical stimulus involved in sensory perception of smell involved_inIEAGO:00049841600115GO_REF:0000108GOCGO_REF:0000108
Or6c216Ratdetection of chemical stimulus involved in sensory perception of smell  IEA (All species)1303377CREATED_DATE field changed to comply with GOC standards. Original CREATED_DATE: 2005-02-17RGD 
Or6c216RatG protein-coupled receptor signaling pathway involved_inIEAUniProtKB-KW:KW-02971600115GO_REF:0000043UniProtGO_REF:0000043
Or6c216RatG protein-coupled receptor signaling pathway  IEA (All species)1303377CREATED_DATE field changed to comply with GOC standards. Original CREATED_DATE: 2005-02-17RGD 
Or6c216RatG protein-coupled receptor signaling pathway involved_inIEAInterPro:IPR000276 and InterPro:IPR0007251600115GO_REF:0000002InterProGO_REF:0000002
Or6c216Ratsensory perception of smell involved_inIEAUniProtKB-KW:KW-05521600115GO_REF:0000043UniProtGO_REF:0000043
Or6c216Ratsignal transduction involved_inIEAUniProtKB-KW:KW-08071600115GO_REF:0000043UniProtGO_REF:0000043

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or6c216Ratmembrane located_inIEAInterPro:IPR000276 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Or6c216Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Or6c216Ratplasma membrane located_inIEAUniProtKB-SubCell:SL-00391600115GO_REF:0000044UniProtGO_REF:0000044
Or6c216Ratplasma membrane located_inIEAUniProtKB-KW:KW-10031600115GO_REF:0000043UniProtGO_REF:0000043

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or6c216RatG protein-coupled receptor activity enablesIEAUniProtKB-KW:KW-02971600115GO_REF:0000043UniProtGO_REF:0000043
Or6c216RatG protein-coupled receptor activity enablesIEAInterPro:IPR0002761600115GO_REF:0000002InterProGO_REF:0000002
Or6c216Ratolfactory receptor activity enablesIEAInterPro:IPR0007251600115GO_REF:0000002InterProGO_REF:0000002
Or6c216Ratolfactory receptor activity  IEA (All species)1303377CREATED_DATE field changed to comply with GOC standards. Original CREATED_DATE: 2005-02-17RGD 
Or6c216Ratolfactory receptor activity enablesIBAMGI:1333764 and PANTHER:PTN0012458721600115GO_REF:0000033GO_CentralGO_REF:0000033

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or6c216Rattaste/olfaction phenotype  IEA 1303377 RGD 

#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, etal., Nature 2004 Apr 1;428(6982):493-521.
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions


.

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Variants in Or6c216
3 total Variants

Predicted Target Of
Summary Value
Count of predictions:14
Count of miRNA genes:14
Interacting mature miRNAs:14
Transcripts:ENSRNOT00000051359
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 11 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat

1 to 10 of 11 rows



endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
reproductive system
2 2 2 1 2 3 1 2



Ensembl Acc Id: ENSRNOT00000051359   ⟹   ENSRNOP00000050994
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl76,422,421 - 6,423,365 (-)Ensembl
Rnor_6.0 Ensembl716,461,899 - 16,462,843 (+)Ensembl
RefSeq Acc Id: NM_001000067   ⟹   NP_001000067
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr877,073,234 - 7,074,178 (-)NCBI
mRatBN7.276,422,421 - 6,423,365 (-)NCBI
Rnor_6.0716,461,899 - 16,462,843 (+)NCBI
Rnor_5.0716,624,358 - 16,625,302 (+)NCBI
RGSC_v3.477,860,576 - 7,861,520 (-)RGD
Celera74,647,787 - 4,648,731 (-)RGD
Sequence:
RefSeq Acc Id: XM_063263097   ⟹   XP_063119167
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr877,072,450 - 7,074,184 (-)NCBI
Protein RefSeqs NP_001000067 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119167 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL89101 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000050994
  ENSRNOP00000050994.3
RefSeq Acc Id: NP_001000067   ⟸   NM_001000067
- UniProtKB: D3ZFB7 (UniProtKB/TrEMBL),   A6K831 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000050994   ⟸   ENSRNOT00000051359
RefSeq Acc Id: XP_063119167   ⟸   XM_063263097
- Peptide Label: isoform X1
- UniProtKB: A6K831 (UniProtKB/TrEMBL)
G-protein coupled receptors family 1 profile

Name Modeler Protein Id AA Range Protein Structure
AF-D3ZFB7-F1-model_v2 AlphaFold D3ZFB7 1-314 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 23 of 23 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-35102 BioCyc
Ensembl Genes ENSRNOG00000030191 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000051359 ENTREZGENE
  ENSRNOT00000051359.4 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro 7TM_GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_supfam UniProtKB/TrEMBL
  Olfact_rcpt UniProtKB/TrEMBL
  Olfact_rcpt_6C-like UniProtKB/TrEMBL
KEGG Report rno:288835 UniProtKB/TrEMBL
NCBI Gene 288835 ENTREZGENE
PANTHER OLFACTORY RECEPTOR UniProtKB/TrEMBL
  OLFACTORY RECEPTOR UniProtKB/TrEMBL
Pfam 7tm_4 UniProtKB/TrEMBL
PhenoGen Or6c216 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  OLFACTORYR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000030191 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A6K831 ENTREZGENE, UniProtKB/TrEMBL
  D3ZFB7 ENTREZGENE, UniProtKB/TrEMBL
1 to 23 of 23 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-08-16 Or6c216  olfactory receptor family 6 subfamily C member 216  Olr1055  olfactory receptor 1055  Symbol and Name Changed 1299863 APPROVED
2008-04-30 Olr1055  olfactory receptor 1055   Olr1055_predicted  olfactory receptor 1055 (predicted)  'predicted' is removed 2292626 APPROVED
2005-02-04 Olr1055_predicted  olfactory receptor 1055 (predicted)      Symbol and Name status set to approved 70820 APPROVED