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Gene: POLA2 (DNA polymerase alpha 2, accessory subunit) Homo sapiens
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Symbol: POLA2
Name: DNA polymerase alpha 2, accessory subunit
Description: Predicted to have protein heterodimerization activity. Predicted to be involved in DNA replication initiation. Localizes to the alpha DNA polymerase:primase complex; cytosol; and nucleoplasm; PARTICIPATES IN DNA replication pathway; purine metabolic pathway; pyrimidine metabolic pathway; INTERACTS WITH (-)-demecolcine; (-)-epigallocatechin 3-gallate; 2-hydroxypropanoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: DNA polymerase alpha 70 kDa subunit; DNA polymerase alpha subunit B; dna polymerase alpha subunit ii; FLJ21662; FLJ37250; polymerase (DNA directed), alpha 2 (70kD subunit); polymerase (DNA directed), alpha 2, accessory subunit; polymerase (DNA) alpha 2, accessory subunit; polymerase (DNA-directed), alpha (70kD)
Orthologs:
Mus musculus (house mouse) : Pola2 (polymerase (DNA directed), alpha 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Pola2 (DNA polymerase alpha 2, accessory subunit)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pola2 (DNA polymerase alpha 2, accessory subunit)
Pan paniscus (bonobo/pygmy chimpanzee) : POLA2 (DNA polymerase alpha 2, accessory subunit)
Canis lupus familiaris (dog) : POLA2 (DNA polymerase alpha 2, accessory subunit)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pola2 (DNA polymerase alpha 2, accessory subunit)
Sus scrofa (pig) : POLA2 (DNA polymerase alpha 2, accessory subunit)
Chlorocebus sabaeus (African green monkey) : POLA2 (DNA polymerase alpha 2, accessory subunit)
Heterocephalus glaber (naked mole-rat) : Pola2 (DNA polymerase alpha 2, accessory subunit)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl1165,261,920 - 65,305,589 (+)Ensembl
GRCh38 Ensembl1165,261,928 - 65,326,543 (+)Ensembl
GRCh381165,261,917 - 65,306,269 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371165,029,432 - 65,065,088 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361164,786,006 - 64,821,664 (+)NCBINCBI36hg18NCBI36
Build 341164,786,007 - 64,821,663NCBI
Celera1162,355,790 - 62,391,446 (+)NCBI
Cytogenetic Map11q13.1NCBI
HuRef1161,356,467 - 61,392,125 (+)NCBIHuRef
CHM1_11164,913,336 - 64,950,169 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on POLA2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731623
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.