Cdh26 (cadherin 26) - Rat Genome Database

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Gene: Cdh26 (cadherin 26) Rattus norvegicus
Analyze
Symbol: Cdh26
Name: cadherin 26
RGD ID: 1311632
Description: Predicted to enable several functions, including alpha-catenin binding activity; beta-catenin binding activity; and delta-catenin binding activity. Predicted to be involved in CD4-positive, alpha-beta T cell activation. Predicted to be located in microtubule cytoskeleton and plasma membrane. Orthologous to human CDH26 (cadherin 26); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; methoxychlor.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cadherin-like 26; cadherin-like protein 26; LOC311693
RGD Orthologs
Human
Mouse
Bonobo
Dog
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83185,898,185 - 185,950,892 (+)NCBIGRCr8
mRatBN7.23165,520,523 - 165,573,191 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3165,520,439 - 165,572,149 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3169,895,152 - 169,945,608 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03178,854,240 - 178,904,699 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03175,520,608 - 175,571,287 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03173,969,004 - 174,020,867 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3173,969,273 - 174,019,766 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03183,071,632 - 183,121,671 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43167,524,338 - 167,589,555 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13167,430,373 - 167,495,591 (+)NCBI
Celera3166,992,038 - 167,040,888 (-)NCBICelera
Cytogenetic Map3q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:28051089  


Genomics

Comparative Map Data
Cdh26
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83185,898,185 - 185,950,892 (+)NCBIGRCr8
mRatBN7.23165,520,523 - 165,573,191 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3165,520,439 - 165,572,149 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3169,895,152 - 169,945,608 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03178,854,240 - 178,904,699 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03175,520,608 - 175,571,287 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03173,969,004 - 174,020,867 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3173,969,273 - 174,019,766 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03183,071,632 - 183,121,671 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43167,524,338 - 167,589,555 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13167,430,373 - 167,495,591 (+)NCBI
Celera3166,992,038 - 167,040,888 (-)NCBICelera
Cytogenetic Map3q43NCBI
CDH26
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382059,958,423 - 60,035,934 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2059,958,423 - 60,034,011 (+)EnsemblGRCh38hg38GRCh38
GRCh372058,533,478 - 58,589,584 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362057,966,877 - 58,021,563 (+)NCBINCBI36Build 36hg18NCBI36
Build 342057,966,876 - 58,021,562NCBI
Celera2055,274,111 - 55,328,792 (+)NCBICelera
Cytogenetic Map20q13.33NCBI
HuRef2055,320,646 - 55,375,337 (+)NCBIHuRef
CHM1_12058,434,534 - 58,489,235 (+)NCBICHM1_1
T2T-CHM13v2.02061,742,679 - 61,822,261 (+)NCBIT2T-CHM13v2.0
Cdh26
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392178,072,263 - 178,129,159 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2178,072,324 - 178,129,159 (+)EnsemblGRCm39 Ensembl
GRCm382178,430,515 - 178,487,366 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2178,430,531 - 178,487,366 (+)EnsemblGRCm38mm10GRCm38
MGSCv372178,165,312 - 178,222,071 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362178,360,015 - 178,416,774 (+)NCBIMGSCv36mm8
Celera2182,517,010 - 182,573,480 (+)NCBICelera
Cytogenetic Map2H4NCBI
cM Map299.94NCBI
CDH26
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22165,710,504 - 65,782,153 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12065,703,626 - 65,775,277 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02056,298,117 - 56,394,044 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12057,652,257 - 57,719,439 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2057,665,787 - 57,719,057 (+)Ensemblpanpan1.1panPan2
CDH26
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12444,566,610 - 44,608,670 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2444,566,467 - 44,608,420 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2443,813,287 - 43,848,019 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02445,435,512 - 45,479,684 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2445,432,932 - 45,475,044 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12444,537,004 - 44,581,115 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02444,656,598 - 44,691,293 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02445,316,625 - 45,351,375 (+)NCBIUU_Cfam_GSD_1.0
CDH26
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.124,136,961 - 4,191,138 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605052,178,429 - 52,248,049 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cdh26
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474126,243,545 - 26,255,170 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cdh26
312 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:146
Count of miRNA genes:119
Interacting mature miRNAs:131
Transcripts:ENSRNOT00000065643
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
2317883Alcrsp26Alcohol response QTL 261.80.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)3145526770169034231Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3145925360166177555Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3145925360166177555Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3145925360166177555Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3145925360166177555Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3145925360166177555Rat
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3145925360166177555Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3145925360166177555Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3145956084169034231Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3149040888168026850Rat
1300161Rf10Renal function QTL 103.57renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)3161192952169034231Rat

Markers in Region
D3Mco85  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23165,559,913 - 165,560,048 (+)MAPPERmRatBN7.2
Rnor_6.03174,008,012 - 174,008,146NCBIRnor6.0
Rnor_5.03183,082,767 - 183,082,901UniSTSRnor5.0
RGSC_v3.43167,563,106 - 167,563,240UniSTSRGSC3.4
Celera3167,001,999 - 167,002,133UniSTS
Cytogenetic Map3q43UniSTS
D3Mco75  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23165,538,050 - 165,538,241 (+)MAPPERmRatBN7.2
Rnor_6.03173,986,278 - 173,986,468NCBIRnor6.0
Rnor_5.03183,104,671 - 183,104,861UniSTSRnor5.0
RGSC_v3.43167,541,321 - 167,541,511UniSTSRGSC3.4
Celera3167,023,879 - 167,024,069UniSTS
Cytogenetic Map3q43UniSTS
AW531498  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23165,539,245 - 165,539,434 (+)MAPPERmRatBN7.2
Rnor_6.03173,987,473 - 173,987,661NCBIRnor6.0
Rnor_5.03183,103,478 - 183,103,666UniSTSRnor5.0
RGSC_v3.43167,542,516 - 167,542,704UniSTSRGSC3.4
Celera3167,022,686 - 167,022,874UniSTS
RH 3.4 Map31510.2UniSTS
Cytogenetic Map3q43UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 17 11 8 9 9 18 11 8
Below cutoff 3 22 23 14 6 14 1 47 26 18

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000083970   ⟹   ENSRNOP00000074411
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3165,520,439 - 165,572,149 (+)Ensembl
Rnor_6.0 Ensembl3173,969,273 - 174,019,766 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000096904   ⟹   ENSRNOP00000085846
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3165,520,439 - 165,572,149 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000098801   ⟹   ENSRNOP00000091097
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3165,520,439 - 165,572,149 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000118182   ⟹   ENSRNOP00000081002
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3165,520,439 - 165,572,149 (+)Ensembl
RefSeq Acc Id: NM_001191745   ⟹   NP_001178674
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83185,898,431 - 185,950,892 (+)NCBI
mRatBN7.23165,520,728 - 165,573,191 (+)NCBI
Rnor_6.03173,969,273 - 174,019,766 (+)NCBI
Rnor_5.03183,071,632 - 183,121,671 (-)NCBI
Celera3166,992,038 - 167,040,888 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008762509   ⟹   XP_008760731
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83185,898,185 - 185,950,713 (+)NCBI
mRatBN7.23165,520,523 - 165,573,191 (+)NCBI
Rnor_6.03173,969,004 - 174,020,867 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039105149   ⟹   XP_038961077
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83185,898,227 - 185,950,713 (+)NCBI
mRatBN7.23165,520,523 - 165,573,191 (+)NCBI
RefSeq Acc Id: XM_039105150   ⟹   XP_038961078
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83185,898,227 - 185,950,713 (+)NCBI
mRatBN7.23165,520,523 - 165,567,312 (+)NCBI
RefSeq Acc Id: XM_039105151   ⟹   XP_038961079
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83185,898,226 - 185,931,731 (+)NCBI
mRatBN7.23165,520,523 - 165,554,027 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001178674   ⟸   NM_001191745
- Peptide Label: precursor
- UniProtKB: A0A0G2K7Z8 (UniProtKB/TrEMBL),   A0A8I6AFI2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008760731   ⟸   XM_008762509
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZRI2 (UniProtKB/TrEMBL),   A0A8I6AFI2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074411   ⟸   ENSRNOT00000083970
RefSeq Acc Id: XP_038961077   ⟸   XM_039105149
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A4R4 (UniProtKB/TrEMBL),   A0A8I6AFI2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961078   ⟸   XM_039105150
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AFI2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961079   ⟸   XM_039105151
- Peptide Label: isoform X4
RefSeq Acc Id: ENSRNOP00000091097   ⟸   ENSRNOT00000098801
RefSeq Acc Id: ENSRNOP00000085846   ⟸   ENSRNOT00000096904
RefSeq Acc Id: ENSRNOP00000081002   ⟸   ENSRNOT00000118182
Protein Domains
Cadherin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K7Z8-F1-model_v2 AlphaFold A0A0G2K7Z8 1-761 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311632 AgrOrtholog
BioCyc Gene G2FUF-46397 BioCyc
Ensembl Genes ENSRNOG00000053332 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000083970 ENTREZGENE
  ENSRNOT00000083970.2 UniProtKB/TrEMBL
  ENSRNOT00000096904.1 UniProtKB/TrEMBL
  ENSRNOT00000098801.1 UniProtKB/TrEMBL
  ENSRNOT00000118182.1 UniProtKB/TrEMBL
Gene3D-CATH Cadherins UniProtKB/TrEMBL
InterPro Cadherin UniProtKB/TrEMBL
  Cadherin UniProtKB/TrEMBL
  Cadherin-like UniProtKB/TrEMBL
  Cadherin_CS UniProtKB/TrEMBL
KEGG Report rno:311693 UniProtKB/TrEMBL
NCBI Gene 311693 ENTREZGENE
PANTHER CADHERIN-LIKE PROTEIN 26 UniProtKB/TrEMBL
  PTHR24027 UniProtKB/TrEMBL
Pfam Cadherin UniProtKB/TrEMBL
PhenoGen Cdh26 PhenoGen
PRINTS CADHERIN UniProtKB/TrEMBL
  DESMOCOLLIN UniProtKB/TrEMBL
PROSITE CADHERIN_1 UniProtKB/TrEMBL
  CADHERIN_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000053332 RatGTEx
SMART SM00112 UniProtKB/TrEMBL
Superfamily-SCOP Cadherin UniProtKB/TrEMBL
UniProt A0A0G2K7Z8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZRI2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A4R4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AFI2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-29 Cdh26  cadherin 26  Cdh26  cadherin-like 26  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Cdh26  cadherin-like 26   Cdh26_predicted  cadherin-like 26 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Cdh26_predicted  cadherin-like 26 (predicted)      Symbol and Name status set to approved 70820 APPROVED