Rtfdc1 (replication termination factor 2 domain containing 1) - Rat Genome Database

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Gene: Rtfdc1 (replication termination factor 2 domain containing 1) Rattus norvegicus
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Symbol: Rtfdc1
Name: replication termination factor 2 domain containing 1
RGD ID: 1311072
Description: Predicted to enable DNA binding activity. Predicted to be involved in DNA replication termination; cellular response to hydroxyurea; and regulation of DNA stability. Predicted to be located in replication fork. Predicted to be active in nucleus. Orthologous to human RTF2 (replication termination factor 2); INTERACTS WITH bisphenol A; vinclozolin; (1->4)-beta-D-glucan (ortholog).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hypothetical protein LOC296410; LOC296410; MGC124670; protein RTF2 homolog; replication termination factor 2; replication termination factor 2 domain-containing protein 1; RGD1311072; RTF2; similar to 2410001C21Rik protein; UPF0549 protein C20orf43 homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83181,624,798 - 181,656,104 (+)NCBIGRCr8
mRatBN7.23161,208,005 - 161,237,687 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3161,208,049 - 161,237,687 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3165,018,080 - 165,047,658 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03173,517,102 - 173,546,680 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03171,258,921 - 171,288,499 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03170,443,895 - 170,473,456 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3170,443,855 - 170,473,456 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03176,519,321 - 176,548,882 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43163,350,088 - 163,379,729 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13163,256,141 - 163,285,754 (+)NCBI
Celera3160,408,098 - 160,437,168 (+)NCBICelera
Cytogenetic Map3q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IBA,IEA)
replication fork  (ISO,ISS)

Molecular Function
DNA binding  (ISO,ISS)
protein binding  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:29290612  


Genomics

Comparative Map Data
Rtfdc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83181,624,798 - 181,656,104 (+)NCBIGRCr8
mRatBN7.23161,208,005 - 161,237,687 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3161,208,049 - 161,237,687 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3165,018,080 - 165,047,658 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03173,517,102 - 173,546,680 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03171,258,921 - 171,288,499 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03170,443,895 - 170,473,456 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3170,443,855 - 170,473,456 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03176,519,321 - 176,548,882 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43163,350,088 - 163,379,729 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13163,256,141 - 163,285,754 (+)NCBI
Celera3160,408,098 - 160,437,168 (+)NCBICelera
Cytogenetic Map3q42NCBI
RTF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382056,468,627 - 56,519,449 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2056,468,585 - 56,519,449 (+)EnsemblGRCh38hg38GRCh38
GRCh372055,043,683 - 55,094,505 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362054,477,092 - 54,527,345 (+)NCBINCBI36Build 36hg18NCBI36
Build 342054,477,091 - 54,527,343NCBI
Celera2051,784,073 - 51,834,372 (+)NCBICelera
Cytogenetic Map20q13.31NCBI
HuRef2051,828,356 - 51,878,628 (+)NCBIHuRef
CHM1_12054,944,770 - 54,995,053 (+)NCBICHM1_1
T2T-CHM13v2.02058,246,116 - 58,296,943 (+)NCBIT2T-CHM13v2.0
Rtf2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392172,282,498 - 172,311,819 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2172,282,476 - 172,311,828 (+)EnsemblGRCm39 Ensembl
GRCm382172,440,578 - 172,469,899 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2172,440,556 - 172,469,908 (+)EnsemblGRCm38mm10GRCm38
MGSCv372172,266,078 - 172,295,399 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362172,131,783 - 172,161,104 (+)NCBIMGSCv36mm8
Celera2178,401,755 - 178,431,767 (+)NCBICelera
Cytogenetic Map2H3NCBI
cM Map294.86NCBI
Rtf2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554452,726,358 - 2,765,104 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554452,729,658 - 2,764,447 (-)NCBIChiLan1.0ChiLan1.0
RTF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22162,213,096 - 62,277,430 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12062,206,098 - 62,270,586 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02052,806,960 - 52,874,887 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12054,094,102 - 54,147,129 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2054,094,102 - 54,147,129 (+)Ensemblpanpan1.1panPan2
RTF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12441,665,259 - 41,706,348 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2441,665,294 - 41,706,348 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2440,912,799 - 40,953,883 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02442,428,031 - 42,469,108 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2442,375,975 - 42,532,550 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12441,615,531 - 41,656,601 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02441,754,883 - 41,795,702 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02442,413,052 - 42,453,911 (+)NCBIUU_Cfam_GSD_1.0
Rtf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640183,671,436 - 183,716,870 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936875369,065 - 414,053 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936875369,065 - 414,522 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RTF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1757,040,967 - 57,084,668 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11757,040,967 - 57,084,677 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21764,152,512 - 64,196,307 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RTF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.127,601,916 - 7,653,374 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl27,602,531 - 7,653,328 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605055,675,275 - 55,727,353 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Rtfdc1
168 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:150
Count of miRNA genes:117
Interacting mature miRNAs:136
Transcripts:ENSRNOT00000006884
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3118839124163839124Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3130193298161695983Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141339013162184794Rat
2317883Alcrsp26Alcohol response QTL 261.80.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)3145526770169034231Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3145925360166177555Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3145925360166177555Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3145925360166177555Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3145925360166177555Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3145925360166177555Rat
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3145925360166177555Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3145925360166177555Rat
1598854Memor10Memory QTL 102exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)3145956084161299569Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3145956084169034231Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3149040888168026850Rat
1300161Rf10Renal function QTL 103.57renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)3161192952169034231Rat

Markers in Region
AI069986  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23161,236,437 - 161,236,638 (+)MAPPERmRatBN7.2
Rnor_6.03170,472,207 - 170,472,407NCBIRnor6.0
Rnor_5.03176,547,633 - 176,547,833UniSTSRnor5.0
RGSC_v3.43163,378,480 - 163,378,680UniSTSRGSC3.4
Celera3160,435,919 - 160,436,119UniSTS
RH 3.4 Map31496.8UniSTS
Cytogenetic Map3q42UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000006884   ⟹   ENSRNOP00000006884
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3161,208,051 - 161,237,629 (+)Ensembl
Rnor_6.0 Ensembl3170,443,855 - 170,473,456 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000117578   ⟹   ENSRNOP00000092936
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3161,208,049 - 161,237,687 (+)Ensembl
RefSeq Acc Id: NM_001033890   ⟹   NP_001029062
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83181,626,460 - 181,656,104 (+)NCBI
mRatBN7.23161,208,038 - 161,237,687 (+)NCBI
Rnor_6.03170,443,895 - 170,473,456 (+)NCBI
Rnor_5.03176,519,321 - 176,548,882 (+)NCBI
RGSC_v3.43163,350,088 - 163,379,729 (+)RGD
Celera3160,408,098 - 160,437,168 (+)RGD
Sequence:
RefSeq Acc Id: XM_039104652   ⟹   XP_038960580
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83181,624,798 - 181,656,104 (+)NCBI
mRatBN7.23161,208,005 - 161,237,687 (+)NCBI
RefSeq Acc Id: NP_001029062   ⟸   NM_001033890
- UniProtKB: Q3T1J8 (UniProtKB/Swiss-Prot),   A0A8L2Q2N4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000006884   ⟸   ENSRNOT00000006884
RefSeq Acc Id: XP_038960580   ⟸   XM_039104652
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000092936   ⟸   ENSRNOT00000117578

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q3T1J8-F1-model_v2 AlphaFold Q3T1J8 1-306 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692707
Promoter ID:EPDNEW_R3231
Type:initiation region
Name:Rtfdc1_1
Description:replication termination factor 2 domain containing 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03170,443,905 - 170,443,965EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311072 AgrOrtholog
BioCyc Gene G2FUF-46538 BioCyc
Ensembl Genes ENSRNOG00000005083 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055003471 UniProtKB/Swiss-Prot
  ENSRNOG00060001160 UniProtKB/Swiss-Prot
  ENSRNOG00065013980 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000006884.6 UniProtKB/TrEMBL
  ENSRNOT00000117578 ENTREZGENE
  ENSRNOT00000117578.1 UniProtKB/Swiss-Prot
  ENSRNOT00055005390 UniProtKB/Swiss-Prot
  ENSRNOT00060001635 UniProtKB/Swiss-Prot
  ENSRNOT00065023084 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7929941 IMAGE-MGC_LOAD
InterPro Rtf2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rtf2_RING-finger UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:296410 UniProtKB/Swiss-Prot
MGC_CLONE MGC:124670 IMAGE-MGC_LOAD
NCBI Gene 296410 ENTREZGENE
PANTHER PTHR12775 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  REPLICATION TERMINATION FACTOR 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Rtf2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rtfdc1 PhenoGen
RatGTEx ENSRNOG00000005083 RatGTEx
  ENSRNOG00055003471 RatGTEx
  ENSRNOG00060001160 RatGTEx
  ENSRNOG00065013980 RatGTEx
UniProt A0A8L2Q2N4 ENTREZGENE, UniProtKB/TrEMBL
  Q3T1J8 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-11-07 Rtfdc1  replication termination factor 2 domain containing 1  RGD1311072  similar to 2410001C21Rik protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1311072  similar to 2410001C21Rik protein  RGD1311072_predicted  similar to 2410001C21Rik protein (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1311072_predicted  similar to 2410001C21Rik protein (predicted)  LOC296410_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC296410_predicted  similar to 2410001C21Rik protein (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL