Ptges2 (prostaglandin E synthase 2) - Rat Genome Database

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Gene: Ptges2 (prostaglandin E synthase 2) Rattus norvegicus
Analyze
Symbol: Ptges2
Name: prostaglandin E synthase 2
RGD ID: 1310836
Description: Predicted to enable DNA binding activity; lyase activity; and prostaglandin-E synthase activity. Predicted to be involved in lipid metabolic process. Predicted to act upstream of or within positive regulation of DNA-templated transcription and secretion. Predicted to be located in Golgi membrane; cytosol; and nucleus. Predicted to be active in mitochondrion. Orthologous to human PTGES2 (prostaglandin E synthase 2); PARTICIPATES IN prostaglandin biosynthetic pathway; type II interferon signaling pathway; arachidonic acid metabolic pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 4-amino-2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC311865
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8336,088,246 - 36,095,430 (+)NCBIGRCr8
mRatBN7.2315,690,501 - 15,697,688 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl315,690,501 - 15,697,688 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx318,759,325 - 18,766,565 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0327,344,320 - 27,351,561 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0325,595,176 - 25,602,293 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0311,424,195 - 11,431,379 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl311,424,099 - 11,431,402 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0316,773,065 - 16,780,249 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4311,521,214 - 11,528,395 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1311,418,096 - 11,424,768 (+)NCBI
Celera310,433,385 - 10,440,575 (+)NCBICelera
Cytogenetic Map3p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ptges2Ratcongenital disorder of glycosylation Iu  ISOPTGES2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:23109149 and PMID:28492532
Ptges2Ratdevelopmental and epileptic encephalopathy  ISOPTGES2 (Homo sapiens)8554872ClinVar Annotator: match by term: Developmental and epileptic encephalopathyClinVarPMID:18469812 more ...
Ptges2Ratdevelopmental and epileptic encephalopathy 31A  ISOPTGES2 (Homo sapiens)8554872ClinVar Annotator: match by term: Epileptic encephalopathy more ...ClinVarPMID:18469812 more ...
Ptges2Ratdystonia  ISOPTGES2 (Homo sapiens)8554872ClinVar Annotator: match by term: Dystonic disorderClinVarPMID:28492532
Ptges2Ratearly infantile epileptic encephalopathy  ISOPTGES2 (Homo sapiens)8554872ClinVar Annotator: match by term: Early infantile epileptic encephalopathyClinVarPMID:18469812 more ...
Ptges2Ratprimary coenzyme Q10 deficiency 7  ISOPTGES2 (Homo sapiens)8554872ClinVar Annotator: match by term: Neonatal encephalomyopathy-cardiomyopathy-respiratory distress syndromeClinVarPMID:22368301 more ...
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ptges2Ratautism spectrum disorder  ISOPTGES2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:35663546
Ptges2RatChemical and Drug Induced Liver Injury  ISOPTGES2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:31444509
Ptges2RatThyroid Neoplasms  ISOPTGES2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22387750

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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ptges2Rat1,2-dimethylhydrazine multiple interactionsEXP 6480464[APC protein affects the susceptibility to 1 and 2-Dimethylhydrazine] which results in decreased expression of PTGES2 mRNACTDPMID:27840820
Ptges2Rat1,2-dimethylhydrazine multiple interactionsISOPtges2 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of PTGES2 mRNACTDPMID:22206623
Ptges2Rat17alpha-ethynylestradiol multiple interactionsISOPtges2 (Mus musculus)6480464[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of PTGES2 mRNACTDPMID:37844793
Ptges2Rat2,2',4,4'-Tetrabromodiphenyl ether decreases expressionISOPTGES2 (Homo sapiens)64804642 more ...CTDPMID:31675489
Ptges2Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOPtges2 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of PTGES2 mRNACTDPMID:21570461
Ptges2Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of PTGES2 mRNACTDPMID:33387578
Ptges2Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOPtges2 (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of PTGES2 mRNACTDPMID:28213091
Ptges2Rat2,4,6-tribromophenol decreases expressionISOPTGES2 (Homo sapiens)64804642 more ...CTDPMID:31675489
Ptges2Rat2-palmitoylglycerol increases expressionISOPTGES2 (Homo sapiens)64804642-palmitoylglycerol results in increased expression of PTGES2 mRNACTDPMID:37199045
Ptges2Rat3,3',5,5'-tetrabromobisphenol A decreases expressionISOPTGES2 (Homo sapiens)6480464tetrabromobisphenol A results in decreased expression of PTGES2 proteinCTDPMID:31675489
Ptges2Rat4,4'-diaminodiphenylmethane decreases expressionISOPtges2 (Mus musculus)64804644 and 4'-diaminodiphenylmethane results in decreased expression of PTGES2 mRNACTDPMID:18648102
Ptges2Rat4-amino-2,6-dinitrotoluene affects expressionEXP 64804644-amino-2 and 6-dinitrotoluene affects the expression of PTGES2 mRNACTDPMID:21346803
Ptges2Rat6-propyl-2-thiouracil increases expressionEXP 6480464Propylthiouracil results in increased expression of PTGES2 mRNACTDPMID:30047161
Ptges2Ratacrylamide decreases expressionISOPTGES2 (Homo sapiens)6480464Acrylamide results in decreased expression of PTGES2 mRNACTDPMID:32763439
Ptges2Ratamitrole increases expressionEXP 6480464Amitrole results in increased expression of PTGES2 mRNACTDPMID:30047161
Ptges2Rataristolochic acid A increases expressionEXP 6480464aristolochic acid I results in increased expression of PTGES2 mRNACTDPMID:36863539
Ptges2Ratarsane affects methylationISOPTGES2 (Homo sapiens)6480464Arsenic affects the methylation of PTGES2 geneCTDPMID:25304211
Ptges2Ratarsenic atom affects methylationISOPTGES2 (Homo sapiens)6480464Arsenic affects the methylation of PTGES2 geneCTDPMID:25304211
Ptges2Ratbenzo[a]pyrene increases expressionISOPtges2 (Mus musculus)6480464Benzo(a)pyrene results in increased expression of PTGES2 proteinCTDPMID:18321868
Ptges2Ratbenzo[a]pyrene decreases methylationISOPTGES2 (Homo sapiens)6480464Benzo(a)pyrene results in decreased methylation of PTGES2 promoterCTDPMID:27901495

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Biological Process
1 to 14 of 14 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ptges2Ratcyclooxygenase pathway involved_inISOPtges2 (Mus musculus)1624291 PMID:35228744RGDPMID:35228744
Ptges2Ratfatty acid biosynthetic process involved_inIEAUniProtKB-KW:KW-02751600115GO_REF:0000043UniProtGO_REF:0000043
Ptges2Ratfatty acid metabolic process involved_inIEAUniProtKB-KW:KW-02761600115GO_REF:0000043UniProtGO_REF:0000043
Ptges2Ratlipid metabolic process involved_inISOPTGES2 (Homo sapiens)1624291 PMID:17585783RGDPMID:17585783
Ptges2Ratlipid metabolic process involved_inIEAUniProtKB-KW:KW-04431600115GO_REF:0000043UniProtGO_REF:0000043
Ptges2Ratlipid metabolic process involved_inIEAUniProtKB:Q9H7Z7 and ensembl:ENSP000003453411600115GO_REF:0000107EnsemblGO_REF:0000107
Ptges2Ratpositive regulation of DNA-templated transcription acts_upstream_of_or_withinIEAUniProtKB:Q8BWM0 and ensembl:ENSMUSP000000281621600115GO_REF:0000107EnsemblGO_REF:0000107
Ptges2Ratpositive regulation of DNA-templated transcription acts_upstream_of_or_withinISOPtges2 (Mus musculus)1624291 PMID:12050152RGDPMID:12050152
Ptges2Ratprostaglandin biosynthetic process involved_inIEAUniPathway:UPA006621600115GO_REF:0000041UniProtGO_REF:0000041
Ptges2Ratprostaglandin biosynthetic process involved_inIEAUniProtKB-KW:KW-06431600115GO_REF:0000043UniProtGO_REF:0000043
Ptges2Ratprostaglandin metabolic process involved_inISOPtges2 (Mus musculus)1624291 PMID:35228744RGDPMID:35228744
Ptges2Ratprostaglandin metabolic process involved_inIEAUniProtKB-KW:KW-06441600115GO_REF:0000043UniProtGO_REF:0000043
Ptges2Ratsecretion acts_upstream_of_or_withinISOPtges2 (Mus musculus)1624291 PMID:16217040RGDPMID:16217040
Ptges2Ratsecretion acts_upstream_of_or_withinIEAUniProtKB:Q8BWM0 and ensembl:ENSMUSP000000281621600115GO_REF:0000107EnsemblGO_REF:0000107
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Cellular Component
1 to 14 of 14 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ptges2Ratcytosol is_active_inISOPtges2 (Mus musculus)1624291 PMID:12835322RGDPMID:12835322
Ptges2Ratcytosol located_inIEAUniProtKB:Q9H7Z7 and ensembl:ENSP000003453411600115GO_REF:0000107EnsemblGO_REF:0000107
Ptges2Ratcytosol located_inIEAUniProtKB:Q8BWM0 and ensembl:ENSMUSP000000281621600115GO_REF:0000107EnsemblGO_REF:0000107
Ptges2Ratcytosol located_inISOPTGES2 (Homo sapiens)1624291 PMID:12835322RGDPMID:12835322
Ptges2Ratcytosol located_inISOPtges2 (Mus musculus)1624291 PMID:12050152RGDPMID:12050152
Ptges2Ratendomembrane system located_inIEAUniProtKB-SubCell:SL-01471600115GO_REF:0000044UniProtGO_REF:0000044
Ptges2RatGolgi membrane located_inISOPTGES2 (Homo sapiens)1624291 PMID:12835322RGDPMID:12835322
Ptges2RatGolgi membrane located_inIEAUniProtKB:Q9H7Z7 and ensembl:ENSP000003453411600115GO_REF:0000107EnsemblGO_REF:0000107
Ptges2Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Ptges2Ratmitochondrion located_inISOPTGES2 (Homo sapiens)1624291 RGDGO_REF:0000054
Ptges2Ratmitochondrion located_inIEAUniProtKB:Q9H7Z7 and ensembl:ENSP000003453411600115GO_REF:0000107EnsemblGO_REF:0000107
Ptges2Ratmitochondrion is_active_inIBAPANTHER:PTN000299939 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Ptges2Ratnucleus located_inIEAUniProtKB:Q8BWM0 and ensembl:ENSMUSP000000281621600115GO_REF:0000107EnsemblGO_REF:0000107
Ptges2Ratnucleus located_inISOPtges2 (Mus musculus)1624291 PMID:12050152RGDPMID:12050152
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Molecular Function
1 to 12 of 12 rows

  
1 to 12 of 12 rows

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ptges2Ratprostaglandin biosynthetic pathway  ISOPTGES2 (Homo sapiens)8552712 RGD 
Ptges2Ratprostaglandin biosynthetic pathway  ISOPTGES2 (Homo sapiens)8552701 RGD 

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ptges2Ratarachidonic acid metabolic pathway  IEA 6907045 KEGGrno:00590

Imported Annotations - PID (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ptges2Rattype II interferon signaling pathway  ISOPTGES2 (Homo sapiens)6484113 PIDPID:200129

#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Prostanoids as regulators of innate and adaptive immunity. Hirata T and Narumiya S, Adv Immunol. 2012;116:143-74. doi: 10.1016/B978-0-12-394300-2.00005-3.
3. Molecular mechanisms regulating the vascular prostacyclin pathways and their adaptation during pregnancy and in the newborn. Majed BH and Khalil RA, Pharmacol Rev. 2012 Jul;64(3):540-82. doi: 10.1124/pr.111.004770. Epub 2012 Jun 7.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:12050152   PMID:12804604   PMID:15358613   PMID:16217040   PMID:16804969   PMID:18614015   PMID:20833797  



Ptges2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8336,088,246 - 36,095,430 (+)NCBIGRCr8
mRatBN7.2315,690,501 - 15,697,688 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl315,690,501 - 15,697,688 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx318,759,325 - 18,766,565 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0327,344,320 - 27,351,561 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0325,595,176 - 25,602,293 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0311,424,195 - 11,431,379 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl311,424,099 - 11,431,402 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0316,773,065 - 16,780,249 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4311,521,214 - 11,528,395 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1311,418,096 - 11,424,768 (+)NCBI
Celera310,433,385 - 10,440,575 (+)NCBICelera
Cytogenetic Map3p12NCBI
PTGES2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389128,120,693 - 128,128,440 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9128,120,693 - 128,128,462 (-)EnsemblGRCh38hg38GRCh38
GRCh379130,882,972 - 130,890,719 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369129,922,793 - 129,930,533 (-)NCBINCBI36Build 36hg18NCBI36
Build 349127,962,526 - 127,970,266NCBI
Celera9101,534,900 - 101,542,641 (-)NCBICelera
Cytogenetic Map9q34.11NCBI
HuRef9100,497,534 - 100,505,316 (-)NCBIHuRef
CHM1_19131,034,931 - 131,042,710 (-)NCBICHM1_1
T2T-CHM13v2.09140,328,727 - 140,336,488 (-)NCBIT2T-CHM13v2.0
Ptges2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39232,285,902 - 32,292,752 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl232,285,908 - 32,295,784 (+)EnsemblGRCm39 Ensembl
GRCm38232,395,890 - 32,402,740 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl232,395,896 - 32,405,772 (+)EnsemblGRCm38mm10GRCm38
MGSCv37232,251,410 - 32,258,260 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36232,218,267 - 32,224,748 (+)NCBIMGSCv36mm8
Celera232,101,545 - 32,108,385 (+)NCBICelera
Cytogenetic Map2BNCBI
cM Map222.09NCBI
Ptges2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955419608,365 - 612,479 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955419608,313 - 612,813 (+)NCBIChiLan1.0ChiLan1.0
PTGES2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21111,224,577 - 11,232,313 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1911,227,499 - 11,234,661 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0999,241,257 - 99,249,022 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19127,911,911 - 127,918,367 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9127,912,363 - 127,918,036 (-)Ensemblpanpan1.1panPan2
PTGES2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1955,343,424 - 55,349,349 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl955,343,424 - 55,348,959 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha954,538,207 - 54,543,755 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0956,265,556 - 56,271,558 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl956,265,645 - 56,271,551 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1955,025,498 - 55,031,060 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0955,340,213 - 55,345,769 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0955,431,910 - 55,437,458 (+)NCBIUU_Cfam_GSD_1.0
Ptges2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947195,934,652 - 195,939,572 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648715,703,153 - 15,707,697 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648715,703,179 - 15,708,408 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTGES2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1268,583,439 - 268,590,855 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11268,585,725 - 268,591,356 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21302,576,191 - 302,582,036 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Ptges2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247607,501,939 - 7,507,093 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247607,501,902 - 7,506,221 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Ptges2
32 total Variants

Predicted Target Of
Summary Value
Count of predictions:52
Count of miRNA genes:44
Interacting mature miRNAs:48
Transcripts:ENSRNOT00000019184
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 20 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32905627547904329Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10450811Scl73Serum cholesterol level QTL 734.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat
10450808Scl72Serum cholesterol level QTL 724.40.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
10450806Scl71Serum cholesterol level QTL 715.80.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)32862533967641995Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3612543751125437Rat

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RH132618  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2315,697,345 - 15,697,562 (+)MAPPERmRatBN7.2
Rnor_6.0311,431,037 - 11,431,253NCBIRnor6.0
Rnor_5.0316,779,907 - 16,780,123UniSTSRnor5.0
RGSC_v3.4311,528,053 - 11,528,269UniSTSRGSC3.4
Celera310,440,233 - 10,440,449UniSTS
RH 3.4 Map360.4UniSTS
Cytogenetic Map3p11UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000019184   ⟹   ENSRNOP00000019184
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl315,690,501 - 15,697,688 (+)Ensembl
Rnor_6.0 Ensembl311,424,099 - 11,431,402 (+)Ensembl
RefSeq Acc Id: NM_001107832   ⟹   NP_001101302
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8336,088,246 - 36,095,430 (+)NCBI
mRatBN7.2315,690,501 - 15,697,688 (+)NCBI
Rnor_6.0311,424,195 - 11,431,379 (+)NCBI
Rnor_5.0316,773,065 - 16,780,249 (+)NCBI
RGSC_v3.4311,521,214 - 11,528,395 (+)RGD
Celera310,433,385 - 10,440,575 (+)RGD
Sequence:
Protein RefSeqs NP_001101302 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL93234 (Get FASTA)   NCBI Sequence Viewer  
  EDL93235 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000019184
  ENSRNOP00000019184.4
RefSeq Acc Id: NP_001101302   ⟸   NM_001107832
- UniProtKB: D4AE56 (UniProtKB/TrEMBL),   A6JU62 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000019184   ⟸   ENSRNOT00000019184
GST N-terminal

Name Modeler Protein Id AA Range Protein Structure
AF-D4AE56-F1-model_v2 AlphaFold D4AE56 1-384 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13691986
Promoter ID:EPDNEW_R2511
Type:multiple initiation site
Name:Ptges2_1
Description:prostaglandin E synthase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0311,424,697 - 11,424,757EPDNEW


1 to 26 of 26 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-50140 BioCyc
BioCyc Pathway PWY66-374 [C20 prostanoid biosynthesis] BioCyc
BioCyc Pathway Image PWY66-374 BioCyc
Ensembl Genes ENSRNOG00000014050 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000019184 ENTREZGENE
  ENSRNOT00000019184.7 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1050.10 UniProtKB/TrEMBL
  6.20.200.30 UniProtKB/TrEMBL
  Glutaredoxin UniProtKB/TrEMBL
InterPro Glutathione-S-Trfase_C_sf UniProtKB/TrEMBL
  Glutathione_S-Trfase_N UniProtKB/TrEMBL
  PGES2 UniProtKB/TrEMBL
  PGES2_C UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/TrEMBL
KEGG Report rno:311865 UniProtKB/TrEMBL
NCBI Gene 311865 ENTREZGENE
PANTHER MICROSOMAL PROSTAGLANDIN E SYNTHASE-2 UniProtKB/TrEMBL
  PROSTAGLANDIN E SYNTHASE 2 UniProtKB/TrEMBL
Pfam GST_N_3 UniProtKB/TrEMBL
PhenoGen Ptges2 PhenoGen
PROSITE GLUTAREDOXIN_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014050 RatGTEx
Superfamily-SCOP GST_C_like UniProtKB/TrEMBL
  Thiordxn-like_fd UniProtKB/TrEMBL
UniProt A6JU62 ENTREZGENE, UniProtKB/TrEMBL
  D4AE56 ENTREZGENE, UniProtKB/TrEMBL
1 to 26 of 26 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Ptges2  prostaglandin E synthase 2   Ptges2_predicted  prostaglandin E synthase 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Ptges2_predicted  prostaglandin E synthase 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED