Cdyl2 (chromodomain Y-like 2) - Rat Genome Database

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Gene: Cdyl2 (chromodomain Y-like 2) Rattus norvegicus
Analyze
Symbol: Cdyl2
Name: chromodomain Y-like 2
RGD ID: 1309548
Description: Predicted to enable methylated histone binding activity and transcription corepressor activity. Predicted to be involved in negative regulation of DNA-templated transcription. Predicted to be active in nucleus. Orthologous to human CDYL2 (chromodomain Y like 2); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: chromodomain protein, Y chromosome-like 2; chromodomain protein, Y-like 2; chromodomain Y-like protein 2; LOC292044
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81961,500,702 - 61,691,746 (-)NCBIGRCr8
mRatBN7.21944,591,734 - 44,783,258 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1944,597,459 - 44,783,022 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1951,411,640 - 51,603,076 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01952,064,666 - 52,256,095 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01954,308,855 - 54,500,293 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01949,087,131 - 49,222,528 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1949,093,355 - 49,198,073 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01959,882,525 - 60,017,444 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41946,465,399 - 46,470,246 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11946,414,023 - 46,475,072 (+)NCBI
Celera1943,886,414 - 43,952,957 (-)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:18450745   PMID:21536231  


Genomics

Comparative Map Data
Cdyl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81961,500,702 - 61,691,746 (-)NCBIGRCr8
mRatBN7.21944,591,734 - 44,783,258 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1944,597,459 - 44,783,022 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1951,411,640 - 51,603,076 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01952,064,666 - 52,256,095 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01954,308,855 - 54,500,293 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01949,087,131 - 49,222,528 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1949,093,355 - 49,198,073 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01959,882,525 - 60,017,444 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41946,465,399 - 46,470,246 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11946,414,023 - 46,475,072 (+)NCBI
Celera1943,886,414 - 43,952,957 (-)NCBICelera
Cytogenetic Map19q12NCBI
CDYL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381680,597,907 - 80,805,037 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1680,597,907 - 80,804,598 (-)EnsemblGRCh38hg38GRCh38
GRCh371680,631,804 - 80,838,495 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361679,195,176 - 79,395,676 (-)NCBINCBI36Build 36hg18NCBI36
Build 341679,195,178 - 79,395,676NCBI
Celera1664,936,574 - 65,136,540 (-)NCBICelera
Cytogenetic Map16q23.2NCBI
HuRef1666,394,243 - 66,500,889 (-)NCBIHuRef
CHM1_11682,048,855 - 82,249,535 (-)NCBICHM1_1
T2T-CHM13v2.01686,659,589 - 86,866,895 (-)NCBIT2T-CHM13v2.0
Cdyl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398117,295,462 - 117,459,730 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8117,301,139 - 117,459,730 (-)EnsemblGRCm39 Ensembl
GRCm388116,568,723 - 116,732,991 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8116,574,400 - 116,732,991 (-)EnsemblGRCm38mm10GRCm38
MGSCv378119,098,300 - 119,256,891 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368119,460,467 - 119,618,821 (-)NCBIMGSCv36mm8
Celera8120,792,913 - 120,952,148 (-)NCBICelera
Cytogenetic Map8E1NCBI
cM Map863.15NCBI
Cdyl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555223,409,054 - 3,571,178 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555223,403,542 - 3,458,029 (-)NCBIChiLan1.0ChiLan1.0
CDYL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21890,341,503 - 90,554,577 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11696,260,834 - 96,473,884 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01661,196,716 - 61,409,662 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11680,624,971 - 80,712,898 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1680,627,731 - 80,837,797 (-)Ensemblpanpan1.1panPan2
CDYL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1571,080,757 - 71,133,585 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl571,045,643 - 71,127,112 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha570,888,163 - 71,083,451 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0571,244,270 - 71,438,459 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl571,279,049 - 71,436,339 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1571,186,747 - 71,381,332 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0571,022,247 - 71,217,831 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0571,499,544 - 71,694,611 (+)NCBIUU_Cfam_GSD_1.0
Cdyl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934931,203,130 - 31,257,999 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647528,336,879 - 28,385,951 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647528,333,471 - 28,386,643 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDYL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl67,420,790 - 7,604,947 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.167,420,477 - 7,707,446 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.267,678,937 - 7,697,301 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CDYL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1566,055,202 - 66,207,508 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl566,061,656 - 66,262,904 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660479,566,412 - 9,774,768 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cdyl2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247466,711,203 - 6,760,431 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247466,593,962 - 6,765,340 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cdyl2
1549 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:453
Count of miRNA genes:226
Interacting mature miRNAs:278
Transcripts:ENSRNOT00000068440
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191560502346559041Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum insulin level (CMO:0000358)193383821455283146Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)193383821455283146Rat
5135224Leukc1Leukocyte quantity QTL 1eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)194434021455283277Rat

Markers in Region
D19Rat64  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21944,267,255 - 44,267,492 (+)MAPPERmRatBN7.2
Rnor_6.01948,760,492 - 48,760,726NCBIRnor6.0
Rnor_5.01959,561,436 - 59,561,670UniSTSRnor5.0
RGSC_v3.41946,434,967 - 46,435,202RGDRGSC3.4
RGSC_v3.41946,434,968 - 46,435,202UniSTSRGSC3.4
RGSC_v3.11946,439,849 - 46,440,083RGD
Celera1943,563,565 - 43,563,799UniSTS
RH 3.4 Map19591.4RGD
RH 3.4 Map19591.4UniSTS
RH 2.0 Map19612.7RGD
SHRSP x BN Map1938.0498RGD
Cytogenetic Map19q12UniSTS
RH135103  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21944,597,639 - 44,597,824 (+)MAPPERmRatBN7.2
Rnor_6.01949,093,036 - 49,093,220NCBIRnor6.0
Rnor_5.01959,888,424 - 59,888,608UniSTSRnor5.0
RGSC_v3.41946,469,881 - 46,470,065UniSTSRGSC3.4
Celera1943,886,595 - 43,886,779UniSTS
RH 3.4 Map19594.6UniSTS
Cytogenetic Map19q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 9 14 7 8
Low 3 43 52 39 10 39 8 11 60 35 34 3 8
Below cutoff 2 2 2

Sequence


RefSeq Acc Id: ENSRNOT00000068440   ⟹   ENSRNOP00000058951
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1944,597,459 - 44,709,503 (-)Ensembl
Rnor_6.0 Ensembl1949,093,355 - 49,198,073 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000117818   ⟹   ENSRNOP00000086896
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1944,597,512 - 44,783,022 (-)Ensembl
RefSeq Acc Id: NM_001106189   ⟹   NP_001099659
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81961,500,702 - 61,691,746 (-)NCBI
mRatBN7.21944,591,734 - 44,782,786 (-)NCBI
Rnor_6.01949,092,855 - 49,159,228 (-)NCBI
Rnor_5.01959,882,525 - 60,017,444 (-)NCBI
RGSC_v3.41946,465,399 - 46,470,246 (+)RGD
Celera1943,886,414 - 43,952,957 (-)RGD
Sequence:
RefSeq Acc Id: XM_017601237   ⟹   XP_017456726
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81961,500,702 - 61,640,652 (-)NCBI
mRatBN7.21944,591,734 - 44,714,100 (-)NCBI
Rnor_6.01949,087,131 - 49,200,397 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017601238   ⟹   XP_017456727
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81961,500,702 - 61,642,054 (-)NCBI
mRatBN7.21944,591,734 - 44,734,449 (-)NCBI
Rnor_6.01949,087,131 - 49,222,528 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039097639   ⟹   XP_038953567
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81961,500,702 - 61,691,670 (-)NCBI
mRatBN7.21944,591,734 - 44,783,258 (-)NCBI
RefSeq Acc Id: XM_039097640   ⟹   XP_038953568
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81961,500,702 - 61,611,955 (-)NCBI
mRatBN7.21944,591,734 - 44,703,005 (-)NCBI
RefSeq Acc Id: NP_001099659   ⟸   NM_001106189
- UniProtKB: A0A8I6GEJ2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456727   ⟸   XM_017601238
- Peptide Label: isoform X2
- UniProtKB: A6IZF6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456726   ⟸   XM_017601237
- Peptide Label: isoform X1
- UniProtKB: F1LT42 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000058951   ⟸   ENSRNOT00000068440
RefSeq Acc Id: XP_038953567   ⟸   XM_039097639
- Peptide Label: isoform X2
- UniProtKB: A6IZF6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953568   ⟸   XM_039097640
- Peptide Label: isoform X2
- UniProtKB: A6IZF6 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000086896   ⟸   ENSRNOT00000117818
Protein Domains
Chromo

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LT42-F1-model_v2 AlphaFold F1LT42 1-551 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309548 AgrOrtholog
BioCyc Gene G2FUF-5565 BioCyc
Ensembl Genes ENSRNOG00000042888 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000068440.4 UniProtKB/TrEMBL
  ENSRNOT00000117818 ENTREZGENE
  ENSRNOT00000117818.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.12.10 UniProtKB/TrEMBL
  2.40.50.40 UniProtKB/TrEMBL
InterPro Chromo/shadow_dom UniProtKB/TrEMBL
  Chromo_domain UniProtKB/TrEMBL
  Chromodomain-like UniProtKB/TrEMBL
  Chromodomain_CS UniProtKB/TrEMBL
  ClpP/crotonase-like_dom UniProtKB/TrEMBL
  Crontonase_C UniProtKB/TrEMBL
  Crotonase_core_superfam UniProtKB/TrEMBL
KEGG Report rno:292044 UniProtKB/TrEMBL
NCBI Gene 292044 ENTREZGENE
PANTHER CHROMODOMAIN Y-LIKE PROTEIN 2 UniProtKB/TrEMBL
  PTHR43684 UniProtKB/TrEMBL
Pfam Chromo UniProtKB/TrEMBL
  ECH_1 UniProtKB/TrEMBL
PhenoGen Cdyl2 PhenoGen
PROSITE CHROMO_1 UniProtKB/TrEMBL
  CHROMO_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000042888 RatGTEx
SMART CHROMO UniProtKB/TrEMBL
Superfamily-SCOP SSF52096 UniProtKB/TrEMBL
  SSF54160 UniProtKB/TrEMBL
UniProt A0A8I6GEJ2 ENTREZGENE, UniProtKB/TrEMBL
  A6IZF6 ENTREZGENE, UniProtKB/TrEMBL
  F1LT42 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-21 Cdyl2  chromodomain Y-like 2  Cdyl2  chromodomain protein, Y-like 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-16 Cdyl2  chromodomain protein, Y-like 2  Cdyl2  chromodomain protein, Y chromosome-like 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Cdyl2  chromodomain protein, Y chromosome-like 2   Cdyl2_predicted  chromodomain protein, Y chromosome-like 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Cdyl2_predicted  chromodomain protein, Y chromosome-like 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED