Eml1 (EMAP like 1) - Rat Genome Database

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Gene: Eml1 (EMAP like 1) Rattus norvegicus
Analyze
Symbol: Eml1
Name: EMAP like 1
RGD ID: 1306374
Description: Predicted to enable microtubule binding activity. Predicted to be involved in brain development; mitotic spindle organization; and neuroblast proliferation. Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Predicted to be located in cytosol and microtubule cytoskeleton. Predicted to colocalize with mitotic spindle. Used to study epilepsy and subcortical band heterotopia. Human ortholog(s) of this gene implicated in skin melanoma and subcortical band heterotopia. Orthologous to human EML1 (EMAP like 1); INTERACTS WITH acetamide; atrazine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: echinoderm microtubule associated protein like 1; echinoderm microtubule-associated protein-like 1; EMAP-1; LOC362783; MGC114510
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Eml1tish  
Genetic Models: SD-Eml1tish/Scrb
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86133,048,271 - 133,221,642 (+)NCBIGRCr8
mRatBN7.26127,283,968 - 127,457,246 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6127,284,029 - 127,457,246 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6127,408,913 - 127,581,347 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06127,703,970 - 127,876,401 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06127,061,846 - 127,234,628 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06132,367,342 - 132,450,488 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6132,383,337 - 132,450,393 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06141,536,753 - 141,619,726 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46132,825,590 - 132,880,169 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16132,831,776 - 132,886,352 (+)NCBI
Celera6124,926,667 - 125,013,010 (+)NCBICelera
Cytogenetic Map6q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
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Term
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Original Reference(s)
Eml1Ratepilepsy  IAGP 597538480 RGD 
Eml1Ratskin melanoma disease_progressionISOEML1 (Homo sapiens)597538489DNA:SNP: :rs10151787 (A>G)RGD 
Eml1Ratsubcortical band heterotopia  ISOEML1 (Homo sapiens)11553226DNA:mutations:cds:RGD 
Eml1Ratsubcortical band heterotopia  ISOEml1 (Mus musculus)597538487DNA:mutation:exon:RGD 
Eml1Ratsubcortical band heterotopia  IAGP 597538480 RGD 
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Original Reference(s)
Eml1Ratgenetic disease  ISOEML1 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868 and PMID:28492532
Eml1Ratsubcortical band heterotopia  ISOEML1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:24859200 more ...
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Original Reference(s)
Eml1Ratsubcortical band heterotopia  ISOEML1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
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Original Reference(s)
Eml1Ratcongenital nervous system abnormality  ISSEml1 (Mus musculus)13592920 MouseDO 
Eml1Ratsubcortical band heterotopia  ISSEml1 (Mus musculus)13592920OMIM:600348MouseDO 
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Original Reference(s)
Eml1Ratsubcortical band heterotopia  ISOEML1 (Homo sapiens)7240710 OMIM 

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Original Reference(s)
Eml1Rat1,2-dichloroethane decreases expressionISOEml1 (Mus musculus)6480464ethylene dichloride results in decreased expression of EML1 mRNACTDPMID:28960355
Eml1Rat1,2-dimethylhydrazine increases expressionISOEml1 (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of EML1 mRNACTDPMID:22206623
Eml1Rat17beta-estradiol multiple interactionsISOEML1 (Homo sapiens)6480464[Estradiol co-treated with TGFB1 protein] results in increased expression of EML1 mRNACTDPMID:30165855
Eml1Rat17beta-hydroxy-5alpha-androstan-3-one increases expressionISOEML1 (Homo sapiens)6480464Dihydrotestosterone results in increased expression of EML1 mRNACTDPMID:29581250
Eml1Rat2,2',4,4'-Tetrabromodiphenyl ether increases expressionISOEML1 (Homo sapiens)64804642 more ...CTDPMID:31675489
Eml1Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOEml1 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of EML1 mRNACTDPMID:21570461
Eml1Rat2,4,6-tribromophenol increases expressionISOEML1 (Homo sapiens)64804642 more ...CTDPMID:31675489
Eml1Rat2-hydroxypropanoic acid decreases expressionISOEML1 (Homo sapiens)6480464Lactic Acid results in decreased expression of EML1 mRNACTDPMID:30851411
Eml1Rat2-palmitoylglycerol increases expressionISOEML1 (Homo sapiens)64804642-palmitoylglycerol results in increased expression of EML1 mRNACTDPMID:37199045
Eml1Rat4,4'-sulfonyldiphenol increases methylationISOEml1 (Mus musculus)6480464bisphenol S results in increased methylation of EML1 exonCTDPMID:33297965
Eml1Rat4,4'-sulfonyldiphenol affects methylationISOEml1 (Mus musculus)6480464bisphenol S affects the methylation of EML1 geneCTDPMID:31683443
Eml1Ratacetamide increases expressionEXP 6480464acetamide results in increased expression of EML1 mRNACTDPMID:31881176
Eml1Ratacrolein multiple interactionsISOEML1 (Homo sapiens)6480464[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of EML1 mRNA more ...CTDPMID:32699268 and PMID:32845096
Eml1Ratacrylamide decreases expressionISOEML1 (Homo sapiens)6480464Acrylamide results in decreased expression of EML1 mRNACTDPMID:32763439
Eml1Rataflatoxin B1 decreases expressionISOEML1 (Homo sapiens)6480464Aflatoxin B1 results in decreased expression of EML1 mRNACTDPMID:21641981 and PMID:22100608
Eml1Ratall-trans-retinoic acid decreases expressionISOEML1 (Homo sapiens)6480464Tretinoin results in decreased expression of EML1 mRNACTDPMID:21934132
Eml1Ratalpha-pinene multiple interactionsISOEML1 (Homo sapiens)6480464[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of EML1 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of EML1 mRNACTDPMID:32699268
Eml1Rataristolochic acid A decreases expressionISOEML1 (Homo sapiens)6480464aristolochic acid I results in decreased expression of EML1 mRNACTDPMID:33212167
Eml1Ratarsenite(3-) multiple interactionsISOEML1 (Homo sapiens)6480464arsenite inhibits the reaction [G3BP1 protein binds to EML1 mRNA]CTDPMID:32406909
Eml1Ratarsenous acid increases expressionISOEml1 (Mus musculus)6480464Arsenic Trioxide results in increased expression of EML1 mRNACTDPMID:35676786

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Biological Process
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Original Reference(s)
Eml1Ratbrain development involved_inIEAUniProtKB:Q05BC3 and ensembl:ENSMUSP000001054861600115GO_REF:0000107EnsemblGO_REF:0000107
Eml1Ratbrain development involved_inISOEml1 (Mus musculus)1624291 PMID:24859200RGDPMID:24859200
Eml1Ratbrain development involved_inISOEML1 (Homo sapiens)1624291 PMID:24859200RGDPMID:24859200
Eml1Ratbrain development involved_inISSUniProtKB:Q05BC31600115GO_REF:0000024UniProtGO_REF:0000024
Eml1Ratbrain development involved_inIEAUniProtKB:O00423 and ensembl:ENSP000002622331600115GO_REF:0000107EnsemblGO_REF:0000107
Eml1Rathematopoietic progenitor cell differentiation acts_upstream_of_or_withinISOEml1 (Mus musculus)1624291MGI:1343184 PMID:24029230RGDPMID:24029230
Eml1Rathematopoietic progenitor cell differentiation acts_upstream_of_or_withinIEAUniProtKB:Q05BC3 and ensembl:ENSMUSP000001054861600115GO_REF:0000107EnsemblGO_REF:0000107
Eml1Ratmicrotubule cytoskeleton organization involved_inIEAUniProtKB:Q05BC3 and ensembl:ENSMUSP000001054861600115GO_REF:0000107EnsemblGO_REF:0000107
Eml1Ratmicrotubule cytoskeleton organization involved_inISOEml1 (Mus musculus)1624291 PMID:24859200RGDPMID:24859200
Eml1Ratmicrotubule cytoskeleton organization involved_inIBAMGI:1915769 and PANTHER:PTN0010105311600115GO_REF:0000033GO_CentralGO_REF:0000033
Eml1Ratmicrotubule cytoskeleton organization involved_inISSUniProtKB:Q05BC31600115GO_REF:0000024UniProtGO_REF:0000024
Eml1Ratmitotic spindle organization involved_inIEAUniProtKB:Q05BC3 and ensembl:ENSMUSP000001054861600115GO_REF:0000107EnsemblGO_REF:0000107
Eml1Ratmitotic spindle organization involved_inISOEml1 (Mus musculus)1624291 PMID:24859200RGDPMID:24859200
Eml1Ratmitotic spindle organization involved_inISSUniProtKB:Q05BC31600115GO_REF:0000024UniProtGO_REF:0000024
Eml1Ratneuroblast proliferation involved_inISSUniProtKB:Q05BC31600115GO_REF:0000024UniProtGO_REF:0000024
Eml1Ratneuroblast proliferation involved_inISOEml1 (Mus musculus)1624291 PMID:24859200RGDPMID:24859200
Eml1Ratneuroblast proliferation involved_inIEAUniProtKB:Q05BC3 and ensembl:ENSMUSP000001054861600115GO_REF:0000107EnsemblGO_REF:0000107
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Cellular Component
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Original Reference(s)
Eml1Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Eml1Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Eml1Ratcytoskeleton located_inIEAUniProtKB-SubCell:SL-00901600115GO_REF:0000044UniProtGO_REF:0000044
Eml1Ratcytoskeleton located_inIEAUniProtKB-KW:KW-02061600115GO_REF:0000043UniProtGO_REF:0000043
Eml1Ratcytosol located_inIEAUniProtKB:Q05BC3 and ensembl:ENSMUSP000001054861600115GO_REF:0000107EnsemblGO_REF:0000107
Eml1Ratcytosol located_inISOEml1 (Mus musculus)1624291 PMID:24859200RGDPMID:24859200
Eml1Ratcytosol located_inISSUniProtKB:Q05BC31600115GO_REF:0000024UniProtGO_REF:0000024
Eml1Ratmicrotubule located_inIEAUniProtKB:O00423 and ensembl:ENSP000002622331600115GO_REF:0000107EnsemblGO_REF:0000107
Eml1Ratmicrotubule located_inISOEML1 (Homo sapiens)1624291 PMID:25740311RGDPMID:25740311
Eml1Ratmicrotubule located_inIEAUniProtKB-KW:KW-04931600115GO_REF:0000043UniProtGO_REF:0000043
Eml1Ratmicrotubule located_inISSUniProtKB:O004231600115GO_REF:0000024UniProtGO_REF:0000024
Eml1Ratmicrotubule cytoskeleton located_inISOEML1 (Homo sapiens)1624291 PMID:24859200RGDPMID:24859200
Eml1Ratmicrotubule cytoskeleton located_inIEAUniProtKB:O00423 and ensembl:ENSP000002622331600115GO_REF:0000107EnsemblGO_REF:0000107
Eml1Ratmitotic spindle located_inIBAMGI:1915769 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Eml1Ratmitotic spindle midzone located_inIEAUniProtKB:Q05BC3 and ensembl:ENSMUSP000001054861600115GO_REF:0000107EnsemblGO_REF:0000107
Eml1Ratmitotic spindle midzone located_inISOEml1 (Mus musculus)1624291 PMID:24859200RGDPMID:24859200
Eml1Ratmitotic spindle midzone located_inISSUniProtKB:Q05BC31600115GO_REF:0000024UniProtGO_REF:0000024
Eml1Ratmitotic spindle pole located_inIEAUniProtKB:Q05BC3 and ensembl:ENSMUSP000001054861600115GO_REF:0000107EnsemblGO_REF:0000107
Eml1Ratmitotic spindle pole located_inISOEml1 (Mus musculus)1624291 PMID:24859200RGDPMID:24859200
Eml1Ratmitotic spindle pole located_inISSUniProtKB:Q05BC31600115GO_REF:0000024UniProtGO_REF:0000024
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Molecular Function
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Original Reference(s)
Eml1Ratmicrotubule binding enablesISOEml1 (Mus musculus)1624291 PMID:24859200RGDPMID:24859200
Eml1Ratmicrotubule binding enablesIBAFB:FBgn0259099 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Eml1Ratmicrotubule binding enablesISOEML1 (Homo sapiens)1624291 PMID:24859200RGDPMID:24859200
Eml1Ratmicrotubule binding enablesIEAUniProtKB:Q05BC3 and ensembl:ENSMUSP000001054861600115GO_REF:0000107EnsemblGO_REF:0000107
Eml1Ratmicrotubule binding enablesIEAUniProtKB:O00423 and ensembl:ENSP000002622331600115GO_REF:0000107EnsemblGO_REF:0000107
Eml1Ratmicrotubule binding enablesISSUniProtKB:Q05BC31600115GO_REF:0000024UniProtGO_REF:0000024
Eml1Ratprotein binding enablesISOEML1 (Homo sapiens)1624291UniProtKB:P13473-2 more ...RGDPMID:16189514 more ...
Eml1Rattubulin binding enablesISOEML1 (Homo sapiens)1624291 PMID:24706829RGDPMID:24706829
Eml1Rattubulin binding enablesIEAUniProtKB:O00423 and ensembl:ENSP000002622331600115GO_REF:0000107EnsemblGO_REF:0000107
Eml1Rattubulin binding enablesISSUniProtKB:O004231600115GO_REF:0000024UniProtGO_REF:0000024
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#
Reference Title
Reference Citation
1. The neuroanatomy of Eml1 knockout mice, a model of subcortical heterotopia. Collins SC, etal., J Anat. 2019 Sep;235(3):637-650. doi: 10.1111/joa.13013. Epub 2019 Jun 7.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. A deletion in Eml1 leads to bilateral subcortical heterotopia in the tish rat. Grosenbaugh DK, etal., Neurobiol Dis. 2020 Jul;140:104836. doi: 10.1016/j.nbd.2020.104836. Epub 2020 Mar 13.
4. Genetic variants of EML1 and HIST1H4E in myeloid cell-related pathway genes independently predict cutaneous melanoma-specific survival. He Y, etal., Am J Cancer Res. 2021 Jun 15;11(6):3252-3262. eCollection 2021.
5. Mutations in Eml1 lead to ectopic progenitors and neuronal heterotopia in mouse and human. Kielar M, etal., Nat Neurosci. 2014 Jul;17(7):923-33. doi: 10.1038/nn.3729. Epub 2014 May 25.
6. A genetic animal model of human neocortical heterotopia associated with seizures. Lee KS, etal., J Neurosci. 1997 Aug 15;17(16):6236-42. doi: 10.1523/JNEUROSCI.17-16-06236.1997.
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:12477932   PMID:24029230   PMID:24625528   PMID:24706829   PMID:38897390  



Eml1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86133,048,271 - 133,221,642 (+)NCBIGRCr8
mRatBN7.26127,283,968 - 127,457,246 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6127,284,029 - 127,457,246 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6127,408,913 - 127,581,347 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06127,703,970 - 127,876,401 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06127,061,846 - 127,234,628 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06132,367,342 - 132,450,488 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6132,383,337 - 132,450,393 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06141,536,753 - 141,619,726 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46132,825,590 - 132,880,169 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16132,831,776 - 132,886,352 (+)NCBI
Celera6124,926,667 - 125,013,010 (+)NCBICelera
Cytogenetic Map6q32NCBI
EML1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381499,737,722 - 99,942,060 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1499,737,693 - 99,942,060 (+)EnsemblGRCh38hg38GRCh38
GRCh3714100,204,059 - 100,408,397 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361499,329,498 - 99,478,150 (+)NCBINCBI36Build 36hg18NCBI36
Build 341499,329,497 - 99,478,146NCBI
Celera1480,314,618 - 80,463,271 (+)NCBICelera
Cytogenetic Map14q32.2NCBI
HuRef1480,500,729 - 80,591,998 (+)NCBIHuRef
CHM1_114100,197,512 - 100,346,159 (+)NCBICHM1_1
T2T-CHM13v2.01493,969,151 - 94,174,609 (+)NCBIT2T-CHM13v2.0
Eml1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912108,337,265 - 108,505,835 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12108,337,216 - 108,505,876 (+)EnsemblGRCm39 Ensembl
GRCm3812108,371,002 - 108,539,576 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12108,370,957 - 108,539,617 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712109,648,865 - 109,777,774 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612108,818,764 - 108,987,383 (+)NCBIMGSCv36mm8
MGSCv3612102,632,098 - 102,805,540 (+)NCBIMGSCv36mm8
Celera12109,653,344 - 109,775,028 (+)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1259.46NCBI
Eml1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543821,078,760 - 21,137,926 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543820,991,432 - 21,137,570 (+)NCBIChiLan1.0ChiLan1.0
EML1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v215100,893,344 - 101,097,011 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan114100,109,839 - 100,313,506 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01480,362,837 - 80,566,996 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11499,717,220 - 99,885,359 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1499,793,812 - 99,885,359 (+)Ensemblpanpan1.1panPan2
EML1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1868,139,741 - 68,295,363 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl868,216,857 - 68,294,080 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha867,628,246 - 67,816,902 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0868,391,782 - 68,580,690 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl868,391,815 - 68,580,640 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1868,052,800 - 68,241,854 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0868,119,216 - 68,308,068 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0868,516,950 - 68,705,827 (+)NCBIUU_Cfam_GSD_1.0
Eml1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244086406,420,280 - 6,584,031 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366043,498,304 - 3,662,244 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366043,498,413 - 3,662,188 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EML1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7120,703,258 - 120,890,791 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17120,703,282 - 120,890,792 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
EML1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12477,694,931 - 77,907,574 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2477,694,971 - 77,907,909 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605364,834,630 - 65,042,702 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Eml1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247344,089,986 - 4,236,776 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247344,090,077 - 4,150,706 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Eml1
1045 total Variants

Predicted Target Of
Summary Value
Count of predictions:268
Count of miRNA genes:91
Interacting mature miRNAs:98
Transcripts:ENSRNOT00000066611, ENSRNOT00000071733, ENSRNOT00000071863
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 27 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6104085867128713626Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6105156861140994061Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)6122549046140994061Rat
2312560Pur20Proteinuria QTL 202.10.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)6125628133137801795Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6100671796132340886Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)693701310128713626Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat

1 to 10 of 27 rows
BF409188  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26127,363,119 - 127,363,238 (+)MAPPERmRatBN7.2
Rnor_6.06132,361,194 - 132,361,312NCBIRnor6.0
Rnor_5.06141,530,620 - 141,530,738UniSTSRnor5.0
RGSC_v3.46132,819,396 - 132,819,514UniSTSRGSC3.4
Celera6124,920,892 - 124,921,010UniSTS
RH 3.4 Map6796.4UniSTS
Cytogenetic Map6q32UniSTS
BM390550  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26127,304,943 - 127,305,163 (+)MAPPERmRatBN7.2
Rnor_6.06132,303,846 - 132,304,065NCBIRnor6.0
Rnor_5.06141,473,785 - 141,474,004UniSTSRnor5.0
RGSC_v3.46132,762,243 - 132,762,462UniSTSRGSC3.4
Celera6124,863,617 - 124,863,836UniSTS
RH 3.4 Map6791.5UniSTS
Cytogenetic Map6q32UniSTS


This gene Eml1 is modified in the following models/strains:




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31


1 to 17 of 17 rows
RefSeq Transcripts NM_001025741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001399709 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001399710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001399711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001399712 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_174190 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_174191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112546 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112547 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112550 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC097450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 17 of 17 rows

Ensembl Acc Id: ENSRNOT00000071733   ⟹   ENSRNOP00000067418
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6127,385,187 - 127,455,903 (+)Ensembl
Rnor_6.0 Ensembl6132,383,337 - 132,450,393 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000071863   ⟹   ENSRNOP00000067636
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6127,284,029 - 127,455,903 (+)Ensembl
Rnor_6.0 Ensembl6132,383,370 - 132,450,393 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107380   ⟹   ENSRNOP00000085896
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6127,284,029 - 127,457,235 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108825   ⟹   ENSRNOP00000097362
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6127,284,075 - 127,457,246 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000114172   ⟹   ENSRNOP00000090244
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6127,341,559 - 127,457,235 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000118546   ⟹   ENSRNOP00000096898
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6127,284,083 - 127,457,245 (+)Ensembl
RefSeq Acc Id: NM_001025741   ⟹   NP_001020912
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86133,133,659 - 133,221,642 (+)NCBI
mRatBN7.26127,369,259 - 127,457,246 (+)NCBI
Rnor_6.06132,367,342 - 132,450,488 (+)NCBI
Rnor_5.06141,536,753 - 141,619,726 (+)NCBI
RGSC_v3.46132,825,590 - 132,880,169 (+)RGD
Celera6124,926,667 - 125,013,010 (+)RGD
Sequence:
RefSeq Acc Id: NM_001399709   ⟹   NP_001386638
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86133,048,430 - 133,221,642 (+)NCBI
mRatBN7.26127,284,024 - 127,457,246 (+)NCBI
RefSeq Acc Id: NM_001399710   ⟹   NP_001386639
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86133,105,934 - 133,221,642 (+)NCBI
mRatBN7.26127,341,530 - 127,457,246 (+)NCBI
RefSeq Acc Id: NM_001399711   ⟹   NP_001386640
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86133,105,934 - 133,221,642 (+)NCBI
mRatBN7.26127,341,530 - 127,457,246 (+)NCBI
RefSeq Acc Id: NM_001399712   ⟹   NP_001386641
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86133,048,430 - 133,221,642 (+)NCBI
mRatBN7.26127,284,024 - 127,457,246 (+)NCBI
RefSeq Acc Id: NR_174190
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86133,048,430 - 133,221,642 (+)NCBI
mRatBN7.26127,284,024 - 127,457,246 (+)NCBI
RefSeq Acc Id: NR_174191
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86133,105,934 - 133,221,642 (+)NCBI
mRatBN7.26127,341,530 - 127,457,246 (+)NCBI
RefSeq Acc Id: XM_039112546   ⟹   XP_038968474
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86133,105,856 - 133,221,631 (+)NCBI
mRatBN7.26127,341,396 - 127,457,246 (+)NCBI
RefSeq Acc Id: XM_039112547   ⟹   XP_038968475
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86133,048,271 - 133,221,631 (+)NCBI
mRatBN7.26127,283,968 - 127,457,246 (+)NCBI
RefSeq Acc Id: XM_039112550   ⟹   XP_038968478
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86133,133,617 - 133,221,631 (+)NCBI
mRatBN7.26127,369,216 - 127,457,246 (+)NCBI
RefSeq Acc Id: XM_039112551   ⟹   XP_038968479
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86133,091,524 - 133,221,631 (+)NCBI
mRatBN7.26127,327,111 - 127,457,246 (+)NCBI
RefSeq Acc Id: XM_039112552   ⟹   XP_038968480
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86133,181,394 - 133,221,631 (+)NCBI
mRatBN7.26127,416,984 - 127,457,246 (+)NCBI
RefSeq Acc Id: XM_039112553   ⟹   XP_038968481
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86133,181,394 - 133,221,631 (+)NCBI
mRatBN7.26127,416,984 - 127,457,235 (+)NCBI
RefSeq Acc Id: XM_063262135   ⟹   XP_063118205
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86133,091,777 - 133,221,631 (+)NCBI
1 to 5 of 18 rows
1 to 5 of 18 rows
RefSeq Acc Id: NP_001020912   ⟸   NM_001025741
- Peptide Label: isoform 5
- UniProtKB: A0A8I6ASI8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000067636   ⟸   ENSRNOT00000071863
Ensembl Acc Id: ENSRNOP00000067418   ⟸   ENSRNOT00000071733
RefSeq Acc Id: XP_038968475   ⟸   XM_039112547
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A157 (UniProtKB/TrEMBL),   A0A8I6ASI8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038968479   ⟸   XM_039112551
- Peptide Label: isoform X3
- UniProtKB: A0A8I6ASI8 (UniProtKB/TrEMBL)

Name Modeler Protein Id AA Range Protein Structure
AF-Q4V8C3-F1-model_v2 AlphaFold Q4V8C3 1-814 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 40 of 41 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-36298 BioCyc
Ensembl Genes ENSRNOG00000043143 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000071733 ENTREZGENE
  ENSRNOT00000107380 ENTREZGENE
  ENSRNOT00000108825 ENTREZGENE
  ENSRNOT00000114172 ENTREZGENE
  ENSRNOT00000118546 ENTREZGENE
Gene3D-CATH 2.130.10.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7456735 IMAGE-MGC_LOAD
InterPro HELP UniProtKB/Swiss-Prot
  Quinoprotein_ADH-like_supfam UniProtKB/Swiss-Prot
  WD40/YVTN_repeat-like_dom_sf UniProtKB/Swiss-Prot
  WD40_repeat UniProtKB/Swiss-Prot
  WD40_repeat_dom_sf UniProtKB/Swiss-Prot
  WD_repeat_EMAP UniProtKB/Swiss-Prot
KEGG Report rno:362783 UniProtKB/Swiss-Prot
MGC_CLONE MGC:114510 IMAGE-MGC_LOAD
NCBI Gene 362783 ENTREZGENE
PANTHER ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 1 UniProtKB/Swiss-Prot
  WD-40 REPEAT PROTEIN UniProtKB/Swiss-Prot
Pfam HELP UniProtKB/Swiss-Prot
  WD40 UniProtKB/Swiss-Prot
PhenoGen Eml1 PhenoGen
PROSITE WD_REPEATS_1 UniProtKB/Swiss-Prot
  WD_REPEATS_2 UniProtKB/Swiss-Prot
  WD_REPEATS_REGION UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000043143 RatGTEx
SMART WD40 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50978 UniProtKB/Swiss-Prot
  SSF50998 UniProtKB/Swiss-Prot
UniProt A0A8I6A157 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AD94 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ASI8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AVR0 ENTREZGENE, UniProtKB/TrEMBL
  A6KBG1_RAT UniProtKB/TrEMBL
  A6KBG2_RAT UniProtKB/TrEMBL
  A6KBG3 ENTREZGENE, UniProtKB/TrEMBL
  EMAL1_RAT UniProtKB/Swiss-Prot
  M0RCT5_RAT UniProtKB/TrEMBL
  M0RDD8_RAT UniProtKB/TrEMBL
1 to 40 of 41 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-12-04 Eml1  EMAP like 1  Eml1  echinoderm microtubule associated protein like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Eml1  echinoderm microtubule associated protein like 1  Eml1_predicted  echinoderm microtubule associated protein like 1 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Eml1_predicted  echinoderm microtubule associated protein like 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED