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Gene: Aifm3 (AIF family member 3) Rattus norvegicus

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Symbol:

Aifm3

Name:

AIF family member 3 (Ensembl:apoptosis inducing factor, mitochondria associated 3)

RGD ID:

1306028

Description:

Predicted to enable oxidoreductase activity, acting on NAD(P)H. Predicted to be involved in execution phase of apoptosis. Predicted to be located in cytosol; endoplasmic reticulum; and mitochondrial inner membrane. Predicted to be active in mitochondrion. Orthologous to human AIFM3 (AIF family member 3); INTERACTS WITH 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

apoptosis inducing factor, mitochondria associated 3; apoptosis-inducing factor 3; apoptosis-inducing factor, mitochondrion-associated 3; LOC303786; MGC109275; RGD1306028; similar to hypothetical protein FLJ30473

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	AIFM3 (AIF family member 3)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Aifm3 (apoptosis-inducing factor, mitochondrion-associated 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Aifm3 (AIF family member 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	AIFM3 (AIF family member 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	AIFM3 (apoptosis inducing factor mitochondria associated 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Aifm3 (AIF family member 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	AIFM3 (apoptosis inducing factor mitochondria associated 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	AIFM3 (AIF family member 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Aifm3 (AIF family member 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	MRM2 (mitochondrial rRNA methyltransferase 2)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Aifm3 (apoptosis-inducing factor, mitochondrion-associated 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	AIFM3 (AIF family member 3)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG10700	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	F20D6.11	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	aifm3	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	97,009,100 - 97,030,601 (-)	NCBI		GRCr8
mRatBN7.2	11	83,504,859 - 83,523,630 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	83,504,861 - 83,521,248 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	11	92,232,276 - 92,247,077 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	84,893,435 - 84,908,236 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	83,947,043 - 83,961,844 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	87,364,452 - 87,380,705 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	87,366,621 - 87,380,704 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	90,417,097 - 90,431,999 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	85,496,302 - 85,512,831 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	11	85,544,286 - 85,551,637 (-)	NCBI
Celera	11	82,273,467 - 82,288,125 (-)	NCBI		Celera
Cytogenetic Map	11	q23	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Aifm3	Rat	autistic disorder		ISO	AIFM3 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Autism	ClinVar	PMID:21681106 and PMID:30208311
Aifm3	Rat	chromosome 22q11.2 deletion syndrome, distal		ISO	AIFM3 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Chromosome 22q11.2 deletion syndrome and distal	ClinVar	PMID:31690835
Aifm3	Rat	chromosome 22q11.2 microduplication syndrome		ISO	AIFM3 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Chromosome 22q11.2 microduplication syndrome	ClinVar	PMID:25741868 and PMID:31690835
Aifm3	Rat	DiGeorge syndrome		ISO	AIFM3 (Homo sapiens)	8554872	ClinVar more ...	ClinVar	PMID:21921585 more ...
Aifm3	Rat	epilepsy		ISO	AIFM3 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Epilepsy	ClinVar
Aifm3	Rat	intellectual disability		ISO	AIFM3 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Intellectual disability	ClinVar
Aifm3	Rat	megacolon		ISO	AIFM3 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Megacolon	ClinVar	PMID:21681106
Aifm3	Rat	Neurodevelopmental Disorders		ISO	AIFM3 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Neurodevelopmental disorder	ClinVar	PMID:25741868
Aifm3	Rat	primary immunodeficiency disease		ISO	AIFM3 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Inherited Immunodeficiency Diseases	ClinVar	PMID:25741868
Aifm3	Rat	schizophrenia		ISO	AIFM3 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Schizophrenia	ClinVar	PMID:21681106 and PMID:30208311
Aifm3	Rat	velocardiofacial syndrome		ISO	AIFM3 (Homo sapiens)	8554872	ClinVar more ...	ClinVar	PMID:25741868

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Aifm3	Rat	1,1-dichloroethene	decreases expression	ISO	Aifm3 (Mus musculus)	6480464	vinylidene chloride results in decreased expression of AIFM3 mRNA	CTD	PMID:26682919
Aifm3	Rat	1-Hydroxypyrene	decreases expression	ISO	AIFM3 (Homo sapiens)	6480464	1-hydroxypyrene results in decreased expression of AIFM3 mRNA	CTD	PMID:21854004
Aifm3	Rat	17beta-estradiol	decreases expression	EXP		6480464	Estradiol results in decreased expression of AIFM3 mRNA	CTD	PMID:32145629
Aifm3	Rat	1H-pyrazole	decreases expression	ISO	Aifm3 (Mus musculus)	6480464	pyrazole results in decreased expression of AIFM3 mRNA	CTD	PMID:17945193
Aifm3	Rat	2,2',4,4'-Tetrabromodiphenyl ether	increases expression	EXP		6480464	2 more ...	CTD	PMID:27291303
Aifm3	Rat	2,3,7,8-tetrachlorodibenzodioxine	decreases expression	ISO	Aifm3 (Mus musculus)	6480464	Tetrachlorodibenzodioxin results in decreased expression of AIFM3 mRNA	CTD	PMID:33956508
Aifm3	Rat	2-(tert-butylimino)-5-phenyl-3-(propan-2-yl)-1,3,5-thiadiazinan-4-one	increases expression	ISO	AIFM3 (Homo sapiens)	6480464	buprofezin results in increased expression of AIFM3 mRNA	CTD	PMID:36287832
Aifm3	Rat	4,4'-sulfonyldiphenol	affects methylation	ISO	Aifm3 (Mus musculus)	6480464	bisphenol S affects the methylation of AIFM3 gene	CTD	PMID:31683443
Aifm3	Rat	4-hydroxyphenyl retinamide	increases expression	ISO	Aifm3 (Mus musculus)	6480464	Fenretinide results in increased expression of AIFM3 mRNA	CTD	PMID:28973697
Aifm3	Rat	6-propyl-2-thiouracil	decreases expression	EXP		6480464	Propylthiouracil results in decreased expression of AIFM3 mRNA	CTD	PMID:24780913
Aifm3	Rat	aristolochic acid A	increases expression	ISO	AIFM3 (Homo sapiens)	6480464	aristolochic acid I results in increased expression of AIFM3 mRNA	CTD	PMID:33212167
Aifm3	Rat	benzo[a]pyrene	increases methylation	ISO	AIFM3 (Homo sapiens)	6480464	Benzo(a)pyrene results in increased methylation of AIFM3 3' UTR	CTD	PMID:27901495
Aifm3	Rat	benzo[a]pyrene	affects methylation	ISO	AIFM3 (Homo sapiens)	6480464	Benzo(a)pyrene affects the methylation of AIFM3 5' UTR and Benzo(a)pyrene affects the methylation of AIFM3 intron	CTD	PMID:27901495 and PMID:30157460
Aifm3	Rat	benzo[b]fluoranthene	increases expression	ISO	Aifm3 (Mus musculus)	6480464	benzo(b)fluoranthene results in increased expression of AIFM3 mRNA	CTD	PMID:26377693
Aifm3	Rat	bisphenol A	decreases expression	EXP		6480464	bisphenol A results in decreased expression of AIFM3 mRNA	CTD	PMID:25181051
Aifm3	Rat	bisphenol A	increases expression	ISO	Aifm3 (Mus musculus)	6480464	bisphenol A results in increased expression of AIFM3 mRNA	CTD	PMID:33221593
Aifm3	Rat	buprofezin	increases expression	ISO	AIFM3 (Homo sapiens)	6480464	buprofezin results in increased expression of AIFM3 mRNA	CTD	PMID:36287832
Aifm3	Rat	butanal	decreases expression	ISO	AIFM3 (Homo sapiens)	6480464	butyraldehyde results in decreased expression of AIFM3 mRNA	CTD	PMID:26079696
Aifm3	Rat	cadmium atom	multiple interactions	ISO	Aifm3 (Mus musculus)	6480464	[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of AIFM3 mRNA	CTD	PMID:37325564
Aifm3	Rat	cadmium dichloride	decreases methylation	EXP		6480464	Cadmium Chloride results in decreased methylation of AIFM3 promoter	CTD	PMID:22457795
Aifm3	Rat	cadmium dichloride	multiple interactions	ISO	Aifm3 (Mus musculus)	6480464	[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of AIFM3 mRNA	CTD	PMID:37325564
Aifm3	Rat	camptothecin	decreases response to substance	ISO	AIFM3 (Homo sapiens)	6480464	AIFM3 mRNA results in decreased susceptibility to Camptothecin	CTD	PMID:25269479
Aifm3	Rat	carbon nanotube	increases expression	ISO	Aifm3 (Mus musculus)	6480464	Nanotubes and Carbon analog results in increased expression of AIFM3 mRNA	CTD	PMID:25554681
Aifm3	Rat	carbon nanotube	decreases expression	ISO	Aifm3 (Mus musculus)	6480464	Nanotubes more ...	CTD	PMID:25620056
Aifm3	Rat	copper(II) sulfate	decreases expression	ISO	AIFM3 (Homo sapiens)	6480464	Copper Sulfate results in decreased expression of AIFM3 mRNA	CTD	PMID:19549813
Aifm3	Rat	Cuprizon	decreases expression	EXP		6480464	Cuprizone results in decreased expression of AIFM3 mRNA	CTD	PMID:26577399 and PMID:27523638
Aifm3	Rat	cyclosporin A	decreases expression	ISO	AIFM3 (Homo sapiens)	6480464	Cyclosporine results in decreased expression of AIFM3 mRNA	CTD	PMID:25562108
Aifm3	Rat	diazinon	increases methylation	ISO	AIFM3 (Homo sapiens)	6480464	Diazinon results in increased methylation of AIFM3 gene	CTD	PMID:22964155
Aifm3	Rat	dorsomorphin	multiple interactions	ISO	AIFM3 (Homo sapiens)	6480464	[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AIFM3 mRNA	CTD	PMID:27188386
Aifm3	Rat	doxorubicin	decreases expression	EXP		6480464	Doxorubicin results in decreased expression of AIFM3 mRNA	CTD	PMID:32289291
Aifm3	Rat	endosulfan	increases expression	EXP		6480464	Endosulfan results in increased expression of AIFM3 mRNA	CTD	PMID:29391264
Aifm3	Rat	ethylparaben	decreases expression	ISO	AIFM3 (Homo sapiens)	6480464	ethyl-p-hydroxybenzoate results in decreased expression of AIFM3 mRNA	CTD	PMID:37690743
Aifm3	Rat	furan	decreases expression	ISO	Aifm3 (Mus musculus)	6480464	furan results in decreased expression of AIFM3 mRNA	CTD	PMID:24183702 and PMID:37517673
Aifm3	Rat	inulin	multiple interactions	ISO	Aifm3 (Mus musculus)	6480464	[perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of AIFM3 mRNA	CTD	PMID:36331819
Aifm3	Rat	methylmercury chloride	decreases expression	ISO	AIFM3 (Homo sapiens)	6480464	methylmercuric chloride results in decreased expression of AIFM3 mRNA	CTD	PMID:28001369
Aifm3	Rat	mono(2-ethylhexyl) phthalate	increases expression	ISO	Aifm3 (Mus musculus)	6480464	mono-(2-ethylhexyl)phthalate results in increased expression of AIFM3 mRNA	CTD	PMID:22401849
Aifm3	Rat	monosodium L-glutamate	increases expression	ISO	Aifm3 (Mus musculus)	6480464	Sodium Glutamate results in increased expression of AIFM3 mRNA	CTD	PMID:22078008
Aifm3	Rat	N-methyl-4-phenylpyridinium	increases expression	EXP		6480464	1-Methyl-4-phenylpyridinium results in increased expression of AIFM3 mRNA	CTD	PMID:28801915
Aifm3	Rat	N-nitrosodiethylamine	decreases expression	ISO	Aifm3 (Mus musculus)	6480464	Diethylnitrosamine results in decreased expression of AIFM3 mRNA	CTD	PMID:24535843
Aifm3	Rat	ozone	multiple interactions	ISO	Aifm3 (Mus musculus)	6480464	[Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased expression of AIFM3 mRNA	CTD	PMID:34911549
Aifm3	Rat	ozone	multiple interactions	ISO	AIFM3 (Homo sapiens)	6480464	[Air Pollutants results in increased abundance of Ozone] which affects the expression of AIFM3 mRNA	CTD	PMID:35430440
Aifm3	Rat	ozone	increases expression	ISO	Aifm3 (Mus musculus)	6480464	Ozone results in increased expression of AIFM3 mRNA	CTD	PMID:33026818
Aifm3	Rat	pentanal	decreases expression	ISO	AIFM3 (Homo sapiens)	6480464	pentanal results in decreased expression of AIFM3 mRNA	CTD	PMID:26079696
Aifm3	Rat	perfluorooctane-1-sulfonic acid	multiple interactions	ISO	Aifm3 (Mus musculus)	6480464	[perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of AIFM3 mRNA	CTD	PMID:36331819
Aifm3	Rat	phenobarbital	decreases expression	ISO	Aifm3 (Mus musculus)	6480464	Phenobarbital results in decreased expression of AIFM3 mRNA	CTD	PMID:19482888
Aifm3	Rat	phenobarbital	multiple interactions	ISO	Aifm3 (Mus musculus)	6480464	NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of AIFM3 mRNA]	CTD	PMID:19482888
Aifm3	Rat	pinostrobin	increases expression	ISO	AIFM3 (Homo sapiens)	6480464	pinostrobin results in increased expression of AIFM3 mRNA	CTD	PMID:37777166
Aifm3	Rat	pioglitazone	multiple interactions	ISO	Aifm3 (Mus musculus)	6480464	[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of AIFM3 mRNA	CTD	PMID:27935865
Aifm3	Rat	pregnenolone 16alpha-carbonitrile	decreases expression	ISO	Aifm3 (Mus musculus)	6480464	Pregnenolone Carbonitrile results in decreased expression of AIFM3 mRNA	CTD	PMID:28903501
Aifm3	Rat	SB 431542	multiple interactions	ISO	AIFM3 (Homo sapiens)	6480464	[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AIFM3 mRNA	CTD	PMID:27188386
Aifm3	Rat	sodium arsenite	increases expression	ISO	Aifm3 (Mus musculus)	6480464	sodium arsenite results in increased expression of AIFM3 mRNA	CTD	PMID:37682722
Aifm3	Rat	Soman	decreases expression	EXP		6480464	Soman results in decreased expression of AIFM3 mRNA	CTD	PMID:19281266
Aifm3	Rat	tetrachloromethane	decreases expression	ISO	Aifm3 (Mus musculus)	6480464	Carbon Tetrachloride results in decreased expression of AIFM3 mRNA	CTD	PMID:31919559
Aifm3	Rat	tetraphene	increases expression	ISO	Aifm3 (Mus musculus)	6480464	benz(a)anthracene results in increased expression of AIFM3 mRNA	CTD	PMID:26377693
Aifm3	Rat	trichloroethene	increases expression	EXP		6480464	Trichloroethylene results in increased expression of AIFM3 mRNA	CTD	PMID:33387578
Aifm3	Rat	trichostatin A	decreases expression	ISO	AIFM3 (Homo sapiens)	6480464	trichostatin A results in decreased expression of AIFM3 mRNA	CTD	PMID:24935251
Aifm3	Rat	urethane	decreases expression	ISO	AIFM3 (Homo sapiens)	6480464	Urethane results in decreased expression of AIFM3 mRNA	CTD	PMID:28818685
Aifm3	Rat	valproic acid	increases methylation	ISO	AIFM3 (Homo sapiens)	6480464	Valproic Acid results in increased methylation of AIFM3 gene	CTD	PMID:29154799
Aifm3	Rat	valproic acid	decreases expression	ISO	AIFM3 (Homo sapiens)	6480464	Valproic Acid results in decreased expression of AIFM3 mRNA	CTD	PMID:23179753 and PMID:26272509
Aifm3	Rat	valproic acid	multiple interactions	ISO	AIFM3 (Homo sapiens)	6480464	[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AIFM3 mRNA	CTD	PMID:27188386

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Aifm3	Rat	execution phase of apoptosis	involved_in	ISO	AIFM3 (Homo sapiens)	1624291	PMID:15764604	RGD	PMID:15764604
Aifm3	Rat	execution phase of apoptosis	involved_in	IEA	UniProtKB:Q96NN9 and ensembl:ENSP00000390798	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Aifm3	Rat	execution phase of apoptosis	involved_in	IBA	PANTHER:PTN002882813 and UniProtKB:Q96NN9	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Aifm3	Rat	cytoplasm	is_active_in	IBA	FB:FBgn0031392 more ...	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Aifm3	Rat	cytosol	located_in	ISO	AIFM3 (Homo sapiens) more ...	1624291		RGD	GO_REF:0000052
Aifm3	Rat	cytosol	located_in	IEA	UniProtKB:Q96NN9 and ensembl:ENSP00000390798	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Aifm3	Rat	endoplasmic reticulum	located_in	IEA	UniProtKB:Q96NN9 and ensembl:ENSP00000390798	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Aifm3	Rat	endoplasmic reticulum	located_in	ISO	AIFM3 (Homo sapiens)	1624291	PMID:15764604	RGD	PMID:15764604
Aifm3	Rat	mitochondrial inner membrane	located_in	ISO	AIFM3 (Homo sapiens)	1624291	PMID:15764604	RGD	PMID:15764604
Aifm3	Rat	mitochondrial inner membrane	located_in	IEA	UniProtKB:Q96NN9 and ensembl:ENSP00000390798	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Aifm3	Rat	mitochondrion	located_in	ISO	AIFM3 (Homo sapiens) more ...	1624291		RGD	GO_REF:0000052
Aifm3	Rat	mitochondrion	located_in	IEA	UniProtKB:Q96NN9 and ensembl:ENSP00000390798	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Aifm3	Rat	mitochondrion	is_active_in	IBA	PANTHER:PTN002882813 and UniProtKB:Q96NN9	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Aifm3	Rat	mitochondrion	located_in	ISO	AIFM3 (Homo sapiens)	1624291	PMID:15764604	RGD	PMID:15764604
Aifm3	Rat	nucleus	NOT\|located_in	ISO	AIFM3 (Homo sapiens)	1624291	PMID:15764604	RGD	PMID:15764604

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Aifm3	Rat	2 iron, 2 sulfur cluster binding	enables	IEA	UniProtKB-KW:KW-0001	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Aifm3	Rat	2 iron, 2 sulfur cluster binding	enables	IEA	InterPro:IPR017941 and InterPro:IPR036922	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Aifm3	Rat	iron-sulfur cluster binding	enables	IEA	UniProtKB-KW:KW-0411	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Aifm3	Rat	metal ion binding	enables	IEA	UniProtKB-KW:KW-0479	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Aifm3	Rat	oxidoreductase activity	enables	IEA	InterPro:IPR023753	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Aifm3	Rat	oxidoreductase activity, acting on NAD(P)H	enables	IBA	MGI:1349419 more ...	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	GOA pipeline	RGD automated data pipeline
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

PMID:12477932	PMID:15764604	PMID:18614015	PMID:21447364	PMID:22085972	PMID:22871113

Aifm3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	97,009,100 - 97,030,601 (-)	NCBI		GRCr8
mRatBN7.2	11	83,504,859 - 83,523,630 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	83,504,861 - 83,521,248 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	11	92,232,276 - 92,247,077 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	84,893,435 - 84,908,236 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	83,947,043 - 83,961,844 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	87,364,452 - 87,380,705 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	87,366,621 - 87,380,704 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	90,417,097 - 90,431,999 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	85,496,302 - 85,512,831 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	11	85,544,286 - 85,551,637 (-)	NCBI
Celera	11	82,273,467 - 82,288,125 (-)	NCBI		Celera
Cytogenetic Map	11	q23	NCBI

AIFM3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	22	20,965,172 - 20,981,358 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	22	20,965,108 - 20,981,360 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	22	21,319,460 - 21,335,647 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	22	19,649,434 - 19,665,649 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	22	4,810,763 - 4,826,996 (+)	NCBI		Celera
Cytogenetic Map	22	q11.21	NCBI
HuRef	22	4,589,741 - 4,603,945 (+)	NCBI		HuRef
CHM1_1	22	21,319,619 - 21,335,846 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	22	21,373,992 - 21,390,168 (+)	NCBI		T2T-CHM13v2.0

Aifm3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	17,307,418 - 17,325,349 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	17,307,475 - 17,325,349 (+)	Ensembl		GRCm39 Ensembl
GRCm38	16	17,489,624 - 17,507,485 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	17,489,611 - 17,507,485 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	16	17,489,784 - 17,507,575 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	16	17,403,254 - 17,421,045 (+)	NCBI		MGSCv36	mm8
Celera	16	18,062,758 - 18,080,551 (+)	NCBI		Celera
Cytogenetic Map	16	A3	NCBI
cM Map	16	10.84	NCBI

Aifm3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955442	19,333,591 - 19,346,438 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955442	19,334,217 - 19,346,438 (-)	NCBI	ChiLan1.0	ChiLan1.0

AIFM3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	23	30,663,078 - 30,688,168 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	22	33,220,882 - 33,237,106 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	22	3,189,169 - 3,205,394 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	22	19,679,872 - 19,695,349 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	22	19,679,873 - 19,695,349 (+)	Ensembl	panpan1.1		panPan2

AIFM3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	30,520,542 - 30,533,256 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	26	30,519,872 - 30,532,796 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	30,478,323 - 30,492,711 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	26	31,928,867 - 31,943,261 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	26	31,910,811 - 31,943,250 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	26	29,974,681 - 29,989,031 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	26	29,598,646 - 29,613,004 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	26	30,687,693 - 30,702,093 (-)	NCBI		UU_Cfam_GSD_1.0

Aifm3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	140,249,410 - 140,263,534 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936619	2,493,256 - 2,504,322 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936619	2,485,840 - 2,505,075 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

AIFM3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	50,562,776 - 50,576,275 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	50,562,611 - 50,576,273 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	54,011,363 - 54,025,438 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

AIFM3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	19	4,901,118 - 4,917,290 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	19	4,904,050 - 4,918,224 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666085	2,052,891 - 2,068,955 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Aifm3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624945	710,820 - 722,621 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624945	710,562 - 724,699 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants in Aifm3
67 total Variants

Assembly: RGSC_v3.4

Chromosome	Start Pos	End Pos	Reference Nucleotide	Variant Nucleotide	Variant Type	Strain	Variant Page
11	85498814	85498815	G	T	snv	SS/JrHsdMcwi (MCW)	View more Information

Predicted Target Of

	Summary Value
Count of predictions:	166
Count of miRNA genes:	113
Interacting mature miRNAs:	118
Transcripts:	ENSRNOT00000040978
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
724554	Iddm17	Insulin dependent diabetes mellitus QTL 17		0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	11	18976208	86241447	Rat
10058954	Gmadr7	Adrenal mass QTL 7	2.49	0.0049	adrenal gland mass (VT:0010420)	both adrenal glands wet weight to body weight ratio (CMO:0002411)	11	60346590	86241447	Rat
1354593	Stl12	Serum triglyceride level QTL 12	3.36		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	11	66422148	86241447	Rat
724561	Plsm4	Polydactyly-luxate syndrome (PLS) morphotypes QTL 4		0.0003	forelimb integrity trait (VT:0010562)	front foot phalanges count (CMO:0001947)	11	54457534	86241447	Rat
634339	Niddm50	Non-insulin dependent diabetes mellitus QTL 50	3.32		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	11	66422148	86241447	Rat
7411658	Foco27	Food consumption QTL 27	16.2	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	11	56351424	86241447	Rat

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31


RefSeq Transcripts	NM_001013977	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008768875	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039088259	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039088260	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063270454	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063270455	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063270456	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010055949	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC089949	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC103647	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CB769270	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000011	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000040978 ⟹ ENSRNOP00000048427

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	11	83,504,861 - 83,519,593 (-)	Ensembl
Rnor_6.0 Ensembl	11	87,366,621 - 87,380,378 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000086117 ⟹ ENSRNOP00000073999

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	11	83,504,862 - 83,510,876 (-)	Ensembl
Rnor_6.0 Ensembl	11	87,374,690 - 87,380,704 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000112032 ⟹ ENSRNOP00000088997

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	11	83,504,925 - 83,521,248 (-)	Ensembl

RefSeq Acc Id:

NM_001013977 ⟹ NP_001013999

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	97,009,100 - 97,023,832 (-)	NCBI
mRatBN7.2	11	83,504,861 - 83,519,593 (-)	NCBI
Rnor_6.0	11	87,365,973 - 87,380,705 (+)	NCBI
Rnor_5.0	11	90,417,097 - 90,431,999 (+)	NCBI
RGSC_v3.4	11	85,496,302 - 85,512,831 (-)	RGD
Celera	11	82,273,467 - 82,288,125 (-)	NCBI

Sequence:

show sequence

GCAGTGACTCTCACGGAAGGAGGTTCTAAAGCTGTCTAGCTGGCATGGCAGCTCCAGCGTCTCTGAGCGCCACAGGGGGTCCAGTCCTACAGGGCTCATCCTAGACCTCGGACAGCTGGACAGCCTGC
CATCCGTGCTCCCACCAGCCGGGCTAGATCCAGGCCATTCAACCATGGGCGGCTGCTTCTCCAAGCCCAAGCCAGTGGAGCTCAAGATCGAAGTGGTGCTGCCAGAGAAAGAGCGGGGCAAGGAAGAG
CTGTCAGCCAGCGGAAAGGGCAGCCCCCGGGGTTACCAGGGCAATGGCACAGCACGTCACTTCCATGCTGAAGAGCGTCTGCCCACTCCACAGCCCTACCCCAGCCCTCAGGACTGTGTGGAGGCTAC
CGTCTGCCATGTCAAGGACCTGGAGAATGGCCAGATGCGGGAAGTGGAGTTGGGCTGGGGAAAGGTGTTGCTGGTGAAGGATAATGGGGAATTCCACGCCCTGGGCCATAAGTGTCCTCACTACGGAG
CACCCCTGGTGAAAGGTGTGCTGTCCCGGGGACGTGTGCGCTGCCCCTGGCATGGTGCCTGCTTCAATATTGGAACTGGGGACCTAGAGGACTTCCCAGGCCTGGACAGTCTGCATAAGTTCCAGGTG
AAGATTGAGAAGGAGAAGGTGACCGTTCGGGCAAGCAAGCAGGCCCTGCAGCTGCAGCGGAGGACAAAGGTGATGGCCAAGTGCATCTCTCCAAGTGCTGGCCACAGCAGCACCAATGTGCTCATAGT
GGGCGCAGGTGCTGCTGGCCTAGTGTGCGCAGAGACACTGAGGCAGGAGGGCTTCTCAGACCGCATTGTCCTTTGCACACTGGATCGACATCTGCCTTATGATCGGGCCAAGCTCAGCAAGTCCCTGG
ATGCACAACCTGAACAGCTGGCCCTGAGACCCAAGGAATTCTTCCGGGCCTATGGCATCGAGATGCTCACTGAAGCTCAGGTGGTCACAGTGGACGTGAGAAATAAGAAGGTTGTGTTCAAGGACGGC
TTCAAGCTAGAGTACAGCAAGCTGCTGCTGGCACCAGGAAGTAGCCCTAAGACCCTGACCTGCAAAGGGAAAGACATAGAGAATGTGTTCACCATCCGCACGCCTGAGGATGCCAACCGCGTGCTGCG
GCTGGCCCGGGGCCGAAATGCTGTTGTTGTGGGAGCAGGCTTTCTGGGGATGGAGGTCGCTGCTTATCTGACTGAAAAAGCCCACTCAGTATCTGTGGTAGAGCTGGAGGAGACGCCCTTCCGCAGGT
TCCTGGGGGAGCGTGTTGGTCGTGCCCTTATGAAGATGTTTGAAAACAACCGGGTGAAGTTCTATATGCAGACAGAGGTGTCAGAGCTGCGGGCTCAAGAGGGCAAGCTGCAGGAGGTGGTGCTGAAG
AGCAGCAAAGTTCTGCGGGCAGACGTCTGCGTGGTAGGCATCGGTGCGGTGCCTGCCACAGGCTTCCTGAGGCAGAGTGGCATTGGTCTGGATTCCCGAGGTTTCATCCCAGTCAACAAGATGATGCA
GACCAACATCCCAGGAGTGTTTGCTGCAGGTGATGCTGTCACCTTTCCTCTTGCCTGGAGGAACAATCGGAAAGTGAACATCCCACACTGGCAGATGGCTCATGCCCAGGGTCGGGTAGCAGCTCAGA
ACATGCTGGCACAGGAGGCAGAGATCAACACGGTACCTTATCTGTGGACTGCCATGTTCGGCAAGAGCCTGCGCTATGCTGGCTACGGAGAAGGCTTCGATGATGTCATCATTCAGGGGGATCTGGAG
GAGCTGAAGTTTGTGGCTTTTTATACCAAAGGTGACGAAGTGATTGCTGTGGCCAGCATGAACTACGACCCCATCGTATCCAAGGTGGCCGAGGTGCTGGCCTCAGGTCGAGCCATCCGGAAGCGGGA
GGTGGAGTTGTTTATGCTGCACAGCAAGACCGGTGACATGTCTTGGCTCACAGGGAAAGGATCCTGAGCTCTCTCTCTCTCTCATGTGGTGGACTTAGGCAGGCCTCTGGGACACCAAGGTCAGAGAC
TAAGTCCCGGGGCAAGTGCCAATCTCCAATATCCCAGGATCCCCCAAGGTGGAATCTGAGTCTTCCAAGGCTTGCCTTCAACTGTCTGCCTCACCTCCAGAGAGGCTACTACTGCCTCCAGAAGATGA
TCCGTTCCGAAGGCCTCAGCTGTCACTGACAGCTGGTTTTAGAGGCAGGACAGGCTCTGTCTCTGCTTCCTCTGTTAGGACTGTTTTCCCAGCAAGCCCCTTCAACATTACCTTAAAATTAAAACACA
TATATCAGCA

hide sequence

RefSeq Acc Id:

XM_008768875 ⟹ XP_008767097

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	97,009,100 - 97,030,601 (-)	NCBI
mRatBN7.2	11	83,505,181 - 83,523,627 (-)	NCBI
Rnor_6.0	11	87,364,452 - 87,380,431 (+)	NCBI

Sequence:

show sequence

GAGGTGGACAGGAGGGTTGGCGTTGGGGTGCCCCGGAAAGGTAAATCACAAGCTGAGGAGCTCC
GAGGCAGCGCTCTCCAGGGCCCCTGACGCCACTGAGGGCCTAGGATAAGCTGGGTTGGGGGAGGGTTGGGGAGGGGGCCGATCTCTCACTCAACACACACCAGGAGCGAAGAGTGGGACTTGGATTGG
AAAAAGAAACAAGCTTCCAGCTGACTTGCACCCCCGGCCGGGTCCTGGAGTCCTGCGGGATCCCGTGGAACCTTTGTGAGGTGGGGGTAACTCAGAACCTGTTTCAGGTTGCTGGAGTTCCTGGGACA
TGGACGCAAACTCCTCTTGTGGAGTGTGCAGCAGGGCAATGTTATAACTTTTCTCGGCAGACGTCTCTCCTCGCAGGCCCAAGAAACTTGTCTTTGAGTTGGAACCACTGGCTCTAAACTGGCCTAGC
ACATCATCATAGGTGGAAGGCATGGTCCCCACCACATCTCCCGCTAGGCCCAAGGAATAAACTCCTGAACACCCGGAAAGGGAGGGACCCCAGATCGAAAAGCCAGTCTGTTTGTAGGGTCTCAGTCC
CAACAGGTGAGGCCTGAAACCAGGCCGGAAGCAGGTGGGCAGCCCTGAGACATGGGTGAAACCAGGACTTCTGAAAGGGTTCCCGGGAAGGGAGCTAGAGGGGCAGTTAGCAACTGAGTTTTATAGAC
ATGCCCTGGTGACAAGGGGGGCTTTGGGTTCCTCCTCCATTGGAGTTTGCATCAAAGGTCAGGAGCCGGCAGTGGCTGGTCCTTTCCCATTCTGCTCTTCCACGGGCTCTTTCCTGGGGTCTGGACAA
ACCGAATGATTCCCAGCACCAGTTCAGTATAAACTTCAGGGAGAGTTTCCTGGTGAACCAGGCCTGCTGTTGGGTAGAATTCGGACAGATTACTTGTAAACAGGGCAGTTACACCTTTGTCCTGACCC
TTCCAAAGTCCACATATTCTAGAAGGCCCACCTATGGCCACAAGGACACAATGGCTGTAGTGATCTGTTTACCAGGTAGTCTTGCCTGCCGGTTTGGAGCCTCAGAGTGATCTGGGGACCTCCCAGGG
CCTTACTTATCTTCGGATTTATTAGGGTGAGGAGTGGGGGAGACCACACAGATGCCCCTAACTGCTGCTTGACCTTAAAGAAACCTTGGCCCCCAGTCCTATCTTCTGTGGGGCGTGACCTCGGCACT
GCACAGCCAGCCTGAGGGGTGGGGGAACTTATGGCTGCTGGGCATGGGGCAGAGGCAGAGCTGTGCGGTTGGGTTGGTTTCCCTCTTTCCTCAACCCCATCAATCCTGGGCTGGCTGCCCGCTCTTTT
CCCCACAGAGCTGGGTTTCCCTGGGGACCAGTGGCTTGGCCTAGCCTCACACCCACAGCCCCCTCCTGGCCACAACTCACGCTAGAAGGAGGGCTGGACCCTCCTGGACCCTGGCCCTCCCTGCCCTG
CTGACCAAGGTCCAGTAGTCTCTCTCCATTGCTGGGCTGGGAGCAAGGAGCAGTGACTCTCACGGAAGGAGGTTCTAAAGCTGTCTAGCTGGCATGGCAGCTCCAGCGTCTCTGAGCGCCACAGGGGG
TCCAGTCCTACAGGGCTCATCCTAGACCTCGGACAGCTGGACAGCCTGCCATCCGTGCTCCCACCAGCCGGGCTAGATCCAGGCCATTCAACCATGGGCGGCTGCTTCTCCAAGCCCAAGCCAGTGGA
GCTCAAGATCGAAGTGGTGCTGCCAGAGAAAGAGCGGGGCAAGGAAGAGCTGTCAGCCAGCGGAAAGGGCAGCCCCCGGGGTTACCAGGGCAATGGCACAGCACGTCACTTCCATGCTGAAGAGCGTC
TGCCCACTCCACAGCCCTACCCCAGCCCTCAGGACTGTGTGGAGGCTACCGTCTGCCATGTCAAGGACCTGGAGAATGGCCAGATGCGGGAAGTGGAGTTGGGCTGGGGAAAGGTGTTGCTGGTGAAG
GATAATGGGGAATTCCACGCCCTGGGCCATAAGTGTCCTCACTACGGAGCACCCCTGGTGAAAGGTGTGCTGTCCCGGGGACGTGTGCGCTGCCCCTGGCATGGTGCCTGCTTCAATATTGGAACTGG
GGACCTAGAGGACTTCCCAGGCCTGGACAGTCTGCATAAGTTCCAGGTGAAGATTGAGAAGGAGAAGGTGACCGTTCGGGCAAGCAAGCAGGCCCTGCAGCTGCAGCGGAGGACAAAGGTGATGGCCA
AGTGCATCTCTCCAAGTGCTGGCCACAGCAGCACCAATGTGCTCATAGTGGGCGCAGGTGCTGCTGGCCTAGTGTGCGCAGAGACACTGAGGCAGGAGGGCTTCTCAGACCGCATTGTCCTTTGCACA
CTGGATCGACATCTGCCTTATGATCGGGCCAAGCTCAGCAAGTCCCTGGATGCACAACCTGAACAGCTGGCCCTGAGACCCAAGGAATTCTTCCGGGCCTATGGCATCGAGATGCTCACTGAAGCTCA
GGTGGTCACAGTGGACGTGAGAAATAAGAAGGTTGTGTTCAAGGACGGCTTCAAGCTAGAGTACAGCAAGCTGCTGCTGGCACCAGGAAGTAGCCCTAAGACCCTGACCTGCAAAGGGAAAGACATAG
AGAATGTGTTCACCATCCGCACGCCTGAGGATGCCAACCGCGTGCTGCGGCTGGCCCGGGGCCGAAATGCTGTTGTTGTGGGAGCAGGCTTTCTGGGGATGGAGGTCGCTGCTTATCTGACTGAAAAA
GCCCACTCAGTATCTGTGGTAGAGCTGGAGGAGACGCCCTTCCGCAGGTTCCTGGGGGAGCGTGTTGGTCGTGCCCTTATGAAGATGTTTGAAAACAACCGGGTGAAGTTCTATATGCAGACAGAGGT
GTCAGAGCTGCGGGCTCAAGAGGGCAAGCTGCAGGAGGTGGTGCTGAAGAGCAGCAAAGTTCTGCGGGCAGACGTCTGCGTGGTAGGCATCGGTGCGGTGCCTGCCACAGGCTTCCTGAGGCAGAGTG
GCATTGGTCTGGATTCCCGAGGTTTCATCCCAGTCAACAAGATGATGCAGACCAACATCCCAGGAGTGTTTGCTGCAGGTGATGCTGTCACCTTTCCTCTTGCCTGGAGGAACAATCGGAAAGTGAAC
ATCCCACACTGGCAGATGGCTCATGCCCAGGGTCGGGTAGCAGCTCAGAACATGCTGGCACAGGAGGCAGAGATCAACACGGTACCTTATCTGTGGACTGCCATGTTCGGCAAGAGCCTGCGCTATGC
TGGCTACGGAGAAGGCTTCGATGATGTCATCATTCAGGGGGATCTGGAGGAGCTGAAGTTTGTGGCTTTTTATACCAAAGGTGACGAAGTGATTGCTGTGGCCAGCATGAACTACGACCCCATCGTAT
CCAAGGTGGCCGAGGTGCTGGCCTCAGGTCGAGCCATCCGGAAGCGGGAGGTGGAGTTGTTTATGCTGCACAGCAAGTACGTGCATTCTTTGTTGACTGTCCTGTGCCTTTCTTCCCCAGCCCAATGA
CTGCACCCTCCCACCTTGCCCAAGTCCACTACCTAGGGGGCACCGGGCTTTGACACAGATCAGTCCCTGTATTCAAGAGTCATAGCTGGTGGTGCCTAGAGTAGGAACCTATCCTCTTCTGCCCTGAC
CCATCCTCCTCTCATTCCTGCAGGACCGGTGACATGTCTTGGCTCACAGGGAAAGGATCCTGAGCTCTCTCTCTCTCTCATGTGGTGGACTTAGGCAGGCCTCTGGGACACCAAGG

hide sequence

RefSeq Acc Id:

XM_039088259 ⟹ XP_038944187

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	97,009,100 - 97,030,601 (-)	NCBI
mRatBN7.2	11	83,505,181 - 83,523,627 (-)	NCBI

RefSeq Acc Id:

XM_039088260 ⟹ XP_038944188

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	97,009,100 - 97,030,601 (-)	NCBI
mRatBN7.2	11	83,505,181 - 83,523,627 (-)	NCBI

RefSeq Acc Id:

XM_063270454 ⟹ XP_063126524

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	97,009,100 - 97,030,601 (-)	NCBI

RefSeq Acc Id:

XM_063270455 ⟹ XP_063126525

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	97,009,100 - 97,030,601 (-)	NCBI

RefSeq Acc Id:

XM_063270456 ⟹ XP_063126526

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	97,009,100 - 97,016,021 (-)	NCBI

RefSeq Acc Id:

XR_010055949

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	97,011,537 - 97,030,601 (-)	NCBI


Protein RefSeqs	NP_001013999	(Get FASTA)	NCBI Sequence Viewer
	XP_008767097	(Get FASTA)	NCBI Sequence Viewer
	XP_038944187	(Get FASTA)	NCBI Sequence Viewer
	XP_038944188	(Get FASTA)	NCBI Sequence Viewer
	XP_063126524	(Get FASTA)	NCBI Sequence Viewer
	XP_063126525	(Get FASTA)	NCBI Sequence Viewer
	XP_063126526	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH89949	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000048427
	ENSRNOP00000048427.2
	ENSRNOP00000073999.1
	ENSRNOP00000088997
	ENSRNOP00000088997.1

RefSeq Acc Id:

NP_001013999 ⟸ NM_001013977

- UniProtKB:

D3ZF03 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MGGCFSKPKPVELKIEVVLPEKERGKEELSASGKGSPRGYQGNGTARHFHAEERLPTPQPYPSPQDCVEATVCHVKDLENGQMREVELGWGKVLLVKDNGEFHALGHKCPHYGAPLVKGVLSRGRVRC
PWHGACFNIGTGDLEDFPGLDSLHKFQVKIEKEKVTVRASKQALQLQRRTKVMAKCISPSAGHSSTNVLIVGAGAAGLVCAETLRQEGFSDRIVLCTLDRHLPYDRAKLSKSLDAQPEQLALRPKEFF
RAYGIEMLTEAQVVTVDVRNKKVVFKDGFKLEYSKLLLAPGSSPKTLTCKGKDIENVFTIRTPEDANRVLRLARGRNAVVVGAGFLGMEVAAYLTEKAHSVSVVELEETPFRRFLGERVGRALMKMFE
NNRVKFYMQTEVSELRAQEGKLQEVVLKSSKVLRADVCVVGIGAVPATGFLRQSGIGLDSRGFIPVNKMMQTNIPGVFAAGDAVTFPLAWRNNRKVNIPHWQMAHAQGRVAAQNMLAQEAEINTVPYL
WTAMFGKSLRYAGYGEGFDDVIIQGDLEELKFVAFYTKGDEVIAVASMNYDPIVSKVAEVLASGRAIRKREVELFMLHSKTGDMSWLTGKGS

hide sequence

RefSeq Acc Id:

XP_008767097 ⟸ XM_008768875

- Peptide Label:

isoform X1

- Sequence:

show sequence

MGGCFSKPKPVELKIEVVLPEKERGKEELSASGKGSPRGYQGNGTARHFHAEERLPTPQPYPSPQDCVEATVCHVKDLENGQMREVELGWGKVLLVKDNGEFHALGHKCPHYGAPLVKGVLSRGRVRC
PWHGACFNIGTGDLEDFPGLDSLHKFQVKIEKEKVTVRASKQALQLQRRTKVMAKCISPSAGHSSTNVLIVGAGAAGLVCAETLRQEGFSDRIVLCTLDRHLPYDRAKLSKSLDAQPEQLALRPKEFF
RAYGIEMLTEAQVVTVDVRNKKVVFKDGFKLEYSKLLLAPGSSPKTLTCKGKDIENVFTIRTPEDANRVLRLARGRNAVVVGAGFLGMEVAAYLTEKAHSVSVVELEETPFRRFLGERVGRALMKMFE
NNRVKFYMQTEVSELRAQEGKLQEVVLKSSKVLRADVCVVGIGAVPATGFLRQSGIGLDSRGFIPVNKMMQTNIPGVFAAGDAVTFPLAWRNNRKVNIPHWQMAHAQGRVAAQNMLAQEAEINTVPYL
WTAMFGKSLRYAGYGEGFDDVIIQGDLEELKFVAFYTKGDEVIAVASMNYDPIVSKVAEVLASGRAIRKREVELFMLHSKYVHSLLTVLCLSSPAQ

hide sequence

Ensembl Acc Id:

ENSRNOP00000048427 ⟸ ENSRNOT00000040978

Ensembl Acc Id:

ENSRNOP00000073999 ⟸ ENSRNOT00000086117

RefSeq Acc Id:	XP_038944188 ⟸ XM_039088260
- Peptide Label:	isoform X1

Protein Domains

FAD/NAD(P)-binding Rieske

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZF03-F1-model_v2	AlphaFold	D3ZF03	1-604	view protein structure

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Database	Acc Id	Source(s)
BioCyc Gene	G2FUF-20590	BioCyc
Ensembl Genes	ENSRNOG00000037957	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000040978	ENTREZGENE
	ENSRNOT00000040978.5	UniProtKB/TrEMBL
	ENSRNOT00000086117.2	UniProtKB/TrEMBL
	ENSRNOT00000112032	ENTREZGENE
	ENSRNOT00000112032.1	UniProtKB/TrEMBL
Gene3D-CATH	2.102.10.10	UniProtKB/TrEMBL
	3.30.390.30	UniProtKB/TrEMBL
	3.50.50.60	UniProtKB/TrEMBL
InterPro	FAD-oxidoreductase/Apoptosis	UniProtKB/TrEMBL
	FAD/NAD-bd_sf	UniProtKB/TrEMBL
	FAD/NAD-linked_Rdtase_dimer	UniProtKB/TrEMBL
	Pyr_nucl-diS_OxRdtase_FAD/NAD	UniProtKB/TrEMBL
	Reductase_C	UniProtKB/TrEMBL
	Rieske_2Fe-2S	UniProtKB/TrEMBL
	Rieske_2Fe-2S_sf	UniProtKB/TrEMBL
KEGG Report	rno:303786	UniProtKB/TrEMBL
NCBI Gene	303786	ENTREZGENE
PANTHER	APOPTOSIS-INDUCING FACTOR 1	UniProtKB/TrEMBL
	APOPTOSIS-INDUCING FACTOR 3	UniProtKB/TrEMBL
Pfam	Pyr_redox_2	UniProtKB/TrEMBL
	Reductase_C	UniProtKB/TrEMBL
	Rieske	UniProtKB/TrEMBL
PhenoGen	Aifm3	PhenoGen
PRINTS	FADPNR	UniProtKB/TrEMBL
	PNDRDTASEI	UniProtKB/TrEMBL
	PNDRDTASEII	UniProtKB/TrEMBL
PROSITE	RIESKE	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000037957	RatGTEx
Superfamily-SCOP	FAD/NAD-linked_reductase_dimer	UniProtKB/TrEMBL
	Rieske_dom	UniProtKB/TrEMBL
	SSF51905	UniProtKB/TrEMBL
UniProt	A0A8I6A793	ENTREZGENE, UniProtKB/TrEMBL
	D3ZF03	ENTREZGENE, UniProtKB/TrEMBL
	Q5FVJ2_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2024-11-07	Aifm3	AIF family member 3	Aifm3	apoptosis inducing factor, mitochondria associated 3	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2015-11-25	Aifm3	apoptosis inducing factor, mitochondria associated 3	Aifm3	apoptosis-inducing factor, mitochondrion-associated 3	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-07	Aifm3	apoptosis-inducing factor, mitochondrion-associated 3	RGD1306028	similar to hypothetical protein FLJ30473	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	RGD1306028	similar to hypothetical protein FLJ30473	RGD1306028_predicted	similar to hypothetical protein FLJ30473 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-20	RGD1306028_predicted	similar to hypothetical protein FLJ30473 (predicted)	LOC303786_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC303786_predicted	similar to hypothetical protein FLJ30473 (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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Imported Disease Annotations - ClinVar