Symbol:
Tnfsf18
Name:
TNF superfamily member 18
RGD ID:
1305066
Description:
Predicted to enable identical protein binding activity and tumor necrosis factor receptor superfamily binding activity. Predicted to be involved in several processes, including positive regulation of NF-kappaB transcription factor activity; regulation of T cell activation; and regulation of leukocyte chemotaxis. Predicted to be located in membrane. Predicted to be active in cell surface. Orthologous to human TNFSF18 (TNF superfamily member 18); PARTICIPATES IN cytokine mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; endosulfan.
Type:
protein-coding
RefSeq Status:
VALIDATED
Previously known as:
LOC364031; Tnlg2a; tumor necrosis factor (ligand) superfamily, member 18; tumor necrosis factor ligand 2a; tumor necrosis factor ligand superfamily member 18; tumor necrosis factor superfamily member 18
RGD Orthologs
Alliance Orthologs
More Info
more info ...
More Info
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
TNFSF18 (TNF superfamily member 18)
HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Tnfsf18 (tumor necrosis factor (ligand) superfamily, member 18)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):
Tnfsf18 (TNF superfamily member 18)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
TNFSF18 (TNF superfamily member 18)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
TNFSF18 (TNF superfamily member 18)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Tnfsf18 (TNF superfamily member 18)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
TNFSF18 (TNF superfamily member 18)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):
TNFSF18 (TNF superfamily member 18)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Tnfsf18 (TNF superfamily member 18)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
TNFSF18 (TNF superfamily member 18)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Mus musculus (house mouse):
Tnfsf18 (tumor necrosis factor (ligand) superfamily, member 18)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Latest Assembly:
GRCr8 - GRCr8 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 13 76,366,790 - 76,440,673 (+) NCBI GRCr8 mRatBN7.2 13 73,833,478 - 73,907,249 (+) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 13 73,831,252 - 73,843,169 (+) Ensembl mRatBN7.2 Ensembl UTH_Rnor_SHR_Utx 13 76,412,930 - 76,422,686 (+) NCBI Rnor_SHR UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 13 77,710,263 - 77,720,018 (+) NCBI Rnor_SHRSP UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 13 74,970,140 - 74,979,895 (+) NCBI Rnor_WKY UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 13 79,378,412 - 79,388,687 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 13 79,378,733 - 79,388,498 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 13 84,270,937 - 84,282,548 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 13 77,137,045 - 77,145,251 (+) NCBI RGSC3.4 RGSC_v3.4 rn4 RGSC3.4 RGSC_v3.1 13 77,151,151 - 77,159,439 (+) NCBI Celera 13 73,609,947 - 73,620,222 (+) NCBI Celera Cytogenetic Map 13 q22 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - KEGG (archival)
Tnfsf18 (Rattus norvegicus - Norway rat)
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 13 76,366,790 - 76,440,673 (+) NCBI GRCr8 mRatBN7.2 13 73,833,478 - 73,907,249 (+) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 13 73,831,252 - 73,843,169 (+) Ensembl mRatBN7.2 Ensembl UTH_Rnor_SHR_Utx 13 76,412,930 - 76,422,686 (+) NCBI Rnor_SHR UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 13 77,710,263 - 77,720,018 (+) NCBI Rnor_SHRSP UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 13 74,970,140 - 74,979,895 (+) NCBI Rnor_WKY UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 13 79,378,412 - 79,388,687 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 13 79,378,733 - 79,388,498 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 13 84,270,937 - 84,282,548 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 13 77,137,045 - 77,145,251 (+) NCBI RGSC3.4 RGSC_v3.4 rn4 RGSC3.4 RGSC_v3.1 13 77,151,151 - 77,159,439 (+) NCBI Celera 13 73,609,947 - 73,620,222 (+) NCBI Celera Cytogenetic Map 13 q22 NCBI
TNFSF18 (Homo sapiens - human)
Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38 1 173,039,202 - 173,050,941 (-) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh38.p14 Ensembl 1 173,039,202 - 173,050,941 (-) Ensembl GRCh38 hg38 GRCh38 GRCh37 1 173,008,342 - 173,020,081 (-) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 1 171,276,983 - 171,286,726 (-) NCBI NCBI36 Build 36 hg18 NCBI36 Build 34 1 169,742,107 - 169,751,713 NCBI Celera 1 146,119,822 - 146,129,565 (-) NCBI Celera Cytogenetic Map 1 q25.1 NCBI HuRef 1 144,235,111 - 144,244,854 (-) NCBI HuRef CHM1_1 1 174,432,835 - 174,442,578 (-) NCBI CHM1_1 T2T-CHM13v2.0 1 172,397,315 - 172,409,046 (-) NCBI T2T-CHM13v2.0
Tnfsf18 (Mus musculus - house mouse)
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm39 1 161,322,221 - 161,333,903 (+) NCBI GRCm39 GRCm39 mm39 GRCm39 Ensembl 1 161,322,224 - 161,332,859 (+) Ensembl GRCm39 Ensembl GRCm38 1 161,494,657 - 161,505,290 (+) NCBI GRCm38 GRCm38 mm10 GRCm38 GRCm38.p6 Ensembl 1 161,494,655 - 161,505,290 (+) Ensembl GRCm38 mm10 GRCm38 MGSCv37 1 163,424,788 - 163,435,421 (+) NCBI GRCm37 MGSCv37 mm9 NCBIm37 MGSCv36 1 163,331,332 - 163,341,967 (+) NCBI MGSCv36 mm8 Celera 1 163,943,104 - 163,953,733 (+) NCBI Celera Cytogenetic Map 1 H2.1 NCBI cM Map 1 69.75 NCBI
Tnfsf18 (Chinchilla lanigera - long-tailed chinchilla)
Chinchilla Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl ChiLan1.0 NW_004955406 13,391,162 - 13,402,479 (-) NCBI ChiLan1.0 ChiLan1.0
TNFSF18 (Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl NHGRI_mPanPan1-v2 1 76,687,163 - 76,700,053 (+) NCBI NHGRI_mPanPan1-v2
TNFSF18 (Canis lupus familiaris - dog)
Dog Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl CanFam3.1 7 25,983,064 - 25,994,605 (+) NCBI CanFam3.1 CanFam3.1 canFam3 CanFam3.1 CanFam3.1 Ensembl 7 25,963,719 - 25,992,801 (+) Ensembl CanFam3.1 canFam3 CanFam3.1 Dog10K_Boxer_Tasha 7 25,514,906 - 25,526,500 (+) NCBI Dog10K_Boxer_Tasha ROS_Cfam_1.0 7 25,734,171 - 25,745,767 (+) NCBI ROS_Cfam_1.0 ROS_Cfam_1.0 Ensembl 7 25,734,080 - 25,744,296 (+) Ensembl ROS_Cfam_1.0 Ensembl UMICH_Zoey_3.1 7 25,652,719 - 25,664,301 (+) NCBI UMICH_Zoey_3.1 UNSW_CanFamBas_1.0 7 25,725,623 - 25,737,220 (+) NCBI UNSW_CanFamBas_1.0 UU_Cfam_GSD_1.0 7 25,879,459 - 25,891,051 (+) NCBI UU_Cfam_GSD_1.0
Tnfsf18 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl HiC_Itri_2 NW_024409344 96,652,746 - 96,661,551 (+) NCBI HiC_Itri_2 SpeTri2.0 Ensembl NW_004936481 14,499,577 - 14,508,017 (+) Ensembl SpeTri2.0 SpeTri2.0 Ensembl SpeTri2.0 NW_004936481 14,499,495 - 14,508,074 (+) NCBI SpeTri2.0 SpeTri2.0 SpeTri2.0
TNFSF18 (Sus scrofa - pig)
Pig Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Sscrofa11.1 Ensembl 9 115,448,973 - 115,460,950 (-) Ensembl Sscrofa11.1 susScr11 Sscrofa11.1 Sscrofa11.1 9 115,447,438 - 115,460,649 (-) NCBI Sscrofa11.1 Sscrofa11.1 susScr11 Sscrofa11.1 Sscrofa10.2 9 127,140,943 - 127,151,861 (+) NCBI Sscrofa10.2 Sscrofa10.2 susScr3
TNFSF18 (Chlorocebus sabaeus - green monkey)
Green Monkey Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl ChlSab1.1 25 56,105,757 - 56,118,249 (+) NCBI ChlSab1.1 ChlSab1.1 chlSab2 ChlSab1.1 Ensembl 25 56,106,584 - 56,118,758 (+) Ensembl ChlSab1.1 ChlSab1.1 Ensembl chlSab2 Vero_WHO_p1.0 NW_023666055 57,711,144 - 57,721,390 (+) NCBI Vero_WHO_p1.0 Vero_WHO_p1.0
Tnfsf18 (Heterocephalus glaber - naked mole-rat)
.
Predicted Target Of
Count of predictions: 148 Count of miRNA genes: 128 Interacting mature miRNAs: 134 Transcripts: ENSRNOT00000039221 Prediction methods: Microtar, Miranda, Rnahybrid, Targetscan Result types: miRGate_prediction
1298066 Bp159 Blood pressure QTL 159 0.004 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 13 46088046 91088046 Rat 10755495 Bp387 Blood pressure QTL 387 3.78 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 13 34663461 87525369 Rat 1354655 Bp241 Blood pressure QTL 241 3.9 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 13 56056920 101056920 Rat 8655951 Rf63 Renal function QTL 63 12.2 blood urea nitrogen amount (VT:0005265) plasma urea nitrogen level (CMO:0000586) 13 69060519 77046890 Rat 70220 Bp55 Blood pressure QTL 55 5.75 arterial blood pressure trait (VT:2000000) blood pressure measurement (CMO:0000003) 13 37374509 82374509 Rat 8655945 Rf61 Renal function QTL 61 3.6 blood creatinine amount (VT:0005328) creatinine clearance (CMO:0000765) 13 69060519 86800898 Rat 71119 Thym2 Thymus enlargement QTL 2 3.8 thymus mass (VT:0004954) thymus weight to body weight ratio (CMO:0000612) 13 46197976 84753113 Rat 4889861 Pur29 Proteinuria QTL 29 13.8 0.005 urine total protein amount (VT:0000032) urine total protein excretion rate (CMO:0000756) 13 37415584 80753406 Rat 1331783 Bp221 Blood pressure QTL 221 3.72886 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 13 69060519 86800898 Rat 12879441 Bp396 Blood pressure QTL 396 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 13 45699983 90699983 Rat 2293687 Bss26 Bone structure and strength QTL 26 4.6 0.0001 femur morphology trait (VT:0000559) femur cross-sectional area (CMO:0001661) 13 65103704 106807694 Rat 1300166 Kidm6 Kidney mass QTL 6 3.93 kidney mass (VT:0002707) single kidney wet weight to body weight ratio (CMO:0000622) 13 69060519 86800898 Rat 619615 Bp80 Blood pressure QTL 80 0.0354 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 13 39754544 84754544 Rat 1581570 Eae17 Experimental allergic encephalomyelitis QTL 17 4.1 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046) 13 8897350 101631289 Rat 61340 Bp25 Blood pressure QTL 25 4.2 0.004 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 13 34535218 79535218 Rat 1581573 Uae36 Urinary albumin excretion QTL 36 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) 13 5994833 77046787 Rat 1549897 Stresp12 Stress response QTL 12 3.35 stress-related behavior trait (VT:0010451) number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960) 13 38433408 83433408 Rat 724564 Uae11 Urinary albumin excretion QTL 11 5.7 urine albumin amount (VT:0002871) urine albumin level (CMO:0000130) 13 59492522 77046890 Rat 7207885 Glom27 Glomerulus QTL 27 3.9 kidney glomerulus integrity trait (VT:0010546) kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139) 13 20605871 101339738 Rat 7387280 Uae43 Urinary albumin excretion QTL 43 5.69 0.4174 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) 13 66451204 106807694 Rat 738026 Lnnr5 Liver neoplastic nodule remodeling QTL 5 3.29 liver integrity trait (VT:0010547) liver remodeling tumorous lesion number (CMO:0001461) 13 59874408 85581182 Rat 70181 BpQTLcluster11 Blood pressure QTL cluster 11 6.922 arterial blood pressure trait (VT:2000000) absolute change in mean arterial blood pressure (CMO:0000533) 13 31241331 93395974 Rat 2293702 Bss34 Bone structure and strength QTL 34 4.61 0.0001 femur strength trait (VT:0010010) femur midshaft polar moment of inertia (CMO:0001669) 13 65103704 106807694 Rat 61349 Bp31 Blood pressure QTL 31 5.75 arterial blood pressure trait (VT:2000000) blood pressure measurement (CMO:0000003) 13 37374509 82374509 Rat 2303563 Bw89 Body weight QTL 89 6 body mass (VT:0001259) body weight (CMO:0000012) 13 32284471 77284471 Rat 1354621 Rf47 Renal function QTL 47 3.7 kidney renin amount (VT:0010559) kidney renin level (CMO:0002166) 13 30395351 101056920 Rat 1581554 Pur11 Proteinuria QTL 11 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) 13 5994833 77046787 Rat 12879477 Bp401 Blood pressure QTL 401 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 13 37262092 82262092 Rat 1331750 Bp220 Blood pressure QTL 220 2.98 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005) 13 37415584 82415584 Rat 1641901 Alcrsp6 Alcohol response QTL 6 response to alcohol trait (VT:0010489) duration of loss of righting reflex (CMO:0002289) 13 52362171 97362171 Rat 12879475 Bp400 Blood pressure QTL 400 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 13 61825626 106807694 Rat 1354666 Bp244 Blood pressure QTL 244 4.9 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 13 1 101056920 Rat
Click on a value in the shaded box below the category label to view a detailed expression data table for that system.
alimentary part of gastrointestinal system
9
10
46
98
66
68
37
25
37
6
186
89
81
43
57
31
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Ensembl Acc Id:
ENSRNOT00000039221 ⟹ ENSRNOP00000035225
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source mRatBN7.2 Ensembl 13 73,831,252 - 73,843,169 (+) Ensembl Rnor_6.0 Ensembl 13 79,378,733 - 79,388,498 (+) Ensembl
RefSeq Acc Id:
NM_001398596 ⟹ NP_001385525
RefSeq Status:
VALIDATED
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 13 76,366,853 - 76,376,608 (+) NCBI mRatBN7.2 13 73,833,534 - 73,843,289 (+) NCBI
RefSeq Acc Id:
XM_039091401 ⟹ XP_038947329
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 13 76,366,790 - 76,440,673 (+) NCBI mRatBN7.2 13 73,833,478 - 73,907,249 (+) NCBI
Ensembl Acc Id:
ENSRNOP00000035225 ⟸ ENSRNOT00000039221
RefSeq Acc Id:
XP_038947329 ⟸ XM_039091401
- Peptide Label:
isoform X1
RefSeq Acc Id:
NP_001385525 ⟸ NM_001398596
- UniProtKB:
D4A3I1 (UniProtKB/TrEMBL), A6ID83 (UniProtKB/TrEMBL)
RGD ID: 13698938
Promoter ID: EPDNEW_R9458
Type: multiple initiation site
Name: Tnfsf18_1
Description: TNF superfamily member 18
SO ACC ID: SO:0000170
Source: EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/ )
Experiment Methods: Single-end sequencing.
Position: Rat Assembly Chr Position (strand) Source Rnor_6.0 13 79,378,733 - 79,378,793 EPDNEW
Date
Current Symbol
Current Name
Previous Symbol
Previous Name
Description
Reference
Status
2017-03-21
Tnfsf18
TNF superfamily member 18
Tnfsf18
tumor necrosis factor superfamily member 18
Nomenclature updated to reflect human and mouse nomenclature
1299863
APPROVED
2015-11-25
Tnfsf18
tumor necrosis factor superfamily member 18
Tnfsf18
tumor necrosis factor (ligand) superfamily, member 18
Nomenclature updated to reflect human and mouse nomenclature
1299863
APPROVED
2008-04-30
Tnfsf18
tumor necrosis factor (ligand) superfamily, member 18
Tnfsf18_predicted
tumor necrosis factor (ligand) superfamily, member 18 (predicted)
'predicted' is removed
2292626
APPROVED
2005-01-12
Tnfsf18_predicted
tumor necrosis factor (ligand) superfamily, member 18 (predicted)
Symbol and Name status set to approved
70820
APPROVED