Dlk2 (delta like non-canonical Notch ligand 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Dlk2 (delta like non-canonical Notch ligand 2) Chinchilla lanigera
Analyze
Symbol: Dlk2
Name: delta like non-canonical Notch ligand 2
RGD ID: 9066185
Description: ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN negative regulation of Notch signaling pathway (ortholog); regulation of fat cell differentiation (ortholog); ASSOCIATED WITH genetic disease (ortholog); infantile Refsum disease (ortholog); Zellweger syndrome (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: delta-like 2 homolog (Drosophila)
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554379,297,557 - 9,302,996 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554379,297,557 - 9,302,581 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Dlk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554379,297,557 - 9,302,996 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554379,297,557 - 9,302,581 (-)NCBIChiLan1.0ChiLan1.0
DLK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38643,450,352 - 43,456,632 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl643,450,352 - 43,456,632 (-)EnsemblGRCh38hg38GRCh38
GRCh37643,418,090 - 43,424,370 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36643,526,068 - 43,531,764 (-)NCBINCBI36Build 36hg18NCBI36
Celera644,969,675 - 44,975,371 (-)NCBICelera
Cytogenetic Map6p21.1NCBI
HuRef643,136,572 - 43,142,259 (-)NCBIHuRef
CHM1_1643,421,234 - 43,426,926 (-)NCBICHM1_1
T2T-CHM13v2.0643,279,119 - 43,285,399 (-)NCBIT2T-CHM13v2.0
Dlk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391746,608,342 - 46,614,197 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1746,608,347 - 46,614,197 (+)EnsemblGRCm39 Ensembl
GRCm381746,297,256 - 46,303,271 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1746,297,421 - 46,303,271 (+)EnsemblGRCm38mm10GRCm38
MGSCv371746,434,370 - 46,440,220 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361745,760,792 - 45,766,612 (+)NCBIMGSCv36mm8
Celera1749,730,873 - 49,737,865 (+)NCBICelera
Cytogenetic Map17CNCBI
cM Map1722.9NCBI
Dlk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8922,174,667 - 22,179,149 (-)NCBIGRCr8
mRatBN7.2914,677,102 - 14,681,584 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl914,676,562 - 14,681,594 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx923,261,278 - 23,265,744 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0928,325,037 - 28,329,521 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0926,624,663 - 26,629,129 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0917,061,187 - 17,065,600 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl917,061,190 - 17,065,600 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0915,957,864 - 15,962,277 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4910,239,661 - 10,244,071 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1910,236,979 - 10,247,497 (-)NCBI
Celera912,424,419 - 12,428,829 (-)NCBICelera
Cytogenetic Map9q12NCBI
DLK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2557,950,499 - 57,956,792 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1653,820,314 - 53,828,424 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0643,042,368 - 43,048,661 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1644,333,540 - 44,339,963 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl644,333,540 - 44,339,963 (-)Ensemblpanpan1.1panPan2
DLK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11211,919,718 - 11,924,663 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1211,919,743 - 11,924,656 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1211,945,667 - 11,950,735 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01212,403,023 - 12,408,091 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1212,403,026 - 12,407,565 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11211,928,459 - 11,933,515 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01212,015,566 - 12,020,628 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01212,108,821 - 12,113,884 (-)NCBIUU_Cfam_GSD_1.0
Dlk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494647,415,417 - 47,419,672 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647616,540,853 - 16,546,499 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647616,540,926 - 16,544,785 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DLK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl738,452,618 - 38,457,603 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1738,452,617 - 38,457,632 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2744,034,734 - 44,040,099 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DLK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11728,698,592 - 28,705,204 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604443,512,507 - 43,518,083 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dlk2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475416,172,524 - 16,177,754 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475416,173,269 - 16,177,847 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000019134   ⟹   ENSCLAP00000018949
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554379,297,557 - 9,302,996 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000019135   ⟹   ENSCLAP00000018950
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554379,297,731 - 9,301,665 (-)Ensembl
RefSeq Acc Id: XM_005389766   ⟹   XP_005389823
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554379,297,557 - 9,302,581 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005389767   ⟹   XP_005389824
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554379,297,557 - 9,301,938 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013516814   ⟹   XP_013372268
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554379,297,557 - 9,301,536 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013516815   ⟹   XP_013372269
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554379,297,557 - 9,300,888 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005389823 (Get FASTA)   NCBI Sequence Viewer  
  XP_005389824 (Get FASTA)   NCBI Sequence Viewer  
  XP_013372268 (Get FASTA)   NCBI Sequence Viewer  
  XP_013372269 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000018949
  ENSCLAP00000018949.1
  ENSCLAP00000018950.1
Reference Protein Sequences
RefSeq Acc Id: XP_005389823   ⟸   XM_005389766
- Peptide Label: isoform X2
- UniProtKB: A0A8C2VVD2 (UniProtKB/TrEMBL),   A0A8C2VPZ9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005389824   ⟸   XM_005389767
- Peptide Label: isoform X2
- UniProtKB: A0A8C2VVD2 (UniProtKB/TrEMBL),   A0A8C2VPZ9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013372268   ⟸   XM_013516814
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_013372269   ⟸   XM_013516815
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSCLAP00000018949   ⟸   ENSCLAT00000019134
RefSeq Acc Id: ENSCLAP00000018950   ⟸   ENSCLAT00000019135
Protein Domains
EGF-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000012976 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000019134 ENTREZGENE
  ENSCLAT00000019134.1 UniProtKB/TrEMBL
  ENSCLAT00000019135.1 UniProtKB/TrEMBL
Gene3D-CATH Laminin UniProtKB/TrEMBL
InterPro EGF-like_Ca-bd_dom UniProtKB/TrEMBL
  EGF-like_CS UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/TrEMBL
NCBI Gene Dlk2 ENTREZGENE
PANTHER CRUMBS FAMILY MEMBER UniProtKB/TrEMBL
  PROTEIN CRUMBS HOMOLOG 2 UniProtKB/TrEMBL
Pfam DL-JAG_EGF-like UniProtKB/TrEMBL
  EGF UniProtKB/TrEMBL
  hEGF UniProtKB/TrEMBL
PRINTS EGFBLOOD UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/TrEMBL
  EGF_1 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
SMART EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/TrEMBL
UniProt A0A8C2VPZ9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2VVD2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Dlk2  delta like non-canonical Notch ligand 2    delta-like 2 homolog (Drosophila)  Symbol and/or name change 5135510 APPROVED