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Gene: Farsa (phenylalanyl-tRNA synthetase subunit alpha) Chinchilla lanigera

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Symbol:

Farsa

Name:

phenylalanyl-tRNA synthetase subunit alpha

RGD ID:

9059681

Description:

ENCODES a protein that exhibits phenylalanine-tRNA ligase activity (ortholog); INVOLVED IN phenylalanyl-tRNA aminoacylation (ortholog); protein heterotetramerization (ortholog); PARTICIPATES IN phenylketonuria pathway; tyrosinemia type II pathway; tyrosinemia type III pathway; ASSOCIATED WITH Aicardi-Goutieres Syndrome 4 (ortholog); alpha-mannosidosis (ortholog); Charcot-Marie-Tooth disease dominant intermediate B (ortholog); FOUND IN cytoplasm (ortholog); phenylalanine-tRNA ligase complex (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

phenylalanine--tRNA ligase alpha subunit; phenylalanyl-tRNA synthetase alpha subunit; phenylalanyl-tRNA synthetase, alpha subunit

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955415	31,968,980 - 31,981,424 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955415	31,972,888 - 31,981,424 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Aicardi-Goutieres Syndrome 4 (ISO)

alpha-mannosidosis (ISO)

Charcot-Marie-Tooth disease dominant intermediate B (ISO)

episodic ataxia type 2 (ISO)

glutaric acidemia I (ISO)

Rajab Interstitial Lung Disease with Brain Calcifications 2 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

phenylalanyl-tRNA aminoacylation (ISO)

protein heterotetramerization (ISO)

Cellular Component

cytoplasm (ISO)

phenylalanine-tRNA ligase complex (ISO)

Molecular Function

phenylalanine-tRNA ligase activity (ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

phenylketonuria pathway (ISO)

tyrosinemia type II pathway (ISO)

tyrosinemia type III pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Farsa
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955415	31,968,980 - 31,981,424 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955415	31,972,888 - 31,981,424 (-)	NCBI	ChiLan1.0	ChiLan1.0

FARSA
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	12,922,479 - 12,933,711 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	12,922,479 - 12,934,037 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	13,033,293 - 13,044,525 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	12,894,284 - 12,905,558 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	19	12,894,292 - 12,905,522	NCBI
Celera	19	12,923,020 - 12,934,291 (-)	NCBI		Celera
Cytogenetic Map	19	p13.13	NCBI
HuRef	19	12,605,186 - 12,616,461 (-)	NCBI		HuRef
CHM1_1	19	13,033,781 - 13,045,058 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	19	13,046,966 - 13,058,199 (-)	NCBI		T2T-CHM13v2.0

Farsa
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	85,583,597 - 85,595,886 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	85,583,618 - 85,595,886 (+)	Ensembl		GRCm39 Ensembl
GRCm38	8	84,856,969 - 84,869,257 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	84,856,989 - 84,869,257 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	87,380,885 - 87,393,156 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	87,747,129 - 87,757,131 (+)	NCBI		MGSCv36	mm8
Celera	8	89,156,659 - 89,168,787 (+)	NCBI		Celera
Cytogenetic Map	8	C3	NCBI
cM Map	8	41.23	NCBI

Farsa
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	19	40,196,255 - 40,205,830 (-)	NCBI		GRCr8
mRatBN7.2	19	23,291,409 - 23,300,985 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	23,268,869 - 23,300,980 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	19	30,114,305 - 30,123,855 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	30,768,669 - 30,778,219 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	32,991,355 - 33,000,904 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	19	25,969,255 - 25,978,777 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	25,969,255 - 25,978,776 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	19	36,944,878 - 36,954,400 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	19	24,947,663 - 24,957,186 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	19	24,952,488 - 24,962,012 (-)	NCBI
Celera	19	22,848,305 - 22,857,809 (-)	NCBI		Celera
Cytogenetic Map	19	q11	NCBI

FARSA
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	17,851,642 - 17,863,414 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	16,852,290 - 16,864,068 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	12,484,607 - 12,496,160 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	13,227,193 - 13,238,085 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	13,227,193 - 13,238,244 (-)	Ensembl	panpan1.1		panPan2

FARSA
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	49,258,827 - 49,267,279 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	49,258,845 - 49,267,198 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	49,131,070 - 49,139,532 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	49,775,682 - 49,784,201 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	49,775,704 - 49,819,242 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	48,986,876 - 48,995,337 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	49,413,365 - 49,421,812 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	49,655,888 - 49,664,348 (+)	NCBI		UU_Cfam_GSD_1.0

Farsa
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	208,364,421 - 208,372,363 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936659	1,981,723 - 1,990,322 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936659	1,982,343 - 1,990,277 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FARSA
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	66,105,429 - 66,118,191 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	66,105,393 - 66,114,867 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	66,271,545 - 66,280,456 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

FARSA
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	11,602,352 - 11,613,851 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	11,600,516 - 11,613,345 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666074	8,173,868 - 8,185,230 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Farsa
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624901	492,817 - 505,911 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624901	492,673 - 505,815 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005381042	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01016704	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBCE01076932	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000022792 ⟹ ENSCLAP00000022584

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955415	31,968,980 - 31,981,424 (-)	Ensembl

RefSeq Acc Id:

XM_005381042 ⟹ XP_005381099

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955415	31,972,888 - 31,981,424 (-)	NCBI

Sequence:

show sequence

GGGCTGGGGCCTGGATTTGCAGGACGTACTGGGAACAGTCATGGCGGATGGTCCTGTGGCGGAG
CAATTGCTTCGGCGGTTGGAGGTGGCAGATGGCGGCCTGGACAGCGCGGACCTAGCGACCCAGC
TGAACGTGGAGCATCAGGTGGTGGTGGGCGCCGTGAAGAGCCTGCAGGCTCTAGGCGAGGTCAT
CGAGGCTGAGCTTCGCTCCACCAAGCGCTGGGAACTGACCGCTGAGGGTGAGGAGATTGCCCGG
GAGGGCAGCCATGAGGTGCGTGTGTTCCGCAGCATCCCCCCGGAGGGCCTGGCCCAAAGCGAGC
TCGTGCACCTGCCCAGCGGCAAGGTGGGTTTTAGCAAGGCCATGTCCAACAAGTGGATCCGCGT
GGACAAGAGCGCGGCTGACGGGCCTCGGGTGTTCCGAGTGGTGGACAAGGTAGAAGATGAGGTG
CAGCGGCGGCTCCAGCTCATCCAGGGAGGCCAGGCTGAAAAGCTGAGCGAGAAGGAGAGGAGCG
AGCTCCGGAAGAGGAAGTTGTTGACTGAAGTGACCTTGAAGACCTACTGGGTGAGCAAGGGCAG
CGCCTTCAGCACCAGTGTCTCCAAGCAGGAGACGGAACTGAGCCCAGAGATGATCACCAGTGGC
TCCTGGCGAGACCAGCCCTTCAAACCCTACAACTTCTCAGCCCGTGGCGTGCTCCCGGACAGTG
GCCACCTGCACCCGCTGCTTAAGGTCCGCTCCCAGTTCCGCCAGATCTTCCTGGAGATGGGGTT
CACCGAGATGCCCACCGACAACTTCATTGAGAGCTCCTTCTGGAACTTCGACGCGCTCTTCCAG
CCACAGCAACACCCTGCACGTGACCAGCATGACACCTTCTTCCTGCAAGACCCGGCCGACGCCC
TGCAGCTCCCCATGGACTACGTCCACCGGGTCAAGCGGACCCACGCACAGGGCGGCTACGGCTC
TCAGGGGTACAAGTACAGCTGGCGCCTGGACGAGGCCCGGAAGAACGTGTTGCGCACCCACACC
ACGGCAGCCAGCGCCCGTGCCCTTTACCGCCTGGCACAGAAGAAGCCGTTCACACCCGTCAAGT
ACTTCTCCATTGATCGTGTGTTCCGCAATGAGACGCTGGATGCCACGCACCTGGCCGAGTTCCA
CCAGATTGAGGGAGTGGTGGCCGACCACGGGCTCACGCTGGGCCACCTCATGGGCGTCCTGCGC
GAGTTCTTCAGCAAGCTGGGCATCACCCAGCTGCGCTTCAAGCCGGCCTACAACCCCTACACGG
AGCCCAGCATGGAGGTGTTCAGCTACCACCAGGGCCTGAAGAAGTGGGTGGAGGTCGGGAACTC
CGGGCTCTTCCGCCCTGAGATGCTGCTGCCCATGGGACTGCCCGAGAACGTGTCTGTCATTGCC
TGGGGCCTCTCCCTGGAGCGCCCGACCATGATCAAGTACGGCATCAACAACATCCGGGAGCTGG
TGGGCCACAAAGTGAACCTGCAGATGGTCTACGACAGTCCCCTGTGCCGCCTGGATGTGGAGCC
CAGGCCCCAGAGGACGCAGGCCGCCGCTTGACCCTAGCTGCCCCACCATCACCGGTGACCCCTT
GTATTTATGAGGCCTCTGTGAGGCCAGCCACCCTCAGCCAGGACCAGGGTTCCAGGACTGGGAA
GCAGGCAACATAATAAAGCAAGCAGTTGTCCTCA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005381099	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000022584
	ENSCLAP00000022584.1

RefSeq Acc Id:

XP_005381099 ⟸ XM_005381042

- UniProtKB:

A0A8C2W5L3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MADGPVAEQLLRRLEVADGGLDSADLATQLNVEHQVVVGAVKSLQALGEVIEAELRSTKRWELT
AEGEEIAREGSHEVRVFRSIPPEGLAQSELVHLPSGKVGFSKAMSNKWIRVDKSAADGPRVFRV
VDKVEDEVQRRLQLIQGGQAEKLSEKERSELRKRKLLTEVTLKTYWVSKGSAFSTSVSKQETEL
SPEMITSGSWRDQPFKPYNFSARGVLPDSGHLHPLLKVRSQFRQIFLEMGFTEMPTDNFIESSF
WNFDALFQPQQHPARDQHDTFFLQDPADALQLPMDYVHRVKRTHAQGGYGSQGYKYSWRLDEAR
KNVLRTHTTAASARALYRLAQKKPFTPVKYFSIDRVFRNETLDATHLAEFHQIEGVVADHGLTL
GHLMGVLREFFSKLGITQLRFKPAYNPYTEPSMEVFSYHQGLKKWVEVGNSGLFRPEMLLPMGL
PENVSVIAWGLSLERPTMIKYGINNIRELVGHKVNLQMVYDSPLCRLDVEPRPQRTQAAA

hide sequence

Ensembl Acc Id:

ENSCLAP00000022584 ⟸ ENSCLAT00000022792

Protein Domains

Aminoacyl-transfer RNA synthetases class-II family

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000015489	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000022792	ENTREZGENE
	ENSCLAT00000022792.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.10.2320	UniProtKB/TrEMBL
	1.10.10.2330	UniProtKB/TrEMBL
	3.30.1370.240	UniProtKB/TrEMBL
InterPro	aa-tRNA-synth_II	UniProtKB/TrEMBL
	aa-tRNA-synth_II/BPL/LPL	UniProtKB/TrEMBL
	Phe-tRNA-synth_IIc_asu	UniProtKB/TrEMBL
	Phenylalanyl-tRNA_Synthase	UniProtKB/TrEMBL
	PheRS_DBD1	UniProtKB/TrEMBL
	PheRS_DBD2	UniProtKB/TrEMBL
	PheRS_DBD3	UniProtKB/TrEMBL
	WH_DNA-bd_sf	UniProtKB/TrEMBL
NCBI Gene	Farsa	ENTREZGENE
PANTHER	PHENYLALANINE--TRNA LIGASE ALPHA SUBUNIT	UniProtKB/TrEMBL
	PHENYLALANYL-TRNA SYNTHETASE	UniProtKB/TrEMBL
Pfam	PheRS_DBD1	UniProtKB/TrEMBL
	PheRS_DBD2	UniProtKB/TrEMBL
	PheRS_DBD3	UniProtKB/TrEMBL
	tRNA-synt_2d	UniProtKB/TrEMBL
PROSITE	AA_TRNA_LIGASE_II	UniProtKB/TrEMBL
Superfamily-SCOP	SSF46785	UniProtKB/TrEMBL
	SSF55681	UniProtKB/TrEMBL
UniProt	A0A8C2W5L3	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-05-01	Farsa	phenylalanyl-tRNA synthetase subunit alpha		phenylalanyl-tRNA synthetase alpha subunit	Symbol and/or name change	5135510	APPROVED
2016-08-16	Farsa	phenylalanyl-tRNA synthetase alpha subunit		phenylalanyl-tRNA synthetase, alpha subunit	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB