Angptl3 (angiopoietin like 3) - Rat Genome Database

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Gene: Angptl3 (angiopoietin like 3) Chinchilla lanigera
Analyze
Symbol: Angptl3
Name: angiopoietin like 3
RGD ID: 9032997
Description: ENCODES a protein that exhibits enzyme inhibitor activity (ortholog); growth factor activity (ortholog); integrin binding (ortholog); INVOLVED IN acylglycerol homeostasis (ortholog); artery morphogenesis (ortholog); cell-matrix adhesion (ortholog); PARTICIPATES IN lipid metabolic pathway; ASSOCIATED WITH congenital disorder of glycosylation It (ortholog); developmental and epileptic encephalopathy 23 (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN cell surface (ortholog); early endosome (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: angiopoietin-like 3; angiopoietin-related protein 3
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542327,109,962 - 27,121,276 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542327,113,378 - 27,121,339 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Angptl3ChinchillaExperimental Diabetes Mellitus  ISORGD:15576829068941protein:increased expression:liverRGDPMID:15094378|REF_RGD_ID:2314234
Angptl3ChinchillaHypertriglyceridemia  ISORGD:15576829068941 RGDPMID:12672813|REF_RGD_ID:1578347
Angptl3Chinchillatype 2 diabetes mellitus  ISORGD:15576829068941protein:increased expression:liverRGDPMID:15094378|REF_RGD_ID:2314234
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Angptl3Chinchillacongenital disorder of glycosylation It  ISORGD:13462608554872ClinVar Annotator: match by term: PGM1-congenital disorder of glycosylationClinVarPMID:28492532
Angptl3Chinchilladevelopmental and epileptic encephalopathy 23  ISORGD:13462608554872ClinVar Annotator: match by term: Developmental and epileptic encephalopathy, 23ClinVarPMID:22247256|PMID:24814191|PMID:25741868|PMID:28492532
Angptl3Chinchillafamilial hypobetalipoproteinemia 2  ISORGD:13462608554872ClinVar Annotator: match by term: ANGPTL3-related condition | ClinVar Annotator: match by term: Familial hypobetalipoproteinemia more ...ClinVarPMID:19075393|PMID:20942659|PMID:22062970|PMID:22247256|PMID:25741868|PMID:28492532|PMID:32041611
Angptl3Chinchillagenetic disease  ISORGD:13462608554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:28492532|PMID:32041611
Angptl3Chinchillaintellectual disability  ISORGD:13462608554872ClinVar Annotator: match by term: Intellectual disability, severeClinVarPMID:25741868
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Angptl3ChinchillaExperimental Liver Cirrhosis  ISORGD:13462609068941CTD Direct Evidence: marker/mechanismCTDPMID:25380136
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Angptl3Chinchillafamilial hypobetalipoproteinemia 2  ISORGD:13462607240710 OMIM 


Biological Process
1 to 20 of 25 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Angptl3Chinchillaacylglycerol homeostasis involved_inISORGD:15576829068941 PMID:17110602BHF-UCLPMID:17110602
Angptl3Chinchillaacylglycerol homeostasis involved_inISORGD:13462609068941 PMID:17110602BHF-UCLPMID:17110602
Angptl3Chinchillaartery morphogenesis involved_inISORGD:15576829068941 PMID:12671033BHF-UCLPMID:12671033
Angptl3Chinchillacell-matrix adhesion involved_inISOUniProtKB:P067569068941 PMID:11877390UniProtPMID:11877390
Angptl3Chinchillacholesterol homeostasis involved_inISORGD:15576829068941 PMID:17110602BHF-UCLPMID:17110602
Angptl3Chinchillacholesterol homeostasis involved_inISORGD:13462609068941 PMID:17110602BHF-UCLPMID:17110602
Angptl3Chinchillacholesterol metabolic process involved_inISORGD:13462609068941 PMID:17110602BHF-UCLPMID:17110602
Angptl3Chinchillafatty acid metabolic process involved_inISORGD:13462609068941 PMID:12565906BHF-UCLPMID:12565906
Angptl3Chinchillaglycerol metabolic process involved_inISORGD:13462609068941 PMID:12565906BHF-UCLPMID:12565906
Angptl3Chinchillalipid homeostasis involved_inISORGD:13462609068941 PMID:17110602BHF-UCLPMID:17110602
Angptl3Chinchillalipid storage involved_inISORGD:13462609068941 PMID:12565906BHF-UCLPMID:12565906
Angptl3Chinchillanegative regulation of very-low-density lipoprotein particle remodeling involved_inISORGD:13462609068941 PMID:19542565BHF-UCLPMID:19542565
Angptl3Chinchillaobsolete negative regulation of phospholipase activity involved_inISORGD:15576829068941 PMID:17110602BHF-UCLPMID:17110602
Angptl3Chinchillaphospholipid catabolic process involved_inISORGD:13462609068941 PMID:17110602BHF-UCLPMID:17110602
Angptl3Chinchillaphospholipid homeostasis involved_inISORGD:13462609068941 PMID:17110602BHF-UCLPMID:17110602
Angptl3Chinchillaphospholipid homeostasis involved_inISORGD:15576829068941 PMID:17110602BHF-UCLPMID:17110602
Angptl3Chinchillaphospholipid metabolic process involved_inISORGD:13462609068941 PMID:17110602BHF-UCLPMID:17110602
Angptl3Chinchillapositive regulation of angiogenesis involved_inISORGD:13462609068941 PMID:11877390UniProtPMID:11877390
Angptl3Chinchillapositive regulation of cell migration involved_inISORGD:13462609068941 PMID:11877390UniProtPMID:11877390
Angptl3Chinchillapositive regulation of lipid catabolic process involved_inISORGD:13462609068941 PMID:12565906BHF-UCLPMID:12565906
1 to 20 of 25 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Angptl3Chinchillacell surface located_inISORGD:13462609068941 PMID:12565906BHF-UCLPMID:12565906
Angptl3Chinchillacell surface located_inISORGD:15576829068941 PMID:23918928MGIPMID:23918928
Angptl3Chinchillaearly endosome located_inISORGD:15576829068941 PMID:23918928MGIPMID:23918928
Angptl3Chinchillaextracellular space located_inISORGD:13462609068941 PMID:17110602BHF-UCLPMID:17110602
Angptl3ChinchillaGolgi apparatus located_inISORGD:15576829068941 PMID:23918928MGIPMID:23918928

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Angptl3Chinchillaenzyme inhibitor activity enablesISORGD:15576829068941 PMID:12097324UniProtPMID:12097324
Angptl3Chinchillagrowth factor activity enablesISORGD:13462609068941 PMID:11877390BHF-UCLPMID:11877390
Angptl3Chinchillaintegrin binding enablesISOUniProtKB:P067569068941 PMID:11877390UniProtPMID:11877390
Angptl3Chinchillalipase binding enablesISOUniProtKB:P068589068941 PMID:19542565BHF-UCLPMID:19542565
Angptl3Chinchillalipase inhibitor activity enablesISORGD:13462609068941 PMID:17110602, PMID:19542565BHF-UCLPMID:17110602|PMID:19542565
Angptl3Chinchillaphospholipase inhibitor activity enablesISORGD:13462609068941 PMID:17110602BHF-UCLPMID:17110602

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Angptl3Chinchillalipid metabolic pathway  ISORGD:13462609068941 RGDPMID:12909640|REF_RGD_ID:1578346

#
Reference Title
Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
PMID:30032202  



Angptl3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542327,109,962 - 27,121,276 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542327,113,378 - 27,121,339 (-)NCBIChiLan1.0ChiLan1.0
ANGPTL3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38162,597,520 - 62,606,313 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl162,597,520 - 62,606,313 (+)EnsemblGRCh38hg38GRCh38
GRCh37163,063,191 - 63,071,984 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36162,835,775 - 62,843,768 (+)NCBINCBI36Build 36hg18NCBI36
Build 34162,775,207 - 62,783,201NCBI
Celera161,352,392 - 61,360,385 (+)NCBICelera
Cytogenetic Map1p31.3NCBI
HuRef161,175,226 - 61,184,044 (+)NCBIHuRef
CHM1_1163,178,532 - 63,187,341 (+)NCBICHM1_1
T2T-CHM13v2.0162,476,065 - 62,484,858 (+)NCBIT2T-CHM13v2.0
Angptl3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39498,919,191 - 98,926,429 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl498,919,191 - 98,934,348 (+)EnsemblGRCm39 Ensembl
GRCm38499,030,954 - 99,038,192 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl499,030,954 - 99,046,111 (+)EnsemblGRCm38mm10GRCm38
MGSCv37498,697,646 - 98,704,879 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36498,523,006 - 98,530,045 (+)NCBIMGSCv36mm8
Celera497,401,867 - 97,409,102 (+)NCBICelera
Cytogenetic Map4C6NCBI
cM Map445.6NCBI
Angptl3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85118,818,494 - 118,825,531 (+)NCBIGRCr8
mRatBN7.25113,703,007 - 113,710,044 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5113,703,012 - 113,709,957 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5116,277,032 - 116,284,068 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05118,002,370 - 118,009,406 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05118,064,903 - 118,071,939 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05117,698,590 - 117,706,729 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5117,698,764 - 117,705,808 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05121,639,555 - 121,647,526 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45119,479,669 - 119,484,358 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera5112,263,891 - 112,268,719 (+)NCBICelera
Cytogenetic Map5q33NCBI
ANGPTL3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21164,233,352 - 164,254,549 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11163,393,857 - 163,403,865 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0161,855,870 - 61,863,476 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1163,670,516 - 63,679,194 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl163,670,516 - 63,679,194 (+)Ensemblpanpan1.1panPan2
ANGPTL3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1547,524,390 - 47,532,931 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl547,525,365 - 47,532,899 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha547,585,756 - 47,594,294 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0547,709,313 - 47,717,848 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl547,709,323 - 47,717,810 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1547,663,840 - 47,672,380 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0547,609,996 - 47,618,532 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0547,872,446 - 47,880,983 (-)NCBIUU_Cfam_GSD_1.0
Angptl3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505875,971,228 - 75,979,701 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936692286,717 - 294,822 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936692286,432 - 295,021 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ANGPTL3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6149,832,542 - 149,845,831 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16149,836,417 - 149,845,854 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26138,100,831 - 138,111,284 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ANGPTL3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12070,452,771 - 70,461,590 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2070,449,227 - 70,460,469 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603346,993,590 - 47,002,411 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Angptl3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474231,260,611 - 31,270,122 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474231,261,719 - 31,269,877 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.





RefSeq Transcripts XM_005385334 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AGCD01024115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GBCQ01000094 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSCLAT00000017349   ⟹   ENSCLAP00000017180
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495542327,109,962 - 27,121,276 (-)Ensembl
RefSeq Acc Id: XM_005385334   ⟹   XP_005385391
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542327,113,378 - 27,121,339 (-)NCBI
Sequence:
Protein RefSeqs XP_005385391 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000017180
  ENSCLAP00000017180.1
RefSeq Acc Id: XP_005385391   ⟸   XM_005385334
- UniProtKB: A0A8C2VN29 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000017180   ⟸   ENSCLAT00000017349
Fibrinogen C-terminal



1 to 16 of 16 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSCLAG00000011792 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000017349 ENTREZGENE
  ENSCLAT00000017349.1 UniProtKB/TrEMBL
Gene3D-CATH 3.90.215.10 UniProtKB/TrEMBL
InterPro Fibrinogen-like_C UniProtKB/TrEMBL
  Fibrinogen_a/b/g_C_1 UniProtKB/TrEMBL
  Fibrinogen_a/b/g_C_dom UniProtKB/TrEMBL
  Fibrinogen_C-term_domain UniProtKB/TrEMBL
NCBI Gene Angptl3 ENTREZGENE
PANTHER ANGIOPOIETIN-RELATED PROTEIN 3 UniProtKB/TrEMBL
  FIBRINOGEN/TENASCIN/ANGIOPOEITIN UniProtKB/TrEMBL
Pfam Fibrinogen_C UniProtKB/TrEMBL
PROSITE FIBRINOGEN_C_2 UniProtKB/TrEMBL
SMART FBG UniProtKB/TrEMBL
Superfamily-SCOP SSF56496 UniProtKB/TrEMBL
UniProt A0A8C2VN29 ENTREZGENE, UniProtKB/TrEMBL
1 to 16 of 16 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-16 Angptl3  angiopoietin like 3    angiopoietin-like 3  Symbol and/or name change 5135510 APPROVED