Angptl3 (angiopoietin like 3) - Rat Genome Database

Name: Angptl3
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Angptl3 (angiopoietin like 3) Ictidomys tridecemlineatus

Analyze

Symbol:

Angptl3

Name:

angiopoietin like 3

RGD ID:

12579196

Description:

ENCODES a protein that exhibits enzyme inhibitor activity (inferred); growth factor activity (inferred); integrin binding (inferred); INVOLVED IN response to hormone (ortholog); triglyceride homeostasis (ortholog); PARTICIPATES IN lipid metabolic pathway; ASSOCIATED WITH developmental and epileptic encephalopathy 23 (ortholog); Experimental Diabetes Mellitus (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN cell surface (inferred); collagen-containing extracellular matrix (inferred); early endosome (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

angiopoietin-related protein 3

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ANGPTL3 (angiopoietin like 3)	NCBI	Ortholog
Mus musculus (house mouse):	Angptl3 (angiopoietin-like 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Angptl3 (angiopoietin-like 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Angptl3 (angiopoietin like 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ANGPTL3 (angiopoietin like 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ANGPTL3 (angiopoietin like 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ANGPTL3 (angiopoietin like 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ANGPTL3 (angiopoietin like 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Angptl3 (angiopoietin like 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	75,971,228 - 75,979,701 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936692	286,717 - 294,822 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936692	286,432 - 295,021 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

developmental and epileptic encephalopathy 23 (ISO)

Experimental Diabetes Mellitus (ISO)

Experimental Liver Cirrhosis (ISO)

familial hypobetalipoproteinemia 2 (ISO)

genetic disease (ISO)

Hypertriglyceridemia (ISO)

intellectual disability (ISO)

type 2 diabetes mellitus (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

acylglycerol homeostasis (IEA)

artery morphogenesis (IEA)

cell-matrix adhesion (IEA)

cholesterol homeostasis (IEA)

cholesterol metabolic process (IEA)

fatty acid metabolic process (IEA)

glycerol metabolic process (IEA)

lipid homeostasis (IEA)

lipid storage (IEA)

phospholipid catabolic process (IEA)

phospholipid homeostasis (IEA)

phospholipid metabolic process (IEA)

positive regulation of angiogenesis (IEA)

positive regulation of cell migration (IEA)

positive regulation of lipid catabolic process (IEA)

response to hormone (ISO)

signal transduction (IEA)

triglyceride homeostasis (IEA,ISO)

Cellular Component

cell surface (IEA)

collagen-containing extracellular matrix (IEA)

early endosome (IEA)

extracellular space (IEA)

Golgi apparatus (IEA)

Molecular Function

enzyme inhibitor activity (IEA)

growth factor activity (IEA)

integrin binding (IEA)

phospholipase inhibitor activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

lipid metabolic pathway (ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Angptl3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	75,971,228 - 75,979,701 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936692	286,717 - 294,822 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936692	286,432 - 295,021 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ANGPTL3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	62,597,520 - 62,606,313 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	62,597,520 - 62,606,313 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	63,063,191 - 63,071,984 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	62,835,775 - 62,843,768 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	62,775,207 - 62,783,201	NCBI
Celera	1	61,352,392 - 61,360,385 (+)	NCBI		Celera
Cytogenetic Map	1	p31.3	NCBI
HuRef	1	61,175,226 - 61,184,044 (+)	NCBI		HuRef
CHM1_1	1	63,178,532 - 63,187,341 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	62,476,065 - 62,484,858 (+)	NCBI		T2T-CHM13v2.0

Angptl3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	98,919,191 - 98,926,429 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	98,919,191 - 98,934,348 (+)	Ensembl		GRCm39 Ensembl
GRCm38	4	99,030,954 - 99,038,192 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	99,030,954 - 99,046,111 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	98,697,646 - 98,704,879 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	98,523,006 - 98,530,045 (+)	NCBI		MGSCv36	mm8
Celera	4	97,401,867 - 97,409,102 (+)	NCBI		Celera
Cytogenetic Map	4	C6	NCBI
cM Map	4	45.6	NCBI

Angptl3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	118,818,494 - 118,825,531 (+)	NCBI		GRCr8
mRatBN7.2	5	113,703,007 - 113,710,044 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	113,703,012 - 113,709,957 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	116,277,032 - 116,284,068 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	118,002,370 - 118,009,406 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	118,064,903 - 118,071,939 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	117,698,590 - 117,706,729 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	117,698,764 - 117,705,808 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	121,639,555 - 121,647,526 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	119,479,669 - 119,484,358 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	5	112,263,891 - 112,268,719 (+)	NCBI		Celera
Cytogenetic Map	5	q33	NCBI

Angptl3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955423	27,109,962 - 27,121,276 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955423	27,113,378 - 27,121,339 (-)	NCBI	ChiLan1.0	ChiLan1.0

ANGPTL3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	164,233,352 - 164,254,549 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	163,393,857 - 163,403,865 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	61,855,870 - 61,863,476 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	63,670,516 - 63,679,194 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	63,670,516 - 63,679,194 (+)	Ensembl	panpan1.1		panPan2

ANGPTL3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	47,524,390 - 47,532,931 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	47,525,365 - 47,532,899 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	47,585,756 - 47,594,294 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	47,709,313 - 47,717,848 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	47,709,323 - 47,717,810 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	47,663,840 - 47,672,380 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	47,609,996 - 47,618,532 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	47,872,446 - 47,880,983 (-)	NCBI		UU_Cfam_GSD_1.0

ANGPTL3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	149,832,542 - 149,845,831 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	149,836,417 - 149,845,854 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	138,100,831 - 138,111,284 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ANGPTL3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	70,452,771 - 70,461,590 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	70,449,227 - 70,460,469 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666033	46,993,590 - 47,002,411 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Angptl3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624742	31,260,611 - 31,270,122 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624742	31,261,719 - 31,269,877 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005337706	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000117	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000005069 ⟹ ENSSTOP00000004549

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936692	286,717 - 294,822 (+)	Ensembl

RefSeq Acc Id:

XM_005337706 ⟹ XP_005337763

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405058	75,971,228 - 75,979,701 (+)	NCBI
SpeTri2.0	NW_004936692	286,432 - 295,021 (+)	NCBI

Sequence:

show sequence

AAAAGTCAACCCCTTAACACTCAAAGCACAGTTTACAATACAGCAAATAATTTGAAATTACTTA
TTAAGTTAGTTGCTCATTTCCTTGATTTTACTTAATATTGATGTAACTCAATGTGAAAGGTTAC
ATTTGTGCAAGTTAACAGAGCTTAACGATTAACTATATTCCCTTGCCAACCTTACTGTTTATAT
AGCAAATAGTGGTATATATAAAGAAGTCTAGGTATGCTTATGGGAGAAAAATAGTTCCAAATTG
CTTAAAATTGAATAATTGGGGTAAAAATGTACAAAATTAAGCTCTTTCTTTTTATAGTTCCTCT
AGTTATTTGTTCCAGAATTGATCAAGACAATTCATCATTTGATTCTATATCTTCAGAACCAAAA
TCAAGATTTGCTATGCTAGATGATGTAAAAATTTTAGCGAATGGCCTCCTTCAGTTGGGACATG
GTCTTAAAGATTTTGTCCATAAGACTAAGGGCCAAATTAATGATATATTTCAAAAACTAAACAT
ATTTGATCAATCTTTTTATGATCTATCACTACAAACTAATGAAATCAAAGAAGAAGAAAAGGAA
TTAAGAAGAACTACATCCAAATTACAAGTCAAAAATGAAGAGGTAAAAAATATGTCACTTGAAC
TCAACTCAAAACTTGAAAGCCTCCTAGAAGAAAAAATTCTACTACAGCACAAAGTGAGATATTT
GGAGGAACAATTAACTAATTTAATTCAAAATCAACCTGAAATTCAGGAACATCCAGAAGTAACT
TCACTTAAGACTTTTGTAGAACAGCAAGATAATAGCATCAAAGACCTTCTCCAGACTGTGGAAG
AGCAATATAAACAATTAAACCAACAGCACAGTCAAATAAAAGAAATAGAAAATCAGCTCAGAAG
GACTGGAATTCAAGAACCCACAGAAAATTCACTTTCTTCCAAATCAAGAGCACCAAGAACTACT
CCCCCTCTGCAGCTGAATGAAACAAAAAATACAGAACAAGATGGCATTCCTGCTGATTGTTCCG
ACATTTATAAAAGAGGTGAACGTACAAGTGGCATATATACCATTAGACCAAGCAACTCACAAGC
TTTTGACGTCTACTGTGAAGTTAAATCAGGTAATCCATGGACCTTAATTCAACACCGAATAGAT
GGATCACAAAACTTCAATGAAACATGGGAGAACTACAGAAATGGTTTTGGGAGACTTGATGGAG
AATTTTGGTTGGGCCTAGAGAAAATATATTCCATAGTGAAAACATCTAATTACATTTTACAATT
TGAGCTAGAAGACTGGAAAGACAACAAGCATTATATTGAGTATTCTTTTCACTTGGGAAATCAT
GAAACCAACTACACACTACATCTAGTTGAGATTGCTGGAAATGTCCCCAAGTCACTCCCAGAAC
ACAGGGATTTGACGTTTTCTACGTGGGATCACAAAGCAAAAGGACACTCCAACTGTCCAGAAAT
GTATTCAGGAGGCTGGTGGTGGCATCATGTATGTGGAGAAAACAACCTAAATGGAAAATATAAT
AAACCAAGAGCAAAATCTAAGCCAGAGAAGAGAAGAGGAATATACTGGAGGTCTCAAAATGGAA
GGTTATACTCTATCAAATCAACCAAAATCTTAATCCATCCAGTAGATTCAGAAAGCTTTGAATG
AACTGAAGCAAACCAAAAAGCCAATAAATTAAACATTAAACTCATCCCAAGTTACTGTGGTTTA
ATAATCTGGTATTAAATTCTTAATGGAAGCCTTGAGAAAATTTTCATTTTAAAGTCACTATCAA
TTTAAATTAAACATCATCACATCACTCAAAGAATAACATTTTTCTCAACCAAAATTCT

hide sequence

Protein Sequences


Protein RefSeqs	XP_005337763	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000004549.3
GenBank Protein	KAG3283298	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005337763 ⟸ XM_005337706

- UniProtKB:

I3M5E9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MYKIKLFLFIVPLVICSRIDQDNSSFDSISSEPKSRFAMLDDVKILANGLLQLGHGLKDFVHKT
KGQINDIFQKLNIFDQSFYDLSLQTNEIKEEEKELRRTTSKLQVKNEEVKNMSLELNSKLESLL
EEKILLQHKVRYLEEQLTNLIQNQPEIQEHPEVTSLKTFVEQQDNSIKDLLQTVEEQYKQLNQQ
HSQIKEIENQLRRTGIQEPTENSLSSKSRAPRTTPPLQLNETKNTEQDGIPADCSDIYKRGERT
SGIYTIRPSNSQAFDVYCEVKSGNPWTLIQHRIDGSQNFNETWENYRNGFGRLDGEFWLGLEKI
YSIVKTSNYILQFELEDWKDNKHYIEYSFHLGNHETNYTLHLVEIAGNVPKSLPEHRDLTFSTW
DHKAKGHSNCPEMYSGGWWWHHVCGENNLNGKYNKPRAKSKPEKRRGIYWRSQNGRLYSIKSTK
ILIHPVDSESFE

hide sequence

RefSeq Acc Id:

ENSSTOP00000004549 ⟸ ENSSTOT00000005069

Protein Domains

Fibrinogen C-terminal

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000005071	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000005069.3	UniProtKB/TrEMBL
Gene3D-CATH	3.90.215.10	UniProtKB/TrEMBL
InterPro	Fibrinogen-like_C	UniProtKB/TrEMBL
	Fibrinogen_a/b/g_C_1	UniProtKB/TrEMBL
	Fibrinogen_a/b/g_C_dom	UniProtKB/TrEMBL
NCBI Gene	Angptl3	ENTREZGENE
PANTHER	ANGIOPOIETIN-RELATED PROTEIN 3	UniProtKB/TrEMBL
	FIBRINOGEN/TENASCIN/ANGIOPOEITIN	UniProtKB/TrEMBL
Pfam	Fibrinogen_C	UniProtKB/TrEMBL
PROSITE	FIBRINOGEN_C_2	UniProtKB/TrEMBL
SMART	FBG	UniProtKB/TrEMBL
Superfamily-SCOP	SSF56496	UniProtKB/TrEMBL
UniProt	I3M5E9	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

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Imported Disease Annotations - CTD

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