Slf1 (SMC5-SMC6 complex localization factor 1) - Rat Genome Database

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Gene: Slf1 (SMC5-SMC6 complex localization factor 1) Chinchilla lanigera
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Symbol: Slf1
Name: SMC5-SMC6 complex localization factor 1
RGD ID: 9018215
Description: ENCODES a protein that exhibits protein-containing complex binding (ortholog); ubiquitin protein ligase binding (ortholog); INVOLVED IN DNA damage response (ortholog); positive regulation of double-strand break repair (ortholog); positive regulation of maintenance of mitotic sister chromatid cohesion (ortholog); ASSOCIATED WITH familial adenomatous polyposis 1 (ortholog); Hereditary Neoplastic Syndromes (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN centrosome (ortholog); cytoplasm (ortholog); nuclear inclusion body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Ankrd32; ankyrin repeat domain 32; ankyrin repeat domain-containing protein 32
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541817,756,861 - 17,810,663 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541817,756,610 - 17,818,552 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Slf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541817,756,861 - 17,810,663 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541817,756,610 - 17,818,552 (-)NCBIChiLan1.0ChiLan1.0
SLF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38594,618,231 - 94,697,621 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl594,618,669 - 94,739,436 (+)EnsemblGRCh38hg38GRCh38
GRCh37593,954,374 - 94,033,326 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36594,040,330 - 94,057,338 (+)NCBINCBI36Build 36hg18NCBI36
Build 34594,040,329 - 94,057,110NCBI
Celera589,816,284 - 89,893,469 (+)NCBICelera
Cytogenetic Map5q15NCBI
HuRef589,127,664 - 89,204,854 (+)NCBIHuRef
CHM1_1593,387,020 - 93,464,202 (+)NCBICHM1_1
T2T-CHM13v2.0595,098,399 - 95,182,005 (+)NCBIT2T-CHM13v2.0
Slf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391377,191,207 - 77,283,632 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1377,191,207 - 77,283,592 (-)EnsemblGRCm39 Ensembl
GRCm381377,043,088 - 77,135,513 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1377,043,088 - 77,135,473 (-)EnsemblGRCm38mm10GRCm38
MGSCv371377,182,349 - 77,274,729 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361377,506,638 - 77,554,806 (-)NCBIMGSCv36mm8
Celera1379,368,270 - 79,463,257 (-)NCBICelera
Cytogenetic Map13C1NCBI
cM Map1340.98NCBI
Slf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr828,498,776 - 8,606,251 (-)NCBIGRCr8
mRatBN7.226,767,015 - 6,874,428 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl26,767,015 - 6,867,149 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx213,879,067 - 13,986,283 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0211,978,347 - 12,085,564 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.026,613,410 - 6,719,621 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.024,095,126 - 4,195,819 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl24,095,129 - 4,195,810 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.024,092,109 - 4,193,740 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.424,361,776 - 4,469,805 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.124,436,397 - 4,492,122 (-)NCBI
Celera23,225,433 - 3,326,221 (-)NCBICelera
Cytogenetic Map2q11NCBI
SLF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2420,684,529 - 20,782,033 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1518,838,281 - 18,935,816 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0520,660,101 - 20,757,072 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1520,817,614 - 20,894,427 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl520,817,614 - 20,884,453 (-)Ensemblpanpan1.1panPan2
SLF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1314,792,851 - 14,877,024 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl314,793,363 - 14,869,755 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha316,131,131 - 16,215,470 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0314,672,489 - 14,756,866 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl314,670,381 - 14,744,679 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1314,635,334 - 14,719,686 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0314,633,850 - 14,718,174 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0314,837,537 - 14,921,894 (-)NCBIUU_Cfam_GSD_1.0
Slf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213170,378,075 - 170,449,166 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365238,563,410 - 8,634,585 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365238,563,662 - 8,634,576 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2101,313,091 - 101,375,607 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12101,286,744 - 101,375,612 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22104,867,972 - 104,919,338 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1488,497,787 - 88,573,966 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl488,499,373 - 88,576,983 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604937,141,458 - 37,236,741 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474313,337,785 - 13,395,618 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474313,327,544 - 13,394,434 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000007455   ⟹   ENSCLAP00000007338
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495541817,756,861 - 17,810,663 (-)Ensembl
RefSeq Acc Id: XM_005382259   ⟹   XP_005382316
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541817,756,610 - 17,818,552 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005382260   ⟹   XP_005382317
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541817,756,610 - 17,818,552 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005382261   ⟹   XP_005382318
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541817,756,610 - 17,811,663 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013512986   ⟹   XP_013368440
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541817,756,610 - 17,813,517 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005382316 (Get FASTA)   NCBI Sequence Viewer  
  XP_005382317 (Get FASTA)   NCBI Sequence Viewer  
  XP_005382318 (Get FASTA)   NCBI Sequence Viewer  
  XP_013368440 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000007338
  ENSCLAP00000007338.1
RefSeq Acc Id: XP_005382316   ⟸   XM_005382259
- UniProtKB: A0A8C2V033 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005382317   ⟸   XM_005382260
- UniProtKB: A0A8C2V033 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005382318   ⟸   XM_005382261
- UniProtKB: A0A8C2V033 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013368440   ⟸   XM_013512986
- UniProtKB: A0A8C2V033 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000007338   ⟸   ENSCLAT00000007455
Protein Domains
BRCT


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000005160 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000007455 ENTREZGENE
  ENSCLAT00000007455.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.20 UniProtKB/TrEMBL
  3.40.50.10190 UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  BRCT_dom UniProtKB/TrEMBL
  BRCT_dom_sf UniProtKB/TrEMBL
  BRCT_SLF1 UniProtKB/TrEMBL
  Slf1 UniProtKB/TrEMBL
NCBI Gene Ankrd32 ENTREZGENE
PANTHER PTHR46677 UniProtKB/TrEMBL
  SMC5-SMC6 COMPLEX LOCALIZATION FACTOR PROTEIN 1 UniProtKB/TrEMBL
Pfam Ank_2 UniProtKB/TrEMBL
  RTT107_BRCT_5 UniProtKB/TrEMBL
PROSITE ANK_REP_REGION UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/TrEMBL
SMART ANK UniProtKB/TrEMBL
  BRCT UniProtKB/TrEMBL
Superfamily-SCOP SSF48403 UniProtKB/TrEMBL
  SSF52113 UniProtKB/TrEMBL
UniProt A0A8C2V033 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-08-25 Slf1  SMC5-SMC6 complex localization factor 1  Ankrd32  ankyrin repeat domain 32  Symbol and/or name change 5135510 APPROVED