Cops8 (COP9 signalosome subunit 8)

Advanced Search (OLGA)

Gene: Cops8 (COP9 signalosome subunit 8) Chinchilla lanigera

Analyze

Symbol:

Cops8

Name:

COP9 signalosome subunit 8

RGD ID:

9002394

Description:

INVOLVED IN activation of NF-kappaB-inducing kinase activity (ortholog); negative regulation of cell population proliferation (ortholog); protein deneddylation (ortholog); ASSOCIATED WITH Bethlem Myopathy 1A (ortholog); chromosome 2q37 deletion syndrome (ortholog); intellectual disability (ortholog); FOUND IN COP9 signalosome (ortholog); cytoplasm (ortholog); cytosol (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

COP9 signalosome complex subunit 8

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955542	3,128,194 - 3,140,232 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955542	3,129,184 - 3,140,232 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Bethlem Myopathy 1A (ISO)

chromosome 2q37 deletion syndrome (ISO)

intellectual disability (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

activation of NF-kappaB-inducing kinase activity (ISO)

negative regulation of cell population proliferation (ISO)

protein deneddylation (ISO)

protein phosphorylation (ISO)

Cellular Component

COP9 signalosome (ISO)

cytoplasm (ISO)

cytosol (ISO)

nucleoplasm (ISO)

nucleus (ISO)

perinuclear region of cytoplasm (ISO)

Molecular Function

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Cops8
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955542	3,128,194 - 3,140,232 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955542	3,129,184 - 3,140,232 (-)	NCBI	ChiLan1.0	ChiLan1.0

COPS8
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	237,085,889 - 237,100,474 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	237,085,882 - 237,100,474 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	237,994,532 - 238,009,117 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	237,658,823 - 237,672,228 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	2	231,707,494 - 231,720,899 (+)	NCBI		Celera
Cytogenetic Map	2	q37.3	NCBI
HuRef	2	229,786,783 - 229,800,188 (+)	NCBI		HuRef
CHM1_1	2	238,000,165 - 238,013,570 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	237,576,980 - 237,591,573 (+)	NCBI		T2T-CHM13v2.0

Cops8
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	90,531,147 - 90,541,063 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	90,530,703 - 90,541,063 (+)	Ensembl		GRCm39 Ensembl
GRCm38	1	90,602,960 - 90,613,341 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	90,602,981 - 90,613,341 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	92,500,000 - 92,509,916 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	92,433,385 - 92,443,499 (+)	NCBI		MGSCv36	mm8
Celera	1	93,547,395 - 93,557,311 (+)	NCBI		Celera
Cytogenetic Map	1	D	NCBI
cM Map	1	45.53	NCBI

Cops8
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	98,655,031 - 98,664,861 (+)	NCBI		GRCr8
mRatBN7.2	9	91,207,427 - 91,217,258 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	91,207,395 - 91,217,258 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	99,633,896 - 99,643,726 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	104,769,782 - 104,779,613 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	103,135,361 - 103,145,192 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	97,772,224 - 97,782,055 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	97,772,184 - 97,782,067 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	97,453,705 - 97,463,536 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	89,802,461 - 89,812,293 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	9	90,007,229 - 90,017,062 (+)	NCBI
Celera	9	88,751,960 - 88,761,790 (+)	NCBI		Celera
Cytogenetic Map	9	q36	NCBI

COPS8
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	13	139,714,290 - 139,727,740 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2B	139,723,752 - 139,742,707 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	124,315,423 - 124,328,830 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	243,168,836 - 243,182,937 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	243,169,322 - 243,182,937 (+)	Ensembl	panpan1.1		panPan2

COPS8
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	25	47,783,241 - 47,796,806 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	25	48,282,068 - 48,295,660 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	25	48,132,414 - 48,146,025 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	25	48,132,431 - 48,146,172 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	25	48,045,560 - 48,059,155 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	25	47,833,252 - 47,846,852 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	25	48,065,106 - 48,078,718 (+)	NCBI		UU_Cfam_GSD_1.0

Cops8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	189,759,148 - 189,770,708 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936525	1,166,946 - 1,180,838 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936525	1,168,995 - 1,180,763 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

COPS8
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	136,828,217 - 136,838,053 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	136,828,222 - 136,838,058 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	151,269,694 - 151,279,487 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

COPS8
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	123,075,589 - 123,089,209 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666040	76,305,259 - 76,318,710 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cops8
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624847	2,609,743 - 2,620,789 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624847	2,609,760 - 2,620,804 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005411238	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01071548	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDI01117246	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000004934 ⟹ ENSCLAP00000004843

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955542	3,128,194 - 3,140,232 (-)	Ensembl

RefSeq Acc Id:

XM_005411238 ⟹ XP_005411295

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955542	3,129,184 - 3,140,232 (-)	NCBI

Sequence:

show sequence

CCGGCGAGGCTGGCTTTACGTCATCGCGGGCGCGACGCCCCGAGGAACAGTCTGGAGTGTGGCG
GTCGGGAAGGTGCGGCGGTGAGACCGGCCGGGAAGATGCCAGTGGCGGTGATGGCGGAAAGTAC
CTTCAGTTTTAGGAAGTTGCTGGATCAGTGCGAGAACCAGGAGCTCGAGGCTCCTGGAGGAATC
GCCACACCCCCAGTGTATGGTCAGCTTCTAGCGTTATATTTGCTCCACAATGACATGAATAACG
CAAGATATCTTTGGAAAAGGATACCCCCTGCTATAAAATCTGCAAATTCTGAACTTGGAGGAAT
TTGGTCAGTAGGACAGAGAATCTGGCAGAGAGATTTCCCTGGGATCTATACGACCATCAACTCC
CACCAGTGGTCTGAGACGGTGCAGCCAATCATGGAAGCGCTCAGAGATGCGACAAGGCGACGCG
CCTTCGCCCTGGTCTCTCAAGCGTACACCTCCATCATCGCCGATGACTTTGCGGCCTTTGTTGG
ACTTCCTGTAGAAGAGGCTGTGAAAGGTATCTTAGAACAAGGATGGCAAGCGGACTCCACCACG
AGAATGGTTCTACCCAGAAAGCCAGTTGCAGGGGCCCTGGATGTTTCCTTTAACAGAATTAATC
CCTTATCAGAGCCTGCCCCAGTTCCGCCGATCCCCAATGAGCAGCAGTTAGCTAGGCTGACCGA
TTATGTGGCTTTCCTTGAAAACTGACTGATCGTCGACTTCAAGACCACCTCCAGAATCCTCTAC
ACTGACAAATAGAGAAATGTAAAATTTTTATTTTCAACTTACTGGATGGATGAAGCACCTCAGC
ATTCCTTACGGAATATGTGATAAAATGCATATATAATATAAAGTATATTATATATATTTTGTCC
TTAAGCATTATGCCGAATAGTTGAGGCAGTTCTCATTTTGTAATAGGTAACAATTTGGCACTGT
CAGTATCATGCCGGTAGTTTACATTCCCTAGTGAATTAGGCATAAGCCCTCCTGCCCCAGTGCG
CTGCGTTCCCATGCGTGCCCGAGTGGGCAGTGGTGGTGCTGCCTCTGGGGCTGGCCGAGGACTG
TCCCAGGGAAGGACTTGAATTGCATGAGTGTGATCCACCCTTGGGAGAATAGGCTTTCTTTTAT
CCCTGCCTCCCCAGAATCGCTAAGGTAGAATACTGAAACGTAGCTGAGGAACAAATGGACATTT
CCGGAGTGAACCAGTTTGTTACAGTCTTTCCCAATAGTATGAGTATATCCATTGCTAGCAGAGG
AGGGCTTGCTGTGACAGTGCCACTTAGGGTGTTCATGAGAAGTATTAAGTTCTAACGTCTGTTT
TCAGAGGAAGGGGCAGGTTAAGTGTGGAGCGCATGGTGTGGGGAAAGGAGCTGTTAAGAGGAGT
GATGCACTTGCACAGCTCTGCTGCAGCCTGTTGGTTGCCTGTTTGTTTAAAGTTCTGCCCTTGG
AAGAAATGCCGAACAAGTCTTTATTCTTTGTGTGACAGCCCCTGAATGTTTGAAGTTACTGTAT
TTTTAGATTAAGATACCCCTTAGATCATTTATTCTGCATTTGTTCAATAAATATTTAATTGAAT
TTTTGAACTGTCA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005411295	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000004843
	ENSCLAP00000004843.1

RefSeq Acc Id:

XP_005411295 ⟸ XM_005411238

- UniProtKB:

A0A8C2URQ1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPVAVMAESTFSFRKLLDQCENQELEAPGGIATPPVYGQLLALYLLHNDMNNARYLWKRIPPAI
KSANSELGGIWSVGQRIWQRDFPGIYTTINSHQWSETVQPIMEALRDATRRRAFALVSQAYTSI
IADDFAAFVGLPVEEAVKGILEQGWQADSTTRMVLPRKPVAGALDVSFNRINPLSEPAPVPPIP
NEQQLARLTDYVAFLEN

hide sequence

Ensembl Acc Id:

ENSCLAP00000004843 ⟸ ENSCLAT00000004934

Protein Domains

PCI

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000003438	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000004934	ENTREZGENE
	ENSCLAT00000004934.1	UniProtKB/TrEMBL
Gene3D-CATH	1.25.40.990	UniProtKB/TrEMBL
InterPro	COP9_CSN8	UniProtKB/TrEMBL
	CSN8_PSD8_EIF3K	UniProtKB/TrEMBL
	PCI_dom	UniProtKB/TrEMBL
NCBI Gene	Cops8	ENTREZGENE
PANTHER	COP9 SIGNALOSOME COMPLEX SUBUNIT 8	UniProtKB/TrEMBL
	PTHR13339	UniProtKB/TrEMBL
Pfam	CSN8_PSD8_EIF3K	UniProtKB/TrEMBL
PROSITE	PCI	UniProtKB/TrEMBL
UniProt	A0A8C2URQ1	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Send us a Message

Imported Disease Annotations - ClinVar