COPS8 (COP9 signalosome subunit 8) - Rat Genome Database
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Gene: COPS8 (COP9 signalosome subunit 8) Sus scrofa
Analyze
Symbol: COPS8
Name: COP9 signalosome subunit 8
RGD ID: 14208807
Description: INVOLVED IN activation of NF-kappaB-inducing kinase activity (inferred); COP9 signalosome assembly (inferred); negative regulation of cell population proliferation (inferred); ASSOCIATED WITH Bethlem Myopathy 1 (ortholog); FOUND IN COP9 signalosome (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: COP9 signalosome complex subunit 8
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15136,827,862 - 136,838,048 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115136,828,222 - 136,838,058 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215151,269,694 - 151,279,487 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:14681463  


Genomics

Comparative Map Data
COPS8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15136,827,862 - 136,838,048 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115136,828,222 - 136,838,058 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215151,269,694 - 151,279,487 (+)NCBISscrofa10.2Sscrofa10.2susScr3
COPS8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2237,085,882 - 237,100,474 (+)EnsemblGRCh38hg38GRCh38
GRCh382237,085,889 - 237,100,474 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372237,994,532 - 238,009,117 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362237,658,823 - 237,672,228 (+)NCBINCBI36hg18NCBI36
Celera2231,707,494 - 231,720,899 (+)NCBI
Cytogenetic Map2q37.3NCBI
HuRef2229,786,783 - 229,800,188 (+)NCBIHuRef
CHM1_12238,000,165 - 238,013,570 (+)NCBICHM1_1
Cops8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39190,531,147 - 90,541,063 (+)NCBIGRCm39mm39
GRCm39 Ensembl190,530,703 - 90,541,063 (+)Ensembl
GRCm38190,602,960 - 90,613,341 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl190,602,981 - 90,613,341 (+)EnsemblGRCm38mm10GRCm38
MGSCv37192,500,000 - 92,509,916 (+)NCBIGRCm37mm9NCBIm37
MGSCv36192,433,385 - 92,443,499 (+)NCBImm8
Celera193,547,395 - 93,557,311 (+)NCBICelera
Cytogenetic Map1DNCBI
Cops8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2991,207,427 - 91,217,258 (+)NCBI
Rnor_6.0 Ensembl997,772,184 - 97,782,067 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0997,772,224 - 97,782,055 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0997,453,705 - 97,463,536 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4989,802,461 - 89,812,293 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1990,007,229 - 90,017,062 (+)NCBI
Celera988,751,960 - 88,761,790 (+)NCBICelera
Cytogenetic Map9q36NCBI
Cops8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555423,128,194 - 3,140,232 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555423,129,184 - 3,140,232 (-)NCBIChiLan1.0ChiLan1.0
COPS8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B243,168,836 - 243,182,937 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B243,169,322 - 243,182,937 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B124,315,423 - 124,328,830 (+)NCBIMhudiblu_PPA_v0panPan3
COPS8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12547,783,241 - 47,796,806 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Cops8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365251,168,995 - 1,180,763 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
COPS8
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110123,075,589 - 123,089,209 (+)NCBI
Cops8
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248472,609,760 - 2,620,804 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 6 4 3 5 2 22 2 3 1
Low 4 1 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000017776   ⟹   ENSSSCP00000017295
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl15136,828,289 - 136,838,048 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000071782   ⟹   ENSSSCP00000071659
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl15136,827,862 - 136,837,178 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000079189   ⟹   ENSSSCP00000073343
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl15136,827,862 - 136,837,178 (+)Ensembl
RefSeq Acc Id: XM_003133761   ⟹   XP_003133809
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.115136,828,222 - 136,838,058 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003133809 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_003133809   ⟸   XM_003133761
- UniProtKB: F1SM07 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000073343   ⟸   ENSSSCT00000079189
RefSeq Acc Id: ENSSSCP00000017295   ⟸   ENSSSCT00000017776
RefSeq Acc Id: ENSSSCP00000071659   ⟸   ENSSSCT00000071782
Protein Domains
CSN8_PSD8_EIF3K   PCI


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000016323 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000017295 UniProtKB/TrEMBL
  ENSSSCP00000071659 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000073343 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000017776 UniProtKB/TrEMBL
  ENSSSCT00000071782 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000079189 UniProtKB/TrEMBL
InterPro COP9_CSN8 UniProtKB/TrEMBL
  CSN8_PSD8_EIF3K UniProtKB/TrEMBL
  PCI_dom UniProtKB/TrEMBL
KEGG Report ssc:100515865 UniProtKB/TrEMBL
NCBI Gene COPS8 ENTREZGENE
PANTHER PTHR13339 UniProtKB/TrEMBL
Pfam CSN8_PSD8_EIF3K UniProtKB/TrEMBL
PROSITE PCI UniProtKB/TrEMBL
UniProt A0A5G2R7V4_PIG UniProtKB/TrEMBL
  A0A5G2RIY7_PIG UniProtKB/TrEMBL
  F1SM07 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:96040 ENTREZGENE