COPS8 (COP9 signalosome subunit 8)

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Gene: COPS8 (COP9 signalosome subunit 8) Sus scrofa

Analyze

Symbol:

COPS8

Name:

COP9 signalosome subunit 8

RGD ID:

14208807

Description:

INVOLVED IN activation of NF-kappaB-inducing kinase activity (inferred); COP9 signalosome assembly (inferred); negative regulation of cell population proliferation (inferred); ASSOCIATED WITH Bethlem Myopathy 1 (ortholog); FOUND IN COP9 signalosome (ortholog); nucleus (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Also known as:

COP9 signalosome complex subunit 8

RGD Orthologs

Human

Mouse

Rat

Chinchilla

Bonobo

Dog

Squirrel

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	COPS8 (COP9 signalosome subunit 8)	HGNC	EggNOG, Ensembl, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Cops8 (COP9 signalosome subunit 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Cops8 (COP9 signalosome subunit 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Cops8 (COP9 signalosome subunit 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	COPS8 (COP9 signalosome subunit 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	COPS8 (COP9 signalosome subunit 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Cops8 (COP9 signalosome subunit 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	COPS8 (COP9 signalosome subunit 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Cops8 (COP9 signalosome subunit 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	136,827,862 - 136,838,048 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	136,828,222 - 136,838,058 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	151,269,694 - 151,279,487 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Bethlem Myopathy 1 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

activation of NF-kappaB-inducing kinase activity (IEA)

COP9 signalosome assembly (IEA)

negative regulation of cell population proliferation (IEA)

protein deneddylation (IEA)

protein phosphorylation (IEA)

Cellular Component

COP9 signalosome (IBA,IEA,ISO)

cytoplasm (IEA)

cytosol (IEA)

nucleoplasm (IEA)

nucleus (ISO)

perinuclear region of cytoplasm (IEA)

Molecular Function

protein binding (ISO)

References

Additional References at PubMed

PMID:14681463

Genomics

Comparative Map Data

COPS8
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	136,827,862 - 136,838,048 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	136,828,222 - 136,838,058 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	151,269,694 - 151,279,487 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

COPS8
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	2	237,085,882 - 237,100,474 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	2	237,085,889 - 237,100,474 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	2	237,994,532 - 238,009,117 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	237,658,823 - 237,672,228 (+)	NCBI	NCBI36		hg18	NCBI36
Celera	2	231,707,494 - 231,720,899 (+)	NCBI
Cytogenetic Map	2	q37.3	NCBI
HuRef	2	229,786,783 - 229,800,188 (+)	NCBI		HuRef
CHM1_1	2	238,000,165 - 238,013,570 (+)	NCBI		CHM1_1

Cops8
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	90,531,147 - 90,541,063 (+)	NCBI	GRCm39		mm39
GRCm39 Ensembl	1	90,530,703 - 90,541,063 (+)	Ensembl
GRCm38	1	90,602,960 - 90,613,341 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	90,602,981 - 90,613,341 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	92,500,000 - 92,509,916 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	1	92,433,385 - 92,443,499 (+)	NCBI			mm8
Celera	1	93,547,395 - 93,557,311 (+)	NCBI		Celera
Cytogenetic Map	1	D	NCBI

Cops8
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	9	91,207,427 - 91,217,258 (+)	NCBI
Rnor_6.0 Ensembl	9	97,772,184 - 97,782,067 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	9	97,772,224 - 97,782,055 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	9	97,453,705 - 97,463,536 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	89,802,461 - 89,812,293 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	9	90,007,229 - 90,017,062 (+)	NCBI
Celera	9	88,751,960 - 88,761,790 (+)	NCBI		Celera
Cytogenetic Map	9	q36	NCBI

Cops8
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955542	3,128,194 - 3,140,232 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955542	3,129,184 - 3,140,232 (-)	NCBI	ChiLan1.0	ChiLan1.0

COPS8
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	2B	243,168,836 - 243,182,937 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	243,169,322 - 243,182,937 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	2B	124,315,423 - 124,328,830 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

COPS8
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	25	47,783,241 - 47,796,806 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Cops8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936525	1,168,995 - 1,180,763 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

COPS8
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	123,075,589 - 123,089,209 (+)	NCBI

Cops8
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624847	2,609,760 - 2,620,804 (+)	NCBI

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	hemolymphoid system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system
High
Medium	6	4	3	5	2	22	2	3	1
Low	4					1			2
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003133761	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AEMK02000101	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK239550	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK398515	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CU915301	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GFLN01047715	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSSSCT00000017776 ⟹ ENSSSCP00000017295

RefSeq Status:

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	15	136,828,289 - 136,838,048 (+)	Ensembl

RefSeq Acc Id:

ENSSSCT00000071782 ⟹ ENSSSCP00000071659

RefSeq Status:

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	15	136,827,862 - 136,837,178 (+)	Ensembl

RefSeq Acc Id:

ENSSSCT00000079189 ⟹ ENSSSCP00000073343

RefSeq Status:

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	15	136,827,862 - 136,837,178 (+)	Ensembl

RefSeq Acc Id:

XM_003133761 ⟹ XP_003133809

RefSeq Status:

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	15	136,828,222 - 136,838,058 (+)	NCBI

Sequence:

show sequence

CGCGCCGGAACCGATGATGCGCCTGCGCACGGGAGCTCGGCGGCGACGGCGGCTTTTACGTCAT
CGCGGGCGCGACGCCCGGAGGGACAAGTCTGGGGTCCAGCTAGAAGGGGAGGTACGGCGGCGGG
ACCGGCCGGGAAGATGCCAGTGGCGGTGATGGCGGAAAGTGCCTTTAATTTCAAAAAGTTGCTG
GATCAGTGCGAGAACCAGGAGCTGGAGGCTCCAGGAGGAATTGCTACACCTCCAGTGTATGGTC
AGCTTCTAGCTTTATATCTGCTCCATAATGACATGAATAATGCAAGATACCTTTGGAAAAGAAT
ACCACCCGCTATAAAGTCGGCAAATTCTGAACTTGGGGGGATTTGGTCAGTGGGACAGAGAATC
TGGCAGAGGGATTTCCCTGGCGTCTACAGCACCATCAACGCCCACCAGTGGTCCGAGACGGTCC
AGCCCATCATGGAAGCACTTAGAGATGCTACCCGGAGGCGCGCCTTCGCCCTGGTTTCTCAAGC
CTACACCTCCATCGTCGCCGACGACTTCGCAGCCTTCGTCGGCCTGCCTGTGGAGGAAGCTGTG
AAAGGGGTGCTGGAGCAGGGGTGGCAGGCTGACTCCTCCACGAGGATGGTGATGCCCAAGAAGC
CAGTTGCAGGTGCCCTGGATGTTTCCTTTAACAGATTTATTCCGTTGTCAGAGGCTGCCCCCGT
CCCGCCCATCCCCAACGAGCAGCAGTTAGCCCGACTCACCGACTACGTGGCTTTCCTCGAAAAC
TGACTGACTCCGAGCTCCAGATCCACCACCAGAATCCTGTATACTGACAAATAGAGAAATGTAA
GGTTTTTATTTGCAATTTTATTGGCTGGATTGAGCACCTCAGCGTTCCTTACTGAGTATGTGAT
AAAACACGTAGAGAAGAATATATATTTTGTCCTTCAACGTTATGCTGAATGGTCGTGGAAACAA
TTCTTATTTTGTGCTAGTTGACGATTTGGACGGAGCCCGTCAGTGTTAGCAGGGAGTTAGTGTT
TCCTAGTGACTCATGAATGAGCTCCCTGCTGCCTGCGGCGCAGCGGCCGTCAGCTGCTTCCTCC
CCGGCTCGAGGCACCCTGCGCCTGCACCGCGGGCTGGTGGCTGCACTGATGCACGGCTGTCCCC
AGGGGCCTATCTGACTGTCTGGGGACCCTGACTCCCCCTCCTCGGGGCTGTGCTCTTCCCCCTC
CCTGCTGAGAATCAGCCATCAAAATGCTGAGCTAGAGCTAAGAACAAAAGACCCGTTTCCGTAG
TAAACCGCTTTGTTAGCTTTAGGTTGTTTGCCGTTTTTGAGAGTGTGAGTACATCCATTGCTGG
CAGTGGAGGGCTTGCCGTGGAGATGGACTTATTAAGACCTTCACGAGAAGCATGAAGTTGCCGT
GTTTCCTTTCGGAAGGAGACTGTGGAGTGCGTTACTTGAGACAGAAGCTGTTGAGTGATCCACT
TTGTCCAGCTACCCTGCAGCCCGTTGGTTGCTTGTATTTATCCCTTGGGTCAAGTTCTGCCTTT
TGAGAAATACTGTACAAGACTTTCATTTTTTGTGTGACAGCCTCTGATGTTTGAAGCTGTTCCT
TGTATCTTCAGGGTGAAGCTACCCCCTAGTTCATTTATTCTGCATTTGTTCAATAAATAATTAA
CTGAATTCCTCAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003133809	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

XP_003133809 ⟸ XM_003133761

- UniProtKB:

F1SM07 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPVAVMAESAFNFKKLLDQCENQELEAPGGIATPPVYGQLLALYLLHNDMNNARYLWKRIPPAI
KSANSELGGIWSVGQRIWQRDFPGVYSTINAHQWSETVQPIMEALRDATRRRAFALVSQAYTSI
VADDFAAFVGLPVEEAVKGVLEQGWQADSSTRMVMPKKPVAGALDVSFNRFIPLSEAAPVPPIP
NEQQLARLTDYVAFLEN

hide sequence

RefSeq Acc Id:

ENSSSCP00000073343 ⟸ ENSSSCT00000079189

RefSeq Acc Id:

ENSSSCP00000017295 ⟸ ENSSSCT00000017776

RefSeq Acc Id:

ENSSSCP00000071659 ⟸ ENSSSCT00000071782

Protein Domains

CSN8_PSD8_EIF3K PCI

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00000016323	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSSSCP00000017295	UniProtKB/TrEMBL
	ENSSSCP00000071659	ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCP00000073343	UniProtKB/TrEMBL
Ensembl Transcript	ENSSSCT00000017776	UniProtKB/TrEMBL
	ENSSSCT00000071782	ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCT00000079189	UniProtKB/TrEMBL
InterPro	COP9_CSN8	UniProtKB/TrEMBL
	CSN8_PSD8_EIF3K	UniProtKB/TrEMBL
	PCI_dom	UniProtKB/TrEMBL
KEGG Report	ssc:100515865	UniProtKB/TrEMBL
NCBI Gene	COPS8	ENTREZGENE
PANTHER	PTHR13339	UniProtKB/TrEMBL
Pfam	CSN8_PSD8_EIF3K	UniProtKB/TrEMBL
PROSITE	PCI	UniProtKB/TrEMBL
UniProt	A0A5G2R7V4_PIG	UniProtKB/TrEMBL
	A0A5G2RIY7_PIG	UniProtKB/TrEMBL
	F1SM07	ENTREZGENE, UniProtKB/TrEMBL
VGNC ID	VGNC:96040	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar