Ifngr2 (interferon gamma receptor 2)

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Gene: Ifngr2 (interferon gamma receptor 2) Chinchilla lanigera

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Symbol:

Ifngr2

Name:

interferon gamma receptor 2

RGD ID:

8995804

Description:

ENCODES a protein that exhibits type II interferon receptor activity (ortholog); INVOLVED IN defense response to virus (ortholog); microglial cell activation (ortholog); positive regulation of NMDA glutamate receptor activity (ortholog); ASSOCIATED WITH amyotrophic lateral sclerosis type 1 (ortholog); autosomal dominant intellectual developmental disorder 7 (ortholog); COVID-19 (ortholog); FOUND IN plasma membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

interferon gamma receptor 2 (interferon gamma transducer 1)

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

NCBI Annotation Information:

Annotation category: partial on reference assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955407	32,843,846 - 32,862,997 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955407	32,846,927 - 32,863,155 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

amyotrophic lateral sclerosis type 1 (ISO)

autosomal dominant intellectual developmental disorder 7 (ISO)

COVID-19 (ISO)

Familial Platelet Disorder with Associated Myeloid Malignancy (ISO)

genetic disease (ISO)

immunodeficiency 27A (ISO)

immunodeficiency 28 (ISO)

Interferon Gamma, Receptor 1, Deficiency (ISO)

Parkinson's disease 20 (ISO)

type 1 diabetes mellitus (ISO)

ZTTK syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

defense response to virus (ISO)

microglial cell activation (ISO)

positive regulation of NMDA glutamate receptor activity (ISO)

type III interferon-mediated signaling pathway (ISO)

Cellular Component

plasma membrane (ISO)

Molecular Function

protein binding (ISO)

type II interferon receptor activity (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

Ifngr2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955407	32,843,846 - 32,862,997 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955407	32,846,927 - 32,863,155 (+)	NCBI	ChiLan1.0	ChiLan1.0

IFNGR2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	21	33,402,882 - 33,437,516 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	21	33,403,413 - 33,479,348 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	21	34,775,188 - 34,809,823 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	21	33,697,072 - 33,731,696 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	21	33,697,071 - 33,731,696	NCBI
Celera	21	19,965,288 - 19,999,915 (+)	NCBI		Celera
Cytogenetic Map	21	q22.11	NCBI
HuRef	21	20,243,995 - 20,278,386 (+)	NCBI		HuRef
CHM1_1	21	34,337,541 - 34,372,485 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	21	31,775,143 - 31,809,789 (+)	NCBI		T2T-CHM13v2.0

Ifngr2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	91,343,947 - 91,360,895 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	91,343,960 - 91,362,511 (+)	Ensembl		GRCm39 Ensembl
GRCm38	16	91,547,059 - 91,564,007 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	91,547,072 - 91,565,623 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	16	91,547,339 - 91,564,252 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	16	91,435,953 - 91,452,866 (+)	NCBI		MGSCv36	mm8
Celera	16	92,623,882 - 92,640,783 (+)	NCBI		Celera
Cytogenetic Map	16	C3.3	NCBI
cM Map	16	53.07	NCBI

Ifngr2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	44,265,703 - 44,283,975 (+)	NCBI		GRCr8
mRatBN7.2	11	30,779,733 - 30,798,005 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	30,779,733 - 30,798,005 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	11	39,473,777 - 39,492,044 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	32,145,213 - 32,163,480 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	31,310,356 - 31,328,702 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	31,694,339 - 31,712,611 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	31,694,339 - 31,712,611 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	35,302,873 - 35,321,145 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	31,508,721 - 31,526,993 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	11	31,547,825 - 31,565,097 (+)	NCBI
Celera	11	30,447,195 - 30,465,467 (+)	NCBI		Celera
Cytogenetic Map	11	q11	NCBI

IFNGR2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	22	29,511,266 - 29,545,324 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	21	24,370,656 - 24,404,725 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	21	19,760,314 - 19,794,851 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	21	33,142,741 - 33,169,137 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	21	33,135,048 - 33,169,137 (+)	Ensembl	panpan1.1		panPan2

IFNGR2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	31	28,909,930 - 28,948,742 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	31	28,008,730 - 28,047,586 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	31	28,215,580 - 28,254,378 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	31	28,224,956 - 28,254,374 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	31	28,082,877 - 28,121,722 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	31	28,095,920 - 28,134,930 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	31	28,596,533 - 28,635,303 (+)	NCBI		UU_Cfam_GSD_1.0

Ifngr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404971	28,530,468 - 28,585,909 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936500	8,882,435 - 8,901,281 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936500	8,881,921 - 8,937,355 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

IFNGR2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	197,007,303 - 197,035,604 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	197,007,303 - 197,035,604 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

IFNGR2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	58,743,365 - 58,779,922 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	58,743,922 - 58,779,356 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666071	1,245,937 - 1,285,069 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ifngr2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624745	21,628,797 - 21,651,652 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624745	21,628,968 - 21,652,305 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_013504273	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01007685	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBCB01022004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDK01022293	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000009333 ⟹ ENSCLAP00000009204

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955407	32,843,846 - 32,862,997 (+)	Ensembl

RefSeq Acc Id:

XM_013504273 ⟹ XP_013359727

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955407	32,846,927 - 32,863,155 (+)	NCBI

Sequence:

show sequence

CGGGGCCGCGCCGGGCGGCTCGGGGCTCCCACACTCCGACGCTCGGGAAGAGGCGGGCCGTGGC
CCTGCGCTCGCCAGGCCCGCGCGGGCGGCGACGTGAGCGGCTTGGCGGGCCCCACGCCGGGGCC
GGCTCGCCCCCGAGTCCCGGCGCCCGGGCCATGCAGCCGCCGTCCCCGGGGCCGTGGCTTCTGC
TGTCGCTCTGCTGCGTCGGAGCCGCGGCGACCCCCCCAGACTGTTTTTCCCAGCTGGCTGCTCC
GCGGAACCCAAAGATTCACCTGTACAATGCCGAGCAGGTTCTGAGCTGGGAATCTTCGTCTGCA
GGCAATGACACAGAACCAGTGCGCTACCGGGTGCAGAATAAATTCACCTCTAACAATTGGGACG
ACGTCAGCCTGGTGAACTGCTCACAGATCACAGCGACGGAGTGTAGATTCACCACGGCCAACTT
CTCCGGGGGCTTCCAGAAGGACTTCAATGTCTCCTTGCGTGTGCGAGCCGAGCTGGGATGCCGT
GTGTCTGCCTGGGCAACGGTCCCTTGGTTTCAGCACTTTCGAAATGTTACCATCGGGCCTCCAG
AAAACATCGTGGTGACCCCTGGAGGAGGCTCCCTCATCGTCACGTTCTCCGCTCCCTTTGACAC
TGGGAGCTCCGCAGAGGCCTCTTTTTCCTATTACGCCCGCTACTGGGGAAAAGGTGGCACCCAA
CAGGTTAAAGGCCCTGAAACGAGCAACTCCATTTTGCTGAATAACCTGAAGCCGTTCCGAGTGT
ACTGTTTACAAGTCCAAGCGCAACTGTTTTGGACAACTCCAAAGATCGTGAAGCCTGGGAATTT
CAGCAACACGTTTTGCCAAGAAACAGCAGCAGACGCCTCCACCAGGCTGCAGCAGATCATCCTG
ATCTCTGTGGGAATCTTTGCGTTGCTGCTGGCGCTGACCGGGGGCTGTTTCTTCCTGGTCCTGA
GATACCAAGAGCTGATCAAGTACTGGTTTCACACTCCACCGGGCATCCCATCACAGATAGAAGA
GTACTTAAAGGATCCCACTCAGCCCATCCTAGAGGTCTTGGACAAGGACAGTTGGCCAAAGGAT
GATGCCTGGGACTCTGTATCCATCATCTCCTCTCCAGAAAAGGAGGGAGAAGACTTTGAACCAA
AGCACTGGTCCAGCCAGGAGACTCCACAGGAGGACATTGAGCAGGGAAACCGATGACATCCAGC
CTGGAACCCACATAGATCACTCCCCAACTCCTGCCTCAGGAGCCTGCCGTGCTGAGCGTCTTGC
GGGAGAAGACAGCTTAGGACTTTTTCTAAGAACTTCCTGAATCGCCGAGCGTGGTGGCACACAC
CTGTGATCCCAGAACTTGGGAG

hide sequence

Protein Sequences


Protein RefSeqs	XP_013359727	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000009204
	ENSCLAP00000009204.1

RefSeq Acc Id:

XP_013359727 ⟸ XM_013504273

- UniProtKB:

A0A8C2YMC2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MQPPSPGPWLLLSLCCVGAAATPPDCFSQLAAPRNPKIHLYNAEQVLSWESSSAGNDTEPVRYR
VQNKFTSNNWDDVSLVNCSQITATECRFTTANFSGGFQKDFNVSLRVRAELGCRVSAWATVPWF
QHFRNVTIGPPENIVVTPGGGSLIVTFSAPFDTGSSAEASFSYYARYWGKGGTQQVKGPETSNS
ILLNNLKPFRVYCLQVQAQLFWTTPKIVKPGNFSNTFCQETAADASTRLQQIILISVGIFALLL
ALTGGCFFLVLRYQELIKYWFHTPPGIPSQIEEYLKDPTQPILEVLDKDSWPKDDAWDSVSIIS
SPEKEGEDFEPKHWSSQETPQEDIEQGNR

hide sequence

Ensembl Acc Id:

ENSCLAP00000009204 ⟸ ENSCLAT00000009333

Protein Domains

Fibronectin type-III

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000006405	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000009333	ENTREZGENE
	ENSCLAT00000009333.1	UniProtKB/TrEMBL
Gene3D-CATH	2.60.40.10	UniProtKB/TrEMBL
InterPro	FN3_dom	UniProtKB/TrEMBL
	FN3_sf	UniProtKB/TrEMBL
	Ig-like_fold	UniProtKB/TrEMBL
	Interferon/interleukin_rcp_dom	UniProtKB/TrEMBL
	Type-II_Cytokine-TF_Rcpt	UniProtKB/TrEMBL
NCBI Gene	Ifngr2	ENTREZGENE
PANTHER	INTERFERON GAMMA RECEPTOR 2	UniProtKB/TrEMBL
	INTERFERON/INTERLEUKIN RECEPTOR	UniProtKB/TrEMBL
Pfam	Interfer-bind	UniProtKB/TrEMBL
	Tissue_fac	UniProtKB/TrEMBL
PROSITE	FN3	UniProtKB/TrEMBL
Superfamily-SCOP	SSF49265	UniProtKB/TrEMBL
UniProt	A0A8C2YMC2	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-01-10	Ifngr2	interferon gamma receptor 2		interferon gamma receptor 2 (interferon gamma transducer 1)	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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