Msx2 (msh homeobox 2) - Rat Genome Database

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Gene: Msx2 (msh homeobox 2) Chinchilla lanigera
Analyze
Symbol: Msx2
Name: msh homeobox 2
RGD ID: 8955621
Description: ENCODES a protein that exhibits DNA binding (ortholog); DNA-binding transcription factor activity, RNA polymerase II-specific (ortholog); DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); INVOLVED IN activation of meiosis (ortholog); anterior/posterior pattern specification (ortholog); BMP signaling pathway (ortholog); ASSOCIATED WITH Craniofacial Abnormalities (ortholog); craniosynostosis (ortholog); craniosynostosis 2 (ortholog); FOUND IN cytosol (ortholog); nuclear speck (ortholog); transcription regulator complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: homeobox protein MSX-2
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540827,323,360 - 27,329,755 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540827,323,405 - 27,329,484 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Msx2Chinchillacraniosynostosis 2  ISOMSX2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10742103 more ...
Msx2ChinchillaCraniosynostosis Syndrome, Autosomal Recessive  ISOMSX2 (Homo sapiens)8554872ClinVar Annotator: match by term: Craniosynostosis syndromeClinVar 
Msx2Chinchillagenetic disease  ISOMSX2 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:10742103 more ...
Msx2Chinchillaparietal foramina  ISOMSX2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10742103 more ...
Msx2ChinchillaParietal Foramina 1  ISOMSX2 (Homo sapiens)8554872ClinVar Annotator: match by term: Parietal foramina 1ClinVarPMID:10742103 more ...
Msx2ChinchillaParietal Foramina with Cleidocranial Dysplasia  ISOMSX2 (Homo sapiens)8554872ClinVar Annotator: match by term: Parietal foramina with cleidocranial dysplasiaClinVarPMID:14571277
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Msx2ChinchillaCraniofacial Abnormalities  ISOMSX2 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:9147639
Msx2ChinchillaFemale Urogenital Diseases  ISOMSX2 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:16513791
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Msx2Chinchillacraniosynostosis  ISOMsx2 (Mus musculus)9068941OMIM:123100 more ...MouseDO 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Msx2Chinchillacraniosynostosis 2  ISOMSX2 (Homo sapiens)7240710 OMIM 
Msx2ChinchillaParietal Foramina 1  ISOMSX2 (Homo sapiens)7240710 OMIM 
Msx2ChinchillaParietal Foramina with Cleidocranial Dysplasia  ISOMSX2 (Homo sapiens)7240710 OMIM 


Biological Process
1 to 20 of 57 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Msx2Chinchillaactivation of meiosis acts_upstream_of_or_withinISOMGI:971689068941 PMID:22071108MGIPMID:22071108
Msx2Chinchillaanterior/posterior pattern specification acts_upstream_of_or_withinISOMGI:971689068941 PMID:21465616MGIPMID:21465616
Msx2ChinchillaBMP signaling pathway acts_upstream_of_or_withinISOMsx2 (Mus musculus)9068941 PMID:18590716MGIPMID:18590716
Msx2ChinchillaBMP signaling pathway acts_upstream_of_or_withinISOMGI:971689068941 PMID:17601530 and PMID:18667074MGIPMID:17601530 and PMID:18667074
Msx2ChinchillaBMP signaling pathway acts_upstream_ofISOMGI:971689068941 PMID:18667074MGIPMID:18667074
Msx2Chinchillabone morphogenesis acts_upstream_of_or_withinISOMGI:971689068941 PMID:17693062MGIPMID:17693062
Msx2Chinchillabone trabecula formation acts_upstream_of_or_withinISOMGI:19263819068941 PMID:10742104MGIPMID:10742104
Msx2Chinchillabranching involved in mammary gland duct morphogenesis acts_upstream_of_or_withinISOMGI:19263819068941 PMID:10742104MGIPMID:10742104
Msx2Chinchillacartilage development  ISOMsx2 (Rattus norvegicus)9068941 RGDPMID:10332146 and REF_RGD_ID:1600462
Msx2Chinchillacartilage development acts_upstream_of_or_withinISOMsx2 (Mus musculus)9068941 PMID:11668602MGIPMID:11668602
Msx2Chinchillacartilage development acts_upstream_of_or_withinISOMGI:19263819068941 PMID:10742104MGIPMID:10742104
Msx2Chinchillacell surface receptor signaling pathway involved in heart development acts_upstream_of_or_withinISOMGI:971689068941 PMID:18667074MGIPMID:18667074
Msx2Chinchillacellular response to estradiol stimulus acts_upstream_of_or_withinISOMsx2 (Mus musculus)9068941 PMID:8787747MGIPMID:8787747
Msx2Chinchillacellular response to growth factor stimulus acts_upstream_of_or_withinISOMsx2 (Mus musculus)9068941 PMID:7848824MGIPMID:7848824
Msx2Chinchillachondrocyte development acts_upstream_of_or_withinISOMGI:19263819068941 PMID:10742104MGIPMID:10742104
Msx2Chinchillaembryonic digit morphogenesis acts_upstream_of_or_withinISOMGI:971689068941 PMID:21465616MGIPMID:21465616
Msx2Chinchillaembryonic forelimb morphogenesis acts_upstream_of_or_withinISOMGI:971689068941 PMID:21465616MGIPMID:21465616
Msx2Chinchillaembryonic hindlimb morphogenesis acts_upstream_of_or_withinISOMGI:971689068941 PMID:21465616MGIPMID:21465616
Msx2Chinchillaembryonic limb morphogenesis acts_upstream_of_or_withinISOMGI:971689068941 PMID:15930102MGIPMID:15930102
Msx2Chinchillaembryonic limb morphogenesis acts_upstream_of_or_withinISOMGI:97168 and MGI:982979068941 PMID:19422820MGIPMID:19422820
1 to 20 of 57 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Msx2Chinchillacytosol located_inISOMSX2 (Homo sapiens)9068941 HPAGO_REF:0000052
Msx2Chinchillanuclear speck located_inISOMSX2 (Homo sapiens)9068941 HPAGO_REF:0000052
Msx2Chinchillatranscription regulator complex part_ofISOPR:P70326 more ...9068941 PMID:18285513MGIPMID:18285513

Molecular Function
1 to 16 of 16 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Msx2ChinchillaDNA binding enablesISOMsx2 (Mus musculus)9068941 PMID:9265625MGIPMID:9265625
Msx2ChinchillaDNA-binding transcription factor activity, RNA polymerase II-specific  ISOMsx2 (Rattus norvegicus)9068941 RGDPMID:7877617 and REF_RGD_ID:5132614
Msx2ChinchillaDNA-binding transcription repressor activity, RNA polymerase II-specific enablesISOMsx2 (Mus musculus)9068941 PMID:20843790 and PMID:8861098BHF-UCLPMID:20843790 and PMID:8861098
Msx2ChinchillaDNA-binding transcription repressor activity, RNA polymerase II-specific enablesISOMsx2 (Mus musculus)9068941 PMID:8861098NTNU_SBPMID:8861098
Msx2Chinchillaprotein binding enablesISOPR:Q625049068941 PMID:10451362MGIPMID:10451362
Msx2Chinchillaprotein binding enablesISOUniProtKB:O15197-2 more ...9068941 PMID:32296183IntActPMID:32296183
Msx2Chinchillaprotein binding enablesISOUniProtKB:G5E9A7 more ...9068941 PMID:32814053IntActPMID:32814053
Msx2Chinchillaprotein binding enablesISOUniProtKB:P12956 and UniProtKB:P130109068941 PMID:12145306UniProtPMID:12145306
Msx2Chinchillaprotein binding enablesISOUniProtKB:Q9QYH69068941 PMID:11084035 and PMID:11959851IntActPMID:11084035 and PMID:11959851
Msx2Chinchillaprotein binding enablesISOUniProtKB:P25233 and UniProtKB:Q9QYH69068941 PMID:15272023IntActPMID:15272023
Msx2ChinchillaRNA polymerase II cis-regulatory region sequence-specific DNA binding  ISOMsx2 (Rattus norvegicus)9068941 RGDPMID:7877617 and REF_RGD_ID:5132614
Msx2ChinchillaRNA polymerase II cis-regulatory region sequence-specific DNA binding enablesISOMsx2 (Mus musculus)9068941 PMID:20843790BHF-UCLPMID:20843790
Msx2ChinchillaRNA polymerase II transcription regulatory region sequence-specific DNA binding enablesISOMsx2 (Mus musculus)9068941 PMID:8861098NTNU_SBPMID:8861098
Msx2Chinchillasequence-specific DNA binding enablesISOMSX2 (Homo sapiens)9068941 PMID:9073066MGIPMID:9073066
Msx2Chinchillasequence-specific double-stranded DNA binding enablesISOMSX2 (Homo sapiens)9068941 PMID:28473536ARUK-UCLPMID:28473536
Msx2Chinchillatranscription cis-regulatory region binding enablesISOMsx2 (Mus musculus)9068941 PMID:15383550UniProtPMID:15383550
1 to 16 of 16 rows


#
Reference Title
Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
PMID:22301074   PMID:30032202  



Msx2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540827,323,360 - 27,329,755 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540827,323,405 - 27,329,484 (+)NCBIChiLan1.0ChiLan1.0
MSX2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385174,724,582 - 174,730,896 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5174,724,582 - 174,730,896 (+)EnsemblGRCh38hg38GRCh38
GRCh375174,151,585 - 174,157,899 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365174,084,181 - 174,090,508 (+)NCBINCBI36Build 36hg18NCBI36
Build 345174,084,207 - 174,090,507NCBI
Celera5170,185,579 - 170,191,910 (+)NCBICelera
Cytogenetic Map5q35.2NCBI
HuRef5169,246,978 - 169,253,303 (+)NCBIHuRef
CHM1_15173,583,988 - 173,590,298 (+)NCBICHM1_1
T2T-CHM13v2.05175,263,949 - 175,271,855 (+)NCBIT2T-CHM13v2.0
Msx2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391353,620,917 - 53,626,816 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1353,620,920 - 53,627,110 (-)EnsemblGRCm39 Ensembl
GRCm381353,466,881 - 53,472,780 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1353,466,884 - 53,473,074 (-)EnsemblGRCm38mm10GRCm38
MGSCv371353,562,250 - 53,568,149 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361353,475,420 - 53,480,608 (-)NCBIMGSCv36mm8
Celera1354,545,172 - 54,551,024 (-)NCBICelera
Cytogenetic Map13B1NCBI
cM Map1327.84NCBI
Msx2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81711,102,284 - 11,107,949 (+)NCBIGRCr8
mRatBN7.21711,097,214 - 11,102,879 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1711,097,103 - 11,102,879 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1711,105,528 - 11,111,192 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01712,641,862 - 12,647,525 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01711,104,006 - 11,109,669 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01711,683,862 - 11,689,527 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1711,683,862 - 11,689,527 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01713,785,024 - 13,790,689 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41717,243,262 - 17,248,927 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11717,247,335 - 17,247,755 (+)NCBI
Celera1711,158,359 - 11,164,024 (+)NCBICelera
RH 3.4 Map17109.2RGD
Cytogenetic Map17p14NCBI
MSX2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24169,845,949 - 169,853,128 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15167,985,531 - 167,992,667 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05170,063,137 - 170,070,226 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15176,968,315 - 176,974,679 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5176,967,902 - 176,976,609 (+)Ensemblpanpan1.1panPan2
MSX2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1438,002,724 - 38,007,407 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl438,002,428 - 38,007,407 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha437,948,799 - 37,953,445 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0438,376,184 - 38,380,830 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl438,375,888 - 38,381,225 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1438,192,821 - 38,197,476 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0438,380,991 - 38,385,645 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0438,891,167 - 38,895,822 (-)NCBIUU_Cfam_GSD_1.0
Msx2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721392,492,782 - 92,498,921 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366091,216,436 - 1,221,561 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366091,216,436 - 1,221,528 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MSX2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1649,765,910 - 49,771,789 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11649,765,587 - 49,771,745 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MSX2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12376,873,499 - 76,879,935 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2376,873,669 - 76,879,553 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660341,717,428 - 1,723,746 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Msx2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473315,288,326 - 15,294,568 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473315,288,417 - 15,294,481 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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RefSeq Transcripts XM_005376360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AGCD01008678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GBCE01057111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSCLAT00000020630   ⟹   ENSCLAP00000020432
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495540827,323,360 - 27,329,755 (+)Ensembl
RefSeq Acc Id: XM_005376360   ⟹   XP_005376417
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540827,323,405 - 27,329,484 (+)NCBI
Sequence:
Protein RefSeqs XP_005376417 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000020432
  ENSCLAP00000020432.1
RefSeq Acc Id: XP_005376417   ⟸   XM_005376360
- UniProtKB: A0A8C2W164 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000020432   ⟸   ENSCLAT00000020630
Homeobox



1 to 19 of 19 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSCLAG00000014001 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000020630 ENTREZGENE
  ENSCLAT00000020630.1 UniProtKB/TrEMBL
Gene3D-CATH Homeodomain-like UniProtKB/TrEMBL
InterPro Homeobox-like_sf UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/TrEMBL
  Homeobox_metazoa UniProtKB/TrEMBL
  Msh_Homeobox_Regulators UniProtKB/TrEMBL
NCBI Gene Msx2 ENTREZGENE
PANTHER HOMEOBOX PROTEIN MSX UniProtKB/TrEMBL
  HOMEOBOX PROTEIN MSX-2 UniProtKB/TrEMBL
Pfam Homeodomain UniProtKB/TrEMBL
PRINTS HOMEOBOX UniProtKB/TrEMBL
PROSITE HOMEOBOX_1 UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/TrEMBL
SMART HOX UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/TrEMBL
UniProt A0A8C2W164 ENTREZGENE, UniProtKB/TrEMBL
1 to 19 of 19 rows