Msx2 (msh homeobox 2) - Rat Genome Database

Name: Msx2
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Msx2 (msh homeobox 2) Mus musculus

Analyze

Symbol:

Msx2

Name:

msh homeobox 2

RGD ID:

10921

MGI Page

MGI

Description:

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II and osteoblast differentiation. Acts upstream of or within several processes, including embryonic limb morphogenesis; heart development; and skeletal system development. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; embryo ectoderm; embryo mesenchyme; genitourinary system; and sensory organ. Used to study parietal foramina. Human ortholog(s) of this gene implicated in craniosynostosis and parietal foramina. Orthologous to human MSX2 (msh homeobox 2).

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

BB122635; homeo box, msh-like 2; homeobox protein Hox-8-1; homeobox protein MSX-2; homeobox, msh-like 2; Hox; Hox-; Hox-8; Hox8; Hox8.; Hox8.1

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MSX2 (msh homeobox 2)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):	Msx2 (msh homeobox 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Msx2 (msh homeobox 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MSX2 (msh homeobox 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MSX2 (msh homeobox 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Msx2 (msh homeobox 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MSX2 (msh homeobox 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	MSX2 (msh homeobox 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Msx2 (msh homeobox 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Msx2 (msh homeobox 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Homo sapiens (human):	MSX2 (msh homeobox 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	msx2b (muscle segment homeobox 2b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid\|ZFIN)
Danio rerio (zebrafish):	msx2a (muscle segment homeobox 2a)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|ZFIN)
Drosophila melanogaster (fruit fly):	Dr	Alliance	DIOPT (Hieranoid\|OrthoInspector\|PANTHER)
Caenorhabditis elegans (roundworm):	vab-15	Alliance	DIOPT (InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	msx2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	53,620,917 - 53,626,816 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	53,620,920 - 53,627,110 (-)	Ensembl		GRCm39 Ensembl
GRCm38	13	53,466,881 - 53,472,780 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	53,466,884 - 53,473,074 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	53,562,250 - 53,568,149 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	13	53,475,420 - 53,480,608 (-)	NCBI		MGSCv36	mm8
Celera	13	54,545,172 - 54,551,024 (-)	NCBI		Celera
Cytogenetic Map	13	B1	NCBI
cM Map	13	27.84	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Craniofacial Abnormalities (ISO)

craniosynostosis (ISO)

Craniosynostosis 2 (ISO)

Craniosynostosis Syndrome, Autosomal Recessive (ISO)

Female Urogenital Diseases (ISO)

Femoral Fractures (ISO)

genetic disease (ISO)

hypertension (ISO)

parietal foramina (IAGP,ISO)

Parietal Foramina 1 (ISO)

Parietal Foramina with Cleidocranial Dysplasia (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine (ISO)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,6-dinitrotoluene (ISO)

2-ethylhexan-1-ol (EXP)

3,7-dihydropurine-6-thione (ISO)

4,4'-sulfonyldiphenol (EXP)

5-fluorouracil (ISO)

acrylamide (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (EXP,ISO)

ammonium chloride (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

belinostat (ISO)

benzalkonium chloride (EXP)

benzo[a]pyrene (EXP,ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP)

cadmium dichloride (ISO)

cadmium sulfate (EXP)

calcitriol (ISO)

carbamazepine (ISO)

carbon nanotube (EXP)

CGP 52608 (ISO)

chlorpyrifos (EXP)

cobalt dichloride (ISO)

copper atom (ISO)

copper(0) (ISO)

coumestrol (ISO)

Cuprizon (ISO)

deoxynivalenol (ISO)

dexamethasone (EXP)

diarsenic trioxide (ISO)

diethylstilbestrol (EXP)

dioxygen (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

entinostat (ISO)

folic acid (EXP)

furan (ISO)

genistein (EXP)

glycerol 2-phosphate (EXP)

hexaconazole (EXP)

L-ascorbic acid (EXP)

lead diacetate (EXP)

lipopolysaccharide (EXP)

manganese(II) chloride (ISO)

mercaptopurine (ISO)

mercury dibromide (ISO)

methapyrilene (ISO)

methylmercury chloride (ISO)

Muraglitazar (ISO)

N-methyl-4-phenylpyridinium (ISO)

N-nitrosodiethylamine (ISO)

p-chloromercuribenzoic acid (ISO)

panobinostat (ISO)

phenethyl caffeate (ISO)

phenylmercury acetate (ISO)

progesterone (EXP)

purine-6-thiol (ISO)

retinyl acetate (EXP)

SB 431542 (ISO)

silicon dioxide (ISO)

sunitinib (ISO)

tebuconazole (ISO)

Tesaglitazar (ISO)

triadimefon (ISO)

trichostatin A (ISO)

tripotassium phosphate (ISO)

troglitazone (ISO)

valproic acid (EXP,ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

activation of meiosis (IPI)

anterior/posterior pattern specification (IGI)

BMP signaling pathway (IDA,IGI)

bone morphogenesis (IGI)

bone trabecula formation (IMP)

branching involved in mammary gland duct morphogenesis (IMP)

cartilage development (IMP,ISO)

cell surface receptor signaling pathway involved in heart development (IGI)

cellular response to estradiol stimulus (IDA)

cellular response to growth factor stimulus (IDA)

chondrocyte development (IMP)

embryonic digit morphogenesis (IGI)

embryonic forelimb morphogenesis (IGI)

embryonic hindlimb morphogenesis (IGI)

embryonic limb morphogenesis (IGI)

embryonic morphogenesis (IBA)

embryonic nail plate morphogenesis (IGI)

enamel mineralization (IMP)

endochondral bone growth (IMP)

epithelial to mesenchymal transition involved in endocardial cushion formation (IGI)

frontal suture morphogenesis (IMP)

mammary gland epithelium development (IGI)

mesenchymal cell apoptotic process (IGI)

negative regulation of apoptotic process (IGI)

negative regulation of cell population proliferation (IGI)

negative regulation of DNA-templated transcription (IDA)

negative regulation of fat cell differentiation (IDA)

negative regulation of keratinocyte differentiation (IMP)

negative regulation of transcription by RNA polymerase II (IDA,IGI,ISO)

odontogenesis (IMP)

ossification (IMP)

osteoblast development (IMP,ISO)

osteoblast differentiation (IDA)

outflow tract morphogenesis (IGI)

outflow tract septum morphogenesis (IGI)

positive regulation of apoptotic process (ISO)

positive regulation of BMP signaling pathway (IGI)

positive regulation of mesenchymal cell apoptotic process (IGI)

positive regulation of osteoblast differentiation (IDA)

positive regulation of response to biotic stimulus (ISO)

positive regulation of timing of catagen (IMP)

regulation of apoptotic process (IDA)

regulation of DNA-templated transcription (IEA)

regulation of transcription by RNA polymerase II (IBA)

signal transduction involved in regulation of gene expression (IGI)

stem cell differentiation (IGI)

transcription by RNA polymerase II (ISO)

wound healing (IMP)

wound healing, spreading of epidermal cells (IMP)

Cellular Component

cytosol (ISO)

nuclear speck (ISO)

nucleoplasm (TAS)

nucleus (IBA)

transcription regulator complex (IPI)

Molecular Function

DNA binding (IDA)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA,ISO)

DNA-binding transcription repressor activity, RNA polymerase II-specific (IDA,IMP)

protein binding (IPI)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IDA,ISO)

RNA polymerase II transcription regulatory region sequence-specific DNA binding (IBA,IMP)

sequence-specific DNA binding (ISO)

sequence-specific double-stranded DNA binding (ISO)

transcription cis-regulatory region binding (IDA)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal apical ectodermal ridge morphology (IAGP)

abnormal appendicular skeleton morphology (IAGP)

abnormal artery morphology (IAGP)

abnormal atrioventricular cushion morphology (IAGP)

abnormal axial skeleton morphology (IAGP)

abnormal bone ossification (IAGP)

abnormal cardiac epithelial to mesenchymal transition (IAGP)

abnormal carotid artery morphology (IAGP)

abnormal carpal bone morphology (IAGP)

abnormal cerebellum anterior vermis morphology (IAGP)

abnormal cerebellum development (IAGP)

abnormal cornea morphology (IAGP)

abnormal craniofacial development (IAGP)

abnormal craniofacial morphology (IAGP)

abnormal enamel organ morphology (IAGP)

abnormal external auditory canal morphology (IAGP)

abnormal eye development (IAGP)

abnormal eye morphology (IAGP)

abnormal frontal bone morphology (IAGP)

abnormal hair shedding (IEA)

abnormal heart valve morphology (IAGP)

abnormal lens morphology (IAGP)

abnormal lens vesicle development (IAGP)

abnormal limb development (IAGP)

abnormal long bone hypertrophic chondrocyte zone (IAGP)

abnormal malleus morphology (IAGP)

abnormal mammary gland development (IAGP)

abnormal mammary gland embryonic development (IAGP)

abnormal Meckel's cartilage morphology (IAGP)

abnormal middle ear ossicle morphology (IAGP)

abnormal nail bed morphology (IAGP)

abnormal nail matrix morphology (IAGP)

abnormal nail morphology (IAGP)

abnormal nail plate morphology (IAGP)

abnormal neural tube morphology (IAGP)

abnormal neurocranium morphology (IAGP)

abnormal optic vesicle formation (IAGP)

abnormal pelvic girdle bone morphology (IAGP)

abnormal retina pigment epithelium morphology (IAGP)

abnormal skeleton development (IAGP)

abnormal stellate reticulum morphology (IAGP)

abnormal stratum intermedium morphology (IAGP)

abnormal tarsal bone morphology (IAGP)

abnormal trabecular bone morphology (IAGP)

abnormal vertebral artery morphology (IAGP)

absent cerebellum vermis lobule IX (IAGP)

absent cerebellum vermis lobule VIII (IAGP)

absent gastric milk in neonates (IAGP)

absent malleus manubrium (IAGP)

absent malleus processus brevis (IAGP)

absent pubis (IAGP)

absent teeth (IAGP)

absent tympanic ring (IAGP)

alopecia (IAGP)

ameloblast degeneration (IAGP)

anterior iris synechia (IAGP)

arrest of tooth development (IAGP)

atrial septal defect (IAGP)

atrioventricular cushion hypoplasia (IAGP)

big ears (IAGP)

brittle teeth (IAGP)

cerebellum vermis hypoplasia (IAGP)

chondrodystrophy (IAGP)

cleft palate (IAGP)

cleft secondary palate (IAGP)

corneal opacity (IAGP)

curly vibrissae (IAGP)

decreased bone mineral density (IAGP)

decreased brain size (IAGP)

decreased chondrocyte number (IAGP)

decreased compact bone thickness (IAGP)

decreased corneal epithelium thickness (IAGP)

decreased embryo size (IAGP)

decreased hair follicle number (IAGP)

decreased osteoclast cell number (IAGP)

decreased spinal cord size (IAGP)

deformed nails (IAGP)

degenerate molars (IAGP)

delaminated cerebellar granule layer (IAGP)

delaminated Purkinje cell layer (IAGP)

delayed hair regrowth (IEA)

embryonic growth retardation (IAGP)

embryonic lethality during organogenesis, incomplete penetrance (IAGP)

exencephaly (IAGP)

frontal bone foramen (IAGP)

fused cornea and lens (IAGP)

increased cornea thickness (IAGP)

increased corneal stroma thickness (IAGP)

interdigital webbing (IAGP)

intracranial aneurysm (IAGP)

intracranial hemorrhage (IAGP)

iris hyperplasia (IAGP)

lethality throughout fetal growth and development, complete penetrance (IAGP)

long nails (IAGP)

long toenails (IAGP)

malocclusion (IAGP)

microphthalmia (IAGP)

narrow eye opening (IAGP)

neonatal lethality (IAGP)

no abnormal phenotype detected (IAGP)

oligodactyly (IAGP)

perinatal lethality (IAGP)

polydactyly (IAGP)

premature hair loss (IAGP)

retina fold (IAGP)

short femur (IAGP)

short limbs (IAGP)

short nails (IAGP)

short snout (IAGP)

short tibia (IAGP)

short vibrissae (IAGP)

small interparietal bone (IAGP)

small lens (IAGP)

small limb buds (IAGP)

small malleus (IAGP)

small scapula (IAGP)

small supraoccipital bone (IAGP)

spina bifida (IAGP)

thoracoabdominoschisis (IAGP)

tonic seizures (IAGP)

vascular smooth muscle hypoplasia (IAGP)

vitreous body deposition (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	Changes in homeobox-containing gene expression during ectopic bone formation induced by bone morphogenetic protein.	Iimura T, etal., Biochem Biophys Res Commun 1994 Jun 15;201(2):980-7.
2.	Regulation of MT melatonin receptor expression in the foetal rat pituitary.	Johnston JD, etal., J Neuroendocrinol. 2006 Jan;18(1):50-6.
3.	Calcification of aortic smooth muscle cells isolated from spontaneously hypertensive rats.	Kanemaru K, etal., J Pharmacol Sci. 2008 Feb;106(2):280-6. Epub 2008 Feb 9.
4.	The molecular basis of Boston-type craniosynostosis: the Pro148-->His mutation in the N-terminal arm of the MSX2 homeodomain stabilizes DNA binding without altering nucleotide sequence preferences.	Ma L, etal., Hum Mol Genet. 1996 Dec;5(12):1915-20.
5.	Electronic Transfer of Homolog Data	MGD and Homologene mouse data transfer
6.	MGDs mouse GO annotations	MGD data from the GO Consortium
7.	MGD IEA	MGD IEA
8.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
9.	Mouse MP Annotation Import Pipeline	RGD automated import pipeline
10.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
12.	Functional haploinsufficiency of the human homeobox gene MSX2 causes defects in skull ossification.	Wilkie AO, etal., Nat Genet. 2000 Apr;24(4):387-90.

Additional References at PubMed

PMID:1358459	PMID:1358591	PMID:1673109	PMID:1677742	PMID:1682128	PMID:7482767	PMID:7537232	PMID:7538067	PMID:7554927	PMID:7554933	PMID:7577436	PMID:7588050
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PMID:8769660	PMID:8787747	PMID:8861098	PMID:8861099	PMID:8887328	PMID:9000753	PMID:9097019	PMID:9111364	PMID:9142497	PMID:9207129	PMID:9226452	PMID:9256341
PMID:9256350	PMID:9265625	PMID:9268572	PMID:9300656	PMID:9477322	PMID:9486790	PMID:9501086	PMID:9541203	PMID:9556061	PMID:9584130	PMID:9651475	PMID:9671575
PMID:9672840	PMID:9714793	PMID:9768360	PMID:9778496	PMID:9799429	PMID:9808626	PMID:9851982	PMID:9853970	PMID:9870533	PMID:9882503	PMID:9917362	PMID:10021345
PMID:10075839	PMID:10098408	PMID:10227293	PMID:10349636	PMID:10391928	PMID:10451362	PMID:10467942	PMID:10469309	PMID:10499585	PMID:10534616	PMID:10602018	PMID:10625557
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PMID:11744114	PMID:11798166	PMID:11807035	PMID:11807043	PMID:11823447	PMID:11854453	PMID:11861914	PMID:11867524	PMID:11937494	PMID:11944941	PMID:11955708	PMID:11959851
PMID:12000792	PMID:12152071	PMID:12193642	PMID:12217322	PMID:12351180	PMID:12358782	PMID:12403705	PMID:12413903	PMID:12441290	PMID:12466204	PMID:12466851	PMID:12477932
PMID:12489206	PMID:12571099	PMID:12588849	PMID:12648495	PMID:12701100	PMID:12736212	PMID:12737212	PMID:12752768	PMID:12754255	PMID:12766037	PMID:12782276	PMID:12783783
PMID:12805214	PMID:12808456	PMID:12812790	PMID:12874124	PMID:12925529	PMID:12925582	PMID:12944425	PMID:12971989	PMID:14512019	PMID:14526104	PMID:14551209	PMID:14597577
PMID:14610273	PMID:14623826	PMID:14648841	PMID:14681479	PMID:14699574	PMID:14728799	PMID:15060165	PMID:15081361	PMID:15105374	PMID:15131132	PMID:15136147	PMID:15155529
PMID:15175325	PMID:15198690	PMID:15201225	PMID:15218525	PMID:15272023	PMID:15342482	PMID:15383550	PMID:15385160	PMID:15385444	PMID:15456894	PMID:15459107	PMID:15469980
PMID:15496517	PMID:15499554	PMID:15509764	PMID:15581864	PMID:15618518	PMID:15673394	PMID:15691760	PMID:15743757	PMID:15803476	PMID:15812993	PMID:15872058	PMID:15930102
PMID:15936012	PMID:15944189	PMID:16087869	PMID:16093251	PMID:16115867	PMID:16141072	PMID:16141073	PMID:16207751	PMID:16221730	PMID:16308330	PMID:16314491	PMID:16314518
PMID:16357211	PMID:16423343	PMID:16495310	PMID:16513791	PMID:16524929	PMID:16537572	PMID:16540516	PMID:16602821	PMID:16630606	PMID:16712836	PMID:16790481	PMID:16806156
PMID:16839541	PMID:16839542	PMID:16881063	PMID:16887830	PMID:16894609	PMID:16900517	PMID:16959237	PMID:17030628	PMID:17035289	PMID:17060321	PMID:17090159	PMID:17119023
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PMID:19251658	PMID:19273610	PMID:19286674	PMID:19338779	PMID:19370755	PMID:19389368	PMID:19391114	PMID:19414008	PMID:19419310	PMID:19422820	PMID:19470461	PMID:19576202
PMID:19648291	PMID:19700620	PMID:19705442	PMID:19766620	PMID:19769717	PMID:19777594	PMID:19783740	PMID:19850029	PMID:19860126	PMID:19913006	PMID:19922873	PMID:20034106
PMID:20035737	PMID:20043884	PMID:20059953	PMID:20206242	PMID:20211142	PMID:20225205	PMID:20356956	PMID:20386744	PMID:20392740	PMID:20394734	PMID:20398647	PMID:20436479
PMID:20440096	PMID:20445055	PMID:20459789	PMID:20460112	PMID:20460368	PMID:20484411	PMID:20510229	PMID:20635397	PMID:20803545	PMID:20843790	PMID:20878775	PMID:20883686
PMID:20932939	PMID:20934968	PMID:20939017	PMID:20962035	PMID:21089072	PMID:21194678	PMID:21237142	PMID:21256124	PMID:21267068	PMID:21303850	PMID:21307092	PMID:21308776
PMID:21309073	PMID:21384471	PMID:21387539	PMID:21465616	PMID:21465622	PMID:21471203	PMID:21512281	PMID:21514273	PMID:21531785	PMID:21539829	PMID:21549111	PMID:21558373
PMID:21693521	PMID:21752813	PMID:21852201	PMID:21873635	PMID:21912524	PMID:21945076	PMID:21953618	PMID:21968101	PMID:21983003	PMID:22071108	PMID:22100262	PMID:22116936
PMID:22174793	PMID:22219353	PMID:22240098	PMID:22275192	PMID:22275227	PMID:22340494	PMID:22383889	PMID:22387309	PMID:22395741	PMID:22432025	PMID:22461561	PMID:22465667
PMID:22503753	PMID:22508726	PMID:22547067	PMID:22573616	PMID:22614360	PMID:22632802	PMID:22633971	PMID:22658483	PMID:22662233	PMID:22718343	PMID:22911573	PMID:22966238
PMID:22988430	PMID:23028704	PMID:23034633	PMID:23071453	PMID:23090744	PMID:23103586	PMID:23123965	PMID:23145080	PMID:23201021	PMID:23213427	PMID:23293290	PMID:23344708
PMID:23358455	PMID:23382810	PMID:23425387	PMID:23459943	PMID:23469192	PMID:23506836	PMID:23560082	PMID:23584732	PMID:23593111	PMID:23630450	PMID:23633963	PMID:23685555
PMID:23702391	PMID:23744351	PMID:23818325	PMID:24007338	PMID:24115909	PMID:24146773	PMID:24238961	PMID:24257627	PMID:24278237	PMID:24336726	PMID:24385915	PMID:24387797
PMID:24586192	PMID:24631216	PMID:24680892	PMID:24715462	PMID:24831012	PMID:24947469	PMID:24990742	PMID:24990743	PMID:25034710	PMID:25056439	PMID:25166858	PMID:25448692
PMID:25460335	PMID:25617432	PMID:25626636	PMID:25687138	PMID:25794678	PMID:25820239	PMID:25931120	PMID:25950518	PMID:26042621	PMID:26093309	PMID:26212322	PMID:26391659
PMID:26441343	PMID:26450968	PMID:26512061	PMID:26538636	PMID:26661618	PMID:26667042	PMID:26677825	PMID:26806701	PMID:26813283	PMID:26826495	PMID:26912775	PMID:26959361
PMID:27048518	PMID:27234308	PMID:27435625	PMID:27524798	PMID:27586544	PMID:27606604	PMID:27713395	PMID:27827819	PMID:28069742	PMID:28333962	PMID:28461333	PMID:28710291
PMID:28794157	PMID:28829997	PMID:28846100	PMID:28893947	PMID:28964716	PMID:29255029	PMID:29321139	PMID:29352015	PMID:29463648	PMID:29577917	PMID:29746183	PMID:29771958
PMID:29773104	PMID:29852132	PMID:29921154	PMID:30097516	PMID:30177510	PMID:30201295	PMID:30575813	PMID:30615824	PMID:30638444	PMID:30683901	PMID:30854720	PMID:30905259
PMID:30953627	PMID:31024170	PMID:31125045	PMID:31221479	PMID:31351040	PMID:31427537	PMID:31869353	PMID:32105214	PMID:32325033	PMID:32467233	PMID:32616504	PMID:32866472
PMID:33046507	PMID:33080014	PMID:33192593	PMID:33206716	PMID:33382037	PMID:33483579	PMID:34041852	PMID:34150743	PMID:34155146	PMID:34292881	PMID:34321664	PMID:34584102
PMID:34822715	PMID:34845330	PMID:34851738	PMID:35514355	PMID:35593225	PMID:35781558	PMID:35830813	PMID:36220812	PMID:36227576	PMID:36941249	PMID:37102702	PMID:37191055
PMID:37385754	PMID:37524711	PMID:37702066

Genomics

Comparative Map Data

Msx2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	53,620,917 - 53,626,816 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	53,620,920 - 53,627,110 (-)	Ensembl		GRCm39 Ensembl
GRCm38	13	53,466,881 - 53,472,780 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	53,466,884 - 53,473,074 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	53,562,250 - 53,568,149 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	13	53,475,420 - 53,480,608 (-)	NCBI		MGSCv36	mm8
Celera	13	54,545,172 - 54,551,024 (-)	NCBI		Celera
Cytogenetic Map	13	B1	NCBI
cM Map	13	27.84	NCBI

MSX2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	174,724,582 - 174,730,896 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	174,724,582 - 174,730,896 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	174,151,585 - 174,157,899 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	174,084,181 - 174,090,508 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	174,084,207 - 174,090,507	NCBI
Celera	5	170,185,579 - 170,191,910 (+)	NCBI		Celera
Cytogenetic Map	5	q35.2	NCBI
HuRef	5	169,246,978 - 169,253,303 (+)	NCBI		HuRef
CHM1_1	5	173,583,988 - 173,590,298 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	5	175,263,949 - 175,271,855 (+)	NCBI		T2T-CHM13v2.0

Msx2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	17	11,097,214 - 11,102,879 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	11,097,103 - 11,102,879 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	17	11,105,528 - 11,111,192 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	12,641,862 - 12,647,525 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	11,104,006 - 11,109,669 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	11,683,862 - 11,689,527 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	11,683,862 - 11,689,527 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	17	13,785,024 - 13,790,689 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	17	17,243,262 - 17,248,927 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	17	17,247,335 - 17,247,755 (+)	NCBI
Celera	17	11,158,359 - 11,164,024 (+)	NCBI		Celera
RH 3.4 Map	17	109.2	RGD
Cytogenetic Map	17	p14	NCBI

Msx2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955408	27,323,360 - 27,329,755 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955408	27,323,405 - 27,329,484 (+)	NCBI	ChiLan1.0	ChiLan1.0

MSX2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	5	167,985,531 - 167,992,667 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	170,063,137 - 170,070,226 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	176,968,315 - 176,974,679 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	176,967,902 - 176,976,609 (+)	Ensembl	panpan1.1		panPan2

MSX2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	4	38,002,724 - 38,007,407 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	4	38,002,428 - 38,007,407 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	4	37,948,799 - 37,953,445 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	4	38,376,184 - 38,380,830 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	4	38,375,888 - 38,381,225 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	4	38,192,821 - 38,197,476 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	4	38,380,991 - 38,385,645 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	4	38,891,167 - 38,895,822 (-)	NCBI		UU_Cfam_GSD_1.0

Msx2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	92,492,782 - 92,498,921 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936609	1,216,436 - 1,221,561 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936609	1,216,436 - 1,221,528 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MSX2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	16	49,765,910 - 49,771,789 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	16	49,765,587 - 49,771,745 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

MSX2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	76,873,499 - 76,879,935 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	23	76,873,669 - 76,879,553 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666034	1,717,428 - 1,723,746 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Msx2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624733	15,288,326 - 15,294,568 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624733	15,288,417 - 15,294,481 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Msx2
275 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	392
Count of miRNA genes:	257
Interacting mature miRNAs:	356
Transcripts:	ENSMUST00000021922
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
26884393	Humsd7_m	humerus midshaft diameter 7, 16 week (mouse)					13	3950000	76048119	Mouse
1301015	Sysbp2_m	systolic blood pressure 2 (mouse)			Not determined		13	20477612	59821605	Mouse
4142147	Mvwf4_m	modifier of von Willebrand factor 4 (mouse)			Not determined			20477612	112898424	Mouse
1357591	Tesq1_m	testis weight QTL 1 (mouse)			Not determined		13	20615512	55720517	Mouse
4142009	Pregq3_m	pregnancy QTL 3 (mouse)			Not determined		13	20615512	72385189	Mouse
10045618	Heal17_m	wound healing/regeneration 17 (mouse)			Not determined		13	20746939	54747056	Mouse
4142489	Ath25_m	atherosclerosis 25 (mouse)			Not determined			25836529	59836529	Mouse
10401111	Pgia40_m	proteoglycan induced arthritis 40 (mouse)			Not determined		13	27918469	61918560	Mouse
1300710	Pcd4ts2_m	p-glycoprotein positive CD4 T cell subset 2 (mouse)			Not determined		13	28210442	62210544	Mouse
1357802	Vtbt15_m	vertebral trabecular bone trait 15 (mouse)			Not determined		13	28217379	62217515	Mouse
10045621	Heal21_m	wound healing/regeneration 21 (mouse)			Not determined		13	28217379	62217515	Mouse
10755533	Chol18_m	cholesterol 18 (mouse)					13	30969467	64969467	Mouse
10755517	Chol15_m	cholesterol 15 (mouse)					13	30969467	64969467	Mouse
12738439	Twq4_m	testis weight QTL 4 (mouse)					13	31129110	65129110	Mouse
14696729	Kidlq2_m	kidney weight, left QTL 2 (mouse)					13	31344736	65344736	Mouse
1301299	Sluc23_m	susceptibility to lung cancer 23 (mouse)			Not determined		13	34921943	68922081	Mouse
10412235	Scgq5_m	spontaneous crescentic glomerulonephritis QTL 5 (mouse)			Not determined		13	36060908	96239162	Mouse
1357587	Pfat3_m	predicted fat percentage 3 (mouse)			Not determined		13	36101530	70101640	Mouse
1301734	Acsns2_m	Angiostrongylus costaricensis nematode susceptibility 2 (mouse)			Not determined		13	36101530	70101640	Mouse
1300561	Heal7_m	wound healing/regeneration 7 (mouse)			Not determined		13	36144820	70144904	Mouse
1300862	Cfbw5_m	cystic fibrosis body weight 5 (mouse)			Not determined		13	38720358	72720517	Mouse
1300985	Bmd13_m	bone mineral density 13 (mouse)			Not determined		13	39629249	73629397	Mouse
1302157	Bwem2_m	body weight day 30 males 2 (mouse)			Not determined		13	39629249	73629397	Mouse
1301801	Cpfd5_m	cerebellum pattern fissures (mouse)			Not determined		13	39629249	73629397	Mouse
15039353	Nmrs35_m	NAFLD-associated magnetic resonance shift 35 (mouse)					13	40588253	74588253	Mouse
1300668	Pas10_m	pulmonary adenoma susceptibility 10 (mouse)			Not determined		13	41489042	75489158	Mouse
4142331	Bxs6_m	BXSB/MpJ autoimmune nephritis 6 (mouse)			Not determined			45210442	83744746	Mouse
10412109	Bxs7_m	BXSB/MpJ autoimmune nephritis 7 (mouse)			Not determined		13	45210442	83744746	Mouse
26884396	Humsd4_m	humerus midshaft diameter 4, 10 week (mouse)					13	47853476	73148119	Mouse
4142372	Moo2_m	modifier of Odc2 (mouse)			Not determined		X	50318411	84318559	Mouse
1301666	Eae13_m	susceptibility to experimental allergic encephalomyelitis 13 (mouse)			Not determined		13	50318411	84318559	Mouse
1300573	Elsgp2_m	elevated serum gp70 2 (mouse)			Not determined		13	50616828	84617027	Mouse
14746975	Manh74_m	mandible shape 74 (mouse)					13	52477269	86477269	Mouse
25671382	Hrsq4_m	host response to SARS QTL 4, vascular cuffing (mouse)					13	52881651	54992738	Mouse

Markers in Region

BB122635

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	13	53,466,963 - 53,467,064	UniSTS	GRCm38
MGSCv37	13	53,562,332 - 53,562,433	UniSTS	GRCm37
Celera	13	54,545,254 - 54,545,355	UniSTS
Cytogenetic Map	13	B1	UniSTS
cM Map	13	32.0	UniSTS
Whitehead/MRC_RH	13	562.84	UniSTS

L11739

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	13	53,468,050 - 53,468,155	UniSTS	GRCm38
MGSCv37	13	53,563,419 - 53,563,524	UniSTS	GRCm37
Celera	13	54,546,312 - 54,546,417	UniSTS
Cytogenetic Map	13	B1	UniSTS
cM Map	13	32.0	UniSTS
Whitehead/MRC_RH	13	562.84	UniSTS

Msx2

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
Cytogenetic Map	13	B1	UniSTS
cM Map	13	32.0	UniSTS

Msx2

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
Cytogenetic Map	13	B1	UniSTS

Msx2

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
Cytogenetic Map	13	B1	UniSTS

Msx2

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
Cytogenetic Map	13	B1	UniSTS

Msx2

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
Cytogenetic Map	13	B1	UniSTS

Msx2

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	13	53,468,458 - 53,468,560	UniSTS	GRCm38
Celera	13	54,546,720 - 54,546,822	UniSTS
Cytogenetic Map	13	B1	UniSTS

Msx2

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	13	53,467,951 - 53,468,209	UniSTS	GRCm38
MGSCv37	13	53,563,320 - 53,563,578	UniSTS	GRCm37
Celera	13	54,546,213 - 54,546,471	UniSTS
Cytogenetic Map	13	B1	UniSTS
cM Map	13	32.0	UniSTS

Msx2

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	13	53,473,658 - 53,473,864	UniSTS	GRCm38
MGSCv37	13	53,569,027 - 53,569,233	UniSTS	GRCm37
Celera	13	54,551,902 - 54,552,111	UniSTS
Cytogenetic Map	13	B1	UniSTS
cM Map	13	32.0	UniSTS

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_013601	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC159201	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AH000034	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AH006876	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK131974	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK133846	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AV230604	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC141132	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466546	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HQ260699	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M38576	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X59252	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSMUST00000021922 ⟹ ENSMUSP00000021922

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	13	53,620,920 - 53,627,110 (-)	Ensembl
GRCm38.p6 Ensembl	13	53,466,884 - 53,473,074 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000188606

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	13	53,625,542 - 53,627,110 (-)	Ensembl
GRCm38.p6 Ensembl	13	53,471,506 - 53,473,074 (-)	Ensembl

RefSeq Acc Id:

NM_013601 ⟹ NP_038629

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	13	53,620,917 - 53,626,816 (-)	NCBI
GRCm38	13	53,466,881 - 53,472,780 (-)	ENTREZGENE
MGSCv37	13	53,562,250 - 53,568,149 (-)	RGD
Celera	13	54,545,172 - 54,551,024 (-)	RGD
cM Map	13		ENTREZGENE

Sequence:

show sequence

AAAAGTTGGAGTCTTCGCTTGAGAGTTGCCAGCGGAGTCGCGCGCCGACAGCTACGCGGCGCAG
AAAGTCATGGCTTCTCCGACTAAAGGCGGTGACTTGTTTTCGTCGGATGAGGAGGGCCCCGCGG
TACTGGCCGGCCCGGGTCCCGGGCCTGGAGGAGCCGAGGGCAGCGCAGAGGAACGCAGGGTCAA
GGTCTCCAGCCTGCCCTTCAGCGTGGAGGCGCTCATGTCCGACAAGAAGCCGCCCAAGGAATCG
CCCGCGGTGCCACCCGACTGCGCCTCGGCTGGCGCTGTCCTGCGGCCGCTGCTGCTGCCGGGAC
ACGGCGTCCGGGACGCTCACAGTCCCGGGCCTCTCGTCAAGCCCTTCGAGACCGCCTCGGTCAA
GTCGGAAAATTCCGAAGACGGAGCACCGTGGATACAGGAGCCCGGCAGATACTCCCCGCCGCCC
AGACATATGAGCCCCACCACCTGCACCCTGAGGAAACACAAGACCAACCGGAAGCCACGCACAC
CCTTCACCACATCCCAGCTTCTAGCCTTGGAGCGCAAGTTCCGCCAGAAACAGTACCTGTCCAT
AGCAGAGCGGGCCGAGTTCTCCAGCTCTCTGAACCTTACAGAGACCCAGGTCAAAATCTGGTTC
CAGAACCGAAGGGCTAAGGCGAAAAGACTGCAAGAGGCGGAACTGGAAAAGCTGAAAATGGCTG
CCAAGCCTATGCTGCCCTCAGGCTTCAGTCTGCCCTTCCCTATCAACTCACCCCTGCAAGCAGC
ATCCATATACGGCGCATCCTACCCCTTCCATAGACCTGTGCTCCCCATCCCGCCTGTTGGACTC
TATGCCACGCCGGTTGGATATGGCATGTACCATCTATCCTAAGGAAGACCAGATGGACCAGACT
CCAGGATGGATGTTTGCATAAAAGCATCCCCCTCCCTCTCCGAGAAGGTGGTGCCAACTCTGCT
CCTGAATGCGAGCCTTGCATTGTCACCCTAAGCGACAGGGCCACTTGATACAGAGTGAATTTGT
TATTTAGGTGAGAGGCACTAAGACCTGTTTTGTTTTCATAATTTTCCAAATGCCCCCTTTCCTC
TCACAAATATTGGCTCTGCTAGTTTTTATGTATAAATATATAATAAAATATAAGACTTTTTATA
TGCCAGATGTAAAAATTCAAGTTATTTTAAAAGGCAAAATTTATATATACATTTATCCATTTTC
TTTTTTTTTCTAGATAGCATCTTCCTAAGATATTGTGTTAAGTCCATTTGCTACATTTTCTTAA
AGGGAAAGAGATTAATTGCAGAATTTGCAAGGATGGTGGACTTGCTTATGGAAAACATAGCAGA
AGTAGACACATTCCATACAGGATGTCACTTCAGACAGATTCTTGCAAGTGAAGGGGGAGGTGTA
ACGTGTTTATTTGCATTTCTGTGCACAAGAAAAAGAAATCTCTTGATGCACATTTGATCCTATT
TTTTTTCTCTTTTTCTCCATTCCATATTATTAAATCTTTGTTGTTGTTTTAAGATCGATGAAAA
GAGGATGAGAATAACTCTGAGAGTTACTCAGGGTAAAGTAGAAAATAGGAAACTCCATGTCAGG
TCCCTGGAGTGAGAGGGGGTTAGAAGGTGAAATATTGTTTGTAAGAATTGATTTCTATGAAATG
CTATCTACATCAGTCCTCACACGGTACAGAGGTGATTGGAAGAGGACATGGTAAATCTCTTCTT
AAAAATGAGTGTCTTATAACTGTGGCCTATATTTTAAATATTCTTCAACAGTCCATAGAATGAG
GAAGGAAAACATGCCTTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTA
GCTCTCTCTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTACTTTGT
GTGCTAAACTTCTTAGGGAAATTTATATACTCTAACGTGTTGGGCAGATGGAGAAGCCATGTGC
TTGAGTTGCTGGAGATGGCGTTGTCAGTCAGCACCTGGGTGTCTCACCTTCCTGTCCATCTCTT
CCCCCAGTATATTTTTATCCCGTTGAATGGGTATCTTGTATAATTTTATATATTTTATTGAAGA
GTTATTTCTTATCTCTTACTCTGAATTAAATTAAAATATTTTATTGCAGT

hide sequence

Protein Sequences


Protein RefSeqs	NP_038629	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA03477	(Get FASTA)	NCBI Sequence Viewer
	AAA37824	(Get FASTA)	NCBI Sequence Viewer
	AAC60657	(Get FASTA)	NCBI Sequence Viewer
	AAI41133	(Get FASTA)	NCBI Sequence Viewer
	AEN94298	(Get FASTA)	NCBI Sequence Viewer
	BAE20914	(Get FASTA)	NCBI Sequence Viewer
	BAE21882	(Get FASTA)	NCBI Sequence Viewer
	CAA41945	(Get FASTA)	NCBI Sequence Viewer
	EDL41125	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSMUSP00000021922
GenBank Protein	Q03358	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_038629 ⟸ NM_013601

- UniProtKB:

Q63856 (UniProtKB/Swiss-Prot), Q03358 (UniProtKB/Swiss-Prot), Q3UZH5 (UniProtKB/TrEMBL), G3DRA8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MASPTKGGDLFSSDEEGPAVLAGPGPGPGGAEGSAEERRVKVSSLPFSVEALMSDKKPPKESPA
VPPDCASAGAVLRPLLLPGHGVRDAHSPGPLVKPFETASVKSENSEDGAPWIQEPGRYSPPPRH
MSPTTCTLRKHKTNRKPRTPFTTSQLLALERKFRQKQYLSIAERAEFSSSLNLTETQVKIWFQN
RRAKAKRLQEAELEKLKMAAKPMLPSGFSLPFPINSPLQAASIYGASYPFHRPVLPIPPVGLYA
TPVGYGMYHLS

hide sequence

RefSeq Acc Id:

ENSMUSP00000021922 ⟸ ENSMUST00000021922

Protein Domains

Homeobox

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q03358-F1-model_v2	AlphaFold	Q03358	1-267	view protein structure

Promoters

RGD ID:

8680418

Promoter ID:

EPDNEW_M18216

Type:

initiation region

Name:

Msx2_1

Description:

Mus musculus msh homeobox 2 , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	13	53,472,770 - 53,472,830	EPDNEW

RGD ID:

6824170

Promoter ID:

MM_KWN:14165

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

ES_Cell, MEF_B4, MEF_B6

Transcripts:

OTTMUST00000049518

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	13	53,567,869 - 53,568,369 (-)	MPROMDB

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:97169	AgrOrtholog
Ensembl Genes	ENSMUSG00000021469	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSMUST00000021922	ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH	Homeodomain-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	Homeobox-like_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Homeobox_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Homeobox_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Homeobox_metazoa	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	mmu:17702	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD	MGI:97169	ENTREZGENE
NCBI Gene	17702	ENTREZGENE
PANTHER	HOMEOBOX PROTEIN MSX	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HOMEOBOX PROTEIN MSX-2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Homeodomain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Msx2	PhenoGen
PRINTS	HOMEOBOX	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	HOMEOBOX_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HOMEOBOX_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	HOX	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF46689	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	G3DRA8	ENTREZGENE, UniProtKB/TrEMBL
	MSX2_MOUSE	UniProtKB/Swiss-Prot, ENTREZGENE
	Q3UZH5	ENTREZGENE, UniProtKB/TrEMBL
	Q63856	ENTREZGENE
UniProt Secondary	Q63856	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-08-06	Msx2	msh homeobox 2	Msx2	homeobox, msh-like 2	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Mammalian Phenotype

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