Guca2a (guanylate cyclase activator 2A)

Gene: Guca2a (guanylate cyclase activator 2A) Chinchilla lanigera

Analyze

Symbol:

Guca2a

Name:

guanylate cyclase activator 2A

RGD ID:

8950644

Description:

ENCODES a protein that exhibits guanylate cyclase activator activity (ortholog); ASSOCIATED WITH Charcot-Marie-Tooth disease dominant intermediate C (ortholog); genetic disease (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

guanylate cyclase activator 2A (guanylin); guanylin

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955537	1,805,671 - 1,807,662 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955537	1,805,671 - 1,808,797 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Charcot-Marie-Tooth disease dominant intermediate C (ISO)

genetic disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Molecular Function

guanylate cyclase activator activity (ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Guca2a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955537	1,805,671 - 1,807,662 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955537	1,805,671 - 1,808,797 (-)	NCBI	ChiLan1.0	ChiLan1.0

GUCA2A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	42,162,690 - 42,164,745 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	42,162,690 - 42,164,745 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	42,628,361 - 42,630,416 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	42,400,949 - 42,402,982 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	42,297,454 - 42,299,488	NCBI
Celera	1	40,910,655 - 40,912,688 (-)	NCBI		Celera
Cytogenetic Map	1	p34.2	NCBI
HuRef	1	40,747,927 - 40,749,960 (-)	NCBI		HuRef
CHM1_1	1	42,745,486 - 42,747,519 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	42,033,343 - 42,035,398 (-)	NCBI		T2T-CHM13v2.0

Guca2a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	119,494,929 - 119,496,662 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	119,494,901 - 119,496,668 (+)	Ensembl		GRCm39 Ensembl
GRCm38	4	119,637,732 - 119,639,465 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	119,637,704 - 119,639,471 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	119,310,337 - 119,312,070 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	119,135,664 - 119,137,397 (+)	NCBI		MGSCv36	mm8
Celera	4	118,370,520 - 118,372,251 (+)	NCBI		Celera
Cytogenetic Map	4	D2.1	NCBI
cM Map	4	55.47	NCBI

Guca2a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	138,522,446 - 138,524,288 (+)	NCBI		GRCr8
mRatBN7.2	5	133,237,177 - 133,239,019 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	133,237,177 - 133,239,018 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	135,965,843 - 135,967,692 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	137,722,285 - 137,724,134 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	137,742,889 - 137,744,738 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	138,685,634 - 138,687,476 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	138,685,624 - 138,687,816 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	142,487,928 - 142,489,770 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	140,227,304 - 140,229,146 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	140,232,529 - 140,234,371 (+)	NCBI
Celera	5	131,760,599 - 131,762,441 (+)	NCBI		Celera
RH 3.4 Map	5	875.9	RGD
Cytogenetic Map	5	q36	NCBI

GUCA2A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	184,647,667 - 184,649,748 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	183,789,725 - 183,791,806 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	41,462,047 - 41,464,122 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	42,841,930 - 42,844,005 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	42,841,930 - 42,844,005 (-)	Ensembl	panpan1.1		panPan2

GUCA2A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	15	1,090,109 - 1,091,277 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	15	1,090,109 - 1,091,375 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	15	1,347,225 - 1,348,394 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	15	1,177,643 - 1,178,815 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	15	1,177,643 - 1,178,913 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	15	1,082,785 - 1,083,953 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	15	1,144,533 - 1,145,694 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	15	1,159,429 - 1,160,598 (+)	NCBI		UU_Cfam_GSD_1.0

Guca2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	57,815,809 - 57,818,040 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936474	23,640,586 - 23,642,599 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936474	23,640,589 - 23,642,573 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GUCA2A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	169,146,334 - 169,148,286 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	169,146,336 - 169,148,284 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	156,476,368 - 156,478,316 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GUCA2A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	90,757,887 - 90,760,598 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666033	26,144,687 - 26,146,880 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Guca2a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624892	1,512,585 - 1,514,339 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624892	1,498,123 - 1,514,419 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005410593	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_013507783	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01070905	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDJ01089620	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000005020 ⟹ ENSCLAP00000004928

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955537	1,805,671 - 1,807,662 (-)	Ensembl

RefSeq Acc Id:

XM_005410593 ⟹ XP_005410650

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955537	1,805,671 - 1,807,662 (-)	NCBI

Sequence:

show sequence

CCAGATGGGACGCTGACAAGGGCTGGAGGTTATTCAGTAACTCTGACCTCCTTAAAAGGTCTGC
TCTTTCCTGACACCAGAACCAGTGTCTGGTCTCCCGGCTTCTGATGCCATGAACACCTTCCTGC
TCTCTGCACTGTGCCTTGGTGCCTGGGCTGCTCTGGCTGGGGCGGTCACTGTACGGGATGGAGA
TTTCTCCTTTCCTCTGGAGTCAGTGAAGAAGCTCAAAGACCTCCAGGAGGTCCCAGAGCCCAAG
GTCCAGGGCCGCAGAAAGTTTGTGACTCCACCGCTCTGCAGTCACCCAGGATTTCCAGAGGAGC
TCCGGCCTGTCTGCAGCCAGCCCAACGCAGAGGACATCCTGCACCGGCTTGAGGCCATCGCTCA
GGACCCGAGCACTTGTGAGATCTGTGCCTACGCCGCCTGCGCCGGATGCTAGGGCGGCCTAGCC
GCTGTCTTCCTCCCAGGGAAGCCCTTTCTTCTGCTGGAAGGGCAACGCGTGATCCTCCCACTCC
TAGCAGCTCAACCTACGCTGCCCCAAGGGAGCTCAGAGAGGGGCTGCGGGATGAGGGCTTCCAG
GCCTGAGACCGAGCTTTGCAAGGTGCATGCCAACCCTCAGCTAATAAACCGGATTCCGAGTA

hide sequence

RefSeq Acc Id:

XM_013507783 ⟹ XP_013363237

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955537	1,805,671 - 1,808,797 (-)	NCBI

Sequence:

show sequence

CCAAGCTTTACTCTATTCAGTCCCTTCTTCAGTATTGACTCTGGCACACAGGCATTCCTGCCCC
ACTGCCCAGCTGGCCAGGCAGTCAGCCCCACAGTGGGTTAGTGGAGCAGAGAGATGGAGCGGCC
AGAGCCGCCCTTCCTCCTGGGCTCACTCATCATGGGTTATGCAATGGCATATGCTGCGGGGCAC
AGCCAGTCTCAGCGGGACTGAAGCGGGGGCACAGAGTCCTACGCAGAGGGGTGTGAGATCCCAT
CGGAGGACCCTGGGGGCAGGACTGGCTGGATGGAGAGGCCAGCACCGGGATGGAGATTTCTCCT
TTCCTCTGGAGTCAGTGAAGAAGCTCAAAGACCTCCAGGAGGTCCCAGAGCCCAAGGTCCAGGG
CCGCAGAAAGTTTGTGACTCCACCGCTCTGCAGTCACCCAGGATTTCCAGAGGAGCTCCGGCCT
GTCTGCAGCCAGCCCAACGCAGAGGACATCCTGCACCGGCTTGAGGCCATCGCTCAGGACCCGA
GCACTTGTGAGATCTGTGCCTACGCCGCCTGCGCCGGATGCTAGGGCGGCCTAGCCGCTGTCTT
CCTCCCAGGGAAGCCCTTTCTTCTGCTGGAAGGGCAACGCGTGATCCTCCCACTCCTAGCAGCT
CAACCTACGCTGCCCCAAGGGAGCTCAGAGAGGGGCTGCGGGATGAGGGCTTCCAGGCCTGAGA
CCGAGCTTTGCAAGGTGCATGCCAACCCTCAGCTAATAAACCGGATTCCGAGTA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005410650	(Get FASTA)	NCBI Sequence Viewer
	XP_013363237	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000004928
	ENSCLAP00000004928.1

RefSeq Acc Id:	XP_005410650 ⟸ XM_005410593
- Peptide Label:	isoform X2
- UniProtKB:	A0A8C2URZ6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MNTFLLSALCLGAWAALAGAVTVRDGDFSFPLESVKKLKDLQEVPEPKVQGRRKFVTPPLCSHP GFPEELRPVCSQPNAEDILHRLEAIAQDPSTCEICAYAACAGC hide sequence

RefSeq Acc Id:	XP_013363237 ⟸ XM_013507783
- Peptide Label:	isoform X1
- Sequence:	show sequence MQWHMLRGTASLSGTEAGAQSPTQRGVRSHRRTLGAGLAGWRGQHRDGDFSFPLESVKKLKDLQ EVPEPKVQGRRKFVTPPLCSHPGFPEELRPVCSQPNAEDILHRLEAIAQDPSTCEICAYAACAG C hide sequence

RefSeq Acc Id:

ENSCLAP00000004928 ⟸ ENSCLAT00000005020

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000003499	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000005020	ENTREZGENE
	ENSCLAT00000005020.1	UniProtKB/TrEMBL
Gene3D-CATH	3.90.1450.10	UniProtKB/TrEMBL
InterPro	Guanylin	UniProtKB/TrEMBL
	Guanylin_sf	UniProtKB/TrEMBL
NCBI Gene	Guca2a	ENTREZGENE
PANTHER	GUANYLIN	UniProtKB/TrEMBL
	PTHR11318	UniProtKB/TrEMBL
Pfam	Guanylin	UniProtKB/TrEMBL
PIRSF	Guanylin	UniProtKB/TrEMBL
PRINTS	GUANYLIN	UniProtKB/TrEMBL
Superfamily-SCOP	SSF89890	UniProtKB/TrEMBL
UniProt	A0A8C2URZ6	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-16	Guca2a	guanylate cyclase activator 2A		guanylate cyclase activator 2A (guanylin)	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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