GUCA2A (guanylate cyclase activator 2A) - Rat Genome Database

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Gene: GUCA2A (guanylate cyclase activator 2A) Canis lupus familiaris
Analyze
Symbol: GUCA2A
Name: guanylate cyclase activator 2A
RGD ID: 12075947
Description: ENCODES a protein that exhibits guanylate cyclase activator activity (ortholog); ASSOCIATED WITH Charcot-Marie-Tooth disease dominant intermediate C (ortholog); genetic disease (ortholog); FOUND IN extracellular region (inferred)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: guanylin
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1151,090,109 - 1,091,277 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl151,090,109 - 1,091,375 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha151,347,225 - 1,348,394 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0151,177,643 - 1,178,815 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl151,177,643 - 1,178,913 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1151,082,785 - 1,083,953 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0151,144,533 - 1,145,694 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0151,159,429 - 1,160,598 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
GUCA2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1151,090,109 - 1,091,277 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl151,090,109 - 1,091,375 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha151,347,225 - 1,348,394 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0151,177,643 - 1,178,815 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl151,177,643 - 1,178,913 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1151,082,785 - 1,083,953 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0151,144,533 - 1,145,694 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0151,159,429 - 1,160,598 (+)NCBIUU_Cfam_GSD_1.0
GUCA2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38142,162,690 - 42,164,745 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl142,162,690 - 42,164,745 (-)EnsemblGRCh38hg38GRCh38
GRCh37142,628,361 - 42,630,416 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36142,400,949 - 42,402,982 (-)NCBINCBI36Build 36hg18NCBI36
Build 34142,297,454 - 42,299,488NCBI
Celera140,910,655 - 40,912,688 (-)NCBICelera
Cytogenetic Map1p34.2NCBI
HuRef140,747,927 - 40,749,960 (-)NCBIHuRef
CHM1_1142,745,486 - 42,747,519 (-)NCBICHM1_1
T2T-CHM13v2.0142,033,343 - 42,035,398 (-)NCBIT2T-CHM13v2.0
Guca2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394119,494,929 - 119,496,662 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4119,494,901 - 119,496,668 (+)EnsemblGRCm39 Ensembl
GRCm384119,637,732 - 119,639,465 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4119,637,704 - 119,639,471 (+)EnsemblGRCm38mm10GRCm38
MGSCv374119,310,337 - 119,312,070 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364119,135,664 - 119,137,397 (+)NCBIMGSCv36mm8
Celera4118,370,520 - 118,372,251 (+)NCBICelera
Cytogenetic Map4D2.1NCBI
cM Map455.47NCBI
Guca2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85138,522,446 - 138,524,288 (+)NCBIGRCr8
mRatBN7.25133,237,177 - 133,239,019 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5133,237,177 - 133,239,018 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5135,965,843 - 135,967,692 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05137,722,285 - 137,724,134 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05137,742,889 - 137,744,738 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05138,685,634 - 138,687,476 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5138,685,624 - 138,687,816 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05142,487,928 - 142,489,770 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45140,227,304 - 140,229,146 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15140,232,529 - 140,234,371 (+)NCBI
Celera5131,760,599 - 131,762,441 (+)NCBICelera
RH 3.4 Map5875.9RGD
Cytogenetic Map5q36NCBI
Guca2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555371,805,671 - 1,807,662 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555371,805,671 - 1,808,797 (-)NCBIChiLan1.0ChiLan1.0
GUCA2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21184,647,667 - 184,649,748 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11183,789,725 - 183,791,806 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0141,462,047 - 41,464,122 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1142,841,930 - 42,844,005 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl142,841,930 - 42,844,005 (-)Ensemblpanpan1.1panPan2
Guca2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505857,815,809 - 57,818,040 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647423,640,586 - 23,642,599 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647423,640,589 - 23,642,573 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GUCA2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6169,146,334 - 169,148,286 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16169,146,336 - 169,148,284 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26156,476,368 - 156,478,316 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GUCA2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12090,757,887 - 90,760,598 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603326,144,687 - 26,146,880 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Guca2a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248921,512,585 - 1,514,339 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248921,498,123 - 1,514,419 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in GUCA2A
10 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5
Low 7 3 1 3 2 3
Below cutoff 4 10 3 5 3 4 2 9 7 6 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000004045   ⟹   ENSCAFP00000003737
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl151,090,109 - 1,091,375 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845031003   ⟹   ENSCAFP00845024294
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl151,177,643 - 1,178,913 (+)Ensembl
RefSeq Acc Id: NM_001198788   ⟹   NP_001185717
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1151,090,109 - 1,091,277 (+)NCBI
Dog10K_Boxer_Tasha151,347,225 - 1,348,394 (+)NCBI
ROS_Cfam_1.0151,177,643 - 1,178,815 (+)NCBI
UMICH_Zoey_3.1151,082,785 - 1,083,953 (+)NCBI
UNSW_CanFamBas_1.0151,144,533 - 1,145,694 (+)NCBI
UU_Cfam_GSD_1.0151,159,429 - 1,160,598 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001185717 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCAFP00000003737.2
  ENSCAFP00030037195.1
  ENSCAFP00040017088.1
  ENSCAFP00845024294
  ENSCAFP00845024294.1
Reference Protein Sequences
RefSeq Acc Id: NP_001185717   ⟸   NM_001198788
- Peptide Label: precursor
- UniProtKB: A0A8C0PMF7 (UniProtKB/TrEMBL),   A0A8C0QU90 (UniProtKB/TrEMBL),   A0A8I3P3W4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000003737   ⟸   ENSCAFT00000004045
RefSeq Acc Id: ENSCAFP00845024294   ⟸   ENSCAFT00845031003


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000002568 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030023197 UniProtKB/TrEMBL
  ENSCAFG00040010628 UniProtKB/TrEMBL
  ENSCAFG00845017500 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000004045.4 UniProtKB/TrEMBL
  ENSCAFT00030042634.1 UniProtKB/TrEMBL
  ENSCAFT00040019686.1 UniProtKB/TrEMBL
  ENSCAFT00845031003 ENTREZGENE
  ENSCAFT00845031003.1 UniProtKB/TrEMBL
Gene3D-CATH 3.90.1450.10 UniProtKB/TrEMBL
InterPro Guanylin UniProtKB/TrEMBL
  Guanylin_sf UniProtKB/TrEMBL
KEGG Report cfa:482446 UniProtKB/TrEMBL
NCBI Gene GUCA2A ENTREZGENE
PANTHER GUANYLIN UniProtKB/TrEMBL
  PTHR11318 UniProtKB/TrEMBL
Pfam Guanylin UniProtKB/TrEMBL
PIRSF Guanylin UniProtKB/TrEMBL
PRINTS GUANYLIN UniProtKB/TrEMBL
Superfamily-SCOP SSF89890 UniProtKB/TrEMBL
UniProt A0A8C0PMF7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0QU90 ENTREZGENE
  A0A8I3P3W4 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:41564 ENTREZGENE