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Gene: Runx1 (RUNX family transcription factor 1) Chinchilla lanigera

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Symbol:

Runx1

Name:

RUNX family transcription factor 1

RGD ID:

8901131

Description:

PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); Alzheimer's disease (ortholog); asthma (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

runt related transcription factor 1; runt-related transcription factor 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955407	34,104,035 - 34,342,928 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955407	34,108,653 - 34,342,657 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute myeloid leukemia (ISO)

Alzheimer's disease (ISO)

asthma (ISO)

B-lymphoblastic leukemia/lymphoma (ISO)

cardiomyopathy (ISO)

Familial Platelet Disorder with Associated Myeloid Malignancy (ISO)

lymphoid leukemia (ISO)

multiple myeloma (ISO)

myelodysplastic syndrome (ISO)

rheumatoid arthritis (ISO)

T-cell acute lymphoblastic leukemia (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

transforming growth factor-beta Smad dependent signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Runx1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955407	34,104,035 - 34,342,928 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955407	34,108,653 - 34,342,657 (-)	NCBI	ChiLan1.0	ChiLan1.0

RUNX1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	21	35,372,507 - 35,580,764 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	21	34,787,801 - 36,004,667 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	21	36,744,805 - 36,953,062 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	21	35,081,968 - 35,343,465 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	21	35,081,968 - 35,343,465	NCBI
Celera	21	21,359,674 - 21,621,110 (-)	NCBI		Celera
Cytogenetic Map	21	q22.12	NCBI
HuRef	21	22,223,523 - 22,431,721 (-)	NCBI		HuRef
CHM1_1	21	36,306,977 - 36,515,166 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	21	33,755,213 - 33,963,788 (-)	NCBI		T2T-CHM13v2.0

RUNX1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	22	30,910,089 - 31,174,441 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	21	25,767,773 - 26,034,261 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	21	21,159,586 - 21,423,946 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	21	34,526,631 - 34,788,930 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	21	34,530,956 - 34,788,544 (-)	Ensembl	panpan1.1		panPan2

Runx1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404971	29,757,531 - 29,981,244 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936500	7,486,954 - 7,709,504 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936500	7,621,328 - 7,710,909 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RUNX1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	78,819,189 - 79,082,491 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	78,819,194 - 78,924,495 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666054	6,636,870 - 6,900,178 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Runx1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624745	22,921,120 - 23,157,876 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624745	22,921,180 - 23,158,250 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005375708	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_005375710	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01007717	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01007718	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01007719	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01007720	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBBH01187973	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000009638 ⟹ ENSCLAP00000009509

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955407	34,104,035 - 34,342,928 (-)	Ensembl

Ensembl Acc Id:

ENSCLAT00000009639 ⟹ ENSCLAP00000009510

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955407	34,104,035 - 34,195,405 (-)	Ensembl

Ensembl Acc Id:

ENSCLAT00000009640 ⟹ ENSCLAP00000009511

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955407	34,157,980 - 34,342,928 (-)	Ensembl

Ensembl Acc Id:

ENSCLAT00000009641 ⟹ ENSCLAP00000009512

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955407	34,187,285 - 34,195,147 (-)	Ensembl

RefSeq Acc Id:

XM_005375708 ⟹ XP_005375765

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955407	34,108,653 - 34,342,656 (-)	NCBI

Sequence:

show sequence

CTCATAAACAACCACAGAACCACAAGTTGGGTAGCCTGGCAGAGTCAGAAGTCTGAGCCCGGCA
TAGTGGTCAGCAGGCGGGACGAATCACACTGAATGCAAACCACAGGGTTTCGTAGAGTGGTAAA
TCATTGAATCCCCCGCCTTCAGAAGAGGGTGCATTTTCACAAGGAAGCAATGGCTTCAGACAGC
ATATTTGAGTCATTTCCTTCGTACCCACAGTGCTTCATGAGAGATGCCAGCACGAGCCGCCGCT
TCACGCCGCCTTCCACCGCGCTGAGTCCGGGCAAGATGAGCGAGGCGCTGCCGCTGGGCGCCCC
GGACGCCGGCGCCGCCCTGGCCGGGAAGCTGAGAAGCGGCGACCGCAGCATGGTGGAGGTGCTG
GCCGACCACCCCGGCGAGCTGGTGCGCACCGACAGCCCCAACTTCCTCTGCTCCGTGCTGCCCA
CGCACTGGCGCTGCAACAAGACCCTGCCCATCGCTTTCAAGGTGGTGGCATTGGGGGAAGTTCC
GGATGGTACTCTGGTCACGGTGATGGCTGGCAATGATGAGAACTACTCAGCCGAGCTCAGAAAT
GCTACTGCGGCCATGAAGAATCAAGTCGCAAGATTCAATGACCTCAGGTTTGTCGGTCGGAGCG
GGAGAGGGAAGAGCTTCACTCTGACCATCACCGTCTTCACAAACCCTCCGCAAGTTGCCACCTA
CCACAGAGCCATCAAAATCACAGTGGATGGACCCCGAGAACCTCGGAGACATCGTCAGAAACTA
GATGATCAGACCAAGCCTGGGAGCTTGTCCTTTTCCGAGCGGCTCAGTGAACTGGAGCAGCTGC
GGCGCACGGCCATGAGGGTCAGCCCGCACCACCCAGCCCCCACGCCCAACCCTCGCGTGAACCA
CTCCACTGCCTTTAACCCTCAGCCTCAGAGCCAGATGCAGGATACAAGGCAGATCCAGCCATCC
CCACCGTGGTCCTATGATCAGTCCTACCAATACCTGGGATCCATCACCACTCCTTCCGTGCACC
CTGCAACACCCATTTCGCCTGGACGTGCCAGTGGCATGACAAGCCTCTCTGCAGAACTTTCCAG
TCGGCTCTCAACTGCTCCTGACCTGACGGCCTTCGGCGACCCACGCCAGTTTCCTGCGCTGCCC
TCCATCTCTGATCCTCGCATGCACTACCCCGGTGCCTTCACCTACTCCCCAACACCGGTCACGT
CGGGCATTGGCATAGGCATGTCAGCCATGAGCTCGGCCACGCGCTACCACACATACCTGCCACC
GCCCTACCCCGGTTCGTCGCAGGCGCAGGGTGGCCCCTTCCAGACCAGCTCTCCTTCCTACCAC
CTGTACTACGGGGCCTCGGCCAGCTCCTACCAGTTCTCCATGGTGGGCGGCGAGCGGTCGCCGC
CACGCATCCTGCCGCCCTGCACCAACGCCTCCACAGGCTCCGCGCTGCTCAACCCCAGCCTCCC
AAACCAGAGCGACGTGGTGGAGGCTGAGGGCAGCCACAGCAACTCGCCCACCAACATGGCACCC
TCTGCACGCCTGGAGGAGGCGGTGTGGCGGCCCTACTGAGCATGCGCAGTGAGCCGTGGACGTC
GTCACCGGAGCCCGGCAGCAGCCGGGCCAGCGCCTGTCCCCGGGTCACGCCGGGCCTCTGCCTC
CTGTGCTTCCGAAGCCACGCAGTTCACTCCGCTGTTGGCCCGGGCCCATCCGTCTTCCCAGCAG
GACACAACTTGAAGGTGTCCACAGGACCACCGCCACGTGGGCACGTTGTAAGGCAAACAGGATG
ATTCCCAGAGGGAAACTGTGAATGCTTCTGATTTAGCAATGCTGTGAATAAAAGAAAGATTTTA
TACCCTTGA

hide sequence

RefSeq Acc Id:

XM_005375710 ⟹ XP_005375767

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955407	34,108,653 - 34,342,657 (-)	NCBI

Sequence:

show sequence

CCTCATAAACAACCACAGAACCACAAGTTGGGTAGCCTGGCAGAGTCAGAAGTCTGAGCCCGGC
ATAGTGGTCAGCAGGCGGGACGAATCACACTGAATGCAAACCACAGGGTTTCGTAGAGTGGTAA
ATCATTGAATCCCCCGCCTTCAGAAGAGGGTGCATTTTCACAAGGAAGCAATGGCTTCAGACAG
CATATTTGAGTCATTTCCTTCGTACCCACAGTGCTTCATGAGAGATGCCAGCACGAGCCGCCGC
TTCACGCCGCCTTCCACCGCGCTGAGTCCGGGCAAGATGAGCGAGGCGCTGCCGCTGGGCGCCC
CGGACGCCGGCGCCGCCCTGGCCGGGAAGCTGAGAAGCGGCGACCGCAGCATGGTGGAGGTGCT
GGCCGACCACCCCGGCGAGCTGGTGCGCACCGACAGCCCCAACTTCCTCTGCTCCGTGCTGCCC
ACGCACTGGCGCTGCAACAAGACCCTGCCCATCGCTTTCAAGGTGGTGGCATTGGGGGAAGTTC
CGGATGGTACTCTGGTCACGGTGATGGCTGGCAATGATGAGAACTACTCAGCCGAGCTCAGAAA
TGCTACTGCGGCCATGAAGAATCAAGTCGCAAGATTCAATGACCTCAGGTTTGTCGGTCGGAGC
GGGAGAGGGAAGAGCTTCACTCTGACCATCACCGTCTTCACAAACCCTCCGCAAGTTGCCACCT
ACCACAGAGCCATCAAAATCACAGTGGATGGACCCCGAGAACCTCGGAATACAAGGCAGATCCA
GCCATCCCCACCGTGGTCCTATGATCAGTCCTACCAATACCTGGGATCCATCACCACTCCTTCC
GTGCACCCTGCAACACCCATTTCGCCTGGACGTGCCAGTGGCATGACAAGCCTCTCTGCAGAAC
TTTCCAGTCGGCTCTCAACTGCTCCTGACCTGACGGCCTTCGGCGACCCACGCCAGTTTCCTGC
GCTGCCCTCCATCTCTGATCCTCGCATGCACTACCCCGGTGCCTTCACCTACTCCCCAACACCG
GTCACGTCGGGCATTGGCATAGGCATGTCAGCCATGAGCTCGGCCACGCGCTACCACACATACC
TGCCACCGCCCTACCCCGGTTCGTCGCAGGCGCAGGGTGGCCCCTTCCAGACCAGCTCTCCTTC
CTACCACCTGTACTACGGGGCCTCGGCCAGCTCCTACCAGTTCTCCATGGTGGGCGGCGAGCGG
TCGCCGCCACGCATCCTGCCGCCCTGCACCAACGCCTCCACAGGCTCCGCGCTGCTCAACCCCA
GCCTCCCAAACCAGAGCGACGTGGTGGAGGCTGAGGGCAGCCACAGCAACTCGCCCACCAACAT
GGCACCCTCTGCACGCCTGGAGGAGGCGGTGTGGCGGCCCTACTGAGCATGCGCAGTGAGCCGT
GGACGTCGTCACCGGAGCCCGGCAGCAGCCGGGCCAGCGCCTGTCCCCGGGTCACGCCGGGCCT
CTGCCTCCTGTGCTTCCGAAGCCACGCAGTTCACTCCGCTGTTGGCCCGGGCCCATCCGTCTTC
CCAGCAGGACACAACTTGAAGGTGTCCACAGGACCACCGCCACGTGGGCACGTTGTAAGGCAAA
CAGGATGATTCCCAGAGGGAAACTGTGAATGCTTCTGATTTAGCAATGCTGTGAATAAAAGAAA
GATTTTATACCCTTGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005375765	(Get FASTA)	NCBI Sequence Viewer
	XP_005375767	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000009509
	ENSCLAP00000009509.1
	ENSCLAP00000009510
	ENSCLAP00000009510.1
	ENSCLAP00000009511.1
	ENSCLAP00000009512.1

RefSeq Acc Id:	XP_005375767 ⟸ XM_005375710
- Peptide Label:	isoform X2
- UniProtKB:	A0A8C2V911 (UniProtKB/TrEMBL)
- Sequence:	show sequence MASDSIFESFPSYPQCFMRDASTSRRFTPPSTALSPGKMSEALPLGAPDAGAALAGKLRSGDRS MVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGEVPDGTLVTVMAGNDENYS AELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRN TRQIQPSPPWSYDQSYQYLGSITTPSVHPATPISPGRASGMTSLSAELSSRLSTAPDLTAFGDP RQFPALPSISDPRMHYPGAFTYSPTPVTSGIGIGMSAMSSATRYHTYLPPPYPGSSQAQGGPFQ TSSPSYHLYYGASASSYQFSMVGGERSPPRILPPCTNASTGSALLNPSLPNQSDVVEAEGSHSN SPTNMAPSARLEEAVWRPY hide sequence

RefSeq Acc Id:	XP_005375765 ⟸ XM_005375708
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C2V6F8 (UniProtKB/TrEMBL), A0A8C2V911 (UniProtKB/TrEMBL)
- Sequence:	show sequence MASDSIFESFPSYPQCFMRDASTSRRFTPPSTALSPGKMSEALPLGAPDAGAALAGKLRSGDRS MVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGEVPDGTLVTVMAGNDENYS AELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRR HRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPTPNPRVNHSTAFNPQPQSQMQDTR QIQPSPPWSYDQSYQYLGSITTPSVHPATPISPGRASGMTSLSAELSSRLSTAPDLTAFGDPRQ FPALPSISDPRMHYPGAFTYSPTPVTSGIGIGMSAMSSATRYHTYLPPPYPGSSQAQGGPFQTS SPSYHLYYGASASSYQFSMVGGERSPPRILPPCTNASTGSALLNPSLPNQSDVVEAEGSHSNSP TNMAPSARLEEAVWRPY hide sequence

Ensembl Acc Id:

ENSCLAP00000009511 ⟸ ENSCLAT00000009640

Ensembl Acc Id:

ENSCLAP00000009512 ⟸ ENSCLAT00000009641

Ensembl Acc Id:

ENSCLAP00000009509 ⟸ ENSCLAT00000009638

Ensembl Acc Id:

ENSCLAP00000009510 ⟸ ENSCLAT00000009639

Protein Domains

Runt

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000006601	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000009638	ENTREZGENE
	ENSCLAT00000009638.1	UniProtKB/TrEMBL
	ENSCLAT00000009639	ENTREZGENE
	ENSCLAT00000009639.1	UniProtKB/TrEMBL
	ENSCLAT00000009640.1	UniProtKB/TrEMBL
	ENSCLAT00000009641.1	UniProtKB/TrEMBL
Gene3D-CATH	2.60.40.720	UniProtKB/TrEMBL
InterPro	AML1_Runt	UniProtKB/TrEMBL
	p53-like_TF_DNA-bd	UniProtKB/TrEMBL
	p53/RUNT-type_TF_DNA-bd_sf	UniProtKB/TrEMBL
	Runt_dom	UniProtKB/TrEMBL
	Runx_central_dom_sf	UniProtKB/TrEMBL
	RunxI_C_dom	UniProtKB/TrEMBL
	TF_Runt-rel_RUNX	UniProtKB/TrEMBL
NCBI Gene	Runx1	ENTREZGENE
PANTHER	PTHR11950	UniProtKB/TrEMBL
	RUNT-RELATED TRANSCRIPTION FACTOR 1	UniProtKB/TrEMBL
Pfam	Runt	UniProtKB/TrEMBL
	RunxI	UniProtKB/TrEMBL
PIRSF	TF_Runt-rel_RUNX	UniProtKB/TrEMBL
PRINTS	ONCOGENEAML1	UniProtKB/TrEMBL
PROSITE	RUNT	UniProtKB/TrEMBL
Superfamily-SCOP	SSF49417	UniProtKB/TrEMBL
UniProt	A0A8C2V582_CHILA	UniProtKB/TrEMBL
	A0A8C2V6F8	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C2V816_CHILA	UniProtKB/TrEMBL
	A0A8C2V911	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-04-09	Runx1	RUNX family transcription factor 1		runt related transcription factor 1	Symbol and/or name change	5135510	APPROVED
2016-08-03	Runx1	runt related transcription factor 1		runt-related transcription factor 1	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

RGD Manual Annotations