Txnrd3 (thioredoxin reductase 3) - Rat Genome Database

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Gene: Txnrd3 (thioredoxin reductase 3) Chinchilla lanigera
Analyze
Symbol: Txnrd3
Name: thioredoxin reductase 3
RGD ID: 8881541
Description: ENCODES a protein that exhibits thioredoxin-disulfide reductase (NADPH) activity (ortholog); INVOLVED IN blastocyst formation (ortholog); glutathione metabolic process (ortholog); ASSOCIATED WITH alkaptonuria (ortholog); cardiomyopathy (ortholog); colorectal adenoma (ortholog); FOUND IN cytosol (ortholog); nucleoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542916,845,526 - 16,879,797 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542916,845,466 - 16,880,481 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Txnrd3Chinchillacolorectal adenoma  ISOTXNRD3 (Homo sapiens)9068941mRNA:increased expression:colorectum (human) RGDPMID:30469315 and REF_RGD_ID:151665806
Txnrd3Chinchillacolorectal carcinoma  ISOTXNRD3 (Homo sapiens)9068941mRNA:increased expression:colorectum (human) RGDPMID:30469315 and REF_RGD_ID:151665806
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Txnrd3Chinchillaalkaptonuria  ISOTXNRD3 (Homo sapiens)8554872ClinVar Annotator: match by term: AlkaptonuriaClinVarPMID:12501223 more ...
Txnrd3ChinchillaPrimary Lymphedema with Myelodysplasia  ISOTXNRD3 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:19449416 more ...
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Txnrd3Chinchillacardiomyopathy  ISOTXNRD3 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:36421005


Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Txnrd3Chinchillablastocyst formation acts_upstream_of_or_withinISOTxnrd3 (Mus musculus)9068941 PMID:27869233MGIPMID:27869233
Txnrd3Chinchillaglutathione metabolic process acts_upstream_of_or_withinISOTxnrd3 (Mus musculus)9068941 PMID:11259642MGIPMID:11259642

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Txnrd3Chinchillacytosol located_inISOTXNRD3 (Homo sapiens)9068941 HPAGO_REF:0000052
Txnrd3Chinchillanucleoplasm located_inISOTXNRD3 (Homo sapiens)9068941 HPAGO_REF:0000052

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Txnrd3Chinchillaprotein binding enablesISOPR:E9Q9D59068941 PMID:23055941MGIPMID:23055941
Txnrd3Chinchillathioredoxin-disulfide reductase (NADPH) activity enablesISOTxnrd3 (Mus musculus)9068941 PMID:11259642MGIPMID:11259642


#
Reference Title
Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
PMID:22301074   PMID:30032202  



Txnrd3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542916,845,526 - 16,879,797 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542916,845,466 - 16,880,481 (+)NCBIChiLan1.0ChiLan1.0
TXNRD3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383126,607,050 - 126,655,124 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3126,571,779 - 126,655,124 (-)EnsemblGRCh38hg38GRCh38
GRCh373126,325,893 - 126,373,967 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363127,808,585 - 127,857,746 (-)NCBINCBI36Build 36hg18NCBI36
Celera3124,750,511 - 124,798,259 (-)NCBICelera
Cytogenetic Map3q21.3NCBI
HuRef3123,706,210 - 123,746,134 (-)NCBIHuRef
CHM1_13126,288,907 - 126,336,657 (-)NCBICHM1_1
T2T-CHM13v2.03129,339,825 - 129,387,575 (-)NCBIT2T-CHM13v2.0
Txnrd3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39689,620,970 - 89,652,511 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl689,620,970 - 89,652,511 (+)EnsemblGRCm39 Ensembl
GRCm38689,643,988 - 89,675,529 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl689,643,988 - 89,675,529 (+)EnsemblGRCm38mm10GRCm38
MGSCv37689,593,982 - 89,625,523 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36689,609,639 - 89,641,155 (+)NCBIMGSCv36mm8
Celera691,567,454 - 91,599,003 (+)NCBICelera
Cytogenetic Map6D1NCBI
cM Map640.01NCBI
Txnrd3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84123,629,768 - 123,669,713 (+)NCBIGRCr8
mRatBN7.24122,072,548 - 122,112,493 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4122,072,548 - 122,112,491 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4127,550,067 - 127,589,990 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04123,324,852 - 123,364,772 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04121,949,094 - 121,989,017 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04121,612,332 - 121,650,543 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4121,612,332 - 121,650,571 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04184,234,159 - 184,271,987 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44123,730,278 - 123,771,572 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14123,926,142 - 124,016,038 (+)NCBI
Celera4111,023,437 - 111,062,376 (+)NCBICelera
Cytogenetic Map4q34NCBI
TXNRD3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22124,531,653 - 124,579,914 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13124,536,126 - 124,584,724 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03123,644,679 - 123,697,563 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13130,966,614 - 131,013,117 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3130,967,026 - 131,013,667 (-)Ensemblpanpan1.1panPan2
TXNRD3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.120782,653 - 844,159 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl20782,653 - 831,351 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha20816,790 - 878,287 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.020794,201 - 855,716 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl20794,201 - 882,976 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.120522,067 - 583,555 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.020851,049 - 912,474 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.020809,928 - 871,488 (-)NCBIUU_Cfam_GSD_1.0
Txnrd3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494221,159,839 - 21,189,862 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367981,203,418 - 1,230,988 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367981,190,975 - 1,231,732 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TXNRD3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1373,275,911 - 73,340,372 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11373,276,249 - 73,336,782 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21380,680,460 - 80,717,823 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TXNRD3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12254,359,169 - 54,417,126 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2254,361,034 - 54,417,397 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041111,873,995 - 111,932,686 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

.






Ensembl Acc Id: ENSCLAT00000015307   ⟹   ENSCLAP00000015147
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495542916,845,526 - 16,879,797 (+)Ensembl
Ensembl Acc Id: ENSCLAT00000015308   ⟹   ENSCLAP00000015148
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495542916,845,526 - 16,879,797 (+)Ensembl
RefSeq Acc Id: XM_005387260   ⟹   XP_005387317
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542916,845,466 - 16,880,481 (+)NCBI
Sequence:
Protein RefSeqs XP_005387317 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000015147
  ENSCLAP00000015147.1
  ENSCLAP00000015148.1
RefSeq Acc Id: XP_005387317   ⟸   XM_005387260
- UniProtKB: A0A8C2VGJ9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000015148   ⟸   ENSCLAT00000015308
Ensembl Acc Id: ENSCLAP00000015147   ⟸   ENSCLAT00000015307


1 to 32 of 32 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSCLAG00000010439 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000015307 ENTREZGENE
  ENSCLAT00000015307.1 UniProtKB/TrEMBL
  ENSCLAT00000015308.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.390.30 UniProtKB/TrEMBL
  3.50.50.60 UniProtKB/TrEMBL
  Glutaredoxin UniProtKB/TrEMBL
InterPro FAD/NAD-bd_sf UniProtKB/TrEMBL
  FAD/NAD-binding_dom UniProtKB/TrEMBL
  FAD/NAD-linked_Rdtase_dimer_sf UniProtKB/TrEMBL
  Glutaredoxin UniProtKB/TrEMBL
  Glutaredoxin_euk/vir UniProtKB/TrEMBL
  GSHR/TRXR-like UniProtKB/TrEMBL
  Pyr_nucl-diS_OxRdtase_dimer UniProtKB/TrEMBL
  Pyr_OxRdtase_I_AS UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/TrEMBL
  Thioredoxin/glutathione_Rdtase UniProtKB/TrEMBL
NCBI Gene Txnrd3 ENTREZGENE
PANTHER GLUTATHIONE REDUCTASE UniProtKB/TrEMBL
  THIOREDOXIN-DISULFIDE REDUCTASE UniProtKB/TrEMBL
Pfam Glutaredoxin UniProtKB/TrEMBL
  Pyr_redox_2 UniProtKB/TrEMBL
  Pyr_redox_dim UniProtKB/TrEMBL
PRINTS FADPNR UniProtKB/TrEMBL
  PNDRDTASEI UniProtKB/TrEMBL
PROSITE GLUTAREDOXIN_2 UniProtKB/TrEMBL
  PYRIDINE_REDOX_1 UniProtKB/TrEMBL
Superfamily-SCOP SSF51905 UniProtKB/TrEMBL
  SSF52833 UniProtKB/TrEMBL
  SSF55424 UniProtKB/TrEMBL
UniProt A0A8C2VGJ9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2VNC8_CHILA UniProtKB/TrEMBL
1 to 32 of 32 rows