TXNRD3 (thioredoxin reductase 3) - Rat Genome Database

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Gene: TXNRD3 (thioredoxin reductase 3) Canis lupus familiaris
Analyze
Symbol: TXNRD3
Name: thioredoxin reductase 3
RGD ID: 12368907
Description: ENCODES a protein that exhibits flavin adenine dinucleotide binding (inferred); oxidoreductase activity (inferred); oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor (inferred); INVOLVED IN blastocyst formation (ortholog); glutathione metabolic process (ortholog); ASSOCIATED WITH alkaptonuria (ortholog); cardiomyopathy (ortholog); colorectal adenoma (ortholog); FOUND IN cytosol (inferred); nucleoplasm (inferred)
Type: protein-coding
RefSeq Status: VALIDATED
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.120782,653 - 844,159 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl20782,653 - 831,351 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha20816,790 - 878,287 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.020794,201 - 855,716 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl20794,201 - 882,976 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.120522,067 - 583,555 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.020851,049 - 912,474 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.020809,928 - 871,488 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IEA)
nucleoplasm  (IEA)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
TXNRD3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.120782,653 - 844,159 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl20782,653 - 831,351 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha20816,790 - 878,287 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.020794,201 - 855,716 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl20794,201 - 882,976 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.120522,067 - 583,555 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.020851,049 - 912,474 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.020809,928 - 871,488 (-)NCBIUU_Cfam_GSD_1.0
TXNRD3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383126,607,050 - 126,655,124 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3126,571,779 - 126,655,124 (-)EnsemblGRCh38hg38GRCh38
GRCh373126,325,893 - 126,373,967 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363127,808,585 - 127,857,746 (-)NCBINCBI36Build 36hg18NCBI36
Celera3124,750,511 - 124,798,259 (-)NCBICelera
Cytogenetic Map3q21.3NCBI
HuRef3123,706,210 - 123,746,134 (-)NCBIHuRef
CHM1_13126,288,907 - 126,336,657 (-)NCBICHM1_1
T2T-CHM13v2.03129,339,825 - 129,387,575 (-)NCBIT2T-CHM13v2.0
Txnrd3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39689,620,970 - 89,652,511 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl689,620,970 - 89,652,511 (+)EnsemblGRCm39 Ensembl
GRCm38689,643,988 - 89,675,529 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl689,643,988 - 89,675,529 (+)EnsemblGRCm38mm10GRCm38
MGSCv37689,593,982 - 89,625,523 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36689,609,639 - 89,641,155 (+)NCBIMGSCv36mm8
Celera691,567,454 - 91,599,003 (+)NCBICelera
Cytogenetic Map6D1NCBI
cM Map640.01NCBI
Txnrd3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84123,629,768 - 123,669,713 (+)NCBIGRCr8
mRatBN7.24122,072,548 - 122,112,493 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4122,072,548 - 122,112,491 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4127,550,067 - 127,589,990 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04123,324,852 - 123,364,772 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04121,949,094 - 121,989,017 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04121,612,332 - 121,650,543 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4121,612,332 - 121,650,571 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04184,234,159 - 184,271,987 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44123,730,278 - 123,771,572 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14123,926,142 - 124,016,038 (+)NCBI
Celera4111,023,437 - 111,062,376 (+)NCBICelera
Cytogenetic Map4q34NCBI
Txnrd3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542916,845,526 - 16,879,797 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542916,845,466 - 16,880,481 (+)NCBIChiLan1.0ChiLan1.0
TXNRD3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22124,531,653 - 124,579,914 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13124,536,126 - 124,584,724 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03123,644,679 - 123,697,563 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13130,966,614 - 131,013,117 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3130,967,026 - 131,013,667 (-)Ensemblpanpan1.1panPan2
Txnrd3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494221,159,839 - 21,189,862 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367981,203,418 - 1,230,988 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367981,190,975 - 1,231,732 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TXNRD3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1373,275,911 - 73,340,372 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11373,276,249 - 73,336,782 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21380,680,460 - 80,717,823 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TXNRD3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12254,359,169 - 54,417,126 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2254,361,034 - 54,417,397 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041111,873,995 - 111,932,686 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in TXNRD3
438 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000006268   ⟹   ENSCAFP00000005807
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl20782,653 - 831,351 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845022490   ⟹   ENSCAFP00845017660
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl20794,201 - 882,976 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845022545   ⟹   ENSCAFP00845017697
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl20794,201 - 882,976 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845022627   ⟹   ENSCAFP00845017751
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl20794,201 - 882,976 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845022686   ⟹   ENSCAFP00845017792
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl20794,201 - 882,976 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845022758   ⟹   ENSCAFP00845017845
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl20794,201 - 847,139 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845022830   ⟹   ENSCAFP00845017895
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl20794,201 - 847,139 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845022874   ⟹   ENSCAFP00845017933
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl20794,201 - 847,139 (-)Ensembl
RefSeq Acc Id: NM_001122778   ⟹   NP_001116250
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.120782,653 - 844,159 (-)NCBI
Dog10K_Boxer_Tasha20816,790 - 878,287 (-)NCBI
ROS_Cfam_1.020794,201 - 855,716 (-)NCBI
UMICH_Zoey_3.120522,067 - 583,555 (-)NCBI
UNSW_CanFamBas_1.020851,049 - 912,474 (-)NCBI
UU_Cfam_GSD_1.020809,928 - 871,488 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001116250   ⟸   NM_001122778
- UniProtKB: A0A8C0JPE7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000005807   ⟸   ENSCAFT00000006268
Ensembl Acc Id: ENSCAFP00845017845   ⟸   ENSCAFT00845022758
Ensembl Acc Id: ENSCAFP00845017895   ⟸   ENSCAFT00845022830
Ensembl Acc Id: ENSCAFP00845017660   ⟸   ENSCAFT00845022490
Ensembl Acc Id: ENSCAFP00845017697   ⟸   ENSCAFT00845022545
Ensembl Acc Id: ENSCAFP00845017792   ⟸   ENSCAFT00845022686
Ensembl Acc Id: ENSCAFP00845017933   ⟸   ENSCAFT00845022874
Ensembl Acc Id: ENSCAFP00845017751   ⟸   ENSCAFT00845022627
Protein Domains
FAD/NAD(P)-binding   Glutaredoxin   Pyridine nucleotide-disulphide oxidoreductase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000003884 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030009782 UniProtKB/TrEMBL
  ENSCAFG00040025742 UniProtKB/TrEMBL
  ENSCAFG00845012644 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000006268.5 UniProtKB/TrEMBL
  ENSCAFT00000094229.1 UniProtKB/TrEMBL
  ENSCAFT00000106057.1 UniProtKB/TrEMBL
  ENSCAFT00030018236.1 UniProtKB/TrEMBL
  ENSCAFT00030018412.1 UniProtKB/TrEMBL
  ENSCAFT00030018515.1 UniProtKB/TrEMBL
  ENSCAFT00040048076.1 UniProtKB/TrEMBL
  ENSCAFT00040048086.1 UniProtKB/TrEMBL
  ENSCAFT00040048093.1 UniProtKB/TrEMBL
  ENSCAFT00845022490.1 UniProtKB/TrEMBL
  ENSCAFT00845022545.1 UniProtKB/TrEMBL
  ENSCAFT00845022627.1 UniProtKB/TrEMBL
  ENSCAFT00845022686.1 UniProtKB/TrEMBL
  ENSCAFT00845022758 ENTREZGENE
  ENSCAFT00845022758.1 UniProtKB/TrEMBL
  ENSCAFT00845022830.1 UniProtKB/TrEMBL
  ENSCAFT00845022874.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.390.30 UniProtKB/TrEMBL
  3.50.50.60 UniProtKB/TrEMBL
  Glutaredoxin UniProtKB/TrEMBL
InterPro FAD/NAD-bd_sf UniProtKB/TrEMBL
  FAD/NAD-binding_dom UniProtKB/TrEMBL
  FAD/NAD-linked_Rdtase_dimer_sf UniProtKB/TrEMBL
  Glutaredoxin UniProtKB/TrEMBL
  Glutaredoxin_euk/vir UniProtKB/TrEMBL
  GSHR/TRXR-like UniProtKB/TrEMBL
  Pyr_nucl-diS_OxRdtase_dimer UniProtKB/TrEMBL
  Pyr_OxRdtase_I_AS UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/TrEMBL
  Thioredoxin/glutathione_Rdtase UniProtKB/TrEMBL
NCBI Gene TXNRD3 ENTREZGENE
PANTHER GLUTATHIONE REDUCTASE UniProtKB/TrEMBL
  THIOREDOXIN REDUCTASE 3 UniProtKB/TrEMBL
Pfam Glutaredoxin UniProtKB/TrEMBL
  Pyr_redox_2 UniProtKB/TrEMBL
  Pyr_redox_dim UniProtKB/TrEMBL
PRINTS FADPNR UniProtKB/TrEMBL
  PNDRDTASEI UniProtKB/TrEMBL
PROSITE GLUTAREDOXIN_2 UniProtKB/TrEMBL
  PYRIDINE_REDOX_1 UniProtKB/TrEMBL
Superfamily-SCOP SSF51905 UniProtKB/TrEMBL
  SSF52833 UniProtKB/TrEMBL
  SSF55424 UniProtKB/TrEMBL
UniProt A0A8C0JPE7 ENTREZGENE
  A0A8C0MXS5_CANLF UniProtKB/TrEMBL
  A0A8C0N0Y9_CANLF UniProtKB/TrEMBL
  A0A8C0Z771_CANLF UniProtKB/TrEMBL
  A0A8I3NDK7_CANLF UniProtKB/TrEMBL
  A0A8I3NDW4_CANLF UniProtKB/TrEMBL
  A0A8I3NHT0_CANLF UniProtKB/TrEMBL
  A0A8I3NPC6_CANLF UniProtKB/TrEMBL
  A0A8I3NPF1_CANLF UniProtKB/TrEMBL
  A0A8I3NYF6_CANLF UniProtKB/TrEMBL
  A0A8I3RX66_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:48023 ENTREZGENE