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Gene: Mesp2 (mesoderm posterior bHLH transcription factor 2) Chinchilla lanigera

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Symbol:

Mesp2

Name:

mesoderm posterior bHLH transcription factor 2

RGD ID:

8841564

Description:

ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription factor activity (ortholog); RNA polymerase II cis-regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN mesodermal cell migration (ortholog); Notch signaling pathway (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH genetic disease (ortholog); hepatocellular carcinoma (ortholog); spondylocostal dysostosis 1 (ortholog); FOUND IN nucleus (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

mesoderm posterior 2 homolog; mesoderm posterior protein 2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

NCBI Annotation Information:

Annotation category: partial on reference assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955416	15,448,377 - 15,450,800 (-)	Ensembl		ChiLan1.0 Ensembl
ChiLan1.0	NW_004955416	15,447,959 - 15,450,209 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

hepatocellular carcinoma (ISO)

spondylocostal dysostosis 1 (ISO)

spondylocostal dysostosis 2 (ISO)

spondylocostal dysostosis 5 (ISO)

Spondylocostal Dysostosis, Autosomal Recessive (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

mesodermal cell migration (ISO)

Notch signaling pathway (ISO)

positive regulation of transcription by RNA polymerase II (ISO)

signal transduction involved in regulation of gene expression (ISO)

somite rostral/caudal axis specification (ISO)

somitogenesis (ISO)

Cellular Component

nucleus (ISO)

Molecular Function

DNA-binding transcription activator activity, RNA polymerase II-specific (ISO)

DNA-binding transcription factor activity (ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (ISO)

sequence-specific double-stranded DNA binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Mesp2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955416	15,448,377 - 15,450,800 (-)	Ensembl		ChiLan1.0 Ensembl
ChiLan1.0	NW_004955416	15,447,959 - 15,450,209 (-)	NCBI	ChiLan1.0	ChiLan1.0

MESP2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	89,776,332 - 89,778,754 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	15	89,760,591 - 89,778,754 (+)	Ensembl		GRCh38.p14 Ensembl	hg38	GRCh38
GRCh37	15	90,319,563 - 90,321,985 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	88,120,593 - 88,122,989 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	15	66,722,377 - 66,724,773 (+)	NCBI		Celera
Cytogenetic Map	15	q26.1	NCBI
HuRef	15	66,432,299 - 66,434,671 (+)	NCBI		HuRef
CHM1_1	15	90,160,596 - 90,162,992 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	15	87,532,244 - 87,534,642 (+)	NCBI		T2T-CHM13v2.0

Mesp2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	79,460,475 - 79,463,179 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	79,460,475 - 79,463,187 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	7	79,810,727 - 79,813,431 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	79,810,727 - 79,813,439 (+)	Ensembl		GRCm38.p6 Ensembl	mm10	GRCm38
MGSCv37	7	86,955,613 - 86,958,317 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	7	79,684,240 - 79,686,946 (+)	NCBI		MGSCv36	mm8
Celera	7	77,209,936 - 77,212,640 (+)	NCBI		Celera
Cytogenetic Map	7	D2	NCBI
cM Map	7	45.18	NCBI

Mesp2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	143,165,914 - 143,168,520 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	143,165,849 - 143,168,511 (+)	Ensembl				GRCr8
mRatBN7.2	1	133,756,601 - 133,759,207 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	133,756,601 - 133,759,198 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	141,665,735 - 141,668,332 (+)	NCBI	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	148,835,140 - 148,837,737 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	141,752,836 - 141,755,433 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	1	142,159,991 - 142,162,588 (+)	NCBI
Lyon_Normotensive	1	147,098,440 - 147,101,037 (+)	NCBI
Lyon_Hypertensive	1	143,758,261 - 143,760,858 (+)	NCBI
F344_StmMcwi	1	142,296,809 - 142,299,406 (+)	NCBI
Rnor_6.0	1	141,550,633 - 141,553,239 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	141,550,633 - 141,553,230 (+)	Ensembl		Rnor_6.0 Ensembl	rn6	Rnor6.0
Rnor_5.0	1	142,511,695 - 142,514,301 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	135,590,020 - 135,592,626 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	125,819,906 - 125,822,512 (+)	NCBI		Celera
RGSC_v3.1	1	135,668,399 - 135,670,416 (+)	NCBI
Cytogenetic Map	1	q31	NCBI

MESP2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	16	79,327,064 - 79,330,074 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	15	83,029,385 - 83,031,781 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	15	68,470,528 - 68,473,209 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	15	87,673,337 - 87,675,698 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2

MESP2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	3	52,757,581 - 52,759,987 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	3	52,756,836 - 52,760,004 (+)	Ensembl		CanFam3.1 Ensembl	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	3	55,391,161 - 55,393,462 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	3	53,173,970 - 53,176,273 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	3	53,173,970 - 53,176,717 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	3	52,695,769 - 52,698,068 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	3	52,905,716 - 52,908,057 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	3	53,246,094 - 53,248,395 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Mesp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mIctTri1.hap1	5	136,178,982 - 136,181,546 (-)	NCBI		mIctTri1.hap1
HiC_Itri_2	NW_024408640	130,777,038 - 130,779,436 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936483	15,555,084 - 15,557,060 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936483	15,555,084 - 15,557,060 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MESP2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	55,342,935 - 55,345,879 (+)	Ensembl		Sscrofa11.1 Ensembl	susScr11	Sscrofa11.1
Sscrofa11.1	7	55,341,941 - 55,345,824 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	60,231,273 - 60,234,781 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MESP2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mChlSab1.0.hap1	29	16,609,367 - 16,611,704 (-)	NCBI		mChlSab1.0.hap1
Vero_WHO_p1.0	NW_023666059	38,495,779 - 38,498,116 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0
ChlSab1.1	29	8,313,022 - 8,316,116 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2

Mesp2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624768	16,832,008 - 16,834,697 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2
HetGla_female_1.0 Ensembl	NW_004624768	16,830,795 - 16,834,798 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl

Mesp2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	2	120,430,946 - 120,433,561 (-)	NCBI	Rrattus_CSIRO_v1	Rrattus_CSIRO_v1

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_013512432	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01017330	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDF01046554	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000017963 ⟹ ENSCLAP00000017787

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955416	15,448,377 - 15,450,800 (-)	Ensembl

RefSeq Acc Id:

XM_013512432 ⟹ XP_013367886

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955416	15,447,959 - 15,450,209 (-)	NCBI

Sequence:

show sequence

CGCGGCGCAGCGCCAGCGAGCGCGAGAAGCTGCGCATGCGCACGCTCGCCCGCGCCCTGCTCGA
GCTGCGCCGCTTTCTGCCGCCGTCCGTGGCGCCCGCCGGCCAGAGCCTCACGAAGATCGAGACG
CTGCGCCTGGCCATCCGCTACATCGGCCACCTGTCGGCCGTGCTGGGCCTCGGCGACGACGGCC
TGCGGCGGCGGCGGCGGCGGCGAGTGGACGCGGCGTCCCCGCGGGGCTGCCCGCTGTGCCCCGA
CGGCGGCGGGGTGTCCTGGGGGTCCCCGAGCGCCTGCCCCGGACCCAGCGCTGCGGCCGAGAGC
CTGGGGAGCAGGGTCTCCGACGCGGATCCCTGGGGAACACCCCCTTACTGCCCCAAGATGCAGT
CGCCCCCGCACCAGCCCCTGGGGATAGCCCCCGACGCTGCTCTTTGGATGCAGCCGCAGGCCTG
CGCGGGGACGCAGCCGTCCCCAGAGCCCGCGAGCGCCGCTGTGCCCTGGACGCCGACGCCGCCT
CCGCCCCCCGAGCTGGTGGCCGTGTACCAGGGGATCTCTGTGCAGGAGTCCTGTCTGTCACTGG
GGAGCCCACCCCTCCTGGCCCACCCTTCATGCCAGAGACTCCAGCCTCACACCCCGTGGGGTTG
CTGGGGCCGCAGTGCCGAGGTGCTGCCCAGCTCAGAGCCCCAGGGGCCCAGGCCCGCCGTCCAG
CCCACTGATGTGAGCCCGGCCCAACGCTCAGGCCTGCGGCTCAGCGGCTGCCCTGAACTTTGCC
AAGAAGATTTGGAGGGCACCCATCTGGGCATCTTCTACTAATGGCTCTGTGGACACCCTTTTCA
GCCTGAAGTCAGGCCCGTTGTGTGGACTGGTCATGTGCTTCTTCGGAGCCTTTTAAAGCTTCCT
TTTGCCAAGGAGCCCTTGTTCTGTGCAGTGCCTACCGATGAAACAGTGTGGGAAAACACATAAT
GGGGGTCCTCCCTGGCCAAAGTGGGGGCCGTGGCAGTGCCCTCCACTGCCGGGCACTGCCCTGT
GGAACCCTGTGTGCCACAGAGCACGGTCCAGGCGGCTCAGACCAGGGCACTGCTTGACCCCAGA
CAAGGCCAGGGTGGGACTGATGGGGAGGCGAGTGGGAGCCAGGCCTGCGCCCTGCCTCTGCGTA
ACAGCTGGCCAGGATCCTGTGTGCTTAGAGACGTTGTAATTCTTTAATAAAGCAAAAATACACC
TAGTAAAAAAAAAAAAAAAAAACGTTAAACATAGAGATTTTACCCCTTCTGAATTTTAGGTATT
TGACCGCATGGAAATGGTCATCTAAGGGAGTTTATGGCAGCTCTTCCTAGCTTATCTAAAGACC
CAGGAAATCTGAACTTTGTTCTGTAACTTTCCAAAATTGACTAATTCTAAGCACCTCTTTCAGT
ATTCAAGTCAAACAACGTTGAAATGGATTGGGTGTTGAAGCATACTGGTCCAAATAGTCCTGAC
ACGGCCAATGATGGCTTTGTACGGCTTAGAGGACTCCCCTTTGGATGTAGCAAGGAAGAAATTG
TTCAGTTCTTCTCAGGGTTGGAAATCGTGCCAAATGGGATAACATTG

hide sequence

Protein Sequences


Protein RefSeqs	XP_013367886	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000017787.1

RefSeq Acc Id:

XP_013367886 ⟸ XM_013512432

- Sequence:

show sequence

MRTLARALLELRRFLPPSVAPAGQSLTKIETLRLAIRYIGHLSAVLGLGDDGLRRRRRRRVDAA
SPRGCPLCPDGGGVSWGSPSACPGPSAAAESLGSRVSDADPWGTPPYCPKMQSPPHQPLGIAPD
AALWMQPQACAGTQPSPEPASAAVPWTPTPPPPPELVAVYQGISVQESCLSLGSPPLLAHPSCQ
RLQPHTPWGCWGRSAEVLPSSEPQGPRPAVQPTDVSPAQRSGLRLSGCPELCQEDLEGTHLGIF
Y

hide sequence

Ensembl Acc Id:

ENSCLAP00000017787 ⟸ ENSCLAT00000017963

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000012204	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000017963.1	UniProtKB/TrEMBL
NCBI Gene	Mesp2	ENTREZGENE
UniProt	A0A8C2VME7_CHILA	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-08-25	Mesp2	mesoderm posterior bHLH transcription factor 2		mesoderm posterior 2 homolog (mouse)	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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