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Gene: Hspb2 (heat shock protein family B (small) member 2) Chinchilla lanigera

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Symbol:

Hspb2

Name:

heat shock protein family B (small) member 2

RGD ID:

8804589

Description:

INVOLVED IN somatic muscle development (ortholog); ASSOCIATED WITH ataxia telangiectasia (ortholog); BH4-deficient hyperphenylalaninemia A (ortholog); Carney-Stratakis syndrome (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

heat shock 27kDa protein 2; heat shock protein beta-2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955412	13,628,098 - 13,631,727 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955412	13,628,098 - 13,631,575 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Hspb2	Chinchilla	ataxia telangiectasia		ISO	HSPB2 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Ataxia-telangiectasia syndrome	ClinVar	PMID:23807571 more ...
Hspb2	Chinchilla	BH4-deficient hyperphenylalaninemia A		ISO	HSPB2 (Homo sapiens)	8554872	ClinVar Annotator: match by term: BH4-deficient hyperphenylalaninemia A	ClinVar	PMID:28492532
Hspb2	Chinchilla	Carney-Stratakis syndrome		ISO	HSPB2 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Carney-Stratakis syndrome	ClinVar	PMID:15531530 more ...
Hspb2	Chinchilla	chromosome 11 partial duplication syndrome		ISO	HSPB2 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Distal trisomy 11q	ClinVar	PMID:25741868
Hspb2	Chinchilla	congenital disorder of glycosylation Il		ISO	HSPB2 (Homo sapiens)	8554872	ClinVar Annotator: match by term: ALG9 congenital disorder of glycosylation	ClinVar	PMID:25966638 and PMID:28492532
Hspb2	Chinchilla	dilated cardiomyopathy 1II		ISO	HSPB2 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Dilated cardiomyopathy 1II	ClinVar	PMID:28492532
Hspb2	Chinchilla	intellectual disability		ISO	HSPB2 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Intellectual disability	ClinVar
Hspb2	Chinchilla	Pyruvate Dehydrogenase E2 Deficiency		ISO	HSPB2 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Pyruvate dehydrogenase E2 deficiency	ClinVar	PMID:28492532

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Hspb2	Chinchilla	somatic muscle development	acts_upstream_of_or_within	ISO	MGI:88516	9068941	PMID:11687538	MGI	PMID:11687538

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Hspb2	Chinchilla	cytoplasm	located_in	ISO	HSPB2 (Homo sapiens)	9068941	PMID:19464326	UniProt	PMID:19464326
Hspb2	Chinchilla	nucleus	located_in	ISO	HSPB2 (Homo sapiens)	9068941	PMID:19464326	UniProt	PMID:19464326

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Hspb2	Chinchilla	protein binding	enables	ISO	UniProtKB:P0DOE7	9068941	PMID:25556234	AgBase	PMID:25556234
Hspb2	Chinchilla	protein binding	enables	ISO	UniProtKB:P02511	9068941	PMID:23188086 and PMID:26465331	IntAct	PMID:23188086 and PMID:26465331
Hspb2	Chinchilla	protein binding	enables	ISO	UniProtKB:Q9UJY1	9068941	PMID:14594798	IntAct	PMID:14594798
Hspb2	Chinchilla	protein binding	enables	ISO	UniProtKB:O95817	9068941	PMID:33961781	IntAct	PMID:33961781
Hspb2	Chinchilla	protein binding	enables	ISO	UniProtKB:P05067	9068941	PMID:32814053	IntAct	PMID:32814053
Hspb2	Chinchilla	protein binding	enables	ISO	UniProtKB:O43711 more ...	9068941	PMID:32296183	IntAct	PMID:32296183

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

PMID:22301074	PMID:30032202

Hspb2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955412	13,628,098 - 13,631,727 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955412	13,628,098 - 13,631,575 (+)	NCBI	ChiLan1.0	ChiLan1.0

HSPB2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	111,912,734 - 111,914,093 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	111,912,734 - 111,914,093 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	111,783,458 - 111,784,817 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	111,288,709 - 111,290,027 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	111,288,708 - 111,290,027	NCBI
Celera	11	108,936,668 - 108,938,025 (+)	NCBI		Celera
Cytogenetic Map	11	q23.1	NCBI
HuRef	11	107,707,366 - 107,708,777 (+)	NCBI		HuRef
CHM1_1	11	111,666,540 - 111,667,897 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	111,922,978 - 111,924,337 (+)	NCBI		T2T-CHM13v2.0

Hspb2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	50,662,372 - 50,663,654 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	50,662,378 - 50,663,654 (-)	Ensembl		GRCm39 Ensembl
GRCm38	9	50,751,072 - 50,752,354 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	50,751,078 - 50,752,354 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	50,559,177 - 50,560,459 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	50,503,308 - 50,504,523 (-)	NCBI		MGSCv36	mm8
Celera	9	48,038,238 - 48,039,519 (-)	NCBI		Celera
Cytogenetic Map	9	A5.3	NCBI
cM Map	9	27.75	NCBI

Hspb2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	59,989,640 - 59,991,215 (-)	NCBI		GRCr8
mRatBN7.2	8	51,093,267 - 51,094,528 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	51,081,342 - 51,094,533 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	56,599,664 - 56,600,635 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	54,878,591 - 54,879,562 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	52,742,846 - 52,743,817 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	55,176,648 - 55,178,227 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	55,176,847 - 55,177,818 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	53,773,887 - 53,775,411 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	54,105,807 - 54,106,778 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	54,124,860 - 54,125,832 (-)	NCBI
Celera	8	50,641,048 - 50,642,019 (-)	NCBI		Celera
Cytogenetic Map	8	q23	NCBI

HSPB2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	112,663,315 - 112,664,617 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	113,756,720 - 113,758,896 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	106,798,674 - 106,800,861 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	110,642,722 - 110,644,893 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	110,642,933 - 110,644,893 (+)	Ensembl	panpan1.1		panPan2

HSPB2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	21,179,875 - 21,181,096 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	21,179,881 - 21,181,017 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	21,102,123 - 21,103,347 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	21,202,794 - 21,204,021 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	21,195,399 - 21,203,924 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	21,264,097 - 21,265,320 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	21,164,562 - 21,165,778 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	21,213,340 - 21,214,564 (-)	NCBI		UU_Cfam_GSD_1.0

Hspb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	94,173,404 - 94,174,785 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936612	2,519,697 - 2,532,195 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936612	2,530,827 - 2,532,148 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HSPB2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	103,262,807 - 103,264,150 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	103,262,897 - 103,263,952 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666043	22,716,678 - 22,718,513 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Hspb2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624784	7,079,910 - 7,081,606 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624784	7,079,923 - 7,081,950 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.


RefSeq Transcripts	XM_005378099	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01012843	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBCE01145042	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000023963 ⟹ ENSCLAP00000023737

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955412	13,628,098 - 13,631,727 (+)	Ensembl

RefSeq Acc Id:

XM_005378099 ⟹ XP_005378156

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955412	13,628,098 - 13,631,575 (+)	NCBI

Sequence:

show sequence

ATAGCAAGGGGAGGGGAGGAGGAGGCAAAGTGGTAGGAATGTGAGTGCACTGATGCAAGCTCATCGTTCTGCAGAATTGTTTTCTCCCCAGGTAACTATTTTTTCCTTGTCTGATGAAAATCTCTTCA
AATAAACACGCTCCTTGGGTGAGGTCTGTCACCAACCACCATGGTATCCCAGGTGTTCCTCTTGGTTATCAGGCCCAAACTTATCTAGAGGCACTGGAAGAAGACAGACCTCCCCCAGGGAACCAGAT
GGATGTGGGCATGGCTTCCGCGGTCTCTCTGACCCCAATGCCCAGCTTTGTCATTTGTCTGTGAGACAAAGGCCTCTTTTACTTGCTCAGTTCTCTGCCAGGTTTCCCACCCATTCAATCTGGAATGT
TCTGCTAGTGCTGCTTGTCCTTCCAAAGCCCTTGCCCACTCAGCTCCTGTTTACTCACACATGAATATTTTTAAACCAGAGTGTTATCTGTGACAGCTTCTGTCAGTGTTACCTGTTCACCCCCTCCC
ACCCTCTTAGGACAAGATAAGGGGCTCCTAAGACTGGACCCACGTTCTTTCCTCATAAGGCTGGGACAGAGGCCAGTGCCCTGTTACAGCCCTGATGAATCCAGAAAATCATAAAGAGGGAACAGAAG
GGAGGACAATACTGGGCTTTTGTCTCCAGCTCCACCCAGTGGGGATGAAGAGCTCAAGGTGACATGGGTCTCTCTGTGCTCTGAAACTTGAAATGATGAAATACCTCATCTACCAGGAGTTTGCGGTC
TCAGAAGAGCTCTCTGGGCAGCTGGAGGGGTCGCGCTGCTCCTGCTGGGGCTGTGCCTCGGACCAGAGTGACTGCAGCCATGTCTGGCCGTTCCGTGCCACATGCCCACCCGGCCACCGCCGAGTACG
AATTTGCCAACCCCAGCCGCCTGGGTGAGCAGCGCTTTGGAGAAGGCCTCCTGCCAGAAGAGATCCTGACCCCCACCCTCTACCATGGCTACTACGTGCGTCCTCGGGTTGCCCGAGCTGGGGAGGGC
AGCAGGGCAGGGGCATCGGAGCTTAGGCTCAGTGAGGGCAAGTTCCAGGCATTTCTGGATGTGAGCCACTTTACCCCTGATGAAGTGACTGTGAGGACTGTGGACAACCTGCTGGAGGTGTCGGCCCG
GCACCCCCAGCGCCTGGACCGCCATGGCTTCGTGTCCCGAGAGTTCTGCCGCACCTATGTCCTGCCTGCTGACGTGGACCCCTGGAGGGTTCGAGCTGCTCTTTCCCATGATGGCATCCTTAACTTGG
AGGCCCCTCGGGGTGGCCGACATTTGGACACAGAAGTCAATGAGGTCTACATCTCCCTGCTCCCTGCGCCTCCCGACCCAGAGGAAGAGGAGGAGGAGGAGGCAGCCAGAGTCGAGCCCTGACTGCCA
AACACCCAGTACGCAGCAAACCCTTTTCTGCCTCCCTCCGTGATTCGAGCAGTTGCCCACCACCCCGGAGGTAGCAGCATCCTTGGGGGGATGGGAATGCTCAAGGTCCGCAATGTATGGTTTGGTCC
CTGGGGACATGTTATAGCCTTTGGTTTAGTTCTGGGTGGAGCTGAATAAACCCAAATCTCAGGGCCGTG

hide sequence


Protein RefSeqs	XP_005378156	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000023737
	ENSCLAP00000023737.1

RefSeq Acc Id:	XP_005378156 ⟸ XM_005378099
- UniProtKB:	A0A8C2W8D2 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSGRSVPHAHPATAEYEFANPSRLGEQRFGEGLLPEEILTPTLYHGYYVRPRVARAGEGSRAGASELRLSEGKFQAFLDVSHFTPDEVTVRTVDNLLEVSARHPQRLDRHGFVSREFCRTYVLPADVD PWRVRAALSHDGILNLEAPRGGRHLDTEVNEVYISLLPAPPDPEEEEEEEAARVEP hide sequence

Ensembl Acc Id:

ENSCLAP00000023737 ⟸ ENSCLAT00000023963

Protein Domains

sHSP

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000016288	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000023963	ENTREZGENE
	ENSCLAT00000023963.1	UniProtKB/TrEMBL
Gene3D-CATH	2.60.40.790	UniProtKB/TrEMBL
InterPro	A-crystallin/Hsp20_dom	UniProtKB/TrEMBL
	Alpha-crystallin/sHSP_animal	UniProtKB/TrEMBL
	Alpha-crystallin_N	UniProtKB/TrEMBL
	HSP20-like_chaperone	UniProtKB/TrEMBL
NCBI Gene	Hspb2	ENTREZGENE
PANTHER	HEAT SHOCK PROTEIN BETA-2	UniProtKB/TrEMBL
	PTHR45640	UniProtKB/TrEMBL
Pfam	Crystallin	UniProtKB/TrEMBL
	HSP20	UniProtKB/TrEMBL
PRINTS	ACRYSTALLIN	UniProtKB/TrEMBL
PROSITE	SHSP	UniProtKB/TrEMBL
Superfamily-SCOP	SSF49764	UniProtKB/TrEMBL
UniProt	A0A8C2W8D2	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-16	Hspb2	heat shock protein family B (small) member 2		heat shock 27kDa protein 2	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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