Hspb2 (heat shock protein family B (small) member 2)

Gene: Hspb2 (heat shock protein family B (small) member 2) Ictidomys tridecemlineatus

Analyze

Symbol:

Hspb2

Name:

heat shock protein family B (small) member 2

RGD ID:

12438688

Description:

ENCODES a protein that exhibits metal ion binding (inferred); structural constituent of eye lens (inferred); unfolded protein binding (inferred); INVOLVED IN somatic muscle development (ortholog); ASSOCIATED WITH ataxia telangiectasia (ortholog); BH4-deficient hyperphenylalaninemia A (ortholog); Carney-Stratakis syndrome (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

heat shock protein beta-2; heat shock protein family B (small) member 2, transcript variant X1; heat shock protein family B (small) member 2, transcript variant X2

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	94,173,404 - 94,174,785 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936612	2,519,697 - 2,532,195 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936612	2,530,827 - 2,532,148 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

ataxia telangiectasia (ISO)

BH4-deficient hyperphenylalaninemia A (ISO)

Carney-Stratakis syndrome (ISO)

Chromosome 11, Partial Trisomy 11q (ISO)

congenital disorder of glycosylation Il (ISO)

dilated cardiomyopathy 1II (ISO)

genetic disease (ISO)

intellectual disability (ISO)

Pyruvate Dehydrogenase E2 Deficiency (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of apoptotic process (IEA)

protein refolding (IEA)

response to heat (IEA)

somatic muscle development (IEA,ISO)

Cellular Component

cytoplasm (IEA)

nucleus (IEA)

Molecular Function

metal ion binding (IEA)

protein binding (ISO)

structural constituent of eye lens (IEA)

unfolded protein binding (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Hspb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	94,173,404 - 94,174,785 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936612	2,519,697 - 2,532,195 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936612	2,530,827 - 2,532,148 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HSPB2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	111,912,734 - 111,914,093 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	111,912,734 - 111,914,093 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	111,783,458 - 111,784,817 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	111,288,709 - 111,290,027 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	111,288,708 - 111,290,027	NCBI
Celera	11	108,936,668 - 108,938,025 (+)	NCBI		Celera
Cytogenetic Map	11	q23.1	NCBI
HuRef	11	107,707,366 - 107,708,777 (+)	NCBI		HuRef
CHM1_1	11	111,666,540 - 111,667,897 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	111,922,978 - 111,924,337 (+)	NCBI		T2T-CHM13v2.0

Hspb2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	50,662,372 - 50,663,654 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	50,662,378 - 50,663,654 (-)	Ensembl		GRCm39 Ensembl
GRCm38	9	50,751,072 - 50,752,354 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	50,751,078 - 50,752,354 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	50,559,177 - 50,560,459 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	50,503,308 - 50,504,523 (-)	NCBI		MGSCv36	mm8
Celera	9	48,038,238 - 48,039,519 (-)	NCBI		Celera
Cytogenetic Map	9	A5.3	NCBI
cM Map	9	27.75	NCBI

Hspb2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	59,989,640 - 59,991,215 (-)	NCBI		GRCr8
mRatBN7.2	8	51,093,267 - 51,094,528 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	51,081,342 - 51,094,533 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	56,599,664 - 56,600,635 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	54,878,591 - 54,879,562 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	52,742,846 - 52,743,817 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	55,176,648 - 55,178,227 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	55,176,847 - 55,177,818 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	53,773,887 - 53,775,411 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	54,105,807 - 54,106,778 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	54,124,860 - 54,125,832 (-)	NCBI
Celera	8	50,641,048 - 50,642,019 (-)	NCBI		Celera
Cytogenetic Map	8	q23	NCBI

Hspb2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955412	13,628,098 - 13,631,727 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955412	13,628,098 - 13,631,575 (+)	NCBI	ChiLan1.0	ChiLan1.0

HSPB2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	112,663,315 - 112,664,617 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	113,756,720 - 113,758,896 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	106,798,674 - 106,800,861 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	110,642,722 - 110,644,893 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	110,642,933 - 110,644,893 (+)	Ensembl	panpan1.1		panPan2

HSPB2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	21,179,875 - 21,181,096 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	21,179,881 - 21,181,017 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	21,102,123 - 21,103,347 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	21,202,794 - 21,204,021 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	21,195,399 - 21,203,924 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	21,264,097 - 21,265,320 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	21,164,562 - 21,165,778 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	21,213,340 - 21,214,564 (-)	NCBI		UU_Cfam_GSD_1.0

HSPB2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	103,262,807 - 103,264,150 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	103,262,897 - 103,263,952 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666043	22,716,678 - 22,718,513 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Hspb2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624784	7,079,910 - 7,081,606 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624784	7,079,923 - 7,081,950 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005334234	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_013362367	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040285201	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000022962 ⟹ ENSSTOP00000022903

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936612	2,519,697 - 2,532,195 (-)	Ensembl

RefSeq Acc Id:

XM_005334234 ⟹ XP_005334291

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404947	94,173,419 - 94,174,785 (+)	NCBI
SpeTri2.0	NW_004936612	2,530,827 - 2,532,148 (-)	NCBI

Sequence:

show sequence

CGCCTCCGCCTCCGACTGAGCTCTAGCTCTCCGGGCAGCTGGAGGGGTCGCGTTGCGCCTGTTG
GGGCCGCACCACAGAGCAGGACTGCTGCAGCGACTGCCGCCATGTCGGGCCGCTCAGTGCCACA
TGCCCACCCGGCCACCGCCGAGTACGAATTTGCCAACCCCAGCCGCCTGGGTGAGCAGCGCTTT
GGCGAAGGCCTACTTCCAGAAGAGATCCTGACCCCCACCCTCTACCATGGCTACTATGTCCGGC
CTCGGGCCACCCAAGCTGGGGAGGGCAGCAGGGCAGGGGCCTCTGAGCTCAGGCTCAGTGAGGG
CAAGTTCCAGGCATTTCTGGATGTGAGCCACTTTACCCCAGATGAGGTGACCGTGAGGACTGTG
GACAACCTACTGGAGGTGTCTGCCAAGCACCCCCAGCGCCTGGACCGCCACGGCTTCGTGTCTC
GAGAGTTCTGCCGCACCTATGTTCTACCTGCTGATGTTGACCCCTGGCGAGTCAAAGCAGCTCT
CTCCCATGATGGCATCCTTAACCTGGAGGCACCACGAGGTGGCCGTCATTTGGACACAGAGGTC
AATGAGGTCTACATCTCCCTGCTCTCTGCACCTCCTGATCCAGAGGAAGAGGAGGAAGCAGCCA
GAGTTGAGTCCTGACTGCCATAGACCCAGCACCCAGCAAGTCCCTTCTACCTCCCGAAGTGATT
TGAGCAGCTGCCCACCACCCCAGAGGTAGCAGCATCCTTGGGGGAAGGGAAAGGTGCATGGTCC
ACAGTGTATGGTTTTGTCTTTTGGGGACGTGTTATAGCATTTGGTTTAGTTCTGGGTGGAACTG
AATAAACCCAAATCTTGGGGCCTT

hide sequence

RefSeq Acc Id:

XM_013362367 ⟹ XP_013217821

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404947	94,173,411 - 94,174,785 (+)	NCBI
SpeTri2.0	NW_004936612	2,530,827 - 2,532,148 (-)	NCBI

Sequence:

show sequence

CGCCTCCGCCTCCGACTGAGCTCTAGCTCTCCGGGCAGCTGGAGGGGTCGCGTTGCGCCTGTTG
GGGCCGCACCACAGAGCAGGACTGCTGCAGCGACTGCCGCCATGTCGGGCCGCTCAGTGCCACA
TGCCCACCCGGCCACCGCCGAGTACGAATTTGCCAACCCCAGCCGCCTGGGTGAGCAGCGCTTT
GGCGAAGATGAGGTGACCGTGAGGACTGTGGACAACCTACTGGAGGTGTCTGCCAAGCACCCCC
AGCGCCTGGACCGCCACGGCTTCGTGTCTCGAGAGTTCTGCCGCACCTATGTTCTACCTGCTGA
TGTTGACCCCTGGCGAGTCAAAGCAGCTCTCTCCCATGATGGCATCCTTAACCTGGAGGCACCA
CGAGGTGGCCGTCATTTGGACACAGAGGTCAATGAGGTCTACATCTCCCTGCTCTCTGCACCTC
CTGATCCAGAGGAAGAGGAGGAAGCAGCCAGAGTTGAGTCCTGACTGCCATAGACCCAGCACCC
AGCAAGTCCCTTCTACCTCCCGAAGTGATTTGAGCAGCTGCCCACCACCCCAGAGGTAGCAGCA
TCCTTGGGGGAAGGGAAAGGTGCATGGTCCACAGTGTATGGTTTTGTCTTTTGGGGACGTGTTA
TAGCATTTGGTTTAGTTCTGGGTGGAACTGAATAAACCCAAATCTTGGGGCCTT

hide sequence

RefSeq Acc Id:

XM_040285201 ⟹ XP_040141135

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404947	94,173,404 - 94,174,785 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_005334291	(Get FASTA)	NCBI Sequence Viewer
	XP_013217821	(Get FASTA)	NCBI Sequence Viewer
	XP_040141135	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000022903.1
GenBank Protein	KAG3286519	(Get FASTA)	NCBI Sequence Viewer
	KAG3286520	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_005334291 ⟸ XM_005334234
- Peptide Label:	isoform X1
- UniProtKB:	I3NEV6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSGRSVPHAHPATAEYEFANPSRLGEQRFGEGLLPEEILTPTLYHGYYVRPRATQAGEGSRAGA SELRLSEGKFQAFLDVSHFTPDEVTVRTVDNLLEVSAKHPQRLDRHGFVSREFCRTYVLPADVD PWRVKAALSHDGILNLEAPRGGRHLDTEVNEVYISLLSAPPDPEEEEEAARVES hide sequence

RefSeq Acc Id:	XP_013217821 ⟸ XM_013362367
- Peptide Label:	isoform X2
- Sequence:	show sequence MSGRSVPHAHPATAEYEFANPSRLGEQRFGEDEVTVRTVDNLLEVSAKHPQRLDRHGFVSREFC RTYVLPADVDPWRVKAALSHDGILNLEAPRGGRHLDTEVNEVYISLLSAPPDPEEEEEAARVES hide sequence

RefSeq Acc Id:	XP_040141135 ⟸ XM_040285201
- Peptide Label:	isoform X3

RefSeq Acc Id:

ENSSTOP00000022903 ⟸ ENSSTOT00000022962

Protein Domains

sHSP

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000023561	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000022962.2	UniProtKB/TrEMBL
Gene3D-CATH	2.60.40.790	UniProtKB/TrEMBL
InterPro	A-crystallin/Hsp20_dom	UniProtKB/TrEMBL
	Alpha-crystallin/sHSP_animal	UniProtKB/TrEMBL
	Alpha-crystallin_N	UniProtKB/TrEMBL
	HSP20-like_chaperone	UniProtKB/TrEMBL
NCBI Gene	Hspb2	ENTREZGENE
PANTHER	HEAT SHOCK PROTEIN BETA-2	UniProtKB/TrEMBL
	PTHR45640	UniProtKB/TrEMBL
Pfam	Crystallin	UniProtKB/TrEMBL
	HSP20	UniProtKB/TrEMBL
PIRSF	Sm_HSP_B1	UniProtKB/TrEMBL
PRINTS	ACRYSTALLIN	UniProtKB/TrEMBL
PROSITE	SHSP	UniProtKB/TrEMBL
Superfamily-SCOP	SSF49764	UniProtKB/TrEMBL
UniProt	I3NEV6	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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