Inpp5e (inositol polyphosphate-5-phosphatase E) - Rat Genome Database

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Gene: Inpp5e (inositol polyphosphate-5-phosphatase E) Chinchilla lanigera
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Symbol: Inpp5e
Name: inositol polyphosphate-5-phosphatase E
RGD ID: 8769532
Description: ENCODES a protein that exhibits inositol-polyphosphate 5-phosphatase activity (ortholog); phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity (ortholog); phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity (ortholog); INVOLVED IN cilium assembly (ortholog); negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (ortholog); negative regulation of protein localization to cilium (ortholog); PARTICIPATES IN phosphoinositide metabolic pathway; ASSOCIATED WITH Adams-Oliver Syndrome 5 (ortholog); autosomal dominant intellectual developmental disorder 8 (ortholog); autosomal dominant nocturnal frontal lobe epilepsy 5 (ortholog); FOUND IN axoneme (ortholog); cilium (ortholog); Golgi membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: 72 kDa inositol polyphosphate 5-phosphatase; inositol polyphosphate-5-phosphatase, 72 kDa
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555134,304,483 - 4,313,087 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555134,304,483 - 4,313,087 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axoneme  (ISO)
cilium  (ISO)
Golgi membrane  (ISO)
nucleus  (ISO)
ruffle  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Inpp5e
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555134,304,483 - 4,313,087 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555134,304,483 - 4,313,087 (+)NCBIChiLan1.0ChiLan1.0
INPP5E
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389136,428,619 - 136,439,845 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9136,428,619 - 136,439,845 (-)EnsemblGRCh38hg38GRCh38
GRCh379139,323,071 - 139,334,297 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369138,442,892 - 138,454,077 (-)NCBINCBI36Build 36hg18NCBI36
Build 349136,598,907 - 136,610,093NCBI
Celera9109,837,914 - 109,848,723 (-)NCBICelera
Cytogenetic Map9q34.3NCBI
HuRef9108,782,431 - 108,793,343 (-)NCBIHuRef
CHM1_19139,471,271 - 139,482,699 (-)NCBICHM1_1
T2T-CHM13v2.09148,657,963 - 148,668,937 (-)NCBIT2T-CHM13v2.0
Inpp5e
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39226,286,261 - 26,299,313 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl226,286,261 - 26,299,215 (-)EnsemblGRCm39 Ensembl
GRCm38226,396,249 - 26,409,244 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl226,396,249 - 26,409,203 (-)EnsemblGRCm38mm10GRCm38
MGSCv37226,251,769 - 26,264,708 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36226,218,258 - 26,231,197 (-)NCBIMGSCv36mm8
Celera226,113,925 - 26,126,902 (-)NCBICelera
Cytogenetic Map2A3NCBI
cM Map218.88NCBI
Inpp5e
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8329,614,868 - 29,627,542 (-)NCBIGRCr8
mRatBN7.239,216,776 - 9,229,539 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl39,216,776 - 9,229,450 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx312,270,758 - 12,283,430 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0320,853,988 - 20,866,660 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0319,109,325 - 19,121,999 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.033,843,307 - 3,856,154 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl33,843,307 - 3,855,981 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.039,204,535 - 9,217,246 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.434,568,909 - 4,582,653 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.134,570,005 - 4,582,079 (-)NCBI
Celera34,036,112 - 4,048,786 (-)NCBICelera
Cytogenetic Map3p13NCBI
INPP5E
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2112,943,387 - 2,956,725 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan192,945,728 - 2,959,063 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09107,502,838 - 107,516,325 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19136,482,815 - 136,492,731 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9136,483,144 - 136,492,731 (-)Ensemblpanpan1.1panPan2
INPP5E
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1949,061,014 - 49,071,474 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl949,061,968 - 49,070,191 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha948,311,690 - 48,322,149 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0949,937,770 - 49,948,230 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl949,937,821 - 49,948,222 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1948,718,526 - 48,728,777 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0949,012,481 - 49,022,941 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0949,059,986 - 49,070,445 (+)NCBIUU_Cfam_GSD_1.0
Inpp5e
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947201,989,771 - 201,998,053 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049366691,377,005 - 1,385,287 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
INPP5E
(Sus scrofa - pig)		 No map positions available.
INPP5E
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1121,763,800 - 1,776,139 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl121,763,865 - 1,776,712 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660583,441,443 - 3,452,583 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Inpp5e
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247601,586,848 - 1,594,835 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247601,586,003 - 1,594,869 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000006210   ⟹   ENSCLAP00000006107
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555134,304,483 - 4,313,087 (+)Ensembl
RefSeq Acc Id: XM_005408490   ⟹   XP_005408547
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555134,304,483 - 4,313,087 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005408547 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000006107
  ENSCLAP00000006107.1
RefSeq Acc Id: XP_005408547   ⟸   XM_005408490
- UniProtKB: A0A8C2YKV6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000006107   ⟸   ENSCLAT00000006210
Protein Domains
Inositol polyphosphate-related phosphatase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000004323 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000006210 ENTREZGENE
  ENSCLAT00000006210.1 UniProtKB/TrEMBL
Gene3D-CATH 3.60.10.10 UniProtKB/TrEMBL
InterPro Endo/exonu/phosph_ase_sf UniProtKB/TrEMBL
  INPP5E UniProtKB/TrEMBL
  IPPc UniProtKB/TrEMBL
NCBI Gene Inpp5e ENTREZGENE
PANTHER PHOSPHATIDYLINOSITOL POLYPHOSPHATE 5-PHOSPHATASE TYPE IV UniProtKB/TrEMBL
  PTHR46625 UniProtKB/TrEMBL
Pfam Exo_endo_phos2 UniProtKB/TrEMBL
SMART IPPc UniProtKB/TrEMBL
Superfamily-SCOP SSF56219 UniProtKB/TrEMBL
UniProt A0A8C2YKV6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-16 Inpp5e  inositol polyphosphate-5-phosphatase E    inositol polyphosphate-5-phosphatase, 72 kDa  Symbol and/or name change 5135510 APPROVED