INPP5E (inositol polyphosphate-5-phosphatase E)

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Gene: INPP5E (inositol polyphosphate-5-phosphatase E) Sus scrofa

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Symbol:

INPP5E

Name:

inositol polyphosphate-5-phosphatase E

RGD ID:

14072864

Description:

ENCODES a protein that exhibits inositol-polyphosphate 5-phosphatase activity (ortholog); phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity (ortholog); phosphatidylinositol-4,5-bisphosphate phosphatase activity (ortholog); INVOLVED IN cilium assembly (ortholog); negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (ortholog); negative regulation of protein localization to cilium (ortholog); PARTICIPATES IN phosphoinositide metabolic pathway; ASSOCIATED WITH Adams-Oliver Syndrome 5 (ortholog); autosomal dominant intellectual developmental disorder 8 (ortholog); autosomal dominant nocturnal frontal lobe epilepsy 5 (ortholog); FOUND IN ruffle (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

72 kDa inositol polyphosphate 5-phosphatase

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

No map positions available.

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Adams-Oliver Syndrome 5 (ISO)

autosomal dominant intellectual developmental disorder 8 (ISO)

autosomal dominant nocturnal frontal lobe epilepsy 5 (ISO)

Ciliary Motility Disorders (ISO)

cleft palate (ISO)

clubfoot (ISO)

cone-rod dystrophy (ISO)

developmental and epileptic encephalopathy 14 (ISO)

Ehlers-Danlos syndrome classic type 1 (ISO)

fundus dystrophy (ISO)

genetic disease (ISO)

Hereditary Eye Diseases (ISO)

Immunodeficiency 103 (ISO)

intellectual disability (ISO)

interstitial lung disease (ISO)

Joubert syndrome (ISO)

Joubert syndrome 1 (ISO)

Kleefstra syndrome 1 (ISO)

Leber congenital amaurosis (ISO)

Leigh disease (ISO)

lung disease (ISO)

Micrognathism (ISO)

MORM Syndrome (ISO)

obesity (ISO)

osteochondrodysplasia (ISO)

patent ductus arteriosus (ISO)

penile disease (ISO)

primary coenzyme Q10 deficiency 7 (ISO)

Pseudarthrosis (ISO)

Rafiq syndrome (ISO)

respiratory failure (ISO)

tuberous sclerosis 1 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cilium assembly (IEA,ISO)

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (ISO)

negative regulation of protein localization to cilium (IEA,ISO)

negative regulation of translation (ISO)

phosphatidylinositol dephosphorylation (IEA,ISO)

phosphatidylinositol metabolic process (IEA,ISO)

response to inositol (IEA,ISO)

Cellular Component

axoneme (IEA)

cilium (IEA)

Golgi membrane (IEA)

nucleus (IEA)

ruffle (ISO)

Molecular Function

inositol-polyphosphate 5-phosphatase activity (IEA,ISO)

phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity (ISO)

phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity (IEA)

phosphatidylinositol-4,5-bisphosphate phosphatase activity (ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

phosphoinositide metabolic pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

INPP5E
(Sus scrofa - pig)

No map positions available.

INPP5E
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	136,428,619 - 136,439,845 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	136,428,619 - 136,439,845 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	9	139,323,071 - 139,334,297 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	138,442,892 - 138,454,077 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	9	136,598,907 - 136,610,093	NCBI
Celera	9	109,837,914 - 109,848,723 (-)	NCBI		Celera
Cytogenetic Map	9	q34.3	NCBI
HuRef	9	108,782,431 - 108,793,343 (-)	NCBI		HuRef
CHM1_1	9	139,471,271 - 139,482,699 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	9	148,657,963 - 148,668,937 (-)	NCBI		T2T-CHM13v2.0

Inpp5e
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	26,286,261 - 26,299,313 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	26,286,261 - 26,299,215 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	26,396,249 - 26,409,244 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	26,396,249 - 26,409,203 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	26,251,769 - 26,264,708 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	26,218,258 - 26,231,197 (-)	NCBI		MGSCv36	mm8
Celera	2	26,113,925 - 26,126,902 (-)	NCBI		Celera
Cytogenetic Map	2	A3	NCBI
cM Map	2	18.88	NCBI

Inpp5e
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	29,614,868 - 29,627,542 (-)	NCBI		GRCr8
mRatBN7.2	3	9,216,776 - 9,229,539 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	9,216,776 - 9,229,450 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	12,270,758 - 12,283,430 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	20,853,988 - 20,866,660 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	19,109,325 - 19,121,999 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	3,843,307 - 3,856,154 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	3,843,307 - 3,855,981 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	9,204,535 - 9,217,246 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	4,568,909 - 4,582,653 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	4,570,005 - 4,582,079 (-)	NCBI
Celera	3	4,036,112 - 4,048,786 (-)	NCBI		Celera
Cytogenetic Map	3	p13	NCBI

Inpp5e
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955513	4,304,483 - 4,313,087 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955513	4,304,483 - 4,313,087 (+)	NCBI	ChiLan1.0	ChiLan1.0

INPP5E
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	2,943,387 - 2,956,725 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	2,945,728 - 2,959,063 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	107,502,838 - 107,516,325 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	136,482,815 - 136,492,731 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	136,483,144 - 136,492,731 (-)	Ensembl	panpan1.1		panPan2

INPP5E
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	49,061,014 - 49,071,474 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	49,061,968 - 49,070,191 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	48,311,690 - 48,322,149 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	49,937,770 - 49,948,230 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	49,937,821 - 49,948,222 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	48,718,526 - 48,728,777 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	49,012,481 - 49,022,941 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	49,059,986 - 49,070,445 (+)	NCBI		UU_Cfam_GSD_1.0

Inpp5e
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	201,989,771 - 201,998,053 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936669	1,377,005 - 1,385,287 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

INPP5E
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	1,763,800 - 1,776,139 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	1,763,865 - 1,776,712 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666058	3,441,443 - 3,452,583 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Inpp5e
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624760	1,586,848 - 1,594,835 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624760	1,586,003 - 1,594,869 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	circulatory system	ectoderm	endocrine system	endoderm	hemolymphoid system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
10	4	23	3	2	5	14	12	23	3	5	3

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_021081144	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021081145	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021081146	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AEMK02000682	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GFLN01109007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Protein Sequences


Protein RefSeqs	XP_020936803	(Get FASTA)	NCBI Sequence Viewer
	XP_020936804	(Get FASTA)	NCBI Sequence Viewer
	XP_020936805	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSSCP00000042349
	ENSSSCP00000042349.1
	ENSSSCP00025006623.1
	ENSSSCP00030015978.1
	ENSSSCP00035011881.1
	ENSSSCP00040019119.1
	ENSSSCP00045011834.1
	ENSSSCP00050015764.1
	ENSSSCP00055022077.1
	ENSSSCP00060013282.1
	ENSSSCP00060013285.1
	ENSSSCP00065012020.1
	ENSSSCP00065012022.1
	ENSSSCP00070003951.1

Protein Domains

Inositol polyphosphate-related phosphatase

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00000040869	ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCG00025012509	UniProtKB/TrEMBL
	ENSSSCG00030025108	UniProtKB/TrEMBL
	ENSSSCG00035023258	UniProtKB/TrEMBL
	ENSSSCG00040033863	UniProtKB/TrEMBL
	ENSSSCG00045010114	UniProtKB/TrEMBL
	ENSSSCG00050028243	UniProtKB/TrEMBL
	ENSSSCG00055014024	UniProtKB/TrEMBL
	ENSSSCG00060022792	UniProtKB/TrEMBL
	ENSSSCG00065022136	UniProtKB/TrEMBL
	ENSSSCG00070002612	UniProtKB/TrEMBL
Ensembl Transcript	ENSSSCT00000061176	ENTREZGENE
	ENSSSCT00000061176.3	UniProtKB/TrEMBL
	ENSSSCT00025016607.1	UniProtKB/TrEMBL
	ENSSSCT00030035050.1	UniProtKB/TrEMBL
	ENSSSCT00035030477.1	UniProtKB/TrEMBL
	ENSSSCT00040045582.1	UniProtKB/TrEMBL
	ENSSSCT00045017162.1	UniProtKB/TrEMBL
	ENSSSCT00050037991.1	UniProtKB/TrEMBL
	ENSSSCT00055027728.1	UniProtKB/TrEMBL
	ENSSSCT00060030943.1	UniProtKB/TrEMBL
	ENSSSCT00060030952.1	UniProtKB/TrEMBL
	ENSSSCT00065029438.1	UniProtKB/TrEMBL
	ENSSSCT00065029444.1	UniProtKB/TrEMBL
	ENSSSCT00070004845.1	UniProtKB/TrEMBL
Gene3D-CATH	3.60.10.10	UniProtKB/TrEMBL
InterPro	Endo/exonu/phosph_ase_sf	UniProtKB/TrEMBL
	INPP5E	UniProtKB/TrEMBL
	IPPc	UniProtKB/TrEMBL
NCBI Gene	INPP5E	ENTREZGENE
PANTHER	PHOSPHATIDYLINOSITOL POLYPHOSPHATE 5-PHOSPHATASE TYPE IV	UniProtKB/TrEMBL
	PTHR46625	UniProtKB/TrEMBL
Pfam	Exo_endo_phos2	UniProtKB/TrEMBL
SMART	IPPc	UniProtKB/TrEMBL
Superfamily-SCOP	SSF56219	UniProtKB/TrEMBL
UniProt	A0A287AEE9	ENTREZGENE, UniProtKB/TrEMBL
	A0A481CEH3	ENTREZGENE, UniProtKB/TrEMBL
	A0A4X1SN31	ENTREZGENE, UniProtKB/TrEMBL
	A0A8D1URM5	ENTREZGENE, UniProtKB/TrEMBL
	A0A8D1Y2H0	ENTREZGENE, UniProtKB/TrEMBL
VGNC ID	VGNC:89144	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB