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Gene: Bud23 (BUD23 rRNA methyltransferase and ribosome maturation factor) Chinchilla lanigera

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Symbol:

Bud23

Name:

BUD23 rRNA methyltransferase and ribosome maturation factor

RGD ID:

8752660

Description:

ENCODES a protein that exhibits protein heterodimerization activity (ortholog); rRNA (guanine) methyltransferase activity (ortholog); INVOLVED IN positive regulation of rRNA processing (ortholog); rRNA (guanine-N7)-methylation (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); autistic disorder (ortholog); intestinal volvulus (ortholog); FOUND IN nucleolus (ortholog); nucleoplasm (ortholog); nucleus (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

BUD23, rRNA methyltransferase and ribosome maturation factor; probable 18S rRNA (guanine-N(7))-methyltransferase; Wbscr22; Williams Beuren syndrome chromosome region 22; Williams-Beuren syndrome chromosome region 22

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955456	14,047,409 - 14,057,939 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955456	14,047,409 - 14,057,483 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Bud23	Chinchilla	autism spectrum disorder		ISO	BUD23 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Autism spectrum disorder	ClinVar	PMID:21658581 more ...
Bud23	Chinchilla	autistic disorder		ISO	BUD23 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Autism	ClinVar	PMID:21681106 and PMID:30208311
Bud23	Chinchilla	intestinal volvulus		ISO	BUD23 (Homo sapiens)	8554872	ClinVar Annotator: match by term: INTESTINAL MALROTATION and FAMILIAL	ClinVar	PMID:25741868
Bud23	Chinchilla	Neurodevelopmental Disorders		ISO	BUD23 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Neurodevelopmental disorder	ClinVar	PMID:25741868
Bud23	Chinchilla	pleomorphic xanthoastrocytoma		ISO	BUD23 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Pleomorphic xanthoastrocytoma	ClinVar	PMID:28299358
Bud23	Chinchilla	schizophrenia		ISO	BUD23 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Schizophrenia	ClinVar	PMID:21681106 and PMID:30208311
Bud23	Chinchilla	Volvulus Of Midgut		ISO	BUD23 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Volvulus of midgut	ClinVar	PMID:25741868
Bud23	Chinchilla	Williams-Beuren syndrome		ISO	BUD23 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Williams syndrome	ClinVar	PMID:25741868

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Bud23	Chinchilla	positive regulation of rRNA processing	involved_in	ISO	BUD23 (Homo sapiens)	9068941	PMID:25851604	UniProt	PMID:25851604
Bud23	Chinchilla	rRNA (guanine-N7)-methylation	involved_in	ISO	BUD23 (Homo sapiens)	9068941	PMID:25851604	UniProt	PMID:25851604

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Bud23	Chinchilla	nucleolus	located_in	ISO	BUD23 (Homo sapiens)	9068941		HPA	GO_REF:0000052
Bud23	Chinchilla	nucleoplasm	located_in	ISO	BUD23 (Homo sapiens)	9068941	PMID:25851604	UniProt	GO_REF:0000052 and PMID:25851604
Bud23	Chinchilla	nucleus	located_in	ISO	BUD23 (Homo sapiens)	9068941	PMID:34948388	UniProt	PMID:34948388
Bud23	Chinchilla	perinuclear region of cytoplasm	located_in	ISO	BUD23 (Homo sapiens)	9068941	PMID:25851604	UniProt	PMID:25851604

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Bud23	Chinchilla	protein binding	enables	ISO	UniProtKB:Q9UI30	9068941	PMID:25851604 more ...	IntAct	PMID:25851604 more ...
Bud23	Chinchilla	protein heterodimerization activity	enables	ISO	BUD23 (Homo sapiens)	9068941	PMID:25851604	UniProt	PMID:25851604
Bud23	Chinchilla	rRNA (guanine) methyltransferase activity	enables	ISO	BUD23 (Homo sapiens)	9068941	PMID:25851604	UniProt	PMID:25851604

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

PMID:22301074	PMID:30032202

Bud23
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955456	14,047,409 - 14,057,939 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955456	14,047,409 - 14,057,483 (-)	NCBI	ChiLan1.0	ChiLan1.0

BUD23
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	73,683,597 - 73,698,212 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	73,683,597 - 73,698,212 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	73,097,927 - 73,112,542 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	72,735,834 - 72,750,478 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	7	72,542,548 - 72,557,192	NCBI
Celera	7	68,576,112 - 68,590,746 (+)	NCBI		Celera
Cytogenetic Map	7	q11.23	NCBI
HuRef	7	68,980,309 - 68,994,966 (+)	NCBI		HuRef
CHM1_1	7	73,243,634 - 73,258,288 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	7	74,884,512 - 74,899,128 (+)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	72,430,970 - 72,445,623 (+)	NCBI

Bud23
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	135,081,811 - 135,093,813 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	135,081,811 - 135,093,813 (-)	Ensembl		GRCm39 Ensembl
GRCm38	5	135,052,957 - 135,064,959 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	135,052,957 - 135,064,959 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	135,528,827 - 135,539,980 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	135,337,586 - 135,349,586 (-)	NCBI		MGSCv36	mm8
Celera	5	132,063,286 - 132,074,439 (-)	NCBI		Celera
Cytogenetic Map	5	G2	NCBI
cM Map	5	74.97	NCBI

Bud23
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	27,266,093 - 27,277,300 (+)	NCBI		GRCr8
mRatBN7.2	12	21,629,551 - 21,640,758 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	21,629,536 - 21,640,751 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	12	22,769,812 - 22,781,449 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	23,382,129 - 23,393,766 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	22,450,784 - 22,461,993 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	24,669,626 - 24,680,833 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	24,669,449 - 24,680,818 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	12	26,669,896 - 26,681,103 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	12	22,724,688 - 22,735,895 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	12	23,392,836 - 23,404,043 (+)	NCBI		Celera
Cytogenetic Map	12	q12	NCBI

BUD23
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	91,201,923 - 91,216,615 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	139,466,554 - 139,481,234 (-)	NCBI		NHGRI_mPanPan1
PanPan1.1	7	80,836,518 - 80,851,501 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	80,836,518 - 80,851,497 (+)	Ensembl	panpan1.1		panPan2

BUD23
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	6,583,612 - 6,596,538 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	6,583,616 - 6,595,281 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	8,281,013 - 8,293,928 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	6,398,642 - 6,411,560 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	6,398,641 - 6,410,307 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	6,388,142 - 6,401,056 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	6,335,879 - 6,348,795 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	6,499,592 - 6,512,508 (-)	NCBI		UU_Cfam_GSD_1.0

Bud23
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	131,127,809 - 131,138,719 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936543	2,897,432 - 2,908,802 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936543	2,897,884 - 2,908,758 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

BUD23
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	10,960,069 - 10,973,081 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	10,960,037 - 10,973,084 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	10,656,154 - 10,669,253 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

BUD23
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	28	9,368,950 - 9,382,951 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	28	9,368,726 - 9,382,925 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666070	7,119,984 - 7,134,024 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Bud23
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624740	14,120,798 - 14,131,933 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624740	14,120,798 - 14,131,490 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.


RefSeq Transcripts	XM_005396771	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01046632	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBBH01060290	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000006887 ⟹ ENSCLAP00000006776

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955456	14,047,409 - 14,057,483 (-)	Ensembl

Ensembl Acc Id:

ENSCLAT00000006888 ⟹ ENSCLAP00000006777

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955456	14,047,461 - 14,057,939 (-)	Ensembl

Ensembl Acc Id:

ENSCLAT00000006889 ⟹ ENSCLAP00000006778

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955456	14,047,461 - 14,057,402 (-)	Ensembl

RefSeq Acc Id:

XM_005396771 ⟹ XP_005396828

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955456	14,047,409 - 14,057,483 (-)	NCBI

Sequence:

show sequence

CAGCGCTGATGACGCAGAAGCTGTGTTCTCGGGGAGGCGTGTGGAGGCGTGTGGCGGCGTGCTGCTTGCTCGAGCTTCAGGATGGCGTCTCGCGGCCGCAGACCCGAGCACGGCGGACCTCCGGAGCT
GTTTTACGACCAGAAAGAAGCCCGGAAATACGTTCGCAACTCGAGGATGATTGATGTCCAGAGCAGGATGACAGAGAGAGCATTGGAGCTCCTTTCTCTGCCCGAGGGACAGCCCTGTTACCTGTTGG
ATATTGGCTGTGGTACTGGTCTGAGTGGAGATTACCTCTCGGACGAGGGGCACTACTGGGTGGGCATGGACATCAGCCCCGCCATGCTGGATGCCGCCTTGGACCGAGAAATCCAGGGAGACGTTCTT
CTGGGGGACATGGGCCAGGGTATTCCTTTCAAACCTGGTTCCTTTGATGGTTGTATCAGCATCTCTGCTGTGCAGTGGCTCTGTAACGCTAACAAGAAGTCTGAGGTCCCTACCAAGCGCCTGTATTG
CTTTTTTTCTTTCCTGTATTCTGTTCTTGTCCGTGGGGCCCGGGCTGTCCTGCAGCTGTACCCGGAGAACCCAGAGCAGTTGGAGCTCATTACGACCCAGGCCACGCGGGCTGGCTTCACGGGCGGCG
TGGTGGTGGATTACCCGAACAGTGCCAAAGCAAAGAAGTTCTATCTCTGTCTGTTCTCTGGGCCTTCGGCCCCTCTGCCCAAGGGGCTGAGCGAAAGTGAGAACAGAGAGGAGGCCACGGAGTCCACG
TTCACCAAGGACAGGGCCCTGCACAGGCTGGTGCGGCGCGGCGTGGTAAAGAAGAGCCGAGAGTGGGTGCTGGAGAAGAAGGCCCGCCGGCGGCGGCAGGGCAAGGAAGTCCGGCCTGACACCCAGTA
CACGGGCCGGAAGCGCGGGCCCCACTTCTGAGCTGCGTGTTTCCCTCCATTACTGACAACATGGCATTTCAGAAGAGTTCTAC

hide sequence


Protein RefSeqs	XP_005396828	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000006776
	ENSCLAP00000006776.1
	ENSCLAP00000006777.1
	ENSCLAP00000006778.1

RefSeq Acc Id:

XP_005396828 ⟸ XM_005396771

- UniProtKB:

A0A8C2UWD4 (UniProtKB/TrEMBL), A0A8C2UX74 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MASRGRRPEHGGPPELFYDQKEARKYVRNSRMIDVQSRMTERALELLSLPEGQPCYLLDIGCGTGLSGDYLSDEGHYWVGMDISPAMLDAALDREIQGDVLLGDMGQGIPFKPGSFDGCISISAVQWL
CNANKKSEVPTKRLYCFFSFLYSVLVRGARAVLQLYPENPEQLELITTQATRAGFTGGVVVDYPNSAKAKKFYLCLFSGPSAPLPKGLSESENREEATESTFTKDRALHRLVRRGVVKKSREWVLEKK
ARRRRQGKEVRPDTQYTGRKRGPHF

hide sequence

Ensembl Acc Id:

ENSCLAP00000006778 ⟸ ENSCLAT00000006889

Ensembl Acc Id:

ENSCLAP00000006777 ⟸ ENSCLAT00000006888

Ensembl Acc Id:

ENSCLAP00000006776 ⟸ ENSCLAT00000006887

Protein Domains

18S rRNA (guanine(1575)-N(7))-methyltransferase Methyltransferase type

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000004776	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000006887	ENTREZGENE
	ENSCLAT00000006887.1	UniProtKB/TrEMBL
	ENSCLAT00000006888.1	UniProtKB/TrEMBL
	ENSCLAT00000006889.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.150	UniProtKB/TrEMBL
InterPro	Bud23-like	UniProtKB/TrEMBL
	Bud23_C	UniProtKB/TrEMBL
	Methyltransf_11	UniProtKB/TrEMBL
	SAM-dependent_MTases	UniProtKB/TrEMBL
NCBI Gene	Wbscr22	ENTREZGENE
PANTHER	18S RRNA (GUANINE-N(7))-METHYLTRANSFERASE-RELATED	UniProtKB/TrEMBL
	PTHR12734	UniProtKB/TrEMBL
Pfam	Methyltransf_11	UniProtKB/TrEMBL
	WBS_methylT	UniProtKB/TrEMBL
Superfamily-SCOP	SSF53335	UniProtKB/TrEMBL
UniProt	A0A8C2UWD4	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C2UX74	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C2YL66_CHILA	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-01-22	Bud23	BUD23 rRNA methyltransferase and ribosome maturation factor		BUD23, rRNA methyltransferase and ribosome maturation factor	Symbol and/or name change	5135510	APPROVED
2017-02-28	Bud23	BUD23, rRNA methyltransferase and ribosome maturation factor	Wbscr22	Williams-Beuren syndrome chromosome region 22	Symbol and/or name change	5135510	APPROVED
2016-08-03	Wbscr22	Williams-Beuren syndrome chromosome region 22		Williams Beuren syndrome chromosome region 22	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable

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