Adra1b (adrenoceptor alpha 1B) - Rat Genome Database

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Gene: Adra1b (adrenoceptor alpha 1B) Chinchilla lanigera
Analyze
Symbol: Adra1b
Name: adrenoceptor alpha 1B
RGD ID: 8729195
Description: ENCODES a protein that exhibits alpha1-adrenergic receptor activity (ortholog); protein heterodimerization activity (ortholog); INVOLVED IN adult heart development (ortholog); behavioral response to cocaine (ortholog); blood vessel remodeling (ortholog); PARTICIPATES IN G protein mediated signaling pathway via Galphaq family; ASSOCIATED WITH Cardiomegaly (ortholog); Experimental Liver Cirrhosis (ortholog); hyperinsulinism (ortholog); FOUND IN cytoplasm (ortholog); intercalated disc (ortholog); membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: alpha-1B adrenergic receptor
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540813,883,574 - 13,937,709 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540813,883,574 - 13,937,798 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Adra1bChinchillahyperinsulinism susceptibilityISOAdra1b (Mus musculus)9068941 RGDPMID:14581480 and REF_RGD_ID:1625772
Adra1bChinchillahypertension  ISOAdra1b (Mus musculus)9068941 RGDPMID:16095979 and REF_RGD_ID:1625771
Adra1bChinchillaInsulin Resistance susceptibilityISOAdra1b (Mus musculus)9068941 RGDPMID:14581480 and REF_RGD_ID:1625772
Adra1bChinchillapolycystic ovary syndrome  ISOAdra1b (Rattus norvegicus)9068941mRNA and protein:increased expression:ovaryRGDPMID:15795180 and REF_RGD_ID:5508374
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Adra1bChinchillaCardiomegaly  ISOADRA1B (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:11278430 and PMID:11940550
Adra1bChinchillaExperimental Liver Cirrhosis  ISOADRA1B (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:25380136
Adra1bChinchillaHypotension  ISOADRA1B (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:11278430
Adra1bChinchillakidney disease  ISOADRA1B (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:18257748
Adra1bChinchillaNerve Degeneration  ISOADRA1B (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:12871582
Adra1bChinchillatoxic encephalopathy  ISOADRA1B (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:19125850


Biological Process
1 to 20 of 25 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Adra1bChinchillaadult heart development acts_upstream_of_or_withinISOMGI:1047739068941 PMID:12782680MGIPMID:12782680
Adra1bChinchillabehavioral response to cocaine acts_upstream_of_or_withinISOMGI:21486389068941 PMID:11923452MGIPMID:11923452
Adra1bChinchillablood vessel remodeling acts_upstream_of_or_withinISOMGI:21486389068941 PMID:15231500MGIPMID:15231500
Adra1bChinchillacell growth involved in cardiac muscle cell development acts_upstream_of_or_withinISOMGI:1047739068941 PMID:12782680MGIPMID:12782680
Adra1bChinchillaglucose homeostasis acts_upstream_of_or_withinISOMGI:21486389068941 PMID:14581480MGIPMID:14581480
Adra1bChinchillaglycogen catabolic process acts_upstream_ofISOMGI:21486389068941 PMID:14581480MGIPMID:14581480
Adra1bChinchillalocomotory behavior acts_upstream_of_or_withinISOMGI:21486389068941 PMID:11222061MGIPMID:11222061
Adra1bChinchillanegative regulation of glycogen catabolic process acts_upstream_of_or_withinISOMGI:21486389068941 PMID:14581480MGIPMID:14581480
Adra1bChinchillanegative regulation of Rho protein signal transduction acts_upstream_of_or_withinISOAdra1b (Rattus norvegicus)9068941PMID:18332105MGIPMID:18332105 and REF_RGD_ID:8554725
Adra1bChinchillaneuron-glial cell signaling involved_inISOUniProtKB:P97714 and UniProtKB:P977189068941 PMID:10493741ARUK-UCLPMID:10493741
Adra1bChinchillaorgan growth acts_upstream_of_or_withinISOMGI:1047739068941 PMID:12782680MGIPMID:12782680
Adra1bChinchillapositive regulation of cytosolic calcium ion concentration  ISOAdra1b (Rattus norvegicus)9068941 RGDPMID:12054611 and REF_RGD_ID:634393
Adra1bChinchillapositive regulation of glycogen catabolic process acts_upstream_of_or_withinISOMGI:21486389068941 PMID:14581480MGIPMID:14581480
Adra1bChinchillapositive regulation of heart rate by epinephrine-norepinephrine acts_upstream_of_or_withinISOMGI:1047739068941 PMID:12782680MGIPMID:12782680
Adra1bChinchillapositive regulation of MAPK cascade involved_inISOADRA1B (Homo sapiens)9068941 PMID:22120526UniProtPMID:22120526
Adra1bChinchillapositive regulation of the force of heart contraction by epinephrine-norepinephrine acts_upstream_of_or_withinISOMGI:1047739068941 PMID:12595294MGIPMID:12595294
Adra1bChinchillaregulation of blood pressure involved_inISOAdra1b (Mus musculus)9068941 PMID:26531127MGIPMID:26531127
Adra1bChinchillaresponse to amphetamine acts_upstream_of_or_withinISOMGI:21486389068941 PMID:11923452 and PMID:12871582MGIPMID:11923452 and PMID:12871582
Adra1bChinchillaresponse to estrogen  ISOAdra1b (Rattus norvegicus)9068941 RGDPMID:11896179 and REF_RGD_ID:1625782
Adra1bChinchillaresponse to hormone  ISOAdra1b (Rattus norvegicus)9068941 RGDPMID:12270752 and REF_RGD_ID:1625781
1 to 20 of 25 rows

Cellular Component

  

Molecular Function

  

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Adra1bChinchillaG protein mediated signaling pathway via Galphaq family  ISOADRA1B (Homo sapiens)9068941 RGDPMID:11454900 and REF_RGD_ID:1559318

#
Reference Title
Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
PMID:22301074   PMID:30032202  



Adra1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540813,883,574 - 13,937,709 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540813,883,574 - 13,937,798 (+)NCBIChiLan1.0ChiLan1.0
ADRA1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385159,865,086 - 159,989,205 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5159,865,080 - 159,973,012 (+)EnsemblGRCh38hg38GRCh38
GRCh375159,343,489 - 159,400,019 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365159,276,318 - 159,332,595 (+)NCBINCBI36Build 36hg18NCBI36
Build 345159,276,317 - 159,332,129NCBI
Celera5155,374,535 - 155,430,824 (+)NCBICelera
Cytogenetic Map5q33.3NCBI
HuRef5154,438,201 - 154,494,477 (+)NCBIHuRef
CHM1_15158,776,756 - 158,833,023 (+)NCBICHM1_1
T2T-CHM13v2.05160,393,464 - 160,517,778 (+)NCBIT2T-CHM13v2.0
Adra1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391143,665,432 - 43,792,076 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1143,665,433 - 43,792,037 (-)EnsemblGRCm39 Ensembl
GRCm381143,774,605 - 43,901,250 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1143,774,606 - 43,901,210 (-)EnsemblGRCm38mm10GRCm38
MGSCv371143,588,108 - 43,649,834 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361143,618,029 - 43,679,755 (-)NCBIMGSCv36mm8
Celera1148,401,465 - 48,463,919 (-)NCBICelera
Cytogenetic Map11B1.1NCBI
cM Map1125.81NCBI
Adra1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81028,756,461 - 28,874,831 (-)NCBIGRCr8
mRatBN7.21028,255,025 - 28,373,418 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1028,255,025 - 28,312,919 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1033,014,641 - 33,072,459 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0101,553,026 - 1,610,850 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01027,985,197 - 28,043,019 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01029,392,762 - 29,450,644 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1029,392,762 - 29,450,644 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01029,233,972 - 29,291,344 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41028,889,092 - 28,946,889 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11028,890,140 - 28,947,938 (-)NCBI
Celera1027,744,674 - 27,802,198 (-)NCBICelera
Cytogenetic Map10q21NCBI
ADRA1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24155,101,569 - 155,158,235 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15153,241,121 - 153,297,783 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05155,307,148 - 155,363,785 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15161,923,708 - 161,954,901 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5161,923,895 - 161,979,461 (+)Ensemblpanpan1.1panPan2
ADRA1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1450,676,816 - 50,724,999 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl450,677,255 - 50,724,999 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha450,570,905 - 50,619,105 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0451,111,625 - 51,159,868 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl451,111,625 - 51,159,868 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1450,919,759 - 50,967,913 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0451,043,059 - 51,091,264 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0451,563,698 - 51,612,138 (-)NCBIUU_Cfam_GSD_1.0
Adra1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213105,074,452 - 105,123,271 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365153,523,797 - 3,572,596 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365153,523,799 - 3,572,467 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADRA1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1663,550,130 - 63,603,034 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11663,550,123 - 64,010,838 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21669,039,634 - 69,092,211 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADRA1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12362,281,500 - 62,338,290 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603415,270,198 - 15,333,460 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adra1b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473329,545,789 - 29,662,028 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473329,545,870 - 29,661,954 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.






Ensembl Acc Id: ENSCLAT00000019615   ⟹   ENSCLAP00000019423
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495540813,883,574 - 13,937,309 (+)Ensembl
Ensembl Acc Id: ENSCLAT00000019616   ⟹   ENSCLAP00000019424
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495540813,883,909 - 13,937,709 (+)Ensembl
RefSeq Acc Id: XM_013506606   ⟹   XP_013362060
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540813,883,574 - 13,937,798 (+)NCBI
Sequence:
Protein RefSeqs XP_013362060 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000019423.1
  ENSCLAP00000019424.1
RefSeq Acc Id: XP_013362060   ⟸   XM_013506606
- UniProtKB: A0A8C2VYS2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000019424   ⟸   ENSCLAT00000019616
Ensembl Acc Id: ENSCLAP00000019423   ⟸   ENSCLAT00000019615


1 to 21 of 21 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSCLAG00000013326 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000019615.1 UniProtKB/TrEMBL
  ENSCLAT00000019616.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro ADR_fam UniProtKB/TrEMBL
  ADRA1B_rcpt UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
NCBI Gene Adra1b ENTREZGENE
PANTHER ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/TrEMBL
  PTHR24248:SF17 UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PRINTS ADRENERGICR UniProtKB/TrEMBL
  ADRENRGCA1BR UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0A8C2VRH1_CHILA UniProtKB/TrEMBL
  A0A8C2VYS2 ENTREZGENE, UniProtKB/TrEMBL
1 to 21 of 21 rows