Prss56 (serine protease 56) - Rat Genome Database

Name: Prss56
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Prss56 (serine protease 56) Chinchilla lanigera

Analyze

Symbol:

Prss56

Name:

serine protease 56

RGD ID:

8713164

Description:

ENCODES a protein that exhibits serine-type endopeptidase activity (ortholog); INVOLVED IN camera-type eye development (ortholog); proteolysis (ortholog); ASSOCIATED WITH angle-closure glaucoma (ortholog); cholangiocarcinoma (ortholog); genetic disease (ortholog); FOUND IN endoplasmic reticulum (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

protease, serine 56; protease, serine, 56

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PRSS56 (serine protease 56)	NCBI	Ortholog
Mus musculus (house mouse):	Prss56 (serine protease 56)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Prss56 (serine protease 56)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PRSS56 (serine protease 56)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PRSS56 (serine protease 56)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Prss56 (serine protease 56)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PRSS56 (serine protease 56)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PRSS56 (serine protease 56)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Prss56 (serine protease 56)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

NCBI Annotation Information:

Annotation category: partial on reference assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955453	3,441,109 - 3,446,090 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955453	3,440,871 - 3,446,090 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

angle-closure glaucoma (ISO)

cholangiocarcinoma (ISO)

genetic disease (ISO)

isolated microphthalmia 6 (ISO)

Joubert syndrome 22 (ISO)

microphthalmia (ISO)

myopia (ISO)

nanophthalmos (ISO)

Perlman syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

camera-type eye development (ISO)

proteolysis (ISO)

Cellular Component

endoplasmic reticulum (ISO)

Molecular Function

serine-type endopeptidase activity (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

Prss56
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955453	3,441,109 - 3,446,090 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955453	3,440,871 - 3,446,090 (-)	NCBI	ChiLan1.0	ChiLan1.0

PRSS56
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	232,520,388 - 232,525,716 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	232,520,388 - 232,525,716 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	233,385,098 - 233,390,426 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	233,093,553 - 233,098,667 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	2	227,149,624 - 227,154,738 (+)	NCBI		Celera
Cytogenetic Map	2	q37.1	NCBI
HuRef	2	225,236,065 - 225,241,318 (+)	ENTREZGENE		HuRef
CHM1_1	2	233,391,262 - 233,396,515 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	233,007,207 - 233,012,535 (+)	NCBI		T2T-CHM13v2.0

Prss56
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	87,111,002 - 87,116,127 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	87,111,035 - 87,116,127 (+)	Ensembl		GRCm39 Ensembl
GRCm38	1	87,183,102 - 87,188,405 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	87,183,313 - 87,188,405 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	89,080,068 - 89,084,979 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	89,014,485 - 89,019,578 (+)	NCBI		MGSCv36	mm8
Celera	1	90,156,389 - 90,161,389 (+)	NCBI		Celera
Cytogenetic Map	1	C5	NCBI
cM Map	1	44.07	NCBI

Prss56
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	95,289,984 - 95,307,877 (+)	NCBI		GRCr8
mRatBN7.2	9	87,842,806 - 87,859,978 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	87,854,805 - 87,859,978 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	9	94,278,981 - 94,284,111 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	94,279,155 - 94,283,919 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	94,002,598 - 94,007,707 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	85,988,860 - 85,993,978 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	9	85,267,921 - 85,273,051 (+)	NCBI		Celera
Cytogenetic Map	9	q35	NCBI

PRSS56
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	13	135,125,817 - 135,131,174 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2B	135,140,780 - 135,146,136 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	119,751,950 - 119,757,308 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	238,670,795 - 238,676,049 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	238,670,931 - 238,675,839 (+)	Ensembl	panpan1.1		panPan2

PRSS56
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	25	44,157,247 - 44,165,625 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	25	44,160,615 - 44,165,625 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	25	44,651,702 - 44,660,089 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	25	44,414,634 - 44,423,021 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	25	44,417,825 - 44,423,024 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	25	44,340,498 - 44,348,884 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	25	44,185,781 - 44,194,164 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	25	44,340,898 - 44,349,293 (+)	NCBI		UU_Cfam_GSD_1.0

Prss56
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	186,363,727 - 186,370,867 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936525	4,568,802 - 4,574,396 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936525	4,568,854 - 4,574,332 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PRSS56
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	133,034,255 - 133,039,367 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	133,033,848 - 133,039,583 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	146,933,579 - 146,939,004 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PRSS56
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	118,538,752 - 118,545,759 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	10	118,540,863 - 118,545,740 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	80,956,137 - 80,961,372 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Prss56
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624843	5,281,709 - 5,287,026 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624843	5,281,581 - 5,287,060 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_013519998	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01044658	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01044659	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBBH01030283	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBBH01042828	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000011727 ⟹ ENSCLAP00000011590

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955453	3,441,109 - 3,446,090 (-)	Ensembl

RefSeq Acc Id:

XM_013519998 ⟹ XP_013375452

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955453	3,440,871 - 3,446,090 (-)	NCBI

Sequence:

show sequence

ATGCTGCTGGCTGCGCTGCTACTATGGCTGCTCCAGTGCCCCCTGGAGCCCTGGTCTGCCCACG
CGCACCCCCTGTACACGCGCCTCCCCCCCAGCACCCTGCAAGTTCTGTCGGCCCAGGGGACGCA
GGCCTTGCAGGCTGCCCAGAGGAGCGCCCAGCGGGCGGTGAAGCGGGTGGCCACGGAGCTCCAG
CTCAAACTGCATGAGTGTCGAGGACCTGGACACCCCAGGCCCCAAGCCCCCCTCCTCCAGGACC
CACCTGAGCCAGGGCCTTGCGGCGAAAGGCGGCCGGCAGCTGCCAACGTGACCCGGGCTCACGG
CCGCATCGTCGGGGGCAGCGCGGCTCCGCCCGGGGCTTGGCCCTGGCTGGTGCGGCTGCAGCTC
GGCGGGCAGCCTCTGTGCGGCGGCGTCCTGGTGGCGGCCTCCTGGGTGCTGACGGCGGCGCACT
GCTTCGCCGGCGCCTCAAATGAGCTCCTGTGGACCGTGGTGCTGGCCGAGGGGCCCCGGGGGGA
GCCGGCGGAGGAGGTGCCGGTGAACCGCATCCTGTCCCACCCCAAGTTTGACCCGCAGACTTTC
CACAGTGACCTGGCCCTCGTGCAGCTGTGGACGCCCGTGAGCCCGGCGGGGCCCGCGCGCCCCG
TGTGCCTGCCCCAGGCGTCCCCGGAGCCCCCTGCCGGCACTCCCTGCGCCATCGCAGGCTGGGG
GGCCCTCTTCGAAGACGGGCCTGAGGCTGAGGCAGTGAGGGAGGCCCGCGTCCCGCTGCTCAGC
CCTGACACTTGCCAAAGGGCGCTGGGGCCCGGGCTGCGCCCCAGCTCCATGCTCTGCGCAGGTT
ACCTGGCGGGTGGCATCGACTCGTGCCAGGGTGACTCTGGAGGCCCCCTAACCTGTTCTGAGCC
TGGTCCGCGTCCCAGGGAGGTTCTCTTTGGAGTCACCTCCTGGGGGGATGGCTGCGGGGAGCCA
GGAAAGCCCGGGGTCTACACCCGCGTGGCTGTGTTCAAAGACTGGCTCCAGCAGCAGATGACGG
CCCCTTCCACGCGCGAGCCCAGCTGCATGGAGCTTCTGGCCCAGGACCCGCCCGAGGAATACCC
AGCCGACGCCCGGCTCTGCGCCTTCTACGCGCGCCGATGCCCGCTGCCCGAAGGCGCCTGTGCG
CGCCTGGCCCGCCAGCAGTGCCTGCAGCGCCGGCGGCGGTGTGAGCTGCGCTCGCTGGCGCACA
CGCTGCTGGACCTGCTGCGCGGCGCGCAGGAACTGCTCGGCGTGCGCCCGGGGCTGCGGCGCGG
GGCCCCAGCCCTGGCCCGCCCCGCTCCGTCGCTGTGGGAGTCCCCGGAGTCGGCAGCCCGCGAG
CAGCGGCTGGACTCAGGACCGCGGGCTGCGAGGGTGCGGTTCCAGAAGCGAAGGCCAGAGCCCC
GCGAGAGCACGAGCGGCTGCCCTGGGCTGGAGCCCCTGCGACAGAAGTTGGCCGCCCTTCAGGG
TTCCCATGCCTGGATCCTGCAGGTCCCTTCCGAGCGGCTGGCCATGCACTTCCAGGAGGTGCTG
GCTGACTTGAGCTCCAAGACACTGACAGGGCTTTTCAGAGCGTGGGTGCAGGCAGGCCTGGGGG
GCCGCCGCGTGGCCTTCAGTGGCCTGGTGGGCCTGGAGCCGGCCACACTGGCTCGAAGCCTGCC
AAGGCTGCTGGTGCAGGCCCTGCAGGCCTTCCGCTCAGCTGCCCTGGCTGAGGGCAAACCTCTG
GGGCTGGAAGTGGGGAGGAAGGGGGTTGCCCCCGGCCAGCTGCCACAGAGGGCACCCACTGCTC
CCAGGAGCTAGGAGAGCCGGGAGCATCTGACAAATGTCACTGTCCCCATGGACCGCACCTGTGG
GCAGGAGGGGTCCTGTGTCTTCCCAGATGTGTGATCAGAGACTCATAGCTGCTTTAATAAAATT
ATTTATAAGCCACGGAGACACTGGCGCTTCTTTGGAATGCAGAACGGGGTGGGTGAACATCTGA
TGGCTGGGGCAGTCTCCAGAAG

hide sequence

Protein Sequences


Protein RefSeqs	XP_013375452	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000011590.1

RefSeq Acc Id:

XP_013375452 ⟸ XM_013519998

- UniProtKB:

A0A8C2V7V6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MLLAALLLWLLQCPLEPWSAHAHPLYTRLPPSTLQVLSAQGTQALQAAQRSAQRAVKRVATELQ
LKLHECRGPGHPRPQAPLLQDPPEPGPCGERRPAAANVTRAHGRIVGGSAAPPGAWPWLVRLQL
GGQPLCGGVLVAASWVLTAAHCFAGASNELLWTVVLAEGPRGEPAEEVPVNRILSHPKFDPQTF
HSDLALVQLWTPVSPAGPARPVCLPQASPEPPAGTPCAIAGWGALFEDGPEAEAVREARVPLLS
PDTCQRALGPGLRPSSMLCAGYLAGGIDSCQGDSGGPLTCSEPGPRPREVLFGVTSWGDGCGEP
GKPGVYTRVAVFKDWLQQQMTAPSTREPSCMELLAQDPPEEYPADARLCAFYARRCPLPEGACA
RLARQQCLQRRRRCELRSLAHTLLDLLRGAQELLGVRPGLRRGAPALARPAPSLWESPESAARE
QRLDSGPRAARVRFQKRRPEPRESTSGCPGLEPLRQKLAALQGSHAWILQVPSERLAMHFQEVL
ADLSSKTLTGLFRAWVQAGLGGRRVAFSGLVGLEPATLARSLPRLLVQALQAFRSAALAEGKPL
GLEVGRKGVAPGQLPQRAPTAPRS

hide sequence

RefSeq Acc Id:

ENSCLAP00000011590 ⟸ ENSCLAT00000011727

Protein Domains

Peptidase S1

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000007988	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000011727.1	UniProtKB/TrEMBL
Gene3D-CATH	2.40.10.10	UniProtKB/TrEMBL
InterPro	Peptidase_S1_PA	UniProtKB/TrEMBL
	Peptidase_S1_PA_chymotrypsin	UniProtKB/TrEMBL
	Peptidase_S1A	UniProtKB/TrEMBL
	Trypsin_dom	UniProtKB/TrEMBL
	TRYPSIN_HIS	UniProtKB/TrEMBL
	TRYPSIN_SER	UniProtKB/TrEMBL
NCBI Gene	Prss56	ENTREZGENE
PANTHER	HYALURONAN-BINDING PROTEIN 2	UniProtKB/TrEMBL
	TRYPSIN-RELATED	UniProtKB/TrEMBL
Pfam	Trypsin	UniProtKB/TrEMBL
PRINTS	CHYMOTRYPSIN	UniProtKB/TrEMBL
PROSITE	TRYPSIN_DOM	UniProtKB/TrEMBL
	TRYPSIN_HIS	UniProtKB/TrEMBL
	TRYPSIN_SER	UniProtKB/TrEMBL
SMART	Tryp_SPc	UniProtKB/TrEMBL
Superfamily-SCOP	SSF50494	UniProtKB/TrEMBL
UniProt	A0A8C2V7V6	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-01-23	Prss56	serine protease 56		protease, serine 56	Symbol and/or name change	5135510	APPROVED
2016-08-16	Prss56	protease, serine 56		protease, serine, 56	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

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