Numbl (NUMB like endocytic adaptor protein) - Rat Genome Database

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Gene: Numbl (NUMB like endocytic adaptor protein) Chinchilla lanigera
Analyze
Symbol: Numbl
Name: NUMB like endocytic adaptor protein
RGD ID: 8703039
Description: INVOLVED IN adherens junction organization (ortholog); axonogenesis (ortholog); cytokine-mediated signaling pathway (ortholog); ASSOCIATED WITH Carpenter Syndrome 2 (ortholog); congenital hypoplastic anemia (ortholog); craniosynostosis 1 (ortholog); FOUND IN cytoplasm (ortholog); glutamatergic synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: numb homolog (Drosophila)-like
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955578636,282 - 661,566 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955578636,298 - 661,566 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species

Genomics

Comparative Map Data
Numbl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955578636,282 - 661,566 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955578636,298 - 661,566 (+)NCBIChiLan1.0ChiLan1.0
NUMBL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381940,665,905 - 40,690,651 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1940,665,905 - 40,690,972 (-)EnsemblGRCh38hg38GRCh38
GRCh371941,171,810 - 41,196,556 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361945,863,650 - 45,888,396 (-)NCBINCBI36Build 36hg18NCBI36
Build 341945,864,436 - 45,888,374NCBI
Celera1937,972,233 - 37,996,968 (-)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1937,605,109 - 37,629,863 (-)NCBIHuRef
CHM1_11941,171,471 - 41,196,210 (-)NCBICHM1_1
T2T-CHM13v2.01943,486,573 - 43,511,317 (-)NCBIT2T-CHM13v2.0
Numbl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39726,957,884 - 26,981,570 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl726,957,858 - 26,981,569 (+)EnsemblGRCm39 Ensembl
GRCm38727,258,438 - 27,282,150 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl727,258,433 - 27,282,144 (+)EnsemblGRCm38mm10GRCm38
MGSCv37728,043,780 - 28,067,169 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36726,967,521 - 26,990,910 (+)NCBIMGSCv36mm8
Celera721,835,674 - 21,859,077 (+)NCBICelera
Cytogenetic Map7A3NCBI
cM Map715.86NCBI
Numbl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8191,677,437 - 91,701,415 (+)NCBIGRCr8
mRatBN7.2182,549,814 - 82,573,788 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl182,550,054 - 82,573,776 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx187,952,653 - 87,976,474 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0196,439,576 - 96,463,388 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0189,708,524 - 89,732,343 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0184,067,841 - 84,091,659 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl184,067,938 - 84,091,671 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0185,278,493 - 85,302,558 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4182,333,804 - 82,356,657 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1182,411,551 - 82,435,519 (+)NCBI
Celera176,962,645 - 76,985,442 (+)NCBICelera
Cytogenetic Map1q21NCBI
NUMBL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22046,925,149 - 46,950,151 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11948,795,345 - 48,820,069 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01937,710,882 - 37,734,873 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11946,217,935 - 46,238,106 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1946,217,935 - 46,238,103 (-)Ensemblpanpan1.1panPan2
NUMBL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11113,076,678 - 113,103,114 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1113,057,141 - 113,102,074 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1112,479,240 - 112,505,295 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01113,675,540 - 113,701,533 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1113,655,984 - 113,701,252 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11113,235,023 - 113,261,128 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01112,866,854 - 112,892,744 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01113,861,016 - 113,887,287 (+)NCBIUU_Cfam_GSD_1.0
Numbl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934914,534,669 - 14,560,586 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366612,963,510 - 2,984,740 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366612,962,741 - 2,984,763 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NUMBL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl648,889,801 - 48,918,173 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1648,890,056 - 48,918,195 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2644,720,850 - 44,748,293 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NUMBL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1635,119,062 - 35,141,712 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607313,253,734 - 13,279,161 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Numbl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624925596,448 - 622,641 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624925595,679 - 623,479 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000000563   ⟹   ENSCLAP00000000533
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_004955578636,282 - 661,566 (+)Ensembl
Ensembl Acc Id: ENSCLAT00000000564   ⟹   ENSCLAP00000000534
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_004955578639,427 - 660,792 (+)Ensembl
Ensembl Acc Id: ENSCLAT00000000565   ⟹   ENSCLAP00000000535
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_004955578639,427 - 660,792 (+)Ensembl
RefSeq Acc Id: XM_005414036   ⟹   XP_005414093
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955578636,298 - 661,566 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005414037   ⟹   XP_005414094
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955578636,298 - 661,566 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005414093 (Get FASTA)   NCBI Sequence Viewer  
  XP_005414094 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000000533
  ENSCLAP00000000533.1
  ENSCLAP00000000534.1
  ENSCLAP00000000535.1
RefSeq Acc Id: XP_005414093   ⟸   XM_005414036
- Peptide Label: isoform X1
- UniProtKB: A0A8C2UL73 (UniProtKB/TrEMBL),   A0A8C2UGB9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005414094   ⟸   XM_005414037
- Peptide Label: isoform X2
- UniProtKB: A0A8C2UGB9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000000533   ⟸   ENSCLAT00000000563
Ensembl Acc Id: ENSCLAP00000000534   ⟸   ENSCLAT00000000564
Ensembl Acc Id: ENSCLAP00000000535   ⟸   ENSCLAT00000000565
Protein Domains
PID


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000000433 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000000563 ENTREZGENE
  ENSCLAT00000000563.1 UniProtKB/TrEMBL
  ENSCLAT00000000564.1 UniProtKB/TrEMBL
  ENSCLAT00000000565.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
InterPro Numb/numb-like UniProtKB/TrEMBL
  Numb_domain UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PTB/PI_dom UniProtKB/TrEMBL
NCBI Gene Numbl ENTREZGENE
PANTHER NUMB-LIKE PROTEIN UniProtKB/TrEMBL
  PTHR47368 UniProtKB/TrEMBL
Pfam NumbF UniProtKB/TrEMBL
  PID UniProtKB/TrEMBL
PIRSF Numb/numb-like UniProtKB/TrEMBL
PROSITE PID UniProtKB/TrEMBL
SMART PTB UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
UniProt A0A8C2UGB4_CHILA UniProtKB/TrEMBL
  A0A8C2UGB9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2UL73 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-01-29 Numbl  NUMB like endocytic adaptor protein    NUMB like, endocytic adaptor protein  Symbol and/or name change 5135510 APPROVED
2016-08-03 Numbl  NUMB like, endocytic adaptor protein    numb homolog (Drosophila)-like  Symbol and/or name change 5135510 APPROVED