Gjb5 (gap junction protein, beta 5) - Rat Genome Database

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Gene: Gjb5 (gap junction protein, beta 5) Mus musculus
Analyze
Symbol: Gjb5
Name: gap junction protein, beta 5
RGD ID: 736420
MGI Page MGI
Description: Predicted to enable gap junction channel activity. Acts upstream of or within labyrinthine layer morphogenesis; spongiotrophoblast differentiation; and trophoblast giant cell differentiation. Predicted to be part of connexin complex. Is expressed in several structures, including early conceptus; reproductive system; sensory organ; and skin. Orthologous to human GJB5 (gap junction protein beta 5).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Cnx31.; Cnx31.1; connexin 31.1; connexin a; connexin-31.1; Cx31.1; Cxna; gap junction beta-5 protein; gap junction membrane channel protein beta 5; Gjb-5
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394127,248,600 - 127,251,957 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4127,248,602 - 127,251,974 (-)EnsemblGRCm39 Ensembl
GRCm384127,354,809 - 127,358,164 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4127,354,809 - 127,358,181 (-)EnsemblGRCm38mm10GRCm38
MGSCv374127,032,053 - 127,035,408 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364126,857,113 - 126,860,468 (-)NCBIMGSCv36mm8
Celera4125,689,190 - 125,692,545 (-)NCBICelera
Cytogenetic Map4D2.2NCBI
cM Map461.51NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gjb5MouseCharcot-Marie-Tooth disease dominant intermediate C  ISOGJB5 (Homo sapiens)8554872ClinVar Annotator: match by term: Charcot-Marie-Tooth disease dominant intermediate CClinVarPMID:28492532
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gjb5MouseSkin Neoplasms  ISOGJB5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:7586191

1 to 20 of 60 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gjb5Mouse1,2,4-trimethylbenzene decreases expressionISOGjb5 (Rattus norvegicus)6480464pseudocumene results in decreased expression of GJB5 proteinCTDPMID:17337753
Gjb5Mouse1,2-dichloroethane decreases expressionEXP 6480464ethylene dichloride results in decreased expression of GJB5 mRNACTDPMID:28960355
Gjb5Mouse17alpha-ethynylestradiol affects expressionEXP 6480464Ethinyl Estradiol affects the expression of GJB5 mRNACTDPMID:17555576
Gjb5Mouse17alpha-ethynylestradiol multiple interactionsEXP 6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GJB5 mRNACTDPMID:17942748
Gjb5Mouse17alpha-ethynylestradiol increases expressionISOGjb5 (Rattus norvegicus)6480464Ethinyl Estradiol results in increased expression of GJB5 mRNACTDPMID:15212814
Gjb5Mouse17alpha-ethynylestradiol increases expressionEXP 6480464Ethinyl Estradiol results in increased expression of GJB5 mRNACTDPMID:17942748
Gjb5Mouse17beta-estradiol multiple interactionsISOGjb5 (Rattus norvegicus)6480464[bisphenol A co-treated with Estradiol] results in increased expression of GJB5 mRNACTDPMID:26496021
Gjb5Mouse2,2',4,4'-Tetrabromodiphenyl ether increases expressionISOGjb5 (Rattus norvegicus)64804642 more ...CTDPMID:27291303
Gjb5Mouse2,3,7,8-tetrachlorodibenzodioxine multiple interactionsEXP 6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GJB5 mRNA and Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to GJB5 promoter]CTDPMID:17942748 and PMID:19654925
Gjb5Mouse2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expressionEXP 64804642 more ...CTDPMID:38648751
Gjb5Mouse6-propyl-2-thiouracil increases expressionISOGjb5 (Rattus norvegicus)6480464Propylthiouracil results in increased expression of GJB5 mRNACTDPMID:24780913
Gjb5Mouse7,12-dimethyltetraphene multiple interactionsEXP 6480464[9 more ...CTDPMID:7586191
Gjb5Mouse7,12-dimethyltetraphene increases expressionEXP 64804649 more ...CTDPMID:32553695
Gjb5Mouseall-trans-retinoic acid decreases expressionEXP 6480464Tretinoin results in decreased expression of GJB5 mRNACTDPMID:16604517
Gjb5Mouseammonium chloride affects expressionISOGjb5 (Rattus norvegicus)6480464Ammonium Chloride affects the expression of GJB5 mRNACTDPMID:16483693
Gjb5Mouseantirheumatic drug decreases expressionISOGJB5 (Homo sapiens)6480464Antirheumatic Agents results in decreased expression of GJB5 mRNACTDPMID:24449571
Gjb5Mousebenzo[a]pyrene increases expressionEXP 6480464Benzo(a)pyrene metabolite results in increased expression of GJB5 mRNACTDPMID:32553695
Gjb5Mousebenzo[a]pyrene decreases expressionISOGjb5 (Rattus norvegicus)6480464Benzo(a)pyrene results in decreased expression of GJB5 mRNACTDPMID:34283317
Gjb5Mousebenzo[a]pyrene decreases methylationISOGJB5 (Homo sapiens)6480464Benzo(a)pyrene results in decreased methylation of GJB5 5' UTRCTDPMID:27901495
Gjb5Mousebenzo[a]pyrene affects methylationISOGJB5 (Homo sapiens)6480464Benzo(a)pyrene affects the methylation of GJB5 promoterCTDPMID:27901495

1 to 20 of 60 rows

Biological Process

  

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gjb5Mouseconnexin complex part_ofIBAPANTHER:PTN008334405 more ...2290270 GO_CentralGO_REF:0000033
Gjb5Mouseconnexin complex part_ofIEAInterPro:IPR000500 more ...2290270 InterProGO_REF:0000002

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gjb5Mousegap junction channel activity enablesIBAPANTHER:PTN008334405 more ...2290270 GO_CentralGO_REF:0000033
Gjb5Mouseprotein binding enablesISOUniProtKB:B2RUZ4 more ...9068941 PMID:32296183IntActPMID:32296183


#
Reference Title
Reference Citation
1. Four novel members of the connexin family of gap junction proteins. Molecular cloning, expression, and chromosome mapping. Haefliger JA, etal., J Biol Chem 1992 Jan 25;267(3):2057-64.
2. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
3. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6. Mouse MP Annotation Import Pipeline RGD automated import pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:1512260   PMID:8631157   PMID:9843209   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11309658   PMID:11967204   PMID:12477932   PMID:14516671   PMID:14610273  
PMID:14681012   PMID:15081111   PMID:15255617   PMID:15466892   PMID:15895417   PMID:16141072   PMID:16141073   PMID:17302988   PMID:17961533   PMID:18384970   PMID:18799693   PMID:20930145  
PMID:21267068   PMID:21873635   PMID:24866916   PMID:30026265   PMID:34639052   PMID:36255053  



Gjb5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394127,248,600 - 127,251,957 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4127,248,602 - 127,251,974 (-)EnsemblGRCm39 Ensembl
GRCm384127,354,809 - 127,358,164 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4127,354,809 - 127,358,181 (-)EnsemblGRCm38mm10GRCm38
MGSCv374127,032,053 - 127,035,408 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364126,857,113 - 126,860,468 (-)NCBIMGSCv36mm8
Celera4125,689,190 - 125,692,545 (-)NCBICelera
Cytogenetic Map4D2.2NCBI
cM Map461.51NCBI
GJB5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38134,755,047 - 34,758,512 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl134,755,047 - 34,758,512 (+)EnsemblGRCh38hg38GRCh38
GRCh37135,220,648 - 35,224,113 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36134,993,308 - 34,996,699 (+)NCBINCBI36Build 36hg18NCBI36
Build 34134,889,813 - 34,893,205NCBI
Celera133,494,445 - 33,497,836 (+)NCBICelera
Cytogenetic Map1p34.3NCBI
HuRef133,338,163 - 33,341,628 (+)NCBIHuRef
CHM1_1135,336,342 - 35,339,807 (+)NCBICHM1_1
T2T-CHM13v2.0134,617,685 - 34,621,150 (+)NCBIT2T-CHM13v2.0
Gjb5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85144,965,133 - 144,968,051 (-)NCBIGRCr8
mRatBN7.25139,680,670 - 139,683,588 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5139,680,671 - 139,683,583 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5142,376,076 - 142,376,891 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05144,146,067 - 144,146,882 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05144,146,880 - 144,147,695 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05145,422,034 - 145,440,558 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5145,422,357 - 145,423,172 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05149,190,009 - 149,193,107 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45146,802,849 - 146,803,664 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15146,812,887 - 146,813,703 (-)NCBI
Celera5138,175,690 - 138,176,505 (-)NCBICelera
Cytogenetic Map5q36NCBI
Gjb5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545212,867,200 - 12,870,427 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545212,867,200 - 12,870,427 (+)NCBIChiLan1.0ChiLan1.0
GJB5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21192,087,232 - 192,090,729 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11191,208,376 - 191,211,883 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0134,022,109 - 34,025,606 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1135,203,658 - 35,207,134 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl135,205,953 - 35,206,774 (+)Ensemblpanpan1.1panPan2
GJB5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1157,196,720 - 7,199,652 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha157,436,219 - 7,439,149 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0157,342,877 - 7,345,807 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl157,343,120 - 7,343,941 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1157,205,189 - 7,208,117 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0157,253,201 - 7,256,124 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0157,267,421 - 7,270,351 (-)NCBIUU_Cfam_GSD_1.0
Gjb5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505851,577,747 - 51,581,737 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647417,405,000 - 17,405,809 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647417,402,804 - 17,406,080 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GJB5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl691,002,163 - 91,002,984 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1690,999,514 - 91,003,301 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2678,819,323 - 78,823,093 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GJB5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12098,128,901 - 98,132,640 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2098,129,262 - 98,130,083 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603318,708,932 - 18,712,511 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gjb5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476417,808,161 - 17,811,372 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476417,807,943 - 17,811,404 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Gjb5
109 total Variants

Predicted Target Of
Summary Value
Count of predictions:247
Count of miRNA genes:200
Interacting mature miRNAs:213
Transcripts:ENSMUST00000046498
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 70 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
4142139Adip12_madiposity 12 (mouse)Not determined4124621281156860686Mouse
10047132Albq19_malbuminuria QTL 19 (mouse)Not determined4112824389146824389Mouse
1301525Lmb1_mlupus in MRL and B6 F2 cross (mouse)Not determined4124264957150676858Mouse
14746982Manh56_mmandible shape 56 (mouse)4117815917151815917Mouse
4141623W6q13_mweight 6 weeks QTL 13 (mouse)Not determined88982069140468203Mouse
12910797Pwgrq4_mpre-weaning growth rate QTL 4 (mouse)4105835310141433838Mouse
25314312Syncl2_msynaptonemal complex length 2 (mouse)465718237146584457Mouse
12910794Pwbwq8_mpost-weaning body weight QTL 8 (mouse)4105835310141433838Mouse
1300743Skull6_mskull morphology 6 (mouse)Not determined4111009051145009280Mouse
1301382Arvm2_mautoimmune renal vasculitis 2 (mouse)Not determined4107791564141791756Mouse

1 to 10 of 70 rows
Gjb5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384127,355,407 - 127,356,277UniSTSGRCm38
MGSCv374127,032,651 - 127,033,521UniSTSGRCm37
Celera4125,689,788 - 125,690,658UniSTS
Cytogenetic Map4D2.2UniSTS
cM Map457.5UniSTS
Gjb5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384127,355,531 - 127,356,019UniSTSGRCm38
MGSCv374127,032,775 - 127,033,263UniSTSGRCm37
Celera4125,689,912 - 125,690,400UniSTS
Cytogenetic Map4D2.2UniSTS
Cytogenetic Map4D1-D3UniSTS
cM Map457.5UniSTS
Gjb5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4D2.2UniSTS
Gjb5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4D2.2UniSTS







Ensembl Acc Id: ENSMUST00000046498   ⟹   ENSMUSP00000045325
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4127,248,602 - 127,251,974 (-)Ensembl
GRCm38.p6 Ensembl4127,354,809 - 127,358,181 (-)Ensembl
RefSeq Acc Id: NM_010291   ⟹   NP_034421
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394127,248,600 - 127,251,957 (-)NCBI
GRCm384127,354,809 - 127,358,164 (-)ENTREZGENE
MGSCv374127,032,053 - 127,035,408 (-)RGD
Celera4125,689,190 - 125,692,545 (-)RGD
cM Map4 ENTREZGENE
Sequence:
1 to 10 of 10 rows
Protein RefSeqs NP_034421 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA37426 (Get FASTA)   NCBI Sequence Viewer  
  AAA37427 (Get FASTA)   NCBI Sequence Viewer  
  AAH11148 (Get FASTA)   NCBI Sequence Viewer  
  BAC38687 (Get FASTA)   NCBI Sequence Viewer  
  EDL30251 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000045325
  ENSMUSP00000045325.3
GenBank Protein Q02739 (Get FASTA)   NCBI Sequence Viewer  
  VZP20174 (Get FASTA)   NCBI Sequence Viewer  
1 to 10 of 10 rows
RefSeq Acc Id: NP_034421   ⟸   NM_010291
- UniProtKB: Q02739 (UniProtKB/Swiss-Prot),   Q542M8 (UniProtKB/TrEMBL),   Q91XA4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000045325   ⟸   ENSMUST00000046498
Name Modeler Protein Id AA Range Protein Structure
AF-Q02739-F1-model_v2 AlphaFold Q02739 1-271 view protein structure

RGD ID:6884700
Promoter ID:EPDNEW_M5801
Type:initiation region
Name:Gjb5_1
Description:Mus musculus gap junction protein, beta 5 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm384127,358,164 - 127,358,224EPDNEW


1 to 26 of 26 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSMUSG00000042357 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000046498 ENTREZGENE
  ENSMUST00000046498.3 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1440.80 UniProtKB/Swiss-Prot
InterPro Connexin UniProtKB/Swiss-Prot
  Connexin303 UniProtKB/Swiss-Prot
  Connexin_CCC UniProtKB/Swiss-Prot
  Connexin_CS UniProtKB/Swiss-Prot
  Connexin_N UniProtKB/Swiss-Prot
  Connexin_N_sf UniProtKB/Swiss-Prot
KEGG Report mmu:14622 UniProtKB/Swiss-Prot
MGD MGI:95723 ENTREZGENE
NCBI Gene 14622 ENTREZGENE
PANTHER GAP JUNCTION BETA-5 PROTEIN UniProtKB/Swiss-Prot
  PTHR11984 UniProtKB/Swiss-Prot
Pfam Connexin UniProtKB/Swiss-Prot
PhenoGen Gjb5 PhenoGen
PRINTS CONNEXIN UniProtKB/Swiss-Prot
  CONNEXINB4 UniProtKB/Swiss-Prot
PROSITE CONNEXINS_1 UniProtKB/Swiss-Prot
  CONNEXINS_2 UniProtKB/Swiss-Prot
SMART CNX UniProtKB/Swiss-Prot
  Connexin_CCC UniProtKB/Swiss-Prot
UniProt CXB5_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q542M8 ENTREZGENE, UniProtKB/TrEMBL
  Q91XA4 ENTREZGENE, UniProtKB/TrEMBL
1 to 26 of 26 rows