UXS1 (UDP-glucuronate decarboxylase 1) - Rat Genome Database

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Gene: UXS1 (UDP-glucuronate decarboxylase 1) Homo sapiens
Analyze
Symbol: UXS1
Name: UDP-glucuronate decarboxylase 1
RGD ID: 735996
HGNC Page HGNC
Description: Exhibits NAD+ binding activity; UDP-glucuronate decarboxylase activity; and protein homodimerization activity. Predicted to be involved in UDP-D-xylose biosynthetic process. Localizes to catalytic complex.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: FLJ23591; SDR6E1; short chain dehydrogenase/reductase family 6E, member 12; UDP-glucuronic acid decarboxylase 1; UGD; UXS-1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2106,093,308 - 106,194,301 (-)EnsemblGRCh38hg38GRCh38
GRCh382106,093,303 - 106,194,336 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372106,709,767 - 106,810,757 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362106,076,191 - 106,177,227 (-)NCBINCBI36hg18NCBI36
Build 342106,168,277 - 106,269,313NCBI
Celera2100,910,185 - 101,011,254 (-)NCBI
Cytogenetic Map2q12.2NCBI
HuRef2100,479,737 - 100,580,558 (-)NCBIHuRef
CHM1_12106,714,842 - 106,815,643 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:8125298   PMID:11877387   PMID:12391314   PMID:12477932   PMID:12975309   PMID:14702039   PMID:15489334   PMID:15815621   PMID:16303743   PMID:16344560   PMID:19027726   PMID:19028698  
PMID:19199708   PMID:19913121   PMID:20379614   PMID:20628086   PMID:20877624   PMID:21294126   PMID:21873635   PMID:23072385   PMID:23656592   PMID:25521717   PMID:26186194   PMID:27503909  
PMID:27609421   PMID:28514442   PMID:28611215   PMID:30021884   PMID:31527615  


Genomics

Comparative Map Data
UXS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2106,093,308 - 106,194,301 (-)EnsemblGRCh38hg38GRCh38
GRCh382106,093,303 - 106,194,336 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372106,709,767 - 106,810,757 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362106,076,191 - 106,177,227 (-)NCBINCBI36hg18NCBI36
Build 342106,168,277 - 106,269,313NCBI
Celera2100,910,185 - 101,011,254 (-)NCBI
Cytogenetic Map2q12.2NCBI
HuRef2100,479,737 - 100,580,558 (-)NCBIHuRef
CHM1_12106,714,842 - 106,815,643 (-)NCBICHM1_1
Uxs1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39143,786,121 - 43,866,999 (-)NCBIGRCm39mm39
GRCm39 Ensembl143,786,126 - 43,866,960 (-)Ensembl
GRCm38143,746,961 - 43,827,839 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl143,746,966 - 43,827,800 (-)EnsemblGRCm38mm10GRCm38
MGSCv37143,807,076 - 43,884,553 (-)NCBIGRCm37mm9NCBIm37
MGSCv36143,693,833 - 43,772,294 (-)NCBImm8
Celera144,100,573 - 44,177,690 (-)NCBICelera
Cytogenetic Map1C1.1NCBI
Uxs1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.29653,740 - 731,121 (+)NCBI
Rnor_6.0 Ensembl911,164,715 - 11,339,790 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0911,165,006 - 11,240,329 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0910,150,134 - 10,226,955 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera97,775,435 - 7,852,399 (-)NCBICelera
Cytogenetic Map9q12NCBI
Uxs1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547010,659,520 - 10,706,269 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495547010,661,210 - 10,706,504 (-)NCBIChiLan1.0ChiLan1.0
UXS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A107,168,081 - 107,234,626 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A107,168,309 - 107,234,632 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A95,652,107 - 95,770,022 (+)NCBIMhudiblu_PPA_v0panPan3
UXS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11037,342,675 - 37,407,725 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1037,342,746 - 37,407,252 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1037,238,647 - 37,332,207 (+)NCBI
ROS_Cfam_1.01038,164,639 - 38,257,518 (+)NCBI
UMICH_Zoey_3.11037,896,777 - 37,989,649 (+)NCBI
UNSW_CanFamBas_1.01038,173,540 - 38,266,403 (+)NCBI
UU_Cfam_GSD_1.01038,367,280 - 38,460,904 (+)NCBI
Uxs1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629292,409,779 - 92,504,443 (-)NCBI
SpeTri2.0NW_0049367295,056 - 99,755 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UXS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl348,870,948 - 48,940,721 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1348,871,036 - 48,940,736 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2351,082,501 - 51,149,409 (-)NCBISscrofa10.2Sscrofa10.2susScr3
UXS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1149,692,449 - 9,808,837 (-)NCBI
ChlSab1.1 Ensembl149,713,123 - 9,808,764 (-)Ensembl
Vero_WHO_p1.0NW_023666041177,415,766 - 177,532,870 (-)NCBI
Uxs1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247499,969,500 - 10,021,931 (-)NCBI

Position Markers
RH36460  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372106,804,626 - 106,804,858UniSTSGRCh37
Build 362106,171,058 - 106,171,290RGDNCBI36
Celera2101,005,083 - 101,005,315RGD
Cytogenetic Map2q12.2UniSTS
HuRef2100,574,425 - 100,574,657UniSTS
GeneMap99-GB4 RH Map2366.75UniSTS
NCBI RH Map2786.5UniSTS
RH70063  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372106,710,129 - 106,710,334UniSTSGRCh37
Build 362106,076,561 - 106,076,766RGDNCBI36
Celera2100,910,555 - 100,910,760RGD
Cytogenetic Map2q12.2UniSTS
HuRef2100,480,107 - 100,480,312UniSTS
GeneMap99-GB4 RH Map2366.65UniSTS
NCBI RH Map2785.4UniSTS
RH26280  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372106,709,873 - 106,710,025UniSTSGRCh37
Build 362106,076,305 - 106,076,457RGDNCBI36
Celera2100,910,299 - 100,910,451RGD
Cytogenetic Map2q12.2UniSTS
HuRef2100,479,851 - 100,480,003UniSTS
SHGC-83592  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372106,756,397 - 106,756,741UniSTSGRCh37
Build 362106,122,829 - 106,123,173RGDNCBI36
Celera2100,956,819 - 100,957,163RGD
Cytogenetic Map2q12.2UniSTS
HuRef2100,526,170 - 100,526,514UniSTS
TNG Radiation Hybrid Map262306.0UniSTS
SHGC-107402  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372106,779,392 - 106,779,730UniSTSGRCh37
Build 362106,145,824 - 106,146,162RGDNCBI36
Celera2100,979,815 - 100,980,153RGD
Cytogenetic Map2q12.2UniSTS
HuRef2100,549,160 - 100,549,498UniSTS
TNG Radiation Hybrid Map262299.0UniSTS
SHGC-142052  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372106,795,478 - 106,795,750UniSTSGRCh37
Build 362106,161,910 - 106,162,182RGDNCBI36
Celera2100,995,928 - 100,996,200RGD
Cytogenetic Map2q12.2UniSTS
HuRef2100,565,272 - 100,565,544UniSTS
TNG Radiation Hybrid Map262253.0UniSTS
SHGC-145369  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372106,801,763 - 106,802,051UniSTSGRCh37
Build 362106,168,195 - 106,168,483RGDNCBI36
Celera2101,002,212 - 101,002,500RGD
Cytogenetic Map2q12.2UniSTS
HuRef2100,571,556 - 100,571,844UniSTS
TNG Radiation Hybrid Map262276.0UniSTS
WIAF-1518  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372106,710,454 - 106,710,580UniSTSGRCh37
Build 362106,076,886 - 106,077,012RGDNCBI36
Celera2100,910,880 - 100,911,006RGD
Cytogenetic Map2q12.2UniSTS
HuRef2100,480,432 - 100,480,558UniSTS
GeneMap99-GB4 RH Map2368.84UniSTS
RH12428  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372106,709,857 - 106,710,028UniSTSGRCh37
Build 362106,076,289 - 106,076,460RGDNCBI36
Celera2100,910,283 - 100,910,454RGD
Cytogenetic Map2q12.2UniSTS
HuRef2100,479,835 - 100,480,006UniSTS
GeneMap99-GB4 RH Map2366.65UniSTS
NCBI RH Map2785.4UniSTS
RH18480  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372106,804,652 - 106,804,831UniSTSGRCh37
Build 362106,171,084 - 106,171,263RGDNCBI36
Celera2101,005,109 - 101,005,288RGD
Cytogenetic Map2q12.2UniSTS
HuRef2100,574,451 - 100,574,630UniSTS
GeneMap99-GB4 RH Map2366.75UniSTS
NCBI RH Map2786.5UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2767
Count of miRNA genes:945
Interacting mature miRNAs:1128
Transcripts:ENST00000283148, ENST00000409032, ENST00000409501, ENST00000416298, ENST00000428048, ENST00000436241, ENST00000441952, ENST00000444193, ENST00000457835, ENST00000470053, ENST00000473338, ENST00000474920, ENST00000479621, ENST00000479774, ENST00000483426, ENST00000497604, ENST00000540130
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 1985 1527 1158 177 1017 110 3124 1048 2523 349 1381 1582 81 882 1885 3
Low 453 1460 568 446 930 355 1232 1149 1209 70 77 31 93 1 322 903 3 1
Below cutoff 1 4 1 4 2 1 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001253875 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001253876 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001377504 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001377505 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001377506 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001377507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001377508 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001377509 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_025076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_045607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_165308 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011511902 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011511903 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017005011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017005014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024453157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC018878 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI217133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK027244 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK056022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK057242 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK075120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK075170 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK122696 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK225592 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK290668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK304872 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL834439 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY147934 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY358541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC009819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI550591 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI825770 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM472113 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX366726 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF242897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CQ783167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CQ783244 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB379311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000283148   ⟹   ENSP00000283148
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2106,093,303 - 106,194,339 (-)Ensembl
RefSeq Acc Id: ENST00000409032   ⟹   ENSP00000387096
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2106,093,604 - 106,138,881 (-)Ensembl
RefSeq Acc Id: ENST00000409501   ⟹   ENSP00000387019
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2106,093,508 - 106,194,299 (-)Ensembl
RefSeq Acc Id: ENST00000416298   ⟹   ENSP00000403612
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2106,104,794 - 106,160,625 (-)Ensembl
RefSeq Acc Id: ENST00000436241   ⟹   ENSP00000397049
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2106,123,052 - 106,138,786 (-)Ensembl
RefSeq Acc Id: ENST00000441952   ⟹   ENSP00000416656
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2106,101,047 - 106,194,299 (-)Ensembl
RefSeq Acc Id: ENST00000444193   ⟹   ENSP00000404468
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2106,112,643 - 106,160,584 (-)Ensembl
RefSeq Acc Id: ENST00000457835   ⟹   ENSP00000399316
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2106,122,971 - 106,194,299 (-)Ensembl
RefSeq Acc Id: ENST00000470053
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2106,100,773 - 106,104,824 (-)Ensembl
RefSeq Acc Id: ENST00000473338
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2106,093,604 - 106,097,710 (-)Ensembl
RefSeq Acc Id: ENST00000474920
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2106,158,058 - 106,166,479 (-)Ensembl
RefSeq Acc Id: ENST00000479621
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2106,145,190 - 106,160,397 (-)Ensembl
RefSeq Acc Id: ENST00000479774
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2106,145,190 - 106,160,112 (-)Ensembl
RefSeq Acc Id: ENST00000483426
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2106,145,269 - 106,194,299 (-)Ensembl
RefSeq Acc Id: ENST00000497604
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2106,093,308 - 106,102,952 (-)Ensembl
RefSeq Acc Id: NM_001253875   ⟹   NP_001240804
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382106,093,311 - 106,194,301 (-)NCBI
GRCh372106,709,759 - 106,810,795 (-)NCBI
HuRef2100,479,737 - 100,580,558 (-)NCBI
CHM1_12106,714,842 - 106,815,643 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001253876   ⟹   NP_001240805
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382106,093,311 - 106,138,881 (-)NCBI
GRCh372106,709,759 - 106,810,795 (-)NCBI
HuRef2100,479,737 - 100,580,558 (-)NCBI
CHM1_12106,714,842 - 106,760,200 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001377504   ⟹   NP_001364433
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382106,093,311 - 106,194,301 (-)NCBI
RefSeq Acc Id: NM_001377505   ⟹   NP_001364434
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382106,093,311 - 106,194,301 (-)NCBI
RefSeq Acc Id: NM_001377506   ⟹   NP_001364435
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382106,093,311 - 106,160,637 (-)NCBI
RefSeq Acc Id: NM_001377507   ⟹   NP_001364436
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382106,093,311 - 106,194,301 (-)NCBI
RefSeq Acc Id: NM_001377508   ⟹   NP_001364437
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382106,093,311 - 106,194,301 (-)NCBI
RefSeq Acc Id: NM_001377509   ⟹   NP_001364438
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382106,093,311 - 106,160,637 (-)NCBI
RefSeq Acc Id: NM_025076   ⟹   NP_079352
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382106,093,311 - 106,194,301 (-)NCBI
GRCh372106,709,759 - 106,810,795 (-)RGD
Build 362106,076,191 - 106,177,227 (-)NCBI Archive
Celera2100,910,185 - 101,011,254 (-)RGD
HuRef2100,479,737 - 100,580,558 (-)ENTREZGENE
CHM1_12106,714,842 - 106,815,643 (-)NCBI
Sequence:
RefSeq Acc Id: NR_045607
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382106,093,311 - 106,194,301 (-)NCBI
GRCh372106,709,759 - 106,810,795 (-)NCBI
HuRef2100,479,737 - 100,580,558 (-)NCBI
CHM1_12106,714,842 - 106,815,643 (-)NCBI
Sequence:
RefSeq Acc Id: NR_165308
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382106,093,311 - 106,194,301 (-)NCBI
RefSeq Acc Id: XM_011511902   ⟹   XP_011510204
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382106,093,426 - 106,193,368 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011511903   ⟹   XP_011510205
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382106,093,426 - 106,193,366 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017005011   ⟹   XP_016860500
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382106,093,303 - 106,194,336 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017005014   ⟹   XP_016860503
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382106,093,426 - 106,194,303 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024453157   ⟹   XP_024308925
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382106,093,303 - 106,158,077 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001240804 (Get FASTA)   NCBI Sequence Viewer  
  NP_001240805 (Get FASTA)   NCBI Sequence Viewer  
  NP_001364433 (Get FASTA)   NCBI Sequence Viewer  
  NP_001364434 (Get FASTA)   NCBI Sequence Viewer  
  NP_001364435 (Get FASTA)   NCBI Sequence Viewer  
  NP_001364436 (Get FASTA)   NCBI Sequence Viewer  
  NP_001364437 (Get FASTA)   NCBI Sequence Viewer  
  NP_001364438 (Get FASTA)   NCBI Sequence Viewer  
  NP_079352 (Get FASTA)   NCBI Sequence Viewer  
  XP_011510204 (Get FASTA)   NCBI Sequence Viewer  
  XP_011510205 (Get FASTA)   NCBI Sequence Viewer  
  XP_016860500 (Get FASTA)   NCBI Sequence Viewer  
  XP_016860503 (Get FASTA)   NCBI Sequence Viewer  
  XP_024308925 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH09819 (Get FASTA)   NCBI Sequence Viewer  
  AAN39844 (Get FASTA)   NCBI Sequence Viewer  
  AAQ88905 (Get FASTA)   NCBI Sequence Viewer  
  AAY15085 (Get FASTA)   NCBI Sequence Viewer  
  BAB15705 (Get FASTA)   NCBI Sequence Viewer  
  BAC11415 (Get FASTA)   NCBI Sequence Viewer  
  BAC11448 (Get FASTA)   NCBI Sequence Viewer  
  BAF83357 (Get FASTA)   NCBI Sequence Viewer  
  BAG53673 (Get FASTA)   NCBI Sequence Viewer  
  BAG65609 (Get FASTA)   NCBI Sequence Viewer  
  CAD39099 (Get FASTA)   NCBI Sequence Viewer  
  CAF86373 (Get FASTA)   NCBI Sequence Viewer  
  CAF86438 (Get FASTA)   NCBI Sequence Viewer  
  EAX01747 (Get FASTA)   NCBI Sequence Viewer  
  EAX01748 (Get FASTA)   NCBI Sequence Viewer  
  EAX01749 (Get FASTA)   NCBI Sequence Viewer  
  EAX01750 (Get FASTA)   NCBI Sequence Viewer  
  Q8NBZ7 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_079352   ⟸   NM_025076
- Peptide Label: isoform 2
- UniProtKB: Q8NBZ7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001240804   ⟸   NM_001253875
- Peptide Label: isoform 1
- UniProtKB: Q8NBZ7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001240805   ⟸   NM_001253876
- Peptide Label: isoform 3
- UniProtKB: Q8NBZ7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011510205   ⟸   XM_011511903
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_011510204   ⟸   XM_011511902
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_016860503   ⟸   XM_017005014
- Peptide Label: isoform X10
- UniProtKB: Q8NBZ7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_016860500   ⟸   XM_017005011
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: XP_024308925   ⟸   XM_024453157
- Peptide Label: isoform X10
- Sequence:
RefSeq Acc Id: NP_001364434   ⟸   NM_001377505
- Peptide Label: isoform 5
RefSeq Acc Id: NP_001364437   ⟸   NM_001377508
- Peptide Label: isoform 8
RefSeq Acc Id: NP_001364433   ⟸   NM_001377504
- Peptide Label: isoform 4
RefSeq Acc Id: NP_001364436   ⟸   NM_001377507
- Peptide Label: isoform 7
RefSeq Acc Id: NP_001364435   ⟸   NM_001377506
- Peptide Label: isoform 6
RefSeq Acc Id: NP_001364438   ⟸   NM_001377509
- Peptide Label: isoform 9
RefSeq Acc Id: ENSP00000283148   ⟸   ENST00000283148
RefSeq Acc Id: ENSP00000416656   ⟸   ENST00000441952
RefSeq Acc Id: ENSP00000403612   ⟸   ENST00000416298
RefSeq Acc Id: ENSP00000399316   ⟸   ENST00000457835
RefSeq Acc Id: ENSP00000404468   ⟸   ENST00000444193
RefSeq Acc Id: ENSP00000387096   ⟸   ENST00000409032
RefSeq Acc Id: ENSP00000387019   ⟸   ENST00000409501
RefSeq Acc Id: ENSP00000397049   ⟸   ENST00000436241
Protein Domains
Epimerase   NAD(P)-bd_dom   UXS1_N

Promoters
RGD ID:6798429
Promoter ID:HG_KWN:34285
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell
Transcripts:OTTHUMT00000329789
Position:
Human AssemblyChrPosition (strand)Source
Build 362106,087,106 - 106,087,606 (-)MPROMDB
RGD ID:6798430
Promoter ID:HG_KWN:34286
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour
Transcripts:OTTHUMT00000329788,   UC002TDL.1
Position:
Human AssemblyChrPosition (strand)Source
Build 362106,120,919 - 106,121,419 (-)MPROMDB
RGD ID:6798425
Promoter ID:HG_KWN:34287
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000329783,   OTTHUMT00000329784,   OTTHUMT00000329785,   OTTHUMT00000329786
Position:
Human AssemblyChrPosition (strand)Source
Build 362106,143,016 - 106,143,957 (-)MPROMDB
RGD ID:6798426
Promoter ID:HG_KWN:34290
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000409501,   NM_025076,   OTTHUMT00000329781,   OTTHUMT00000329782,   OTTHUMT00000329787,   UC002TDO.1
Position:
Human AssemblyChrPosition (strand)Source
Build 362106,177,046 - 106,177,552 (-)MPROMDB
RGD ID:6861252
Promoter ID:EPDNEW_H3791
Type:initiation region
Name:UXS1_1
Description:UDP-glucuronate decarboxylase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382106,194,299 - 106,194,359EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 2q11.2-12.3(chr2:100378510-108472871)x3 copy number gain See cases [RCV000050836] Chr2:100378510..108472871 [GRCh38]
Chr2:100994972..109089327 [GRCh37]
Chr2:100361404..108455759 [NCBI36]
Chr2:2q11.2-12.3
pathogenic
GRCh38/hg38 2q12.2-12.3(chr2:105828398-108080417)x3 copy number gain See cases [RCV000052691] Chr2:105828398..108080417 [GRCh38]
Chr2:106444854..108696873 [GRCh37]
Chr2:105811286..108063305 [NCBI36]
Chr2:2q12.2-12.3
uncertain significance
GRCh38/hg38 2q11.2-13(chr2:97672522-110211318)x3 copy number gain See cases [RCV000052947] Chr2:97672522..110211318 [GRCh38]
Chr2:98288985..110968895 [GRCh37]
Chr2:97655417..110326184 [NCBI36]
Chr2:2q11.2-13
pathogenic
GRCh38/hg38 2q12.1-12.3(chr2:104381722-107312459)x1 copy number loss See cases [RCV000135282] Chr2:104381722..107312459 [GRCh38]
Chr2:104998180..107928915 [GRCh37]
Chr2:104364612..107295347 [NCBI36]
Chr2:2q12.1-12.3
likely pathogenic
GRCh38/hg38 2q12.1-12.2(chr2:105239034-106152100)x3 copy number gain See cases [RCV000135475] Chr2:105239034..106152100 [GRCh38]
Chr2:105855491..106768556 [GRCh37]
Chr2:105221923..106134988 [NCBI36]
Chr2:2q12.1-12.2
benign
GRCh38/hg38 2q11.2-13(chr2:101710825-110791418)x3 copy number gain See cases [RCV000138645] Chr2:101710825..110791418 [GRCh38]
Chr2:102327287..111548995 [GRCh37]
Chr2:101693719..111265466 [NCBI36]
Chr2:2q11.2-13
pathogenic
GRCh38/hg38 2q11.1-13(chr2:94678532-110602409)x3 copy number gain See cases [RCV000141075] Chr2:94678532..110602409 [GRCh38]
Chr2:95344257..111359986 [GRCh37]
Chr2:94707984..111076455 [NCBI36]
Chr2:2q11.1-13
pathogenic
GRCh38/hg38 2q11.2-12.2(chr2:100478285-106498909)x3 copy number gain See cases [RCV000141445] Chr2:100478285..106498909 [GRCh38]
Chr2:101094747..107115365 [GRCh37]
Chr2:100461179..106481797 [NCBI36]
Chr2:2q11.2-12.2
uncertain significance
GRCh38/hg38 2q12.2-12.3(chr2:106170872-106809420)x3 copy number gain See cases [RCV000142302] Chr2:106170872..106809420 [GRCh38]
Chr2:106787328..107425876 [GRCh37]
Chr2:106153760..106792308 [NCBI36]
Chr2:2q12.2-12.3
uncertain significance
GRCh37/hg19 2q12.2-14.1(chr2:106423310-115054828)x1 copy number loss See cases [RCV000240053] Chr2:106423310..115054828 [GRCh37]
Chr2:2q12.2-14.1
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:14238-243048760)x3 copy number gain not provided [RCV000752802] Chr2:14238..243048760 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:15672-243101834)x3 copy number gain not provided [RCV000752804] Chr2:15672..243101834 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2q11.1-12.3(chr2:95529039-108518266) copy number gain See cases [RCV000449270] Chr2:95529039..108518266 [GRCh37]
Chr2:2q11.1-12.3
pathogenic
GRCh37/hg19 2q11.1-13(chr2:95327499-111370025)x4 copy number gain See cases [RCV000446842] Chr2:95327499..111370025 [GRCh37]
Chr2:2q11.1-13
pathogenic
GRCh37/hg19 2q12.2(chr2:106791392-107425876)x3 copy number gain See cases [RCV000448657] Chr2:106791392..107425876 [GRCh37]
Chr2:2q12.2
uncertain significance
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384) copy number gain See cases [RCV000512056] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2q12.2(chr2:106794872-107014384)x1 copy number loss See cases [RCV000511743] Chr2:106794872..107014384 [GRCh37]
Chr2:2q12.2
likely benign
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384)x3 copy number gain See cases [RCV000511212] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2q11.1-12.2(chr2:95518497-107186127) copy number gain See cases [RCV000511158] Chr2:95518497..107186127 [GRCh37]
Chr2:2q11.1-12.2
uncertain significance
GRCh37/hg19 2q12.1-24.3(chr2:104172062-168223828)x1 copy number loss PARP Inhibitor response [RCV000626436] Chr2:104172062..168223828 [GRCh37]
Chr2:2q12.1-24.3
drug response
GRCh37/hg19 2q12.2(chr2:106788511-107425876)x3 copy number gain not provided [RCV000682095] Chr2:106788511..107425876 [GRCh37]
Chr2:2q12.2
uncertain significance
GRCh37/hg19 2q11.1-13(chr2:96353030-114045463)x3 copy number gain not provided [RCV000682168] Chr2:96353030..114045463 [GRCh37]
Chr2:2q11.1-13
pathogenic
Single allele inversion not provided [RCV000714264] Chr2:40608411..146900718 [GRCh37]
Chr2:2p22.1-q22.3
likely pathogenic
GRCh37/hg19 2q12.2(chr2:106547252-106992981)x3 copy number gain not provided [RCV001005301] Chr2:106547252..106992981 [GRCh37]
Chr2:2q12.2
uncertain significance
GRCh37/hg19 2q12.2-12.3(chr2:106596090-107516533)x3 copy number gain not provided [RCV000848935] Chr2:106596090..107516533 [GRCh37]
Chr2:2q12.2-12.3
uncertain significance
GRCh37/hg19 2q12.1-12.2(chr2:102917327-106755564)x1 copy number loss not provided [RCV000848959] Chr2:102917327..106755564 [GRCh37]
Chr2:2q12.1-12.2
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:17729 AgrOrtholog
COSMIC UXS1 COSMIC
Ensembl Genes ENSG00000115652 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000283148 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000387019 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000387096 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000397049 UniProtKB/TrEMBL
  ENSP00000399316 UniProtKB/TrEMBL
  ENSP00000403612 UniProtKB/TrEMBL
  ENSP00000404468 UniProtKB/TrEMBL
  ENSP00000416656 UniProtKB/TrEMBL
  ENSP00000502305 UniProtKB/TrEMBL
  ENSP00000502335 UniProtKB/TrEMBL
  ENSP00000502540 UniProtKB/TrEMBL
Ensembl Transcript ENST00000283148 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000409032 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000409501 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000416298 UniProtKB/TrEMBL
  ENST00000436241 UniProtKB/TrEMBL
  ENST00000441952 UniProtKB/TrEMBL
  ENST00000444193 UniProtKB/TrEMBL
  ENST00000457835 UniProtKB/TrEMBL
  ENST00000479621 UniProtKB/TrEMBL
  ENST00000479774 UniProtKB/TrEMBL
  ENST00000483426 UniProtKB/TrEMBL
GTEx ENSG00000115652 GTEx
HGNC ID HGNC:17729 ENTREZGENE
Human Proteome Map UXS1 Human Proteome Map
InterPro Epimerase_deHydtase_N UniProtKB/TrEMBL
  NAD(P)-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UXS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UXS1_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:80146 UniProtKB/Swiss-Prot
NCBI Gene 80146 ENTREZGENE
OMIM 609749 OMIM
PANTHER PTHR43078 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Epimerase UniProtKB/TrEMBL
  GDP_Man_Dehyd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UXS1_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA38465 PharmGKB
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A6Q8PGM4_HUMAN UniProtKB/TrEMBL
  A0A6Q8PGN2_HUMAN UniProtKB/TrEMBL
  A0A6Q8PH60_HUMAN UniProtKB/TrEMBL
  B3KV61_HUMAN UniProtKB/TrEMBL
  C9J3T9_HUMAN UniProtKB/TrEMBL
  C9JCB7_HUMAN UniProtKB/TrEMBL
  C9JE50_HUMAN UniProtKB/TrEMBL
  C9JFU6_HUMAN UniProtKB/TrEMBL
  C9JW33_HUMAN UniProtKB/TrEMBL
  Q8NBZ7 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q8NBX3 UniProtKB/Swiss-Prot
  Q9H5C2 UniProtKB/Swiss-Prot