Semg1 (semenogelin 1) - Rat Genome Database

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Gene: Semg1 (semenogelin 1) Mus musculus
Analyze
Symbol: Semg1
Name: semenogelin 1
RGD ID: 734353
MGI Page MGI
Description: Predicted to enable protease binding activity and zinc ion binding activity. Acts upstream of or within fertilization and sperm capacitation. Located in acrosomal vesicle. Is expressed in alimentary system; bladder; and male reproductive gland or organ. Orthologous to human SEMG1 (semenogelin 1) and SEMG2 (semenogelin 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: BB115391; MGC130221; semenoclotin; semenogelin I; seminal vesicle protein, secretion 2; seminal vesicle secretory protein 2; Svs2; SvsII
RGD Orthologs
Human
Rat
Bonobo
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392164,077,849 - 164,080,261 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2164,077,849 - 164,080,386 (-)EnsemblGRCm39 Ensembl
GRCm382164,235,929 - 164,238,341 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2164,235,929 - 164,238,466 (-)EnsemblGRCm38mm10GRCm38
MGSCv372164,061,665 - 164,064,077 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362163,927,370 - 163,929,706 (-)NCBIMGSCv36mm8
Celera2170,167,839 - 170,170,251 (-)NCBICelera
Cytogenetic Map2H3NCBI
cM Map284.82NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The evolution of a genetic locus encoding small serine proteinase inhibitors. Clauss A, etal., Biochem Biophys Res Commun 2005 Jul 29;333(2):383-9.
2. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. Somatic cell hybrids for high-density mapping of chromosome 2 breakpoints in radiation-induced myeloid leukemia cell lines from inbred mice. Pazzaglia S, etal., Mol Carcinog 2000 Mar;27(3):219-28.
6. Mouse MP Annotation Import Pipeline RGD automated import pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8631362   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11752298   PMID:12477932   PMID:16141072   PMID:16141073   PMID:17123940   PMID:18753612   PMID:21267068   PMID:21873635  
PMID:24194600   PMID:24591616   PMID:25395676   PMID:27626380   PMID:31540031   PMID:32044375   PMID:32486486   PMID:38355793  


Genomics

Comparative Map Data
Semg1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392164,077,849 - 164,080,261 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2164,077,849 - 164,080,386 (-)EnsemblGRCm39 Ensembl
GRCm382164,235,929 - 164,238,341 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2164,235,929 - 164,238,466 (-)EnsemblGRCm38mm10GRCm38
MGSCv372164,061,665 - 164,064,077 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362163,927,370 - 163,929,706 (-)NCBIMGSCv36mm8
Celera2170,167,839 - 170,170,251 (-)NCBICelera
Cytogenetic Map2H3NCBI
cM Map284.82NCBI
SEMG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382045,207,033 - 45,209,768 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2045,207,033 - 45,209,768 (+)EnsemblGRCh38hg38GRCh38
GRCh372043,835,674 - 43,838,409 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362043,269,088 - 43,271,823 (+)NCBINCBI36Build 36hg18NCBI36
Build 342043,269,087 - 43,271,822NCBI
Celera2040,544,235 - 40,547,011 (+)NCBICelera
Cytogenetic Map20q13.12NCBI
HuRef2040,577,518 - 40,580,294 (+)NCBIHuRef
CHM1_12043,738,369 - 43,740,966 (+)NCBICHM1_1
T2T-CHM13v2.02046,942,926 - 46,945,661 (+)NCBIT2T-CHM13v2.0
Semg1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83173,329,413 - 173,332,261 (-)NCBIGRCr8
mRatBN7.23152,910,033 - 152,912,882 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3152,910,034 - 152,912,882 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3156,717,524 - 156,720,371 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03165,216,464 - 165,219,312 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03162,961,782 - 162,964,620 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03160,627,609 - 160,630,457 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3160,627,610 - 160,630,457 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03166,811,166 - 166,814,014 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43155,179,283 - 155,182,131 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13155,085,319 - 155,088,167 (-)NCBI
Celera3151,554,969 - 151,557,817 (-)NCBICelera
Cytogenetic Map3q42NCBI
SEMG2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22150,955,090 - 50,957,081 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12050,948,198 - 50,950,189 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02041,552,614 - 41,554,605 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12042,642,620 - 42,644,611 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2042,642,620 - 42,644,611 (+)Ensemblpanpan1.1panPan2
SEMG2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366605067,243,594 - 67,246,751 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Semg1
147 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:244
Count of miRNA genes:191
Interacting mature miRNAs:210
Transcripts:ENSMUST00000044953, ENSMUST00000109374
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301907Rends_mrenal disease susceptibility (mouse)Not determined2135699221169699361Mouse
1300688Nidd2k_mNidd2 on KK-A (mouse)Not determined2158078337178442452Mouse
1301783Bhr1_mbronchial hyperresponsiveness 1 (mouse)Not determined2142593476178442452Mouse
12790983Bwq12_mbody weight QTL 12 (mouse)2148238204181755017Mouse
1558867Gnf3_mgrowth and fatness 3 (mouse)Not determined2152699221169117924Mouse
11038701Ltpr2e_mLeishmania tropica response 2e (mouse)2150212221181755017Mouse
11038702Ltpr2_mLeishmania tropica response 2 (mouse)2103095716167212356Mouse
1301019Bmd6_mbone mineral density 6 (mouse)Not determined2151778297181755017Mouse
1558939Gnf1_mgrowth and fatness 1 (mouse)Not determined2143773445169117924Mouse
4142450Lmr16_mleishmaniasis resistance 16 (mouse)Not determined2150212221181755017Mouse
1301085Lrnx10_mlearning-contextual 10 (mouse)Not determined2150212221181755017Mouse
11353826Bdln10_mbody length 10 (mouse)2140441482174441482Mouse
1300867Lore2_mloss of righting induced by ethanol 2 (mouse)Not determined2144515861180896594Mouse
1558917Gct8_mgranulosa cell tumorigenesis 8 (mouse)Not determined2149236907181755017Mouse
1300806Aod4_mautoimmune ovarian dysgenesis 4 (mouse)Not determined2145228719179228841Mouse
12910800Pwgrq3_mpre-weaning growth rate QTL 3 (mouse)2160611165169794802Mouse
1558991Tailq4_mtail length QTL 4 (mouse)Not determined2162736926178442452Mouse
1301961Bts1_mbladder tumor susceptibility 1 (mouse)Not determined2132024159166024330Mouse
14747002Mancz3_mmandible centroid size 3 (mouse)2152329820181755017Mouse
1300751Bdt1_mbone density traits 1 (mouse)Not determined2149988902181755017Mouse
1300622Cfld1_mcystic fibrosis lung disease 1 (mouse)Not determined2155823920181755017Mouse
12910810Pwbwq2_mpre-weaning body weight QTL 2 (mouse)2160611165169794802Mouse
1302003Sluc17_msusceptibility to lung cancer 17 (mouse)Not determined2162433493181755017Mouse
1301618Bglu1_mblood glucose level 1 (mouse)Not determined2117942930174324863Mouse
27226749Femd10_mfemur midshaft diameter 10, 16 week (mouse)2124441920168241920Mouse
10054066Bwq9_mbody weight QTL 9 (mouse)Not determined2135699221169699361Mouse
10043956Gnf5_mgrowth and fatness 5 (mouse)Not determined2135699221169699361Mouse
1302013Tbbmd3_mtotal body bone mineral density 3 (mouse)Not determined2145196949179197085Mouse
10412080Hylaq2_mHyperlocomotor activity related QTL 2 (mouse)Not determined2151640941164119146Mouse
5491196Mobq6_mmultigenic obesity QTL 6 (mouse)Not determined285724269180896594Mouse
1357435Epfq2_mepididymal fat pad weight QTL 2 (mouse)Not determined2162736926178442452Mouse
12801456Intmrm1_mintima/media ratio modifier 1 (mouse)2142428347176428450Mouse
1357537Lith12_mlithogenic gene 12 (mouse)Not determined2156196464181755017Mouse
11049566Lmr28e_mleishmaniasis resistance 28e (mouse)2133144911167145058Mouse
12801461Intim1_mintima modifier 1 (mouse)2142428347176428450Mouse
11049567Lmr28f_mleishmaniasis resistance 28f (mouse)2133144911167145058Mouse
1301348Alcp5_malcohol preference locus 5 (mouse)Not determined2163486407181755017Mouse
11341717Rvfs1_mRift Valley fever susceptibility 1 (mouse)2135432544173449616Mouse
4141703Chlq13_mcirculating hormone level QTL 13 (mouse)Not determined2135699221169699361Mouse
1357484Bsbob_mBSB obesity (mouse)Not determined2143773445165665019Mouse
1301865Hdlq19_mHDL QTL 19 (mouse)Not determined2145518775179518926Mouse
4142211Nilac3_mnicotine induced locomotor activity 3 (mouse)Not determined2148664893181755017Mouse
12910520Scgq3_mspontaneous crescentic glomerulonephritis QTL 3 (mouse)2151709273174389124Mouse
1300846Pbwg11_mpostnatal body weight growth 11 (mouse)Not determined2138966600172966729Mouse
1301677Alcp6_malcohol preference locus 6 (mouse)Not determined2163486407181755017Mouse

Markers in Region
BB115391  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382164,236,084 - 164,236,189UniSTSGRCm38
MGSCv372164,061,820 - 164,061,925UniSTSGRCm37
Celera2170,167,994 - 170,168,099UniSTS
Cytogenetic Map2H3UniSTS
cM Map280.9UniSTS
Whitehead/MRC_RH21879.65UniSTS
X91270  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382164,236,064 - 164,236,224UniSTSGRCm38
MGSCv372164,061,800 - 164,061,960UniSTSGRCm37
Celera2170,167,974 - 170,168,134UniSTS
Cytogenetic Map2H3UniSTS
cM Map280.9UniSTS
Whitehead_YAC2 UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_017390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK020661 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK035204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK040724 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK090151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK090302 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK136679 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK144285 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK144389 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK144429 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK144524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK165704 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK165713 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK165727 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK165753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK165825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL591512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB871464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC107275 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC107276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DV056729 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X91270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000044953   ⟹   ENSMUSP00000042389
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2164,077,849 - 164,080,386 (-)Ensembl
GRCm38.p6 Ensembl2164,235,929 - 164,238,466 (-)Ensembl
Ensembl Acc Id: ENSMUST00000109374   ⟹   ENSMUSP00000104999
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2164,078,448 - 164,080,184 (-)Ensembl
GRCm38.p6 Ensembl2164,236,528 - 164,238,264 (-)Ensembl
RefSeq Acc Id: NM_017390   ⟹   NP_059086
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392164,077,849 - 164,080,261 (-)NCBI
GRCm382164,235,929 - 164,238,341 (-)ENTREZGENE
MGSCv372164,061,665 - 164,064,077 (-)RGD
Celera2170,167,839 - 170,170,251 (-)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_059086   ⟸   NM_017390
- Peptide Label: precursor
- UniProtKB: Q3UN62 (UniProtKB/TrEMBL),   Q8BS30 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000104999   ⟸   ENSMUST00000109374
Ensembl Acc Id: ENSMUSP00000042389   ⟸   ENSMUST00000044953

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8BS30-F1-model_v2 AlphaFold Q8BS30 1-375 view protein structure

Promoters
RGD ID:6879624
Promoter ID:EPDNEW_M3259
Type:initiation region
Name:Svs2_1
Description:Mus musculus seminal vesicle secretory protein 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm382164,238,265 - 164,238,325EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1858275 AgrOrtholog
Ensembl Genes ENSMUSG00000040132 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000044953 ENTREZGENE
  ENSMUST00000044953.3 UniProtKB/TrEMBL
  ENSMUST00000109374.2 UniProtKB/TrEMBL
InterPro Semenogelin UniProtKB/TrEMBL
  Seminal_vesicle_protein_repeat UniProtKB/TrEMBL
  SVP_II_CS UniProtKB/TrEMBL
KEGG Report mmu:53878 UniProtKB/TrEMBL
MGD MGI:1858275 ENTREZGENE
NCBI Gene 53878 ENTREZGENE
PANTHER SEMENOGELIN/SEMINAL VESICLE SECRETORY PROTEIN UniProtKB/TrEMBL
  SEMINAL VESICLE SECRETORY PROTEIN 2 UniProtKB/TrEMBL
Pfam Semenogelin UniProtKB/TrEMBL
  SVS_QK UniProtKB/TrEMBL
PhenoGen Semg1 PhenoGen
PROSITE SVP_II UniProtKB/TrEMBL
UniProt Q3B802_MOUSE UniProtKB/TrEMBL
  Q3UN62 ENTREZGENE, UniProtKB/TrEMBL
  Q8BS30 ENTREZGENE, UniProtKB/TrEMBL
  Q8C1W4_MOUSE UniProtKB/TrEMBL
  Q8CBV5_MOUSE UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-07-12 Semg1  semenogelin 1  Svs2  seminal vesicle secretory protein 2  Symbol and/or name updated 27372883 PROVISIONAL
2011-07-27 Svs2  seminal vesicle secretory protein 2  Semg1  semenogelin I  Symbol and/or name change 5135510 APPROVED