SEMG1 (semenogelin 1) - Rat Genome Database

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Gene: SEMG1 (semenogelin 1) Homo sapiens
Analyze
Symbol: SEMG1
Name: semenogelin 1
RGD ID: 1349203
HGNC Page HGNC:10742
Description: Enables zinc ion binding activity. Involved in several processes, including negative regulation of calcium ion import; negative regulation of flagellated sperm motility; and positive regulation of serine-type endopeptidase activity. Located in extracellular space. Part of protein-containing complex.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: cancer/testis antigen 103; CT103; dJ172H20.2; FLJ78262; MGC14719; semen coagulating protein; semenogelin I; semenogelin-1; SEMG; SGI; SgI-29
RGD Orthologs
Mouse
Rat
Bonobo
Green Monkey
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382045,207,033 - 45,209,768 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2045,207,033 - 45,209,768 (+)EnsemblGRCh38hg38GRCh38
GRCh372043,835,674 - 43,838,409 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362043,269,088 - 43,271,823 (+)NCBINCBI36Build 36hg18NCBI36
Build 342043,269,087 - 43,271,822NCBI
Celera2040,544,235 - 40,547,011 (+)NCBICelera
Cytogenetic Map20q13.12NCBI
HuRef2040,577,518 - 40,580,294 (+)NCBIHuRef
CHM1_12043,738,369 - 43,740,966 (+)NCBICHM1_1
T2T-CHM13v2.02046,942,926 - 46,945,661 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1517240   PMID:2757795   PMID:2912989   PMID:3889920   PMID:3972122   PMID:6422553   PMID:6484484   PMID:6698208   PMID:8444163   PMID:8654389   PMID:8665951   PMID:8665956  
PMID:8833737   PMID:9092810   PMID:9523691   PMID:10411640   PMID:10412373   PMID:11027412   PMID:11780052   PMID:11784334   PMID:11870067   PMID:12200457   PMID:12399526   PMID:12477932  
PMID:12771235   PMID:14562960   PMID:14581514   PMID:14613901   PMID:14629036   PMID:15342556   PMID:15489334   PMID:15563730   PMID:15590901   PMID:15930278   PMID:15962837   PMID:16344560  
PMID:16582407   PMID:16713569   PMID:17567961   PMID:17624925   PMID:17680810   PMID:17683036   PMID:18314226   PMID:18468680   PMID:18482984   PMID:18714013   PMID:19089943   PMID:19241194  
PMID:19380743   PMID:19889947   PMID:20378931   PMID:21319273   PMID:21525168   PMID:21557275   PMID:21630459   PMID:21873635   PMID:22075473   PMID:22177559   PMID:22617231   PMID:22699487  
PMID:23085372   PMID:23289976   PMID:23533145   PMID:23658844   PMID:24312623   PMID:24811874   PMID:24981860   PMID:25027395   PMID:25458010   PMID:25631074   PMID:26186194   PMID:28514442  
PMID:28675297   PMID:29509190   PMID:29863498   PMID:30097533   PMID:30575326   PMID:30884312   PMID:31180492   PMID:31300519   PMID:31409639   PMID:31535590   PMID:31753913   PMID:32296183  
PMID:32486486   PMID:32707033   PMID:33311447   PMID:33961781   PMID:34732716   PMID:35384245   PMID:36057605   PMID:36225252   PMID:36517590   PMID:38496616  


Genomics

Comparative Map Data
SEMG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382045,207,033 - 45,209,768 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2045,207,033 - 45,209,768 (+)EnsemblGRCh38hg38GRCh38
GRCh372043,835,674 - 43,838,409 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362043,269,088 - 43,271,823 (+)NCBINCBI36Build 36hg18NCBI36
Build 342043,269,087 - 43,271,822NCBI
Celera2040,544,235 - 40,547,011 (+)NCBICelera
Cytogenetic Map20q13.12NCBI
HuRef2040,577,518 - 40,580,294 (+)NCBIHuRef
CHM1_12043,738,369 - 43,740,966 (+)NCBICHM1_1
T2T-CHM13v2.02046,942,926 - 46,945,661 (+)NCBIT2T-CHM13v2.0
Semg1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392164,077,849 - 164,080,261 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2164,077,849 - 164,080,386 (-)EnsemblGRCm39 Ensembl
GRCm382164,235,929 - 164,238,341 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2164,235,929 - 164,238,466 (-)EnsemblGRCm38mm10GRCm38
MGSCv372164,061,665 - 164,064,077 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362163,927,370 - 163,929,706 (-)NCBIMGSCv36mm8
Celera2170,167,839 - 170,170,251 (-)NCBICelera
Cytogenetic Map2H3NCBI
cM Map284.82NCBI
Semg1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83173,329,413 - 173,332,261 (-)NCBIGRCr8
mRatBN7.23152,910,033 - 152,912,882 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3152,910,034 - 152,912,882 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3156,717,524 - 156,720,371 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03165,216,464 - 165,219,312 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03162,961,782 - 162,964,620 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03160,627,609 - 160,630,457 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3160,627,610 - 160,630,457 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03166,811,166 - 166,814,014 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43155,179,283 - 155,182,131 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13155,085,319 - 155,088,167 (-)NCBI
Celera3151,554,969 - 151,557,817 (-)NCBICelera
Cytogenetic Map3q42NCBI
SEMG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22150,940,267 - 50,942,436 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12050,933,374 - 50,935,543 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02041,537,773 - 41,539,964 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12042,628,856 - 42,631,405 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2042,628,856 - 42,631,405 (+)Ensemblpanpan1.1panPan2
LOC103214213
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1218,600,260 - 18,626,326 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605067,269,118 - 67,272,402 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in SEMG1
38 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 20q13.12-13.33(chr20:44787704-64277321)x3 copy number gain See cases [RCV000053035] Chr20:44787704..64277321 [GRCh38]
Chr20:43416345..62908674 [GRCh37]
Chr20:42849759..62379118 [NCBI36]
Chr20:20q13.12-13.33		 pathogenic
NM_003007.3(SEMG1):c.133G>A (p.Gly45Ser) single nucleotide variant Malignant melanoma [RCV000063751] Chr20:45207430 [GRCh38]
Chr20:43836071 [GRCh37]
Chr20:43269485 [NCBI36]
Chr20:20q13.12		 not provided
NM_003007.3(SEMG1):c.1171C>T (p.Pro391Ser) single nucleotide variant Malignant melanoma [RCV000063752] Chr20:45208468 [GRCh38]
Chr20:43837109 [GRCh37]
Chr20:43270523 [NCBI36]
Chr20:20q13.12		 not provided
GRCh38/hg38 20p13-q13.33(chr20:99557-64277321)x3 copy number gain See cases [RCV000135859] Chr20:99557..64277321 [GRCh38]
Chr20:80198..62908674 [GRCh37]
Chr20:28198..62379118 [NCBI36]
Chr20:20p13-q13.33		 pathogenic
GRCh38/hg38 20q11.22-13.12(chr20:35237946-47631818)x1 copy number loss See cases [RCV000140816] Chr20:35237946..47631818 [GRCh38]
Chr20:33825749..46260562 [GRCh37]
Chr20:33289165..45693969 [NCBI36]
Chr20:20q11.22-13.12		 pathogenic
GRCh37/hg19 20p13-q13.33(chr20:61569-62915555)x3 copy number gain See cases [RCV000510832] Chr20:61569..62915555 [GRCh37]
Chr20:20p13-q13.33		 pathogenic
NM_003007.5(SEMG1):c.689A>T (p.His230Leu) single nucleotide variant not specified [RCV004330618] Chr20:45207986 [GRCh38]
Chr20:43836627 [GRCh37]
Chr20:20q13.12		 uncertain significance
NM_003007.5(SEMG1):c.265G>A (p.Ala89Thr) single nucleotide variant not specified [RCV004301151] Chr20:45207562 [GRCh38]
Chr20:43836203 [GRCh37]
Chr20:20q13.12		 uncertain significance
NM_003007.5(SEMG1):c.696T>A (p.Ser232Arg) single nucleotide variant not specified [RCV004282596] Chr20:45207993 [GRCh38]
Chr20:43836634 [GRCh37]
Chr20:20q13.12		 uncertain significance
GRCh37/hg19 20p13-q13.33(chr20:61569-62915555) copy number gain See cases [RCV000512450] Chr20:61569..62915555 [GRCh37]
Chr20:20p13-q13.33		 pathogenic
GRCh37/hg19 20p13-q13.33(chr20:63244-62948788)x3 copy number gain not provided [RCV000741058] Chr20:63244..62948788 [GRCh37]
Chr20:20p13-q13.33		 pathogenic
GRCh37/hg19 20p13-q13.33(chr20:63244-62961294)x3 copy number gain not provided [RCV000741059] Chr20:63244..62961294 [GRCh37]
Chr20:20p13-q13.33		 pathogenic
GRCh37/hg19 20p13-q13.33(chr20:63244-62912463)x3 copy number gain not provided [RCV000741057] Chr20:63244..62912463 [GRCh37]
Chr20:20p13-q13.33		 pathogenic
Single allele deletion Focal-onset seizure [RCV001004039] Chr20:34980430..46806549 [GRCh37]
Chr20:20q11.23-13.13		 likely pathogenic
GRCh37/hg19 20q13.12-13.13(chr20:42985044-48599046)x1 copy number loss Developmental and epileptic encephalopathy, 26 [RCV001801198] Chr20:42985044..48599046 [GRCh37]
Chr20:20q13.12-13.13		 pathogenic
NC_000020.10:g.(?_42223339)_(44638757_?)del deletion Combined immunodeficiency due to STK4 deficiency [RCV003109483] Chr20:42223339..44638757 [GRCh37]
Chr20:20q13.12		 pathogenic
NM_003007.5(SEMG1):c.1028C>T (p.Ala343Val) single nucleotide variant not specified [RCV004333616] Chr20:45208325 [GRCh38]
Chr20:43836966 [GRCh37]
Chr20:20q13.12		 uncertain significance
NM_003007.5(SEMG1):c.244A>C (p.Ser82Arg) single nucleotide variant not specified [RCV004146577] Chr20:45207541 [GRCh38]
Chr20:43836182 [GRCh37]
Chr20:20q13.12		 uncertain significance
NM_003007.5(SEMG1):c.858A>G (p.Ile286Met) single nucleotide variant not specified [RCV004133155] Chr20:45208155 [GRCh38]
Chr20:43836796 [GRCh37]
Chr20:20q13.12		 uncertain significance
NM_003007.5(SEMG1):c.190T>C (p.Ser64Pro) single nucleotide variant not specified [RCV004222956] Chr20:45207487 [GRCh38]
Chr20:43836128 [GRCh37]
Chr20:20q13.12		 uncertain significance
NM_003007.5(SEMG1):c.565G>A (p.Gly189Arg) single nucleotide variant not specified [RCV004239768] Chr20:45207862 [GRCh38]
Chr20:43836503 [GRCh37]
Chr20:20q13.12		 uncertain significance
NM_003007.5(SEMG1):c.1040C>T (p.Ser347Leu) single nucleotide variant not specified [RCV004197991] Chr20:45208337 [GRCh38]
Chr20:43836978 [GRCh37]
Chr20:20q13.12		 uncertain significance
NM_003007.5(SEMG1):c.1243C>G (p.Gln415Glu) single nucleotide variant not specified [RCV004098068] Chr20:45208540 [GRCh38]
Chr20:43837181 [GRCh37]
Chr20:20q13.12		 uncertain significance
NM_003007.5(SEMG1):c.1067G>A (p.Arg356Lys) single nucleotide variant not specified [RCV004191158] Chr20:45208364 [GRCh38]
Chr20:43837005 [GRCh37]
Chr20:20q13.12		 uncertain significance
NM_003007.5(SEMG1):c.395G>A (p.Gly132Glu) single nucleotide variant not specified [RCV004154378] Chr20:45207692 [GRCh38]
Chr20:43836333 [GRCh37]
Chr20:20q13.12		 uncertain significance
NM_003007.5(SEMG1):c.514A>C (p.Ser172Arg) single nucleotide variant not specified [RCV004143546] Chr20:45207811 [GRCh38]
Chr20:43836452 [GRCh37]
Chr20:20q13.12		 uncertain significance
NM_003007.5(SEMG1):c.1058C>T (p.Thr353Met) single nucleotide variant not specified [RCV004072826] Chr20:45208355 [GRCh38]
Chr20:43836996 [GRCh37]
Chr20:20q13.12		 uncertain significance
NM_003007.5(SEMG1):c.338G>A (p.Gly113Asp) single nucleotide variant not specified [RCV004228468] Chr20:45207635 [GRCh38]
Chr20:43836276 [GRCh37]
Chr20:20q13.12		 uncertain significance
NM_003007.5(SEMG1):c.98C>T (p.Pro33Leu) single nucleotide variant not specified [RCV004176956] Chr20:45207395 [GRCh38]
Chr20:43836036 [GRCh37]
Chr20:20q13.12		 uncertain significance
NM_003007.5(SEMG1):c.1348G>A (p.Ala450Thr) single nucleotide variant not specified [RCV004114986] Chr20:45208645 [GRCh38]
Chr20:43837286 [GRCh37]
Chr20:20q13.12		 likely benign
NM_003007.5(SEMG1):c.400A>C (p.Lys134Gln) single nucleotide variant not specified [RCV004208141] Chr20:45207697 [GRCh38]
Chr20:43836338 [GRCh37]
Chr20:20q13.12		 likely benign
NM_003007.5(SEMG1):c.832C>G (p.Gln278Glu) single nucleotide variant not specified [RCV004242419] Chr20:45208129 [GRCh38]
Chr20:43836770 [GRCh37]
Chr20:20q13.12		 likely benign
NM_003007.5(SEMG1):c.634A>G (p.Asn212Asp) single nucleotide variant not specified [RCV004201574] Chr20:45207931 [GRCh38]
Chr20:43836572 [GRCh37]
Chr20:20q13.12		 uncertain significance
NM_003007.5(SEMG1):c.218C>T (p.Ala73Val) single nucleotide variant not specified [RCV004074480] Chr20:45207515 [GRCh38]
Chr20:43836156 [GRCh37]
Chr20:20q13.12		 uncertain significance
NM_003007.5(SEMG1):c.1027G>A (p.Ala343Thr) single nucleotide variant not specified [RCV004076794] Chr20:45208324 [GRCh38]
Chr20:43836965 [GRCh37]
Chr20:20q13.12		 uncertain significance
NM_003007.5(SEMG1):c.638C>T (p.Ser213Phe) single nucleotide variant not specified [RCV004248840] Chr20:45207935 [GRCh38]
Chr20:43836576 [GRCh37]
Chr20:20q13.12		 uncertain significance
NM_003007.5(SEMG1):c.65T>C (p.Met22Thr) single nucleotide variant not specified [RCV004252537] Chr20:45207118 [GRCh38]
Chr20:43835759 [GRCh37]
Chr20:20q13.12		 uncertain significance
NM_003007.5(SEMG1):c.1368C>G (p.Asp456Glu) single nucleotide variant not specified [RCV004275139] Chr20:45208665 [GRCh38]
Chr20:43837306 [GRCh37]
Chr20:20q13.12		 uncertain significance
NM_003007.5(SEMG1):c.1198G>A (p.Gly400Ser) single nucleotide variant not specified [RCV004275995] Chr20:45208495 [GRCh38]
Chr20:43837136 [GRCh37]
Chr20:20q13.12		 uncertain significance
NM_003007.5(SEMG1):c.335A>G (p.Glu112Gly) single nucleotide variant not specified [RCV004355415] Chr20:45207632 [GRCh38]
Chr20:43836273 [GRCh37]
Chr20:20q13.12		 uncertain significance
NM_003007.5(SEMG1):c.194T>C (p.Ile65Thr) single nucleotide variant not specified [RCV004359313] Chr20:45207491 [GRCh38]
Chr20:43836132 [GRCh37]
Chr20:20q13.12		 uncertain significance
NM_003007.5(SEMG1):c.347A>G (p.His116Arg) single nucleotide variant not specified [RCV004450772] Chr20:45207644 [GRCh38]
Chr20:43836285 [GRCh37]
Chr20:20q13.12		 uncertain significance
NM_003007.5(SEMG1):c.804C>G (p.His268Gln) single nucleotide variant not specified [RCV004450777] Chr20:45208101 [GRCh38]
Chr20:43836742 [GRCh37]
Chr20:20q13.12		 uncertain significance
NM_003007.5(SEMG1):c.1307T>C (p.Ile436Thr) single nucleotide variant not specified [RCV004450769] Chr20:45208604 [GRCh38]
Chr20:43837245 [GRCh37]
Chr20:20q13.12		 uncertain significance
NM_003007.5(SEMG1):c.647A>G (p.Asn216Ser) single nucleotide variant not specified [RCV004450774] Chr20:45207944 [GRCh38]
Chr20:43836585 [GRCh37]
Chr20:20q13.12		 uncertain significance
NM_003007.5(SEMG1):c.755A>G (p.Asp252Gly) single nucleotide variant not specified [RCV004450776] Chr20:45208052 [GRCh38]
Chr20:43836693 [GRCh37]
Chr20:20q13.12		 uncertain significance
NM_003007.5(SEMG1):c.1342C>T (p.His448Tyr) single nucleotide variant not specified [RCV004450770] Chr20:45208639 [GRCh38]
Chr20:43837280 [GRCh37]
Chr20:20q13.12		 uncertain significance
NM_003007.5(SEMG1):c.188T>C (p.Phe63Ser) single nucleotide variant not specified [RCV004450771] Chr20:45207485 [GRCh38]
Chr20:43836126 [GRCh37]
Chr20:20q13.12		 uncertain significance
NM_003007.5(SEMG1):c.443A>C (p.Asn148Thr) single nucleotide variant not specified [RCV004450773] Chr20:45207740 [GRCh38]
Chr20:43836381 [GRCh37]
Chr20:20q13.12		 uncertain significance
NC_000020.10:g.(?_42223339)_(45362473_?)del deletion Severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-negative, due to adenosine deaminase deficiency [RCV004579451] Chr20:42223339..45362473 [GRCh37]
Chr20:20q13.12		 pathogenic
NM_003007.5(SEMG1):c.758T>C (p.Ile253Thr) single nucleotide variant not specified [RCV004667100] Chr20:45208055 [GRCh38]
Chr20:43836696 [GRCh37]
Chr20:20q13.12		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:191
Count of miRNA genes:178
Interacting mature miRNAs:180
Transcripts:ENST00000244069, ENST00000372781
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300007BP29_HBlood pressure QTL 29 (human)Blood pressurehypertension susceptibility203653600562536005Human

Markers in Region
RH71011  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372043,834,983 - 43,835,151UniSTSGRCh37
Build 362043,268,397 - 43,268,565RGDNCBI36
Celera2040,543,580 - 40,543,748RGD
Cytogenetic Map20q12-q13.2UniSTS
HuRef2040,576,863 - 40,577,031UniSTS
GeneMap99-GB4 RH Map20237.62UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
255 833 610 520 1044 334 745 163 967 64 596 2499 2174 7 598 397 769 426 103

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_003007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA687874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL049767 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY174423 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY174424 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY174437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY174438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY174439 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY174440 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY174446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY174447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY174448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY256465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY256466 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY256467 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY256468 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY256469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC005229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC007096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC011442 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC055416 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP325874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT007177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA874748 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J04440 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M81650 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z47556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000372781   ⟹   ENSP00000361867
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2045,207,033 - 45,209,768 (+)Ensembl
RefSeq Acc Id: NM_003007   ⟹   NP_002998
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382045,207,033 - 45,209,768 (+)NCBI
GRCh372043,835,605 - 43,838,414 (+)NCBI
Build 362043,269,088 - 43,271,823 (+)NCBI Archive
HuRef2040,577,518 - 40,580,294 (+)ENTREZGENE
CHM1_12043,738,336 - 43,740,966 (+)NCBI
T2T-CHM13v2.02046,942,926 - 46,945,661 (+)NCBI
Sequence:
RefSeq Acc Id: NP_002998   ⟸   NM_003007
- Peptide Label: preproprotein
- UniProtKB: Q86U64 (UniProtKB/Swiss-Prot),   Q6Y823 (UniProtKB/Swiss-Prot),   Q6Y822 (UniProtKB/Swiss-Prot),   Q6Y809 (UniProtKB/Swiss-Prot),   Q6X4I9 (UniProtKB/Swiss-Prot),   Q53ZV2 (UniProtKB/Swiss-Prot),   Q53ZV1 (UniProtKB/Swiss-Prot),   Q53ZV0 (UniProtKB/Swiss-Prot),   Q96QM3 (UniProtKB/Swiss-Prot),   P04279 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSP00000361867   ⟸   ENST00000372781

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P04279-F1-model_v2 AlphaFold P04279 1-462 view protein structure

Promoters
RGD ID:6851728
Promoter ID:EP73669
Type:multiple initiation site
Name:HS_SEMG1
Description:Semenogelin I.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 362043,269,089 - 43,269,149EPD
RGD ID:13207037
Promoter ID:EPDNEW_H27099
Type:initiation region
Name:SEMG1_1
Description:semenogelin I
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382045,207,037 - 45,207,097EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:10742 AgrOrtholog
COSMIC SEMG1 COSMIC
Ensembl Genes ENSG00000124233 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000372781 ENTREZGENE
  ENST00000372781.4 UniProtKB/Swiss-Prot
GTEx ENSG00000124233 GTEx
HGNC ID HGNC:10742 ENTREZGENE
Human Proteome Map SEMG1 Human Proteome Map
InterPro Semenogelin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:6406 UniProtKB/Swiss-Prot
NCBI Gene 6406 ENTREZGENE
OMIM 182140 OMIM
PANTHER SEMENOGELIN-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SEMENOGELIN/SEMINAL VESICLE SECRETORY PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Semenogelin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA35664 PharmGKB
UniProt A0JLP2_HUMAN UniProtKB/TrEMBL
  P04279 ENTREZGENE
  Q53ZV0 ENTREZGENE
  Q53ZV1 ENTREZGENE
  Q53ZV2 ENTREZGENE
  Q6X4I9 ENTREZGENE
  Q6Y806_HUMAN UniProtKB/TrEMBL
  Q6Y808_HUMAN UniProtKB/TrEMBL
  Q6Y809 ENTREZGENE
  Q6Y822 ENTREZGENE
  Q6Y823 ENTREZGENE
  Q86U64 ENTREZGENE
  Q96QM3 ENTREZGENE
  SEMG1_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary Q53ZV0 UniProtKB/Swiss-Prot
  Q53ZV1 UniProtKB/Swiss-Prot
  Q53ZV2 UniProtKB/Swiss-Prot
  Q6X4I9 UniProtKB/Swiss-Prot
  Q6Y809 UniProtKB/Swiss-Prot
  Q6Y822 UniProtKB/Swiss-Prot
  Q6Y823 UniProtKB/Swiss-Prot
  Q86U64 UniProtKB/Swiss-Prot
  Q96QM3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-02-13 SEMG1  semenogelin 1  SEMG1  semenogelin I  Symbol and/or name change 5135510 APPROVED