Gene: KCNH3 (potassium voltage-gated channel subfamily H member 3) Homo sapiens
Symbol: KCNH3
Name: potassium voltage-gated channel subfamily H member 3
Description: The protein encoded by this gene is a voltage-gated potassium channel alpha subunit predominantly expressed in the forebrain. Studies in mice have found that cognitive function increases when this gene is knocked out. In humans, the encoded protein has been shown to be capable of binding glycoprotein 120 of the human immunodeficiency virus type 1 (HIV-1) envelope. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BEC1; brain-specific eag-like channel 1; ELK channel 2; ELK2; ether-a-go-go K(+) channel family member; ether-a-go-go-like potassium channel 2; KIAA1282; Kv12.2; OTTHUMP00000241404; potassium channel, voltage gated eag related subfamily H, member 3; potassium voltage-gated channel, subfamily H (eag-related), member 3; voltage-gated potassium channel subunit Kv12.2
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381249,538,541 - 49,558,312 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371249,932,834 - 49,952,091 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361248,219,207 - 48,238,344 (+)NCBINCBI36hg18NCBI36
Build 341248,219,206 - 48,238,344NCBI
Celera1248,727,399 - 48,746,536 (+)NCBI
Cytogenetic Map12q13.12NCBI
HuRef1246,963,792 - 46,982,929 (+)NCBIHuRef
CHM1_11249,899,177 - 49,918,332 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on KCNH3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733984
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2018-03-13
Status: ACTIVE